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Results for "

L. major

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Natural
Products

5

Recombinant Proteins

2

Isotope-Labeled Compounds

3

Antibodies

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-175246
    Antitoxoplasmal agent-1

    		Parasite Infection
    Antitoxoplasmal agent-1 (Compound 4) is an antiparasitic agent. Antitoxoplasmal agent-1 has strong activity and selectivity against T. gondii, with an IC50 of 3.1 μM. Antitoxoplasmal agent-1 also has certain activity against L. major amastigotes, with an EC50 of 23.3 μM. Antitoxoplasmal agent-1 can be used in the research of parasite-related diseases .
    Antitoxoplasmal agent-1
  • HY-149956
    Antileishmanial agent-15

    		Parasite Infection
    Antileishmanial agent-15 (compound 13c) is a potent antileishmanial agent. Antileishmanial agent-15 shows antileishmanial and cytotoxic activity against L. major promastigotes and amastigotes, with IC50 values of 0.78 and 0.99 μM, respectively .
    Antileishmanial agent-15
  • HY-149957
    Antileishmanial agent-16

    		Parasite Infection
    Antileishmanial agent-16 (compound 14c) is an anti-Leishmania agent. Antileishmanial agent-16 has superior anti-Leishmania major promastigotes activity (IC50 = 0.59 µM) and anti-Leishmania major amastigotes activity (IC50 = 0.81 µM). Antileishmanial agent-16 has good safety to mammalian cells (VERO cells) .
    Antileishmanial agent-16
  • HY-N16426
    Mycoleptone A

    		Parasite Infection Cancer
    Mycoleptone A is an azafluorenone compound. Mycoleptone A exhibits certain anti-leishmanial activity, with an LD50 of 28.5 μM against L. major. Mycoleptone A shows cytotoxicity against human prostate cancer cell line PC3, with an IC50 of 10.0 μM. Mycoleptone A can be used in research on anti-parasitic and anti-tumor aspects .
    Mycoleptone A
  • HY-168918
    Insecticidal agent 19

    		Parasite Dihydrofolate reductase (DHFR) Infection
    Insecticidal agent 19 (Compound 7b) exhibits antimalarial activity by inhibiting dihydrofolate reductase-thymidylate synthase (DHFR-TS) and pteridine reductase 1 (PTR1) through the folic acid metabolic pathway. Insecticidal agent 19 inhibits Leishmania major promastigote and amastigote with IC50 of 1.43 μM and 3.78 μM .
    Insecticidal agent 19
  • HY-W654154
    Dexmedetomidine-d4 L-tartrate (-d4-major)

    		Isotope-Labeled Compounds Others
    Dexmedetomidine-d4 L-tartrate (-d4-major) is deuterium labeled Dexmedetomidine L-tartrate (-d4-major) .
    Dexmedetomidine-d4 L-tartrate (-d4-major)
  • HY-151935
    Antileishmanial agent-13

    		Parasite Infection
    Antileishmanial agent-13 is a quinoline-isatin hybrid, acts as an antileishmanial agent against L. Major Leishmania strain. Antileishmanial agent-13 acquires the antileishmanial activity via the anti-folate mechanism. Antileishmanial agent-13 has potent inhibition against both promastigote and amastigote forms with IC50s of 0.604 μM and 0.508 μM, respectively .
    Antileishmanial agent-13
  • HY-W777166
    Aprepitant-13C2,d2 (Major)

    MK-0869--13C2,d2; MK-869-13C2,d2; L-754030--13C2,d2

    		 Isotope-Labeled Compounds HIV Antibiotic Neurokinin Receptor Bacterial Neurological Disease Endocrinology Cancer
    Aprepitant- 13C2,d2 (Major) (MK-0869- 13C2,d2) is 13C labeled Aprepitant. Aprepitant (MK-0869) is a selective and high-affinity neurokinin 1 receptor antagonist with a Kd of 86 pM.
    Aprepitant-13C2,d2 (Major)

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