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  5. phospho-LATS1+LATS2 (Thr1079 +Thr1041) Antibody

phospho-LATS1+LATS2 (Thr1079 +Thr1041) Antibody

Cat. No.: HY-P81210
COA
SDS
User Guide for Antibodies Technical Support

phospho-LATS1+LATS2 (Thr1079 +Thr1041) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to phospho-LATS1+LATS2 (Thr1079 +Thr1041).

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

phospho-LATS1+LATS2 (Thr1079 +Thr1041) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to phospho-LATS1+LATS2 (Thr1079 +Thr1041).
Background

LATS1 is a negative regulator of YAP1 in the Hippo signaling pathway, playing a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway consists of a kinase cascade where STK3/MST2 and STK4/MST1, in complex with SAV1, phosphorylate and activate LATS1/2 in complex with MOB1, which then phosphorylates and inactivates the oncoproteins YAP1 and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its nuclear translocation, thereby regulating genes important for cell proliferation, death, and migration. As a tumor suppressor, LATS1 maintains ploidy through its roles in mitotic progression and the G1 tetraploidy checkpoint. It negatively regulates G2/M transition by downregulating CDK1 kinase activity and is involved in controlling p53 expression. Additionally, LATS1 affects cytokinesis by negatively modulating LIMK1 to regulate actin polymerization. It may also function in endocrine processes and promotes mammary gland epithelial cell differentiation through both the Hippo pathway and intracellular estrogen receptor signaling by facilitating ESR1 degradation. Recent studies show LATS1 activates the NLRP3 inflammasome by mediating phosphorylation of NLRP3 at Ser-265 following its palmitoylation.
Gene ID
SwissProt ID
Synonyms
LATS1 +LATS2 (phospho T1079 + T1041); Serine/threonine protein kinase LATS2; KPM; Large tumor supressor, homolog 1; LATS, large tumor suppressor, homolog 1 (Drosophila); LATS, large tumor suppressor, homolog 2 (Drosophila); LATS1 +LATS2 (phospho T1079 + T1041); p-LATS1 +LATS2(Thr1079 +Thr1041); RGD1564085; Serine/threonine protein kinase LATS1; WARTS; WARTS protein kinase; wts; 4932411G09Rik; AV277261; AW208599; AW228608; FLJ13161; LATS1_HUMAN.
Molecular Weight

Predicted band size: 124 kDa; Observed band size: 124 kDa
Purity

affinity purified
Subcellular Location

Cytoplasm, cytoskeleton, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole.
Conjugation

Non-conjugated
Modification

Phosphorylated
RRID
Product Categories

Primary Antibody; Rabbit Polyclonal Antibody
Clonality

Polyclonal
Host

Rabbit
Reactivity

Human, Mouse
Predicted Reactivity

Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit

Note: The predicted reactivity is for reference only, not as a product performance guarantee.
Dilution Ratio

WB: 1:500-2000;ELISA: 1:5000-10000;IHC-P: 1:100-500;IHC-F: 1:100-500;IF: 1:100-500

Application

WB, ELISA, IHC-P, IHC-F, ICC/IF
Appearance

Liquid
Formulation

Supplied in 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

KLH conjugated synthesised phosphopeptide derived from human LATS1 around the phosphorylation site of Thr1079: EF(P-T)FR
Database

Entrez Gene: 9113 Human ;

SwissProt: O95835 Human ; Q9NRM7 Human ;

OMIM: 603473 Human

Documentation
SDS (252 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

phospho-LATS1+LATS2 (Thr1079 +Thr1041) Antibody Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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phospho-LATS1+LATS2 (Thr1079 +Thr1041) Antibody
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