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Results for "

MSA

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

1

Natural
Products

2

Antibodies

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-136927
    MSA-2
    15+ Cited Publications

    		 STING Inflammation/Immunology Cancer
    MSA-2, a potent and orally available non-nucleotide STING agonist, is bound to STING as a noncovalent dimer with nanomolar affinity. MSA-2 shows EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models .
    MSA-2
  • HY-141514
    MSA-2 dimer
    1 Publications Verification

    		 STING Inflammation/Immunology Cancer
    MSA-2 dimer is a selective, orally active non-nucleotide STING agonist (Kd=145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer is bound to STING as a non-covalent dimer exhibiting higher permeability than cyclic dinucleotide .
    MSA-2 dimer
  • HY-N3265
    Methyl sinapate

    MSA

    		 Others Others
    Methyl sinapate (MSA), a hydroxycinnamic acid, is a natural UV screening agent .
    Methyl sinapate
  • HY-162133
    MSA-2-Pt

    		STING Cancer
    MSA-2-Pt is an orally active STING agonist that has good cell membrane permeability. MSA-2-Pt can induce cell death by Pt, which may release damaged DNA to activate the cGAS-STING pathway. Besides, MSA-2-Pt can activate the STING pathway directly by MSA-2. MSA-2-Pt can be used for the research of cancer .
    MSA-2-Pt
  • HY-123439
    FTY720-C2

    		Others Neurological Disease
    FTY720-C2 is a derivative of FTY72 (HY-12005). FTY720-C2 promotes the expression of brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) in multiple system atrophy (MSA) models, without causing immunosuppression. FTY720-C2 improves motor dysfunction and reduces the levels of insoluble alpha-synuclein (αSyn) in MSA mouse models. FTY720-C2 is blood-brain barrier penetrate .
    FTY720-C2
  • HY-153575
    BacPROTAC-1

    		PROTACs Bacterial Infection
    BacPROTAC-1 is a mSA BacPROTAC degrader. BacPROTAC-1 binds mSA and ClpCNTD with high affinity (KDs of 3.9 and 2.8 μM, respectively) .
    BacPROTAC-1
  • HY-173316
    STING-IN-12

    		STING Inflammation/Immunology
    STING-IN-12 (compound Y2) is an inhibitor of STING. STING-IN-12 inhibits IFNβ gene expression (IC50=0.75μM) induced by SR717. STING-IN-12 inhibits STING pathway activation induced by the STING agonist SR717 in THP1 cells and MSA-2-induced STING pathway activation in vivo in mice .
    STING-IN-12
  • HY-RS20731
    Exo1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Exo1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Exo1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Exo1 Mouse Pre-designed siRNA Set A
    Exo1 Mouse Pre-designed siRNA Set A
  • HY-163749
    STING-IN-8

    		STING Inflammation/Immunology
    STING-IN-8 (Compound 15b) emerges as a potent stimulator of interferon gene (STING) inhibitor with an IC50 value of 0.121 μM in human and an IC50 value of 0.033 μM in mouse. STING-IN-8 inhibits MSA-2 (HY-136927) or 2’, 3’ -cGAMP (HY-100564)-stimulated STING signaling and suppresses immune-inflammatory cytokine levels in both human and murine cells. STING-IN-8 is promising for research in the field of STING-associated inflammatory and autoimmune diseases .
    STING-IN-8
  • HY-RS14941
    TPO Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    TPO Human Pre-designed siRNA Set A contains three designed siRNAs for TPO gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TPO Human Pre-designed siRNA Set A
    TPO Human Pre-designed siRNA Set A
  • HY-B1435A
    Moxisylyte

    Thymoxamine

    		 Adrenergic Receptor Neurological Disease
    Moxisylyte (Thymoxamine) is an alpha 1-selective antagonist with activity that improves bladder emptying. Moxisylyte is used to suppress urinary difficulties in patients with multiple system atrophy (MSA) by blocking alpha 1-adrenergic receptors to reduce the amount of residual urine after urination. Moxisylyte is also used to suppress erectile dysfunction and can improve blood circulation problems caused by Raynaud's syndrome in the short term. In addition, Moxisylyte can be applied topically to the eye to reverse the mydriasis caused by phenylephrine and other sympathetic stimulants .
    Moxisylyte
  • HY-160116
    α-Synuclein aggregate binder 1

    		Radionuclide-Drug Conjugates (RDCs) Fluorescent Dye α-synuclein Neurological Disease
    α-Synuclein aggregate binder 1 (Compound C05-05) is a specific binder for α-synuclein aggregates and can inhibit α-synuclein aggregation. α-Synuclein aggregate binder 1 can be used as a fluorescent probe (excitation wavelength 900 nm, detection wavelength 500-550 nm) for optical imaging, and can also inhibit α-synuclein fibril formation by blocking the aggregation process. α-Synuclein aggregate binder 1 can be used for positron emission tomography (PET) imaging after being labeled with 18F. α-Synuclein aggregate binder 1 can be used for visual diagnosis of brain lesions and mechanism research of neurodegenerative diseases such as Parkinson's disease and Lewy body dementia .
    α-Synuclein aggregate binder 1

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