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Pathways Recommended: Stem Cell/Wnt Cell Cycle/DNA Damage
Results for "

MKN1 cell

" in MedChemExpress (MCE) Product Catalog:
Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-163815
    CDK2 degrader 2

    		PROTACs CDK Cancer
    CDK2 degrader 2 (Compound I-10) is a PROTAC degrader for CDK2 that degrades CDK2 in MKN1 cell with a DC50 <100 nM . (Pink: ligand for target protein (HY-176124); Black: linker (HY-W687952); Blue: ligand for E3 ligase CRBN (HY-45512))
    CDK2 degrader 2
  • HY-W687952
    Piperidine-C-piperidine-Boc

    		PROTAC Linkers Others
    Piperidine-C-piperidine-Boc is a PROTAC linker. Piperidine-C-piperidine-Boc is the linker of CDK2 degrader 2 (HY-163815) .
    Piperidine-C-piperidine-Boc
  • HY-U00447
    PK11000

    		MDM-2/p53 DNA Alkylator/Crosslinker Cancer
    PK11000 is an alkylating agent, and stabilizes the DNA-binding domain of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding. PK11000 has anti-tumor activities .
    PK11000
  • HY-156465
    RIOK2-IN-2

    		Ser/Thr Kinase Cancer
    RIOK2-IN-2 (8) is a RIOK2 inhibitor, with IC50 values of 3.02 μM and 5.34 μM in MKN-1 and MOLT4 cells, respectively .
    RIOK2-IN-2
  • HY-161463
    CDK2-IN-28

    		CDK Cancer
    CDK2-IN-28 (compound 22) is a CDK2 inhibitor with good selectivity and cellular effects against other CDKs. CDK2-IN-28 has anti-proliferative effects on MKN1 cells (EC50: 0.31 μM) .
    CDK2-IN-28
  • HY-156792
    RIOK2-IN-1

    		Ser/Thr Kinase Cancer
    RIOK2-IN-1 (com 4) is a potent and selective RIOK2 inhibitor (Kd=150 nM), but has low cellular activity (IC50=14,600 nM). RIOK2 is an atypical kinase associated with a variety of human cancers and is involved in ribosome maturation and cell cycle progression. The small molecule inhibitor CQ211 (HY-147655), an improvement of RIOK2-IN-1 as the lead compound, has good in vivo and in vitro activity, inhibits the proliferation of MKN-1 and HT-29 cancer cells, and can xenograft MKN in mice -1 model inhibits tumor progression .
    RIOK2-IN-1
  • HY-176124
    CDK2 ligand-2

    		Ligands for Target Protein for PROTAC Cancer
    CDK2 ligand-2 is a PROTAC target protein ligand (Ligands for Target Protein for PROTAC). CDK2 ligand-2 combined with E3 Ligase Ligand-linker Conjugate 184 (HY-176125) can be used to synthesize PROTAC degrader (CDK2 degrader 2 (HY-163815)) .
    CDK2 ligand-2

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