LMP2

By Targets:	Apoptosis (2) EBV (1) IFNAR (1) Liposome (1) Proteasome (8) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (3) Infection (1) Inflammation/Immunology (7)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P5470

LMP2A (426-434)	EBV IFNAR	Inflammation/Immunology
LMP2A (426-434) is a HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope of Epstein-Barr virus (EBV) latent membrane protein 2A (LMP2A). LMP2A (426-434) can trigger an immune response in individuals expressing different HLA-A02 subtypes (A02:01, A02:03, A02:06 and A02:07). LMP2A (426-434) can induce a strong IFN-γ* secretion response, stimulating the production of a high proportion of CD8 ⁺ IFN-γ ⁺ T cells. LMP2A (426-434) induces specific CTLs to effectively kill target cells expressing LMP2A. LMP2A (426-434) can be used to study EBV-related malignant tumors (such as Hodgkin's disease and nasopharyngeal carcinoma) ^[2].

HY-123052

Ac-PAL-AMC	Proteasome	Inflammation/Immunology
Ac-PAL-AMC is a fluorogenic substrate specific for 20S proteasome *LMP2/β1i* activity .

HY-101786

KZR-504 3 Publications Verification	Proteasome	Inflammation/Immunology
KZR-504 is a highly selective inhibitor of immunoproteasome low molecular mass polypeptide 2 *(LMP2), with IC₅₀s* of 51 nM, 4.274 μM for LMP2 and LMP7, respectively. KZR-504 is of interest for the treatment of autoimmune disease .

HY-114170

ML604440 2 Publications Verification	Proteasome	Inflammation/Immunology
ML604440 is a specific and cell-permeable Proteasome β1i (LMP2) subunit inhibitor. ML604440 can be used in experimental colitis, EAE and autoimmune disease research. ML604440 shows synergistic effects and advantageous when combined with LMP7 inhibitor ^[2] .

HY-114419A

Zetomipzomib maleate 2 Publications Verification KZR-616 maleate	Proteasome	Inflammation/Immunology
Zetomipzomib (KZR-616) maleate, a first-in-class immunoproteasome inhibitor, selectively targets the LMP7 (IC₅₀: 39/57 nM=hLMP7/mLMP7) and LMP2 (IC₅₀: 131/179 nM=hLMP2/mLMP2) subunits of the immunoproteasome. Zetomipzomib maleate has the potential for the research of multiple autoimmune diseases ^[2].

HY-114419

Zetomipzomib 2 Publications Verification KZR-616	Proteasome	Inflammation/Immunology
Zetomipzomib (KZR-616), a first-in-class inhibitor of the immunoproteasome, selectively targets the LMP7 (IC₅₀: 39/57 nM=hLMP7/mLMP7) and LMP2 (IC₅₀: 131/179 nM=hLMP7/mLMP7) subunits of the immunoproteasome. Zetomipzomib has the potential for the research of multiple autoimmune diseases ^[2].

HY-119037

UK-101	Proteasome Apoptosis	Cancer
UK-101 is a potent and selective immunoproteasome β1i (LMP2) inhibitor with an IC₅₀ value of 104 nM, displays 144- and 10-fold selectivity over β1c (IC₅₀=15 μM) and β5 subunit (IC₅₀=1 μM), respectivey . UK-101 induces cell apoptosis and can be used for the study of prostate cancer ^[2].

HY-162754

LMP7/LMP2-IN-1	Proteasome	Inflammation/Immunology
LMP7/LMP2-IN-1 (Compound 19) is the orally active inhibitor for immunoproteasome subunits *LMP7* and *LMP2* with IC₅₀ of 257 and 10 nM. LMP7/LMP2-IN-1 reduces the generation of antibody, downregulates the cells in spleen germinal center B and in plasma in NP-OVA-immunized mice, and can be used in research about autoimmune diseases .

HY-108553

Dihydroeponemycin	Proteasome Apoptosis	Cancer
Dihydroeponemycin, an analogue of the antitumor and antiangiogenic natural product eponemycin, selectively targets the 20S proteasome. Dihydroeponemycin covalently modifies a subset of catalytic proteasomal subunits, binding preferentially to the IFN-gamma-inducible subunits LMP2 and LMP7. Dihydroeponemycin-mediated proteasome inhibition induces a spindle-like cellular morphological change and apoptosis .

HY-169480

Lipid C2	Liposome	Infection Cancer
Lipid C2 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNP) for mRNA delivery in vivo. LNPs containing Lipid C2 and encapsulating an mRNA reporter selectively accumulate in the liver and spleen but not the heart, lungs, or kidneys in mice. LNP containing Lipid C2 and encapsulating mRNA encoding the Epstein-Barr virus (EBV) protein latent membrane protein 2 (LMP-2), in combination with an anti-programmed cell death protein 1 (PD-1) antibody, decrease tumor volume and reverse T cell exhaustion, as well as increase the percentage of CD3 ⁺CD8 ⁺ central and CD3 ⁺CD8 ⁺ effector memory T cells and decrease the percentage of CD3 ⁺ T cells expressing Pd-1, in the spleen in a CT26 murine EBV-infected colon cancer model .

HY-RS17772

Psmb9 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Psmb9 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Psmb9 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Psmb9 Mouse Pre-designed siRNA Set A Psmb9 Mouse Pre-designed siRNA Set A

HY-RS24239

Psmb9 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Psmb9 Rat Pre-designed siRNA Set A contains three designed siRNAs for Psmb9 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Psmb9 Rat Pre-designed siRNA Set A Psmb9 Rat Pre-designed siRNA Set A

HY-RS11309

PSMB9 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PSMB9 Human Pre-designed siRNA Set A contains three designed siRNAs for PSMB9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PSMB9 Human Pre-designed siRNA Set A PSMB9 Human Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area

HY-P5470

LMP2A (426-434)	EBV IFNAR	Inflammation/Immunology
LMP2A (426-434) is a HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope of Epstein-Barr virus (EBV) latent membrane protein 2A (LMP2A). LMP2A (426-434) can trigger an immune response in individuals expressing different HLA-A02 subtypes (A02:01, A02:03, A02:06 and A02:07). LMP2A (426-434) can induce a strong IFN-γ* secretion response, stimulating the production of a high proportion of CD8 ⁺ IFN-γ ⁺ T cells. LMP2A (426-434) induces specific CTLs to effectively kill target cells expressing LMP2A. LMP2A (426-434) can be used to study EBV-related malignant tumors (such as Hodgkin's disease and nasopharyngeal carcinoma) ^[2].

Species:	Human (9) Mouse (2)
Tag:	His (11) Avi (11)
Source:	HEK293 (11)

Cat. No.	Compare	Product Name	Species	Source

HY-P77766

	*HLA-A02:01&B2M&LMP2(CLGGLLTMV) Monomer Protein, Human (HEK293, His-Avi)** MHC; RMF; LMP2; LMP-2; Macropain chain 7; Proteasome chain 7; PSMB9; RING12	Human	HEK293

HY-P77768

	*HLA-A02:01&B2M&LMP2(CLGGLLTMV) Tetramer Protein, Human (HEK293, His-Avi)** MHC; RMF; LMP2; LMP-2; Macropain chain 7; Proteasome chain 7; PSMB9; RING12	Human	HEK293

HY-P700933

	*HLA-A11:01&B2M&LMP2(SSCSSCPLTK) Monomer Protein, Human (HEK293, His-Avi)** MHC; RMF; LMP2; LMP-2; Macropain chain 7; Proteasome chain 7; PSMB9; RING12	Human	HEK293

HY-P700934

	*HLA-A11:01&B2M&LMP2(SSCSSCPLTK) Tetramer Protein, Human (HEK293, His-Avi)** MHC; RMF; LMP2; LMP-2; Macropain chain 7; Proteasome chain 7; PSMB9; RING12	Human	HEK293

HY-P77767

	*HLA-A02:01&B2M&LMP2(CLGGLLTMV) Monomer Protein, Human (Biotinylated, HEK293, His-Avi)** MHC; RMF; LMP2; LMP-2; Macropain chain 7; Proteasome chain 7; PSMB9; RING12	Human	HEK293

HY-P700932

	*HLA-A11:01&B2M&LMP2(SSCSSCPLTK) Monomer Protein, Human (Biotinylated, HEK293, His-Avi)** MHC; RMF; LMP2; LMP-2; Macropain chain 7; Proteasome chain 7; PSMB9; RING12	Human	HEK293

HY-P77772

	*Chimeric HLA-A02:01(mα3)&B2M&LMP2(CLGGLLTMV) Tetramer Protein, Human&Mouse (HEK293, His-Avi)** MHC; RMF; LMP2; LMP-2; Macropain chain 7; Proteasome chain 7; PSMB9; RING12	Mouse	HEK293

HY-P77771

	*Chimeric HLA-A02:01(mα3)&B2M&LMP2(CLGGLLTMV) Monomer Protein, Human&Mouse (HEK293, His-Avi)** MHC; RMF; LMP2; LMP-2; Macropain chain 7; Proteasome chain 7; PSMB9; RING12	Mouse	HEK293

HY-P705308

	*HLA-A02:01&B2M&EBV LMP2(FLYALALLL) Monomer Protein, Human (Biotinylated, HEK293, His-Avi)** HLA-A0201 & B2M & EBV LMP*2 (FLYALALLL)	Human	HEK293

HY-P705353

	*HLA-A11:01&B2M&EBV LMP2(SSCSSCPLSK) Monomer Protein, Human (Biotinylated, HEK293, His-Avi)** HLA-A1101 & B2M & EBV LMP*2 (SSCSSCPLSK)	Human	HEK293

HY-P705309

	*HLA-A02:01&B2M&EBV LMP2A(CLGGLLTMV) Monomer Protein, Human (Biotinylated, HEK293, His-Avi)** HLA-A0201 & B2M & EBV LMP*2A (CLGGLLTMV)	Human	HEK293

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HY-P82002

	*Proteasome 20S LMP2* Antibody (YA1747)** Beta1i; LMP2; PSMB 9; PSMB6i; PSMB9; RING12	WB, ICC/IF	Human, Mouse, Rat
	Proteasome 20S LMP2 Antibody (YA1747) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Proteasome 20S LMP2.

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Cat. No.	Product Name		Classification

HY-RS17772

Psmb9 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Psmb9 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Psmb9 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24239

Psmb9 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Psmb9 Rat Pre-designed siRNA Set A contains three designed siRNAs for Psmb9 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS11309

PSMB9 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PSMB9 Human Pre-designed siRNA Set A contains three designed siRNAs for PSMB9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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