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NPCs

" in MedChemExpress (MCE) Product Catalog:

63

Inhibitors & Agonists

1

Fluorescent Dye

6

Peptides

3

Inhibitory Antibodies

9

Natural
Products

4

Isotope-Labeled Compounds

10

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-113845
    (+)-Intermedine

    		Others Neurological Disease
    (+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs) .
    (+)-Intermedine
  • HY-P99544
    Tagitanlimab

    HBM-9167; KL-A167

    		 PD-1/PD-L1 Cancer
    Tagitanlimab (HBM-9167) is a humanized anti-PD-L1 antibody (IgG1κ type). Tagitanlimab selectively blocks the interaction of PD-L1 and PD-1. Tagitanlimab has the potential to be studied in recurrent or metastatic nasopharyngeal carcinoma (NPC) .
    Tagitanlimab
  • HY-169652
    NPC26

    		Reactive Oxygen Species AMPK Cancer
    NPC26 is a small molecule mitochondrial disruptor with anti-tumor activity. NPC-26 shows significant anti-proliferative and cytotoxic effects on CRC cell lines (HCT-116, DLD-1, and HT-29). NPC26 can damage mitochondrial function, leading to the opening of the mitochondrial permeability transition pore (mPTP) and the production of reactive oxygen species, ultimately inducing cell death. NPC-26 can kill CRC cells by activating the AMP-activated protein kinase (AMPK) signaling pathway .
    NPC26
  • HY-116815
    Lalistat 1

    		Beta-lactamase Bacterial Infection Neurological Disease
    Lalistat 1 is a potent, selective, and competitive inhibitor of lysosomal acid lipase (LAL) and against purified human LAL (phLAL) with an IC50 of 68 nM. Lalistat 1 is a inhibitor of immunoglobulin A1 protease (IgA1P) proteases for H. influenzae, has less effects on other serine hydrolases (trypsin or β-lactamase, etc.). Lalistat 1 can be used for the research of niemann-pick type C (NPC) disease .
    Lalistat 1
  • HY-16459
    Glycididazole sodium

    Sodium glycididazole

    		 Apoptosis Cancer
    Glycididazole sodium (Sodium glycididazole) is a radiosensitizer. Glycididazole sodium increases the sensitivity of nasopharyngeal carcinoma cells to radiation, through increaased DNA damage and enhanced apoptosis in NPC cells
    Glycididazole sodium
  • HY-137135
    Cantharidic acid

    		Phosphatase Apoptosis ERK p38 MAPK JNK Cancer
    Cantharidic acid is a selective inhibitor for protein phosphatase 2 (PP2A) and protein phosphatase 1 (PP1). Cantharidic acid inhibits cell viability and arrest cell cycle at sub G1 phase, induces apoptosis in cells NPC-39 and HONE-1 through the upregulation of ERK1/2, p38, and JNK1/2 pathway .
    Cantharidic acid
  • HY-P10412
    A11

    ANXA1-derived 11 amino acid–long peptide

    		 Ephrin Receptor Cancer
    A11 (ANXA1-derived 11 amino acid–long peptide) is an ANXA1-EphA2 interaction blocker peptide. A11 decreases ANXA1 bound to EphA2 and increased Cbl (an E3 ubiquitin ligase of EphA2) bound to EphA2. A11 efficiently decreases EphA2 level, and substantially increases EphA2 ubiquitination. A11 increases EphA2 internalization and colocalization of EphA2 and Cbl in the NPC cells. A11 inhibits nasopharyngeal carcinoma (NPC) cell proliferation, migration and invasion. A11 inhibits angiogenesis .
    A11
  • HY-P2118
    NPC-567

    		Bradykinin Receptor Inflammation/Immunology
    NPC-567 is a bradykinin B2 receptor antagonist. NPC-567 is effective in inhibiting the acute response to allergen in the airways .
    NPC-567
  • HY-129980
    NPC-15437 dihydrochloride

    		PKC Neurological Disease
    NPC-15437 dihydrochloride is a selective, penetrable and reversible protein kinase C (PKC) inhibitor, with an IC50 of 19 μM. NPC-15437 dihydrochloride interferes with mechanisms underlying memory consolidation .
    NPC-15437 dihydrochloride
  • HY-RS09474
    NPC1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    NPC1 Human Pre-designed siRNA Set A contains three designed siRNAs for NPC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    NPC1 Human Pre-designed siRNA Set A
    NPC1 Human Pre-designed siRNA Set A
  • HY-RS09476
    NPC2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    NPC2 Human Pre-designed siRNA Set A contains three designed siRNAs for NPC2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    NPC2 Human Pre-designed siRNA Set A
    NPC2 Human Pre-designed siRNA Set A
  • HY-RS17456
    Npc2 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Npc2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Npc2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Npc2 Mouse Pre-designed siRNA Set A
    Npc2 Mouse Pre-designed siRNA Set A
  • HY-RS23218
    Npc1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Npc1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Npc1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Npc1 Rat Pre-designed siRNA Set A
    Npc1 Rat Pre-designed siRNA Set A
  • HY-RS23913
    Npc2 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Npc2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Npc2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Npc2 Rat Pre-designed siRNA Set A
    Npc2 Rat Pre-designed siRNA Set A
  • HY-P1721
    NPC 17731

    		Bradykinin Receptor Cardiovascular Disease
    NPC 17731 is a new bradykinin (BK) receptor antagonist. NPC 17731 antagonized both the contractile and relaxant responses caused by BK in longitudinal smooth muscle with IC50 of 23 and 29 nM, respectively .
    NPC 17731
  • HY-RS16778
    Npc1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Npc1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Npc1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Npc1 Mouse Pre-designed siRNA Set A
    Npc1 Mouse Pre-designed siRNA Set A
  • HY-RS09475
    NPC1L1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    NPC1L1 Human Pre-designed siRNA Set A contains three designed siRNAs for NPC1L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    NPC1L1 Human Pre-designed siRNA Set A
    NPC1L1 Human Pre-designed siRNA Set A
  • HY-RS23972
    Npc1l1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Npc1l1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Npc1l1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Npc1l1 Rat Pre-designed siRNA Set A
    Npc1l1 Rat Pre-designed siRNA Set A
  • HY-RS17515
    Npc1l1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Npc1l1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Npc1l1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Npc1l1 Mouse Pre-designed siRNA Set A
    Npc1l1 Mouse Pre-designed siRNA Set A
  • HY-P99362
    Ensituximab

    Anti-MUC5AC Reference Antibody (ensituximab); NEO-102

    		 Mucin Cancer
    Ensituximab (NEO-102; NPC-1C) is a chimeric monoclonal IgG1 antibody targeting a variant of MUC5AC. Ensituximab shows specificity to colorectal and pancreatic cancer .
    Ensituximab
  • HY-100961
    NPC 200

    1,3-Dipropyl-8-phenylxanthine

    		 Adenosine Receptor Inflammation/Immunology
    NPC 200 is a potent and selective antagonist of Adenosine A1 Receptor. NPC 200 reverses NECA-induced left and right atrial depression with EC50s of 1.08 and 2.03 μM .
    NPC 200
  • HY-W014780
    α-Amylcinnamaldehyde

    2-Benzylideneheptanal; α-Pentylcinnamaldehyde

    		 CETP Others
    α-Amylcinnamaldehyde is a ligand for the Niemann-Pick type C2 (NPC2) protein of arthropod moths and may play a key role in the identification of moth volatiles. NPC2 is a key enzyme for cholesterol transport in the body .
    α-Amylcinnamaldehyde
  • HY-N6842
    ArnicolideC

    		Others Infection Cancer
    ArnicolideC is a sesquiterpene lactone isolated Centipeda minima . ArnicolideC exertes a cytotoxic effect on the panel of Nasopharyngeal carcinoma (NPC) cells, significantly inhibiting cell growth in a dose- and time- dependent manner. ArnicolideC also exhibits inhibitory effects on NPC proliferation .
    ArnicolideC
  • HY-P99621
    Fiztasovimab

    NPC-21; EV2038

    		 CMV Infection
    Fiztasovimab (NPC-21; EV2038) is a fully human IgG1λ mAb against human cytomegalovirus (hCMV). Fiztasovimab acts neutralizing activity by binding to the antigenic domain 1 of glycoprotein B on hCMV envelope. Fiztasovimab inhibits cell-to-cell transmission of hCMV .
    Fiztasovimab
  • HY-140694
    m-PEG-NPC (MW 20000)

    		PROTAC Linkers Cancer
    m-PEG-NPC (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
    m-PEG-NPC (MW 20000)
  • HY-120429
    SKLB-163

    		Apoptosis Cancer
    SKLB-163 is an orally active inhibitor for Rho GDP-dissociation (RhoGDI). SKLB-163 inhibits highly expressed RhoGDI tumor cell proliferation and migration, and increases radiosensitivity of tumor cells. SKLB-163 induces cancer cell Apoptosis .
    SKLB-163
  • HY-111355B
    Cholesteryl sulfate sodium

    		Endogenous Metabolite Metabolic Disease
    Cholesteryl sulfate sodium is an orally available, NPC2-targeted cholesterol biosynthesis agonist. Cholesteryl sulfate sodium activates SREBP2 by competitively binding to NPC2, promoting cholesterol synthesis (EC50=50 μM). Cholesteryl sulfate sodium enhances the self-assembly ability of Mitoxantrone hydrochloride (HY-13502A), while repairing the intestinal mucosal barrier and inhibiting inflammation by regulating serine protease activity and PKCη signaling pathway. Cholesteryl sulfate sodium is a component of the platelet cell membrane and supports platelet adhesion. Cholesteryl sulfate sodium also regulates the activity of selective protein kinase C isoforms and modulates the specificity of PI3K, playing a role in keratinocyte differentiation .
    Cholesteryl sulfate sodium
  • HY-W010514
    trans-Cyclohexane-1,2-diol

    		Endogenous Metabolite Metabolic Disease
    trans-Cyclohexane-1,2-diol (TCHD) is a transient dilator of the nuclear pore complex (NPC). By interacting with the hydrophobic core (FG nucleoporin) of the NPC, trans-Cyclohexane-1,2-diol can disrupt the NPC structure and reversibly increase the permeability of the nuclear pore, allowing macromolecules larger than 40 kDa (such as plasmid DNA) to enter the cell nucleus by passive diffusion, thereby enhancing the nuclear import efficiency of non-viral vectors. trans-Cyclohexane-1,2-diol can improve the efficiency of in vitro electrotransfection or lipid-mediated gene transfection, especially significantly increasing gene expression in differentiated airway epithelial cells .
    trans-Cyclohexane-1,2-diol
  • HY-103641C
    Octyl-α-hydroxyglutarate

    Octyl-2-HG

    		 Histone Methyltransferase Cancer
    Octyl-α-hydroxyglutarate (octyl-2-HG) increases histone methylation and enhances viability of LMP1-negative NPC cells .
    Octyl-α-hydroxyglutarate
  • HY-D2314
    Cyanine 7-amine chloride hydrochloride

    		Liposome Others
    Cyanine 7-amine (chloride hydrochloride) can be used to label cationic nanoparticles (NPs) or to NP conjugates (NPCs). It can track the residence time and clearance of nanoparticles in the body .
    Cyanine 7-amine chloride hydrochloride
  • HY-N2292
    Kinsenoside
    3 Publications Verification

    		 Keap1-Nrf2 Apoptosis Inflammation/Immunology
    Kinsenoside is the main active ingredient of the genus plant, and has various biological activities. Kinsenoside and Nrf2 depend on the protection of nuclear cells (NPCs), which significantly reduces their ability to survive. Kinsenoside Active NPC Medium AKT-ERK1/2-Nrf2 Signal passage, Prevent physical decline, aging, harmonious physical function impairment. Kinsenoside can improve the puncture guide model for intermediate vertebral wall discharge (IDD).
    Kinsenoside
  • HY-100638A
    RPR132595A hydrochloride

    NPC hydrochloride

    		 Drug Metabolite Cancer
    RPR132595A (NPC) hydrochloride is an active metabolite of CPT-11, which is generated by cytochrome P-450 3A4 (CYP3A4) and finally excreted through urine .
    RPR132595A hydrochloride
  • HY-100638
    RPR132595A

    NPC

    		 Drug Metabolite Cancer
    RPR132595A (NPC) is an active metabolite of CPT-11, which is generated by cytochrome P-450 3A4 (CYP3A4) and finally excreted through urine .
    RPR132595A
  • HY-10996
    KHS101

    		FGFR Neurological Disease
    KHS101 is a small molecule that accelerates neuronal differentiation. KHS101 can distributes to the brain and resulted in a significant increase in neuronal differentiation .
    KHS101
  • HY-17376
    Ezetimibe
    5+ Cited Publications

    SCH 58235

    		 Keap1-Nrf2 Autophagy Cardiovascular Disease Cancer
    Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
    Ezetimibe
  • HY-17376S
    Ezetimibe-d4

    SCH 58235-d4

    		 Autophagy Keap1-Nrf2 Isotope-Labeled Compounds Cardiovascular Disease Cancer
    Ezetimibe-d4 is the deuterium labeled Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
    Ezetimibe-d4
  • HY-17640
    Nicodicosapent

    		Fatty Acid Synthase (FASN) Autophagy Metabolic Disease
    Nicodicosapent is a fatty acid niacin conjugate that is also an inhibitor of the sterol regulatory element binding protein (SREBP), a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1.
    Nicodicosapent
  • HY-136433
    N,N'-Dinitrosopiperazine

    1,4-Dinitrosopiperazine; DNP

    		 Others Cancer
    N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) is a carcinogen with specificity for nasopharyngeal epithelium and facilitates NPC metastasis. N,N'-Dinitrosopiperazine regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568 .
    N,N'-Dinitrosopiperazine
  • HY-160880
    EBOV-IN-5

    		Filovirus Infection
    EBOV-IN-5 (compound 14) is an antiviral agent that inhibits Ebola virus (EBOV) infection. EBOV-IN-5 inhibits the binding of the EBOV glycoprotein EBOV-GPcl to NPC1, an indispensable host receptor required for viral fusion/entry .
    EBOV-IN-5
  • HY-135388
    ent-Ezetimibe

    ent-SCH 58235

    		 Drug Metabolite Cardiovascular Disease
    ent-Ezetimibe (ent-SCH 58235) is the RRS-enantiomer of Ezetimibe. Ezetimibe is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator .
    ent-Ezetimibe
  • HY-136059
    Desfluoro-ezetimibe

    		Keap1-Nrf2 Autophagy Cardiovascular Disease Cancer
    Desfluoro-ezetimibe is a desfluoro impurity of Ezetimibe. Ezetimibe is a potent, metabolically stable cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator .
    Desfluoro-ezetimibe
  • HY-17376S1
    Ezetimibe-d4-1

    SCH 58235-d4-1

    		 Keap1-Nrf2 Autophagy Cardiovascular Disease Cancer
    Ezetimibe-d4-1 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
    Ezetimibe-d4-1
  • HY-133114
    Ezetimibe ketone

    EZM-K

    		 Keap1-Nrf2 Autophagy Cardiovascular Disease Cancer
    Ezetimibe ketone (EZM-K) is a phase-I metabolite of Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe is a potent cholesterol absorption inhibitor .
    Ezetimibe ketone
  • HY-160882
    EBOV-IN-7

    		Filovirus Infection
    EBOV-IN-7 (compound 26) is an inhibitor of the Ebola virus EBOV with an IC50 of 2.04 μM against EBOV-GP pseudotyped virus (pEBOV). EBOV-IN-7 has inhibitory effects on cancer cells and inhibits the EBOV-GPcl/NPC1 interaction .
    EBOV-IN-7
  • HY-17376R
    Ezetimibe (Standard)
    5+ Cited Publications

    SCH 58235 (Standard)

    		 Keap1-Nrf2 Autophagy Cardiovascular Disease Cancer
    Ezetimibe (Standard) is the analytical standard of Ezetimibe. This product is intended for research and analytical applications. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
    Ezetimibe (Standard)
  • HY-160581
    OH-C-Chol

    		Liposome Others
    OH-C-Chol is a cationic liposome that serves as a siRNA delivery vehicle. OH-C-Chol (LP-C) and OH-NC-Chol (LP-NC)/siRNA complexes (lipoplexes) showed better performance than NP-C and NP-NC/siRNA complexes (nanocomplexes), respectively. ) greater gene silencing effect .
    OH-C-Chol
  • HY-136433S
    N,N'-Dinitrosopiperazine-d8

    1,4-Dinitrosopiperazine-d8; DNP-d8

    		 Isotope-Labeled Compounds Cancer
    N,N'-Dinitrosopiperazine-d8 is the deuterium labeled N,N'-Dinitrosopiperazine . N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine;DNP) is a carcinogen with specificity for nasopharyngeal epithelium and facilitates NPC metastasis. N,N'-Dinitrosopiperazine regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568 .
    N,N'-Dinitrosopiperazine-d8
  • HY-113427
    trans-Vaccenic acid
    1 Publications Verification

    		 Endogenous Metabolite Bcl-2 Family Apoptosis Cardiovascular Disease Cancer
    trans-Vaccenic acid is a naturally occurring trans fatty acid (TFA). trans-Vaccenic acid inhibits nasopharyngeal carcinoma (NPC) cell growth and induces apoptosis through the inhibition of Bad/Akt phosphorylation. trans-Vaccenic acid is a precursor for the synthesis of saturated fatty acid in the rumen and of conjugated Linoleic acid (CLA) at the tissue level. trans-Vaccenic acid exerts hypolipidemic effects in a rat model of obesity .
    trans-Vaccenic acid
  • HY-W395779
    EBOV-IN-1

    		Filovirus Infection
    EBOV-IN-1 (com 3.47) is an adamantane dipeptide piperazine and an inhibitor of Ebola virus (EBOV). EBOV-IN-1 targets Niemann-Pick C1 (NPC1) and inhibits its binding to the EBOV glycoprotein (GP) that activates and mediates viral penetration into host cells, thereby inhibiting EBOV infection. EBOV-IN-1 inhibits pseudotyped EBOV infection with an IC50 of 13 nM .
    EBOV-IN-1
  • HY-121315
    BRD4097

    		HDAC Metabolic Disease
    BRD4097 is an inhibitor of histone deacetylase (HDAC). BRD4097 acts by inhibiting the activity of HDACs, especially HDAC 1,2 and 3, through metal chelation and spatial rejection mechanisms, and this inhibition may help regulate gene expression and alter chromatin structure, thereby affecting a variety of biological processes. BRD4097 is used to study the role of HDAC in cholesterol metabolism and NPC1 diseases .
    BRD4097

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