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Results for "

NUGC3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (1) HIF/HIF Prolyl-Hydroxylase (1) MDM-2/p53 (3)
By Research Areas:	Cancer (4)

Inhibitors & Agonists

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-120373

MB710 1 Publications Verification	MDM-2/p53	Cancer
MB710, an aminobenzothiazole derivative, is a stabilizer of oncogenic p53 mutation Y220C. MB710 binds tightly to the Y220C pocket and stabilizes p53-Y220C, with a K_d of 4.1 μM. MB710 shows anticancer activity in p53-Y220C cell lines .

HY-175318S

p53 Activator 15	MDM-2/p53	Cancer
p53 Activator 15 (Compound 2) is an orally active p53 activator. p53 Activator 15 enhances the bind ability of p53 Y220C to DNA and significantly suppresses cancer cells proliferation (IC₅₀: 58  nM for NUGC-3 cells), without inhibitory activity against CYP enzyme. p53 Activator 15 potently inhibits tumor growth in NUGC-3 xenograft mice model. p53 Activator 15 has a broad-spectrum anti-cancer activity, such as breast, stomach and lung cancer .

HY-160450

p53 Activator 11	MDM-2/p53	Cancer
p53 Activator 11 (compound A-1) is a potent p53 activator with an EC₅₀ value of 0.478 µM for p53 (Y220C). p53 Activator 11 has the potential for the research of cancer .

HY-170027

LW1564	HIF/HIF Prolyl-Hydroxylase AMPK	Cancer
LW1564 is an inhibitor for HIF-1α with an IC₅₀ of 1.2 µM in HepG2. LW1564 inhibits mitochondrial respiration, reduces ATP production, stimulates HIF-1α degradation, and inhibits proliferation of various cancer cells with GI₅₀ of 0.4-4.6 μM. LW1564 activates AMPK signaling pathway and inhibits lipid synthesis. LW1564 exhibits antitumor in HepG2 xenograft mouse model .

Cat. No.	Product Name	Chemical Structure

HY-175318S

p53 Activator 15
p53 Activator 15 (Compound 2) is an orally active p53 activator. p53 Activator 15 enhances the bind ability of p53 Y220C to DNA and significantly suppresses cancer cells proliferation (IC₅₀: 58  nM for NUGC-3 cells), without inhibitory activity against CYP enzyme. p53 Activator 15 potently inhibits tumor growth in NUGC-3 xenograft mice model. p53 Activator 15 has a broad-spectrum anti-cancer activity, such as breast, stomach and lung cancer .

p53 Activator 15

p53 Activator 15 (Compound 2) is an orally active p53 activator. p53 Activator 15 enhances the bind ability of p53 Y220C to DNA and significantly suppresses cancer cells proliferation (IC₅₀: 58  nM for NUGC-3 cells), without inhibitory activity against CYP enzyme. p53 Activator 15 potently inhibits tumor growth in NUGC-3 xenograft mice model. p53 Activator 15 has a broad-spectrum anti-cancer activity, such as breast, stomach and lung cancer .

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