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JAK1-IN-17

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-16641
    JAK1-IN-17

    		JAK Cancer
    JAK1-IN-17 (Compound 31) is a highly selective inhibitor of JAK1 with a Ki of 1.9 nM. JAK1-IN-17 exhibits a low whole blood shift, which allows maintaining good whole blood potency. JAK1-IN-17 is also a nitrile-containing analogue with consistent, yet weak reversible inhibition of CYP3A4 using a midazolam probe (IC50 = 7.9 μM). JAK1-IN-17 can be studied in cancer research .
    JAK1-IN-17

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