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NCX reverse mode

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-123785
    ORM-10962
    2 Publications Verification

    		 Na+/Ca2+ Exchanger Metabolic Disease
    ORM-10962 is a potent, highly selective sodium-calcium exchanger (NCX) inhibitor, with IC50 values of 67 and 55 nM for the reverse and forward mode inhibition, respectively. ORM-10962 shows antiarrhythmic effect .
    ORM-10962
  • HY-125942
    SKF-96365

    		CRAC Channel TRP Channel Na+/Ca2+ Exchanger Calcium Channel CaMK Akt Apoptosis Autophagy Neurological Disease Cancer
    SKF-96365 is a blocker of calcium store-operated calcium influx (SOCE) and transient receptor potential channels (TRPC). SKF-96365 reduces the increase in intracellular calcium concentration by blocking TRPC channels and SOCE. SKF-96365 enhances the reverse operation of Na⁺/Ca²⁺ exchanger (NCX) (Ca²⁺ influx) in glioblastoma, leading to intracellular calcium overload and cytotoxicity. SKF-96365 inhibits the CaMKIIγ/AKT pathway and simultaneously induces apoptosis and cell protective autophagy in colorectal cancer cells. SKF-96365 can be used in calcium signaling and cancer research .
    SKF-96365

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