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Results for "

IL-6-IN-2

" in MedChemExpress (MCE) Product Catalog:

20

Inhibitors & Agonists

1

Peptides

1

Inhibitory Antibodies

6

Natural
Products

2

Isotope-Labeled Compounds

2

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-150738C
    ODN 2088 sodium

    		Toll-like Receptor (TLR) Inflammation/Immunology
    ODN 2088 sodium is a potent TLR3, TLR7 and TLR9 inhibitor. ODN 2088 sodium shows no cytotoxic. ODN 2088 inhibits the release of IFN-α and IL-6 .
    ODN 2088 sodium
  • HY-150738
    ODN 2088

    		Toll-like Receptor (TLR) Inflammation/Immunology
    ODN 2088 is a potent TLR3, TLR7 and TLR9 inhibitor. ODN 2088 shows no cytotoxic. ODN 2088 inhibits the release of IFN-α and IL-6 .
    ODN 2088
  • HY-N0710
    alpha-Cyperone
    3 Publications Verification

    α-Cyperone; (+)-α-Cyperone

    		 Endogenous Metabolite Inflammation/Immunology
    alpha-Cyperone (α-Cyperone) is associated with the down-regulation of COX-2, IL-6, Nck-2, Cdc42 and Rac1, resulting in reduction of inflammation, which would be highly beneficial for treatment of inflammatory diseases such as AD.
    alpha-Cyperone
  • HY-111346
    1-Linoleoyl Glycerol

    1-LINoleoyl-rac-glycerol; 1-MonolINoleIN

    		 Phospholipase Apolipoprotein Interleukin Related Metabolic Disease Inflammation/Immunology
    1-Linoleoyl glycerol is a LpPLA2 inhibitor. 1-Linoleoyl glycerol acts as a precursor for synthesizing various functional lipids, such as phospholipids. 1-Linoleoyl glycerol mitigates inflammation induced by Apolipoprotein CIII (reduction of IL-6) .
    1-Linoleoyl Glycerol
  • HY-155335
    FPR2 agonist 3

    		Formyl Peptide Receptor (FPR) Inflammation/Immunology
    FPR2 agonist 3 (compound CMC23) can limit the lactate dehydrogenase release in LPS (HY-D1056) -stimulated cultures and decrease the levels of pro-inflammatory IL-1β and IL-6. FPR2 agonist 3 decrease the level of phosphor-STAT3 via the STAT3/SOCS3 signaling pathway .
    FPR2 agonist 3
  • HY-B0026
    Ceftiofur hydrochloride
    4 Publications Verification

    		 Antibiotic Bacterial NF-κB p38 MAPK TNF Receptor Interleukin Related Infection
    Ceftiofur hydrochloride is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur hydrochloride exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur hydrochloride also inhibits the activation of NF-κB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 .
    Ceftiofur hydrochloride
  • HY-177063
    IL-6-IN-2

    		Interleukin Related Others
    IL-6-IN-2 (Compound 15) is an inhibitor of the IL-6/IL-6R protein interaction. The ∆G binding energy of IL-6-IN-2 is −36.50 kcal/mol. Contributions of Lys66, Phe74, Gln175, Ser176, and Arg179 to IL-6 binding are −1.10, −8.68, −6.91, −3.69, and −1.72 kcal/mol, respectively. IL-6-IN-2 exhibits low gastrointestinal (GI) absorption .
    IL-6-IN-2
  • HY-N3380
    Linderaspirone A

    		PGE synthase Interleukin Related Inflammation/Immunology
    Linderaspirone A is a natural compound that can be isolated from the roots of Lindera aggregate. Linderaspirone A shows significant inhibitory effects on the production of prostaglandin E2 (PGE2),TNF-α, and IL-6 .
    Linderaspirone A
  • HY-N0710R
    alpha-Cyperone (Standard)

    α-Cyperone (Standard); (+)-α-Cyperone (Standard)

    		 Reference Standards Endogenous Metabolite Inflammation/Immunology
    alpha-Cyperone (Standard) is the analytical standard of alpha-Cyperone. This product is intended for research and analytical applications. alpha-Cyperone (α-Cyperone) is associated with the down-regulation of COX-2, IL-6, Nck-2, Cdc42 and Rac1, resulting in reduction of inflammation, which would be highly beneficial for treatment of inflammatory diseases such as AD.
    alpha-Cyperone (Standard)
  • HY-111346R
    1-Linoleoyl Glycerol (Standard)

    		Phospholipase Apolipoprotein Interleukin Related Metabolic Disease Inflammation/Immunology
    1-Linoleoyl Glycerol (Standard) is the analytical standard of 1-Linoleoyl Glycerol. This product is intended for research and analytical applications. 1-Linoleoyl glycerol is a LpPLA2 inhibitor. 1-Linoleoyl glycerol acts as a precursor for synthesizing various functional lipids, such as phospholipids. 1-Linoleoyl glycerol mitigates inflammation induced by Apolipoprotein CIII (reduction of IL-6) .
    1-Linoleoyl Glycerol (Standard)
  • HY-N7102
    Ceftiofur
    4 Publications Verification

    		 Antibiotic Bacterial NF-κB p38 MAPK TNF Receptor Interleukin Related Infection
    Ceftiofur is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur also inhibits the activation of NF-κB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 .
    Ceftiofur
  • HY-B0898
    Ceftiofur sodium
    4 Publications Verification

    sodium ceftiofur

    		 Antibiotic Bacterial NF-κB p38 MAPK TNF Receptor Interleukin Related Infection
    Ceftiofur sodium is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur sodium exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur sodium also inhibits the activation of NF-κB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 .
    Ceftiofur sodium
  • HY-W778692
    1-Linoleoyl Glycerol-d5

    1-LINoleoyl-rac-glycerol-d5; 1-MonolINoleIN-d5

    		 Isotope-Labeled Compounds Interleukin Related Phospholipase Apolipoprotein Metabolic Disease
    1-Linoleoyl Glycerol-d5 (1-Linoleoyl-rac-glycerol-d5; 1-Monolinolein-d5) is the deuterium labeled 1-Linoleoyl Glycerol (HY-111346). 1-Linoleoyl glycerol is a LpPLA2 inhibitor. 1-Linoleoyl glycerol acts as a precursor for synthesizing various functional lipids, such as phospholipids. 1-Linoleoyl glycerol mitigates inflammation induced by Apolipoprotein CIII (reduction of IL-6) .
    1-Linoleoyl Glycerol-d5
  • HY-B0898R
    Ceftiofur sodium (Standard)

    sodium ceftiofur (Standard)

    		 Reference Standards Antibiotic Bacterial NF-κB p38 MAPK TNF Receptor Interleukin Related Infection
    Ceftiofur sodium (Standard) is the analytical standard of Ceftiofur sodium (HY-B0898). This product is intended for research and analytical applications. Ceftiofur sodium is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur sodium exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur sodium also inhibits the activation of NF-κB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 .
    Ceftiofur sodium (Standard)
  • HY-B0026R
    Ceftiofur hydrochloride (Standard)

    		Reference Standards Antibiotic Bacterial NF-κB p38 MAPK TNF Receptor Interleukin Related Infection
    Ceftiofur hydrochloride (Standard) is the analytical standard of Ceftiofur hydrochloride (HY-B0026). This product is intended for research and analytical applications. Ceftiofur hydrochloride is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur hydrochloride exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur hydrochloride also inhibits the activation of NF-κB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 .
    Ceftiofur hydrochloride (Standard)
  • HY-N7102R
    Ceftiofur (Standard)

    		Reference Standards Antibiotic Bacterial NF-κB p38 MAPK TNF Receptor Interleukin Related Infection
    Ceftiofur (Standard) is the analytical standard of Ceftiofur (HY-N7102). This product is intended for research and analytical applications. Ceftiofur is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur also inhibits the activation of NF-κB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 .
    Ceftiofur (Standard)
  • HY-B0898S
    Ceftiofur-d3 sodium

    		Isotope-Labeled Compounds Antibiotic Bacterial NF-κB p38 MAPK TNF Receptor Interleukin Related Infection
    Ceftiofur-d3 sodium is deuterium labeled Ceftiofur sodium (HY-B0898). Ceftiofur sodium is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur sodium exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur sodium also inhibits the activation of NF-κB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 .
    Ceftiofur-d3 sodium
  • HY-168482
    NF-κB/MAPK-IN-2

    		NF-κB p38 MAPK Cancer
    NF-κB/MAPK-IN-2 (compound 14) is a potent NF-κB and MAPK Inhibitor. NF-κB/MAPK-IN-2 decreases the protein expression of p-p65, p-IκB, p-p38, p-JNK, and p-ERK. NF-κB/MAPK-IN-2 reduces the LPS-induced release of TNF-α and IL-6. NF-κB/MAPK-IN-2 inhibits nuclear translocation of p65 and c-Fos. NF-κB/MAPK-IN-2 has the potential for the research of sepsis .
    NF-κB/MAPK-IN-2
  • HY-P1137
    10Panx

    		Gap Junction Protein Others
    10Panx is a competitive inhibitor of selective Pannexin 1 (PANX1) channels. 10Panx blocks the opening of PANX1 channels, inhibits ATP release and downstream P2X7 receptor-mediated signaling pathways, thereby reducing cell death and inflammatory responses. 10Panx can be used in the study of diseases such as neuropathic pain, inflammatory bowel disease, and Clostridioides difficile infection. 10Panx can effectively reduce mechanical hyperalgesia and enhanced C-reflexes, and inhibit the expression of pro-inflammatory factors such as IL-6[1][2][3].
    10Panx
  • HY-N4288
    4-Methylesculetin
    1 Publications Verification

    		 Glutathione Peroxidase Cathepsin Phosphatase Inflammation/Immunology Cancer
    4-Methylesculetin is an orally active coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase activity. 4-Methylesculetin protects bone resorption by reducing the elevated levels of bone-joint exoglycosidases, cathepsin-D and tartrate resistant acid phosphatases. 4-Methylesculetin ameliorats the upregulated non-enzymatic inflammatory markers like TNF-α, IL-1β, IL-6, COX-2 and PGE2, which is promising for research of inflammatory diseases .
    4-Methylesculetin

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