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Results for "

MKK3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (1) COX (1) Ferroptosis (1) Isotope-Labeled Compounds (1) MEK (2) NF-κB (1) NO Synthase (1) p38 MAPK (4) PKC (3) Reactive Oxygen Species (ROS) (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (3) Infection (1) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (3)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

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Isotope-Labeled Compounds

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-150612

(R)-STU104	p38 MAPK	Cancer
(R)-STU104 is a potent and orally active TAK1-MKK3 interaction inhibitor with IC₅₀s of 0.58 μM and 4.0 μM for TNF-α and MKK3 phosphorylation. (R)-STU104 suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signal pathways through binding with MKK3 and disrupting the TAK1 phosphorylating MKK3. (R)-STU104 can be used for researching ulcerative colitis .

HY-150612S

(R)-STU104-d6	Isotope-Labeled Compounds p38 MAPK	Cancer
(R)-STU104-d₆ is a deuterium labeled (R)-STU104 (HY-150612). (R)-STU104 is a potent and orally active TAK1-MKK3 interaction inhibitor with IC₅₀s of 0.58 μM and 4.0 μM for TNF-α and MKK3 phosphorylation. (R)-STU104 suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signal pathways through binding with MKK3 and disrupting the TAK1 phosphorylating MKK3. (R)-STU104 can be used for researching ulcerative colitis .

HY-119917

Gossypetin 1 Publications Verification	p38 MAPK MEK Bacterial	Infection Cancer
Gossypetin is a hexahydroxylated flavonoid and is a potent mitogen-activated protein kinase kinase (MKK)3 and *MKK6* inhibitor with strongly attenuates the *MKK3/6-p38* signaling pathway, has various pharmacological activities, including antioxidant, antibacterial and anticancer activities .

HY-13866

Ro 31-8220 mesylate Maximum Cited Publications 13 Publications Verification Ro 31-8220 methanesulfonate; Bisindolylmaleimide IX mesylate	PKC	Cardiovascular Disease Neurological Disease Cancer
Ro 31-8220 mesylate is a potent PKC inhibitor, with IC₅₀s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC₅₀s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7.

HY-N0811

Anemarsaponin B	NO Synthase COX NF-κB MEK	Inflammation/Immunology
Anemarsaponin B is a steroidal saponin. Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of NF-κB by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect .

HY-13866A

Ro 31-8220 Bisindolylmaleimide IX	PKC	Cardiovascular Disease Neurological Disease
Ro 31-8220 is a potent PKC inhibitor, with IC₅₀s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC₅₀s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7.

HY-P10852

*TAT-MKK3b*	p38 MAPK Ferroptosis Reactive Oxygen Species (ROS)	Metabolic Disease
TAT-MKK3b is a p38 peptide inhibitor. TAT-MKK3b can inhibit p38 phosphorylation. TAT-MKK3b has renal targeting, ROS-scavenging, and ferroptosis-mitigating capabilities. TAT-MKK3b improves acute kidney injury and its progression to chronic kidney disease .

HY-13866R

Ro 31-8220 mesylate (Standard)	PKC	Cardiovascular Disease Neurological Disease Cancer
Ro 31-8220 (mesylate) (Standard) is the analytical standard of Ro 31-8220 (mesylate). This product is intended for research and analytical applications. Ro 31-8220 mesylate is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7.

HY-RS08039

MAP2K3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MAP2K3 Human Pre-designed siRNA Set A contains three designed siRNAs for MAP2K3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MAP2K3 Human Pre-designed siRNA Set A MAP2K3 Human Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area

HY-P10852

*TAT-MKK3b*	p38 MAPK Ferroptosis Reactive Oxygen Species (ROS)	Metabolic Disease
TAT-MKK3b is a p38 peptide inhibitor. TAT-MKK3b can inhibit p38 phosphorylation. TAT-MKK3b has renal targeting, ROS-scavenging, and ferroptosis-mitigating capabilities. TAT-MKK3b improves acute kidney injury and its progression to chronic kidney disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-119917

Gossypetin 1 Publications Verification	Infection Flavonols Structural Classification Flavonoids Classification of Application Fields Rhodiola rosea Linn. Crassulaceae Source classification Phenols Polyphenols Plants Disease Research Fields	p38 MAPK MEK Bacterial
Gossypetin is a hexahydroxylated flavonoid and is a potent mitogen-activated protein kinase kinase (MKK)3 and *MKK6* inhibitor with strongly attenuates the *MKK3/6-p38* signaling pathway, has various pharmacological activities, including antioxidant, antibacterial and anticancer activities .

HY-N0811

Anemarsaponin B	Structural Classification Liliaceae Classification of Application Fields Source classification Anemarrhena asphodeloides Bunge Plants Inflammation/Immunology Disease Research Fields Steroids	NO Synthase COX NF-κB MEK
Anemarsaponin B is a steroidal saponin. Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of NF-κB by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect .

Cat. No.	Compare	Product Name	Species	Source

HY-P703587

	MAP2K3 Protein, Human (sf9, His, GST) MEK3; MKK3; PRKMK3; SKK2	Human	Sf9 insect cells
	MAP2K3 Protein, Human (sf9, His, GST) is the recombinant human-derived MAP2K3, expressed by sf9 insect cells , with His, GST labeled tag. ,

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Cat. No.	Product Name	Chemical Structure

HY-150612S

(R)-STU104-d6
(R)-STU104-d₆ is a deuterium labeled (R)-STU104 (HY-150612). (R)-STU104 is a potent and orally active TAK1-MKK3 interaction inhibitor with IC₅₀s of 0.58 μM and 4.0 μM for TNF-α and MKK3 phosphorylation. (R)-STU104 suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signal pathways through binding with MKK3 and disrupting the TAK1 phosphorylating MKK3. (R)-STU104 can be used for researching ulcerative colitis .

(R)-STU104-d6

(R)-STU104-d₆ is a deuterium labeled (R)-STU104 (HY-150612). (R)-STU104 is a potent and orally active TAK1-MKK3 interaction inhibitor with IC₅₀s of 0.58 μM and 4.0 μM for TNF-α and MKK3 phosphorylation. (R)-STU104 suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signal pathways through binding with MKK3 and disrupting the TAK1 phosphorylating MKK3. (R)-STU104 can be used for researching ulcerative colitis .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P84341

	MAP2K3 Antibody (YA4038) MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2	IHC-P, ICC/IF, FC, ELISA	Human
	MAP2K3 Antibody (YA4038) is a mouse-derived and non-conjugated IgG1 antibody, targeting to MAP2K3. It can be applicated for IHC-P, ICC/IF, FC, ELISA assays, in the background of human.

HY-P83469

	MEK3 Antibody (YA3214) AW212142; dual specificity mitogen activated protein kinase kinase 3; Dual specificity mitogen activated protein kinase kinase 6; Dual specificity mitogen-activated protein kinase kinase 3; MAP kinase kinase 3; MAP kinase kinase 6; map2k3; MAP2K6; MAPK ERK kinase 3; MAPK/ERK kinase 3; MAPK/ERK kinase 6; MAPKK 3; MAPKK 6; MAPKK3; MAPKK6; MEK 3; MEK 6; MEK3; Mitogen activated protein kinase kinase 3; Mitogen activated protein kinase kinase 6; MKK 3; MKK3; MKK6; mMKK3b; MP2K3_HUMAN; PRKMK 3; PRKMK3; PRKMK6; Protein kinase; mitogen activated; kinase 6 (MAP kinase kinase 6); protein kinase; mitogen-activated; kinase 3; SAPK kinase 2; SAPKK 2; SAPKK 3; SAPKK-2; SAPKK2; SAPKK3; Stress activated protein kinase kinase 2; Stress activated protein kinase kinase 3; Stress-activated protein kinase kinase 2.	WB, ICC/IF, IP	Human, Mouse, Rat
	MEK3 Antibody (YA3214) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3214), targeting MEK3, with a predicted molecular weight of 39 kDa (observed band size: 38-40 kDa). MEK3 Antibody (YA3214) can be used for WB, ICC/IF,IP experiment in human, mouse, rat background.

HY-P86356

	MEK-3 Antibody (YA6048) MAP2K3; MEK3; MKK3; PRKMK3; SKK2; Dual specificity mitogen-activated protein kinase kinase 3; MAP kinase kinase 3; MAPKK 3; MAPK/ERK kinase 3; MEK 3; Stress-activated protein kinase kinase 2; SAPK kinase 2; SAPKK-2; SAPKK2	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	MEK-3 Antibody (YA6048) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEK-3. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.