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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

NUGC-3 cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibody-Drug Conjugates (ADCs) (1) DNA Alkylator/Crosslinker (1) EGFR (1) MDM-2/p53 (2)
By Research Areas:	Cancer (3) Inflammation/Immunology (1)

Inhibitors & Agonists

Isotope-Labeled Compounds

Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor Programmed Cell Death 4 (PDCD4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-U00447

PK11000	MDM-2/p53 DNA Alkylator/Crosslinker	Cancer
PK11000 is an alkylating agent, and stabilizes the DNA-binding domain of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding. PK11000 has anti-tumor activities .

HY-175318S

p53 Activator 15	MDM-2/p53	Cancer
p53 Activator 15 (Compound 2) is an orally active p53 activator. p53 Activator 15 enhances the bind ability of p53 Y220C to DNA and significantly suppresses cancer cells proliferation (IC₅₀: 58  nM for NUGC-3 cells), without inhibitory activity against CYP enzyme. p53 Activator 15 potently inhibits tumor growth in NUGC-3 xenograft mice model. p53 Activator 15 has a broad-spectrum anti-cancer activity, such as breast, stomach and lung cancer .

HY-177414

BB-1701	Antibody-Drug Conjugates (ADCs) EGFR	Inflammation/Immunology Cancer
BB-1701 is an anti-HER2 antibody-drug conjugate (ADC). BB-1701 is composed of a humanized anti-HER2 antibody (Trastuzumab) (HY-P9907), a linker (Mal-PEG2-VCP), a microtubule inhibitor (Eribulin) (HY-13442), and the drug-linker conjugate for ADC is Mal-PEG2-VCP-Eribulin (HY-128870). BB-1701 has a potent cytotoxicity and bystander effects on tumors with heterogeneous target expression. BB-1701 significantly induces immunogenic cell death and the activation of the immune .

Cat. No.	Product Name	Chemical Structure

HY-175318S

p53 Activator 15
p53 Activator 15 (Compound 2) is an orally active p53 activator. p53 Activator 15 enhances the bind ability of p53 Y220C to DNA and significantly suppresses cancer cells proliferation (IC₅₀: 58  nM for NUGC-3 cells), without inhibitory activity against CYP enzyme. p53 Activator 15 potently inhibits tumor growth in NUGC-3 xenograft mice model. p53 Activator 15 has a broad-spectrum anti-cancer activity, such as breast, stomach and lung cancer .

p53 Activator 15

p53 Activator 15 (Compound 2) is an orally active p53 activator. p53 Activator 15 enhances the bind ability of p53 Y220C to DNA and significantly suppresses cancer cells proliferation (IC₅₀: 58  nM for NUGC-3 cells), without inhibitory activity against CYP enzyme. p53 Activator 15 potently inhibits tumor growth in NUGC-3 xenograft mice model. p53 Activator 15 has a broad-spectrum anti-cancer activity, such as breast, stomach and lung cancer .

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