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Results for "

KRAS-IN-5

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

1

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-174261
    KRAS-IN-5

    		Ras Cancer
    KRAS-IN-5 (Compound Ex 6) is an orally active and selective inhibitor targeting KRAS mutants (including KRAS G12D, KRAS G12V, KRAS WT) with a GNE IC50 value of 1.3 nM against KRAS G12D. KRAS-IN-5 blocks tumor cell proliferation by inhibiting KRAS-mediated signaling pathways (e.g., reducing ERK phosphorylation). KRAS-IN-5 is promising for research of KRAS mutation-related cancers, such as pancreatic cancer, colorectal cancer, lung cancer .
    KRAS-IN-5
  • HY-163299
    pan-KRAS-IN-5

    		Ras Apoptosis Cancer
    pan-KRAS-IN-5 (compound 15a) is a pan-KRAS translation inhibitor by targeting 5′-UTR RNA G-quadruplexes (rG4s). pan-KRAS-IN-5 induces cell cycle arrest and promptes apoptosis in KRAS-driven cancer cells .
    pan-KRAS-IN-5
  • HY-162445S
    KRASG12D-IN-3-d3

    		Isotope-Labeled Compounds Others
    pan-KRAS-IN-5-d3 is deuterated labeled pan-KRAS-IN-5.
    KRASG12D-IN-3-d3
  • HY-168678
    PROTAC K-Ras Degrader-6

    		PROTACs Ras Cancer
    pan-KRAS degrader 5 (compound 102) is a potent cereblon-based KRAS PROTAC degrader, with a DC50 of <100 nM. pan-KRAS degrader 5 shows anticancer effects. (Pink: ligand for target protein (HY-168679); Black: linker (HY-168670); Blue: E3 ligase ligand (HY-W580113)) .
    PROTAC K-Ras Degrader-6
  • HY-168680
    E3 Ligase Ligand-linker Conjugate 135

    		E3 Ligase Ligand-Linker Conjugates Cancer
    E3 Ligase Ligand-linker Conjugate 135 is a conjugate of E3 ligase ligand and linker that serve as a key intermediate for the synthesis of complete PROTAC molecule pan-KRAS degrader 5 (HY-168678) .
    E3 Ligase Ligand-linker Conjugate 135
  • HY-168056
    KRAS ligand 5

    		Others Others
    KRAS ligand 5 is the target protein ligand for PROTAC K-Ras Degrader-3 (HY-168054). PROTAC K-Ras Degrader-3 can specifically degrade KRAS mutated proteins .
    KRAS ligand 5

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