2. Immunology/Inflammation
  3. STING
  4. STING agonist-47

STING agonist-47 is a STING agonist with an EC50 of 0.72 μM and a Kd of 176 nM. STING agonist-47 is a dimer of MSA-2 (HY-136927). STING agonist-47 can be used for the research of cancer, such as breast cancer.

For research use only. We do not sell to patients.

STING agonist-47

STING agonist-47 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

STING agonist-47 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

STING agonist-47 is a STING agonist with an EC50 of 0.72 μM and a Kd of 176 nM. STING agonist-47 is a dimer of MSA-2 (HY-136927). STING agonist-47 can be used for the research of cancer, such as breast cancer[1].

In Vitro

STING agonist-47 (Compound SC2S) (0.71 μM, 24 h) activates the interferon pathway in THP-1 Lucia ISG cells[1].
STING agonist-47 (5 μM, 0.5-4 h) treatment of THP-1 Lucia ISG cells leads to significantly increased phosphorylation levels of key STING pathway proteins (pSTING, pTBK1, pIRF3)[1].
STING agonist-47 (25 μM, 6 h) induces IFN-β secretion in THP-1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

STING agonist-47 Related Antibodies
In Vivo

STING agonist-47 (Compound SC2S) (0.62 μM, immersion administration, daily from 1 day post-infection to 4 for 3 consecutive days) inhibits tumor growth in 2-day-post-fertilization casper or nacre mutant zebrafish xenografted with Hs578T triple-negative breast cancer cells[1].
STING agonist-47 (8.6 mg/kg, intratumoral injection) inhibits tumor growth in BALB/c mice inoculated with CT26mβGUS colon cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 2-day-post-fertilization (dpf) casper or nacre mutant zebrafish xenografted with Hs578T triple-negative breast cancer cells[1]
Dosage: 0.62 μM
Administration: Immersion administration, daily from 1 day post-infection to 4 for 3 consecutive days
Result: Induced tumor cell apoptosis (activates Caspase3).
Reduced tumor size and increased the number of tumor-associated macrophages (TAM).
Promoted macrophage polarization to the proinflammatory M1 phenotype (expressing TNF).
Molecular Weight

618.76

Formula

C28H26O8S4
SMILES

COC1=CC2=C(C=C1SCCSC3=CC4=C(SC(C(CCC(O)=O)=O)=C4)C=C3OC)C=C(S2)C(CCC(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

STING agonist-47 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STING agonist-47STING agonist47STING agonist 47STINGStimulator of Interferon GenesTMEM173MITAERISMPYSdimercancerbreast cancerTHP-1ISGIFN-βcolon cancerInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
STING agonist-47
Cat. No.:
HY-178338
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.