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Results for "

IRS1

" in MedChemExpress (MCE) Product Catalog:

20

Inhibitors & Agonists

2

Peptides

3

Natural
Products

2

Recombinant Proteins

1

Isotope-Labeled Compounds

2

Antibodies

5

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-115461
    MID-1

    		Insulin Receptor Metabolic Disease
    MID-1 is a disruptor of MG53-IRS-1 (Mitsugumin 53-insulin receptor substrate-1) interaction. MID-1 disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake [1].
    MID-1
  • HY-145935
    NT219

    		Insulin Receptor STAT Cancer
    NT219 is a potent and dual inhibitor of insulin receptor substrates 1/2 (IRS1/2) and STAT3. IRS1/2 and STAT3 are major signaling junctions regulated by various oncogenes. NT219 affects IRS1/2 degradation and inhibits STAT3 phosphorylation. NT219 has the potential for the research of cancer diseases [1].
    NT219
  • HY-N3628
    Coronarin A

    		mTOR Ribosomal S6 Kinase (RSK) Metabolic Disease Inflammation/Immunology
    Coronarin A is an orally active natural compound that inhibits mTORC1 and S6K1 to increase IRS1 activity. Coronarin A shows anti-inflammatory activity and can also be used for type 2 diabetes mellitus research [1].
    Coronarin A
  • HY-RS23337
    Irs1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Irs1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Irs1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Irs1 Rat Pre-designed siRNA Set A
    Irs1 Rat Pre-designed siRNA Set A
  • HY-RS06917
    IRS1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    IRS1 Human Pre-designed siRNA Set A contains three designed siRNAs for IRS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    IRS1 Human Pre-designed siRNA Set A
    IRS1 Human Pre-designed siRNA Set A
  • HY-RS16895
    Irs1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Irs1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Irs1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Irs1 Mouse Pre-designed siRNA Set A
    Irs1 Mouse Pre-designed siRNA Set A
  • HY-P5433F
    IRS-1 Peptide, FAM labeled

    		Insulin Receptor Others
    IRS-1 Peptide, FAM labeled is a biological active peptide. (Insulin receptor substrate)
    IRS-1 Peptide, FAM labeled
  • HY-153479
    Aganirsen

    		Insulin Receptor Inflammation/Immunology
    Aganirsen is a 25 mer DNA antisense oligonucleotide, which silences expression of insulin receptor substrate-1 (IRS-1).
    Aganirsen
  • HY-153479A
    Aganirsen sodium

    		Insulin Receptor Inflammation/Immunology
    Aganirsen sodium is a 25 mer DNA antisense oligonucleotide, which silences expression of insulin receptor substrate-1 (IRS-1).
    Aganirsen sodium
  • HY-N3542
    Carpachromene

    		Glycosidase Cancer
    Carpachromene is a potent α-glucosidase enzyme inhibitor. Carpachromene ameliorates insulin resistance in HepG2 cells via modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 pathway [1].
    Carpachromene
  • HY-107758
    Y-29794 oxalate

    		Prolyl Endopeptidase (PREP) Cancer
    Y-29794 oxalate is a selective, orally active and blood-brain barrier permeable non-peptide prolyl endopeptidase inhibitor. Y-29794 oxalate blocks the IRS1-AKT-mTORC1 pathway and inhibits tumor growth. Y-29794 oxalate is also effective in inhibiting the progression of Aβ-like deposition in the hippocampus of aging-accelerated mice (SAM) [1] .
    Y-29794 oxalate
  • HY-15113
    Y-29794

    		Prolyl Endopeptidase (PREP) Neurological Disease Cancer
    Y-29794 is a selective, orally active inhibitor for non-peptide prolyl endopeptidase (PREP), with an IC50 of 3 nM and a Ki of 0.95 nM. Y-29794 enhances the effect of thyrotropin-releasing hormone (TRH) on the release of ACh in the rat hippocampus, exhibits potential neuroprotective efficacy. Y-29794 exhibits anticancer activity through inhibition of the IRS1-AKT-mTORC1 pathway. Y-29794 penetrates the brain-blood barrier (BBB) [1] .
    Y-29794
  • HY-15113A
    Y-29794 tosylate

    		Prolyl Endopeptidase (PREP) Neurological Disease Cancer
    Y-29794 tosylate is a selective, orally active inhibitor for non-peptide prolyl endopeptidase (PREP), with an IC50 of 3 nM and a Ki of 0.95 nM. Y-29794 tosylate enhances the effect of thyrotropin-releasing hormone (TRH) on the release of ACh in the rat hippocampus, exhibits potential neuroprotective efficacy. Y-29794 tosylate exhibits anticancer activity through inhibition of the IRS1-AKT-mTORC1 pathway. Y-29794 tosylate penetrates the brain-blood barrier (BBB) [1] .
    Y-29794 tosylate
  • HY-B1885
    Fenitrothion

    		Insecticide Parasite Cholinesterase (ChE) AMPK PI3K Akt Apoptosis SOD Infection
    Fenitrothion is a broad-spectrum and orally active insecticide/acaricide. Fenitrothion inhibits cholinesterase, AMPKα and IRS1/PI3K/AKT. Fenitrothion causes Apoptosis, reduces SOD activity. Fenitrothion shows insecticidal effect against Rhyzopertha dominica and Tribolium castaneum adults. Fenitrothion is widely used in cotton crops, vegetable crops, fruit crops and field crops, especially rice. Fenitrothion can be used for brain and spleen toxicology studies [1] .
    Fenitrothion
  • HY-161321
    PTP1B-IN-24

    		Phosphatase Insulin Receptor Akt Metabolic Disease
    PTP1B-IN-24 (Compound 9) is a reversible PTP1B inhibitor with an IC50 value of 1.4 μM, and PTP1B-IN-24 can enhance the thermal stability of PTP1B. PTP1B-IN-24 can restore PA- (HY-N0830) induced insulin resistance by increasing the phosphorylation levels of IRS1 and AKT [1].
    PTP1B-IN-24
  • HY-B1885S
    Fenitrothion-d6

    		Isotope-Labeled Compounds Insecticide Cholinesterase (ChE) AMPK PI3K Akt Apoptosis SOD Infection
    Fenitrothion-d6 is the deuterium labeled Fenitrothion (HY-B1885). Fenitrothion is a broad-spectrum and orally active insecticide/acaricide. Fenitrothion inhibits cholinesterase, AMPKα and IRS1/PI3K/AKT. Fenitrothion causes Apoptosis, reduces SOD activity. Fenitrothion shows insecticidal effect against Rhyzopertha dominica and Tribolium castaneum adults. Fenitrothion is widely used in cotton crops, vegetable crops, fruit crops and field crops, especially rice. Fenitrothion can be used for brain and spleen toxicology studies [1] .
    Fenitrothion-d6
  • HY-B1885R
    Fenitrothion (Standard)

    		Insecticide Parasite Cholinesterase (ChE) AMPK PI3K Akt Apoptosis SOD Infection
    Fenitrothion (Standard) is the analytical standard of Fenitrothion (HY-B1885). This product is intended for research and analytical applications. Fenitrothion is a broad-spectrum and orally active insecticide/acaricide. Fenitrothion inhibits cholinesterase, AMPKα and IRS1/PI3K/AKT. Fenitrothion causes Apoptosis, reduces SOD activity. Fenitrothion shows insecticidal effect against Rhyzopertha dominica and Tribolium castaneum adults. Fenitrothion is widely used in cotton crops, vegetable crops, fruit crops and field crops, especially rice. Fenitrothion can be used for brain and spleen toxicology studies [1] .
    Fenitrothion (Standard)
  • HY-162499
    MY17

    		Phosphatase Metabolic Disease
    MY17 is an inhibitor of protein tyrosine phosphatase 1B (PTP1B) (IC50=0.41±0.05 μM). MY17 alleviates palmitic acid (PA) -induced insulin resistance by up-regulating the expression of phosphorylated insulin receptor substrate (IRS1) and protein kinase B (AKT). By binding with PTP1B, MY17 can inhibit the activity of PTP1B, thereby improving insulin signaling and having anti-diabetic activity. MY17 can be used in the study of type 2 diabetes [1].
    MY17
  • HY-N0479
    Licarin B
    1 Publications Verification

    (-)-Licarin B

    		 PPAR GLUT Metabolic Disease
    Licarin B, a nitric oxide production inhibitor extracted from the component of the seeds of Myristica fragrans, improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway [1] .
    Licarin B
  • HY-100037
    NT157
    1 Publications Verification

    Tyrphostin NT157

    		 Insulin Receptor STAT Endocrinology Cancer
    NT157 (Tyrphostin NT157) is a selective IRS-1/2 inhibitor that induces Ser-phosphorylation and consequently the degradation of IRS-1/2. NT157 (Tyrphostin NT157) is a first-in-class anti-cancer agent that also targets Stat3 signaling pathway [1] .
    NT157

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