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MTX

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (1) Androgen Receptor (1) Antifolate (7) Apoptosis (2) Bacterial (1) Biochemical Assay Reagents (1) Deubiquitinase (1) Drug Derivative (1) Drug Isomer (1) Drug Metabolite (2) EGFR (4) Endogenous Metabolite (7) Fluorescent Dye (1) Isotope-Labeled Compounds (2) Mitophagy (1) p38 MAPK (1) PI3K (4) PPAR (1) PROTACs (1) Reference Standards (2) Small Interfering RNA (siRNA) (5) Syk (1) Thymidylate Synthase (1)
By Research Areas:	Cancer (18) Infection (1) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (3) siRNAs (5)

Inhibitors & Agonists

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Isotope-Labeled Compounds

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107364

MTX-211 3 Publications Verification Mol 211	EGFR PI3K	Cancer
MTX-211 (Mol 211) is a dual inhibitor of EGFR and PI3K with IC₅₀ values of ＜100 nM. MTX-211 can be used for the research of cancer and other diseases .

HY-148771

MTX-23 PROTAC AR-V7 degrader-2	PROTACs Androgen Receptor Apoptosis	Cancer
MTX-23 is an AR-based PROTAC. MTX-23 inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. MTX-23 induces apoptosis .

HY-160019

MTX115325	Deubiquitinase Mitophagy	Neurological Disease
MTX115325 (Example 1) is an orally active, brain-penetrating USP30 inhibitor (IC₅₀=12 nM) with neuroprotective activity. MTX115325 increases ubiquitination (EC₅₀=32 nM) of the mitochondrial outer membrane protein TOM20 (a USP30 substrate), increasing mitophagy. MTX115325 prevents dopaminergic neuron loss and preserves striatal dopamine .

HY-162713

MTX-531	EGFR PI3K PPAR	Cancer
MTX-531 is an oral drug that inhibits EGFR (with an IC₅₀ of 14.7 nM) and PI3K (with IC₅₀ values of 6.4, 233, 8.3, and 1.1 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ respectively), and it has anti-tumor effects. MTX-531 also acts as a weak agonist of PPARγ, with an IC₅₀ of 2.5 µM, helping to alleviate hyperglycemia induced by PI3K inhibitors .

HY-RS22244

Mtx1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mtx1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mtx1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mtx1 Mouse Pre-designed siRNA Set A Mtx1 Mouse Pre-designed siRNA Set A

HY-RS08828

MTX1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MTX1 Human Pre-designed siRNA Set A contains three designed siRNAs for MTX1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MTX1 Human Pre-designed siRNA Set A MTX1 Human Pre-designed siRNA Set A

HY-156872

MTX-216	PI3K EGFR Syk Apoptosis	Cancer
MTX-216 is a dual ATP-competitive inhibitor of PI3K and EGFR. MTX-216 cosuppresses Ki-67 and ribosomal S6 phosphorylation and induces apoptosis in NF1 ^LOF cells. MTX-216 suppresses the activity of SYK kinase, with an IC₅₀ of 281 nM. MTX-216 is used in the research of Melanoma .

HY-149556

MTX-241F	EGFR PI3K	Cancer
MTX-241F is a selective small molecule inhibitor targeting EGFR and PI3 kinase family members. MTX-241F is able to penetrate the blood-brain barrier and control tumor growth over the long term. MTX-241F exhibits radiosensitizing activity in patient-derived DIPG neurospheres and may be used in the study of diffuse intrinsic pontine glioma (DIPG) .

HY-RS08829

MTX2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MTX2 Human Pre-designed siRNA Set A contains three designed siRNAs for MTX2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MTX2 Human Pre-designed siRNA Set A MTX2 Human Pre-designed siRNA Set A

HY-RS28766

Mtx1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mtx1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mtx1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mtx1 Rat Pre-designed siRNA Set A Mtx1 Rat Pre-designed siRNA Set A

HY-RS08830

MTX3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MTX3 Human Pre-designed siRNA Set A contains three designed siRNAs for MTX3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MTX3 Human Pre-designed siRNA Set A MTX3 Human Pre-designed siRNA Set A

HY-D2435

MTX-PEG-Cy3	Fluorescent Dye	Inflammation/Immunology Cancer
CDDP-PEG-Cy3 is a MTX-PEG conjugate labeled with Cy3 (HY-D0822). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. The maximum emission wavelength of Cy3 is approximately 562-570 nm. Methotrexate (Amethopterin; MTX) (HY-14519), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .

HY-169067

10-Methoxy-canthin-6-one MTX-C	p38 MAPK	Cancer
0-Methoxy-canthin-6-one (Mtx-C) is a DNA damage inducer. 0-Methoxy-canthin-6-one promotes cell cycle arrest at the G2/M phase by intercalating into DNA, thereby inducing myeloid differentiation of acute myeloid leukemia (AML) cells and leukemic stem cells (LSCs). The myeloid differentiation in AML and LSC cells is characterized by increased expression of myeloperoxidase, CD15, CD11b, and CD14, as well as activation of p38 MAPK. 0-Methoxy-canthin-6-one can be used in leukemia research .

HY-17556A

Folinic acid disodium Leucovorin disodium	Endogenous Metabolite Antifolate	Cancer
Folinic acid (Leucovorin) disodium is a biological folic acid and is a forms of vitamin B9. Folinic acid disodium is generally administered along with Methotrexate (HY-14519) as a rescue agent to decrease MTX-induced toxicity. Folinic acid disodium and Sfluorouracil adjuvant chemotherapy shows effective in colon carcinoma .

HY-130569

7-Hydroxymethotrexate	Drug Metabolite	Inflammation/Immunology Cancer
7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .

HY-13617

Edatrexate CGP 30694	Antifolate	Cancer
Edatrexate (CGP 30694), as known as 10-Ethyl-10-deazaaminopterin, is Methotrexate (HY-14519) analog, exhibits antitumor activity against MTX-resistant tumors. Edatrexate is an antifolate antimetabolite, can be used for reasearch of non-small-cell lung cancer, breast cancer, non-Hodgkin's lymphoma, and cancer of the head and neck .

HY-13664

Folinic acid calcium Maximum Cited Publications 11 Publications Verification Leucovorin calcium; Calcium folinate	Antifolate Endogenous Metabolite	Cancer
Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity .

HY-B0080

Folinic acid calcium salt pentahydrate Maximum Cited Publications 11 Publications Verification Leucovorin calcium salt pentahydrate	Antifolate Endogenous Metabolite	Cancer
Folinic acid calcium salt pentahydrate (Leucovorin calcium salt pentahydrate) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity .

HY-115429

Calcium dextrofolinate 6R-Leucovorin calcium; (6R)-Folinic acid calcium	Drug Isomer	Metabolic Disease
Calcium dextrofolinate is a stereoisomer of Calcium folinate. Calcium folinate (Folinic acid calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity .

HY-13664R

Folinic acid calcium (Standard) Leucovorin calcium (Standard); Calcium folinate (Standard)	Reference Standards Antifolate Endogenous Metabolite	Cancer
Folinic acid (calcium) (Standard) is the analytical standard of Folinic acid (calcium). This product is intended for research and analytical applications. Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity .

HY-W653912A

Leucovorin-d4 (calcium hydrate), >90%	Isotope-Labeled Compounds	Cancer
Leucovorin-d₄ (Leucovorin-d₄) calcium hydrate, >90% is a deuterated labeled Folinic acid (Leucovorin, HY-17556). Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity .

HY-17556

Folinic acid Maximum Cited Publications 11 Publications Verification leucovorin	Antifolate Endogenous Metabolite	Cancer
Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (HY-14519) as a rescue agent to decrease MTX-induced toxicity .

HY-N0913

Manninotriose	Endogenous Metabolite	Others
Manninotriose is a novel and important player in the RFO(Raffinose family oligosaccharides) metabolism of red dead deadnettle; potential to improve the side effects of MTX for ALL treatment.

HY-W047788

H-Dab(Boc)-OH	Amino Acid Derivatives	Others
H-Dab(Boc)-OH is an amino acid derivative with a Boc protecting group, which can be used to synthesize methotrexate (MTX) analogs with antitumor and antifolate activities .

HY-121702

Dihydrohomofolic acid	Drug Derivative	Cancer
Dihydrohomofolic acid, an analog of dihydrofolic acid (H₂F), might be effective against tumor in which resistance to methotrexate (MTX) is associated with high leveIs of H₂F-reductase .

HY-17556R

Folinic acid (Standard) leucovorin (Standard)	Reference Standards Antifolate Endogenous Metabolite	Cancer
Folinic acid (Standard) is the analytical standard of Folinic acid. This product is intended for research and analytical applications. Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (HY-14519) as a rescue agent to decrease MTX-induced toxicity .

HY-W654227

7-Hydroxy methotrexate-d3 ammonium salt	Isotope-Labeled Compounds Drug Metabolite	Inflammation/Immunology
7-Hydroxy methotrexate-d₃ (ammonium salt) is deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .

HY-P11101

plCSA-BP	Biochemical Assay Reagents	Others
plCSA-BP is a Placental CSA-binding peptide. plCSA-BP binds specifically to trophoblasts and not to other cell types in the placenta or to CSA-expressing cells in other tissues. plCSA-BP can guide nanoparticles for the targeted delivery of payloads (such as Indocyanine green (ICG) (HY-D0711) and Methotrexate (MTX) (HY-14519)) to the placenta, promising for placenta-specific drug delivery .

HY-124093

8-Deazahomofolic acid	Thymidylate Synthase Bacterial	Infection Cancer
8-Deazahomofolic acid is an inhibitor of thymidylate synthase (TS) and other folate-related enzymes. 8-Deazahomofolic acid shows inhibitory activity against folate-dependent S. faecium, L. casei, and MTX (HY-14519) resistant strains. 8-Deazahomofolic acid also inhibits the growth of L1210 leukemia cells, with an IC₅₀ value of 87.5 μM. 8-Deazahomofolic acid can be used in research on bacterial infections and tumors .

Cat. No.	Product Name	Type

HY-D2435

MTX-PEG-Cy3	Dyes
CDDP-PEG-Cy3 is a MTX-PEG conjugate labeled with Cy3 (HY-D0822). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. The maximum emission wavelength of Cy3 is approximately 562-570 nm. Methotrexate (Amethopterin; MTX) (HY-14519), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .

MTX-PEG-Cy3

Dyes

CDDP-PEG-Cy3 is a MTX-PEG conjugate labeled with Cy3 (HY-D0822). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. The maximum emission wavelength of Cy3 is approximately 562-570 nm. Methotrexate (Amethopterin; MTX) (HY-14519), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .

Cat. No.	Product Name	Target	Research Area

HY-W047788

H-Dab(Boc)-OH	Amino Acid Derivatives	Others
H-Dab(Boc)-OH is an amino acid derivative with a Boc protecting group, which can be used to synthesize methotrexate (MTX) analogs with antitumor and antifolate activities .

HY-P11101

plCSA-BP	Biochemical Assay Reagents	Others
plCSA-BP is a Placental CSA-binding peptide. plCSA-BP binds specifically to trophoblasts and not to other cell types in the placenta or to CSA-expressing cells in other tissues. plCSA-BP can guide nanoparticles for the targeted delivery of payloads (such as Indocyanine green (ICG) (HY-D0711) and Methotrexate (MTX) (HY-14519)) to the placenta, promising for placenta-specific drug delivery .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13664

Folinic acid calcium Maximum Cited Publications 11 Publications Verification Leucovorin calcium; Calcium folinate	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Antifolate Endogenous Metabolite
Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity .

HY-B0080

Folinic acid calcium salt pentahydrate Maximum Cited Publications 11 Publications Verification Leucovorin calcium salt pentahydrate	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Antifolate Endogenous Metabolite
Folinic acid calcium salt pentahydrate (Leucovorin calcium salt pentahydrate) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity .

HY-17556

Folinic acid Maximum Cited Publications 11 Publications Verification leucovorin	Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Plants Moraceae Endogenous metabolite Disease Research Fields Morus alba Linn. Cancer	Antifolate Endogenous Metabolite
Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (HY-14519) as a rescue agent to decrease MTX-induced toxicity .

HY-N0913

Manninotriose	Structural Classification Polysaccharides Microorganisms other families Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields Saccharides	Endogenous Metabolite
Manninotriose is a novel and important player in the RFO(Raffinose family oligosaccharides) metabolism of red dead deadnettle; potential to improve the side effects of MTX for ALL treatment.

HY-17556R

Folinic acid (Standard) leucovorin (Standard)	Natural Products Human Gut Microbiota Metabolites Source classification Plants Moraceae Endogenous metabolite Morus alba Linn.	Reference Standards Antifolate Endogenous Metabolite
Folinic acid (Standard) is the analytical standard of Folinic acid. This product is intended for research and analytical applications. Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (HY-14519) as a rescue agent to decrease MTX-induced toxicity .

HY-17556A

Folinic acid disodium Leucovorin disodium	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Antifolate
Folinic acid (Leucovorin) disodium is a biological folic acid and is a forms of vitamin B9. Folinic acid disodium is generally administered along with Methotrexate (HY-14519) as a rescue agent to decrease MTX-induced toxicity. Folinic acid disodium and Sfluorouracil adjuvant chemotherapy shows effective in colon carcinoma .

HY-13664R

Folinic acid calcium (Standard) Leucovorin calcium (Standard); Calcium folinate (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Antifolate Endogenous Metabolite
Folinic acid (calcium) (Standard) is the analytical standard of Folinic acid (calcium). This product is intended for research and analytical applications. Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity .

Cat. No.	Product Name	Chemical Structure

HY-W653912A

Leucovorin-d4 (calcium hydrate), >90%
Leucovorin-d₄ (Leucovorin-d₄) calcium hydrate, >90% is a deuterated labeled Folinic acid (Leucovorin, HY-17556). Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity .

HY-W654227

7-Hydroxy methotrexate-d3 ammonium salt
7-Hydroxy methotrexate-d₃ (ammonium salt) is deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83516

	MTX3 Antibody (YA3261) Metaxin-3	WB	Mouse, Rat
	MTX3 Antibody (YA3261) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MTX3.

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MTX

Inhibitors & Agonists

Fluorescent Dye

Peptides

NaturalProducts

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Natural
Products