2. Search Result
Search Result
Isoforms Recommended: LATS1
Results for "

LATS1

" in MedChemExpress (MCE) Product Catalog:

16

Inhibitors & Agonists

1

Biochemical Assay Reagents

2

Recombinant Proteins

2

Antibodies

1

Click Chemistry

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-138489
    TRULI
    Maximum Cited Publications
    22 Publications Verification

    LATS-IN-1

    		 YAP Others
    TRULI (Lats-IN-1) is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. TRULI promotes Yap-dependent proliferation in postmitotic mammalian tissues [1].
    TRULI
  • HY-147165
    VT02956

    		YAP Cancer
    VT02956 is a LATS inhibitor (IC50: 0.76 nM for LATS1, 0.52 nM for LATS2). VT02956 targets the Hippo pathway. VT02956 inhibits ESR1 expression and growth of ER+ breast cancer cell lines and patient-derived tumor organoids [1]. VT02956 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    VT02956
  • HY-139330
    MGH-CP1
    1 Publications Verification

    		 Apoptosis Cancer
    MGH-CP1 is a potent and orally active TEAD2 and TEAD4 auto-palmitoylation inhibitor with IC50s of 710 nM and 672 nM, respectively. MGH-CP1 can decrease the palmitoylation levels of endogenous or ectopically expressed TEAD proteins in cells. MGH-CP1 can suppress Myc expression, inhibit epithelial over-proliferation, and induce apoptosis when together with Lats1/2 deletion [1].
    MGH-CP1
  • HY-147082
    GA-017
    3 Publications Verification

    		 YAP Cancer
    GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids [1].
    GA-017
  • HY-120139
    KMH-233
    1 Publications Verification

    		 Amino acid Transporter Cancer
    KMH-233, a potent, reversible and selective inhibitor of l-type amino acid transporter LAT1/SLC7A5, inhibits the uptake of LAT1 substrate, l-leucin (IC50=18 μM) as well as cell growth. KMH-233 significantly potentiates the efficacy of Bestatin and Cisplatin even at low concentrations (25 μM) [1].
    KMH-233
  • HY-RS23797
    Lats1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Lats1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Lats1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Lats1 Rat Pre-designed siRNA Set A
    Lats1 Rat Pre-designed siRNA Set A
  • HY-RS17343
    Lats1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Lats1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lats1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Lats1 Mouse Pre-designed siRNA Set A
    Lats1 Mouse Pre-designed siRNA Set A
  • HY-RS07538
    LATS1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    LATS1 Human Pre-designed siRNA Set A contains three designed siRNAs for LATS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    LATS1 Human Pre-designed siRNA Set A
    LATS1 Human Pre-designed siRNA Set A
  • HY-175247
    DDO-4033

    		E1/E2/E3 Enzyme YAP Cancer
    DDO-4033 is a SPOP inhibitor (IC50 = 16.9 μM, Kd = 15.1 μM). DDO-4033 impairs the malignant migration, invasion, and proliferation of clear cell renal cell carcinoma (ccRCC) cell lines. DDO-4033 disrupts SPOP recruitment to its substrate LATS1, inhibits its polyubiquitination and subsequent degradation, and upregulates LATS1 expression. DDO-4033 has promising antitumor activity and is promising for renal cell carcinoma research [1].
    DDO-4033
  • HY-147165A
    VT02956 hydrochloride

    		YAP Cancer
    VT02956 is a LATS inhibitor (IC50: 0.76 nM for LATS1, 0.52 nM for LATS2). VT02956 targets the Hippo pathway. VT02956 inhibits ESR1 expression and growth of ER+ breast cancer cell lines and patient-derived tumor organoids [1]. VT02956 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    VT02956 hydrochloride
  • HY-120139A
    (R)-KMH-233

    		ASCT Cancer
    (R)-KMH-233 is the isomer of KMH-233 (HY-120139), and can be used as an experimental control. KMH-233, a potent, reversible and selective l-type amino acid transporter 1 (LAT1) inhibitor, inhibits the uptake of LAT1 substrate, l-leucin (IC50=18 μM) as well as cell growth. KMH-233 significantly potentiates the efficacy of Bestatin and Cisplatin even at low concentrations (25 μM) [1].
    (R)-KMH-233
  • HY-108540
    BCH
    5+ Cited Publications

    2-Amino-2-norbornanecarboxylic acid; LAT1-IN-1

    		 Apoptosis Cancer
    BCH (2-Amino-2-norbornanecarboxylic acid) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis [1] .
    BCH
  • HY-164401
    QBS10072S

    		EAAT Cancer
    QBS10072S is a bifunctional chemotherapeutic agent, through combination of a cytotoxin and a selective LAT1 transporter substrate. QBS10072S exhibits cytotoxicity in MDA-MB-231 cell and antitumor efficacy in mice. QBS10072S is blood-brain barrier (BBB) penetrable [1].
    QBS10072S
  • HY-108540R
    BCH (Standard)

    		Apoptosis Cancer
    BCH (Standard) is the analytical standard of BCH. This product is intended for research and analytical applications. BCH (2-Amino-2-norbornanecarboxylic acid) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis [1] .
    BCH (Standard)
  • HY-W011391
    GPNA hydrochloride
    5+ Cited Publications

    		 Apoptosis ASCT Cancer
    GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na +-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na +-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells [1].
    GPNA hydrochloride
  • HY-W087830
    L-p-Boronophenylalanine

    		Biochemical Assay Reagents Cancer
    L-p-Boronophenylalanine is a boron-containing substrate for L-type amino acid transporters (LAT1 and LAT2). L-p-Boronophenylalanine enters tumor cells by competing with natural amino acids for LAT, selectively accumulating boron in cancer cells. L-p-Boronophenylalanine can be used in boron neutron capture therapy (BNCT). When boron-10 captures thermal neutrons, a nuclear reaction occurs, producing high-energy alpha particles and lithium nuclei, which kill cancer cells at close range with little damage to surrounding tissues. L-p-Boronophenylalanine can be used in cancer research, especially glioblastoma and anaplastic astrocytoma [1] .
    L-p-Boronophenylalanine

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: