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NFAT 133

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N16431
    NFAT-133

    		AMPK Nuclear Factor of activated T Cells (NFAT) Interleukin Related Endogenous Metabolite Metabolic Disease Inflammation/Immunology
    NFAT-133 is an aromatic polyketide with immunosuppressive and antidiabetic activity. NFAT-133 activates the AMPK pathway, promoting glucose uptake in L6 muscle fibers, thereby resisting diabetes. NFAT-133 inhibits the transcriptional activity of activated T-cell nuclear factor (NFAT), thereby suppressing the expression of IL-2 and the proliferation of T cells, demonstrating an immunosuppressive effect. NFAT-133 does not exhibit antibacterial activity or cytotoxicity, but it can weaken the production of NO in RAW264.7 cells induced by Lipopolysaccharide (LPS) (HY-D1056) .
    NFAT-133

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