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J774 macrophages

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adrenergic Receptor (3) Antibiotic (4) Apoptosis (1) Bacterial (1) c-Fms (1) COX (1) Drug Metabolite (4) Farnesyl Transferase (1) Histamine Receptor (1) Isocitrate Dehydrogenase (IDH) (1) Liposome (1) Microtubule/Tubulin (1) NOD-like Receptor (NLR) (1) Nuclear Factor of activated T Cells (NFAT) (1) P2X Receptor (1) p38 MAPK (1) Parasite (2) PERK (1) Reference Standards (2)
By Research Areas:	Cancer (1) Endocrinology (3) Infection (3) Inflammation/Immunology (2) Metabolic Disease (1)

Inhibitors & Agonists

Fluorescent Dye

Natural
Products

Targets Recommended: Macrophage migration inhibitory factor (MIF)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-131521

Oxalomalic acid trisodium Oxalomalate trisodium	Isocitrate Dehydrogenase (IDH)	Cancer
Oxalomalic acid (Oxalomalate) trisodium is a aconitase and NADP-dependent isocitrate dehydrogenase inhibitor. Oxalomalic acid trisodium inhibits nitrite production and iNOS protein expression in lipopolysaccharide (HY-D1056)-activated J774 macrophages .

HY-138056

7-Acetyl paclitaxel	Microtubule/Tubulin	Others
7-Acetyl paclitaxel is a microtubule depolymerization inhibitor which inhibits calcium-induced microtubule depolymerization. 7-Acetyl paclitaxel reduces the growth of J774.2 macrophages (IC₅₀ ~ 60 nM) and increases the levels of nitric oxide (NO) and TNF in isolated mouse peritoneal macrophages .

HY-129959

Aluminum phthalocyanine chloride AlClPc	Parasite	Infection
Aluminum phthalocyanine chloride is a photosensitizer that effectively inhibits the parasite Leishmania amazonensis (the causative agent of cutaneous leishmaniasis) by light-mediated cytolysis. Aluminum phthalocyanine chloride causes parasite morphology and cytolysis of isolated amasilians, while higher photosensitizer concentrations and light intensities are required to induce lysis of mammalian cells. Aluminum phthalocyanine chloride lyses parasites within infected J774 macrophages and can be used to further investigate the study of leishmaniasis .

HY-117432

JC-171	NOD-like Receptor (NLR)	Inflammation/Immunology
JC-171 is a selective NLRP3 inflammasome inhibitor, with an IC₅₀ of 8.45 μM for inhibiting LPS/ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages .

HY-B0802A

Terbutaline	Drug Metabolite Adrenergic Receptor Antibiotic	Endocrinology
Terbutaline is an orally active β₂-adrenergic receptor agonist and an active metabolite of bambuterol . Terbutaline can be used in asthma symptom research .

HY-126489

Tetromycin B	Parasite	Infection
Tetromycin B is a cysteine protease inhibitor with Ki values of 0.62, 1.42, 32.5, and 1.59 μM for rhodesain, falcipain-2, cathepsin L, and cathepsin B, respectively. It inhibits the growth of T. brucei in vitro (IC₅₀=30.87 μM). Tetromycin B is also cytotoxic to HEK293T kidney cells and J774.1 macrophages (IC₅₀s=71.77 and 20.2 μM, respectively).

HY-B2097

Incadronate disodium YM 175; Bisphonal	Farnesyl Transferase	Metabolic Disease
Incadronate disodium (YM 175) is a bisphosphonate with strong inhibitory activity on bone resorption. Incadronate disodium indirectly stimulates renal 25-hydroxyvitamin D-1-hydroxylase by increasing circulating parathyroid hormone. Incadronate disodium, a cholesterol-lowering agent, is a potent inhibitor of rat liver microsomal squalene synthase (K_i=57 nM). Incadronate disodium inhibits sterol biosynthesis in mouse macrophage J774 cells (IC₅₀=64 μM). Incadronate disodium has the potential for malignant tumors research .

HY-171905

N-Sterol	Liposome	Others
N-Sterol is a sterol lipid that has been used to generate lipid nanoparticles (LNPs) for delivery of mRNA in vitro and in vivo. N-Sterol LNPs are taken up in J774A.1 macrophages in a lipid composition-dependent manner via clathrin caveolae, caveolin-mediated endocytosis, micropinocytosis, or phagocytosis at different frequencies .

HY-B0802AR

Terbutaline (Standard)	Drug Metabolite Reference Standards Adrenergic Receptor Antibiotic	Endocrinology
Benactyzine hydrochloride (Standard) is the analytical standard of Benactyzine hydrochloride. This product is intended for research and analytical applications. Benactyzine hydrochloride is a competitive BChE inhibitor with a Ki of 0.01 mM. Benactyzine hydrochloride is an anticholinergic drug. Benactyzine hydrochloride has the potential for organophosphate poisoning research .

HY-137575R

Terbutalone (Standard)	Reference Standards Drug Metabolite	Others
Terbutalone (Standard) is the analytical standard of Terbutalone. This product is intended for research and analytical applications. Terbutalone is a derivative of Terbutaline (HY-B0802A). Terbutaline is an orally active β2-adrenergic receptor agonist and an active metabolite of Bambuterol (HY-17501). Terbutaline can be used in asthma symptom research .

HY-137575

Terbutalone	Drug Metabolite	Others
Terbutalone is a derivative of Terbutaline (HY-B0802A). Terbutaline is an orally active β₂-adrenergic receptor agonist and an active metabolite of Bambuterol (HY-17501). Terbutaline can be used in asthma symptom research .

HY-111248

ABD-295	Nuclear Factor of activated T Cells (NFAT) c-Fms	Others
ABD-295, a biphenylsulfide derivative, is an antiresorptive agent, osteoclast inhibitor. ABD-295 has potent inhibitory effects on osteoclastic bone resorption in vitro. ABD-295 prevents ovariectomy-induced bone loss in vivo ^{[1] ^.}

HY-B0802

Terbutaline sulfate Terbutaline hemisulfate	Adrenergic Receptor Antibiotic	Endocrinology
Terbutaline sulfate is an orally active β₂-adrenergic receptor agonist and an active metabolite of bambuterol . Terbutaline sulfate can be used in asthma symptom research .

HY-125416

Streptothricin F	Antibiotic Bacterial	Infection
Streptothricin F is a bactericidal antibiotic. Streptothricin F interacts with the 30S subunit of 70S ribosome. Streptothricin F shows rapid, bactericidal activity against highly drug-resistant, carbapenem-resistant Enterobacterales (CRE) (MIC₅₀ and MIC₉₀: 2 and 4 μM, respectively) and Acinetobacter baumannii .

HY-123205

Oxatomide KW-4354	Histamine Receptor P2X Receptor 5-HT Receptor Apoptosis PERK p38 MAPK COX	Inflammation/Immunology
Oxatomide (KW-4354) is an orally active dual antagonist of the H1-histamine receptor and the P2X7 receptor, as well as an inhibitor of serotonin. Oxatomide possesses antihistaminic, antiallergic and anti-inflammatory activities. Oxatomide can be used in the research of allergic diseases .

Cat. No.	Product Name	Type

HY-129959

Aluminum phthalocyanine chloride AlClPc	Dyes
Aluminum phthalocyanine chloride is a photosensitizer that effectively inhibits the parasite Leishmania amazonensis (the causative agent of cutaneous leishmaniasis) by light-mediated cytolysis. Aluminum phthalocyanine chloride causes parasite morphology and cytolysis of isolated amasilians, while higher photosensitizer concentrations and light intensities are required to induce lysis of mammalian cells. Aluminum phthalocyanine chloride lyses parasites within infected J774 macrophages and can be used to further investigate the study of leishmaniasis .

Aluminum phthalocyanine chloride

AlClPc

Dyes

Aluminum phthalocyanine chloride is a photosensitizer that effectively inhibits the parasite Leishmania amazonensis (the causative agent of cutaneous leishmaniasis) by light-mediated cytolysis. Aluminum phthalocyanine chloride causes parasite morphology and cytolysis of isolated amasilians, while higher photosensitizer concentrations and light intensities are required to induce lysis of mammalian cells. Aluminum phthalocyanine chloride lyses parasites within infected J774 macrophages and can be used to further investigate the study of leishmaniasis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125416

Streptothricin F	Microorganisms Source classification	Antibiotic Bacterial
Streptothricin F is a bactericidal antibiotic. Streptothricin F interacts with the 30S subunit of 70S ribosome. Streptothricin F shows rapid, bactericidal activity against highly drug-resistant, carbapenem-resistant Enterobacterales (CRE) (MIC₅₀ and MIC₉₀: 2 and 4 μM, respectively) and Acinetobacter baumannii .

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