Search Result

Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

NUGC-3 cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA Alkylator/Crosslinker (1) MDM-2/p53 (2)
By Research Areas:	Cancer (2)

Inhibitors & Agonists

Isotope-Labeled Compounds

Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor Programmed Cell Death 4 (PDCD4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-U00447

PK11000	MDM-2/p53 DNA Alkylator/Crosslinker	Cancer
PK11000 is an alkylating agent, and stabilizes the DNA-binding domain of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding. PK11000 has anti-tumor activities .

HY-175318S

p53 Activator 15	MDM-2/p53	Cancer
p53 Activator 15 (Compound 2) is an orally active p53 activator. p53 Activator 15 enhances the bind ability of p53 Y220C to DNA and significantly suppresses cancer cells proliferation (IC₅₀: 58  nM for NUGC-3 cells), without inhibitory activity against CYP enzyme. p53 Activator 15 potently inhibits tumor growth in NUGC-3 xenograft mice model. p53 Activator 15 has a broad-spectrum anti-cancer activity, such as breast, stomach and lung cancer .

Cat. No.	Product Name	Chemical Structure

HY-175318S

p53 Activator 15
p53 Activator 15 (Compound 2) is an orally active p53 activator. p53 Activator 15 enhances the bind ability of p53 Y220C to DNA and significantly suppresses cancer cells proliferation (IC₅₀: 58  nM for NUGC-3 cells), without inhibitory activity against CYP enzyme. p53 Activator 15 potently inhibits tumor growth in NUGC-3 xenograft mice model. p53 Activator 15 has a broad-spectrum anti-cancer activity, such as breast, stomach and lung cancer .

p53 Activator 15

p53 Activator 15 (Compound 2) is an orally active p53 activator. p53 Activator 15 enhances the bind ability of p53 Y220C to DNA and significantly suppresses cancer cells proliferation (IC₅₀: 58  nM for NUGC-3 cells), without inhibitory activity against CYP enzyme. p53 Activator 15 potently inhibits tumor growth in NUGC-3 xenograft mice model. p53 Activator 15 has a broad-spectrum anti-cancer activity, such as breast, stomach and lung cancer .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Name
Email *

	Sorry, but the email address you supplied was invalid.