2. GPCR/G Protein Immunology/Inflammation Apoptosis
  3. Neuropeptide S Receptor Interleukin Related TNF Receptor
  4. NPSR1 antagonist-1

NPSR1 antagonist-1 is a potent and peripherally restricted neuropeptide S receptor 1 (NPSR1) antagonist. NPSR1 antagonist-1 can inhibit IL-6, PTGS2, IL-20, and CXCL8 expression. NPSR1 antagonist-1 can reduce TNF-α cytokine levels. NPSR1 antagonist-1 can be used for the research of inflammation, such as peritonitis.

For research use only. We do not sell to patients.

NPSR1 antagonist-1

NPSR1 antagonist-1 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

NPSR1 antagonist-1 Related Antibodies

Top Publications Citing Use of Products

View All Interleukin Related Isoform Specific Products:

View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

View All TNF Receptor Isoform Specific Products:

View All Isoforms
TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

NPSR1 antagonist-1 is a potent and peripherally restricted neuropeptide S receptor 1 (NPSR1) antagonist. NPSR1 antagonist-1 can inhibit IL-6, PTGS2, IL-20, and CXCL8 expression. NPSR1 antagonist-1 can reduce TNF-α cytokine levels. NPSR1 antagonist-1 can be used for the research of inflammation, such as peritonitis[1].

IC50 & Target[1]

IL-6

 

IL-20

 

TNF-α

 

In Vitro

NPSR1 antagonist-1 (Compound 6) exhibits an IC50 of 0.35 nM and 0.15 nM against NPSR1-A and NPSR1-B, respectively[1].
NPSR1 antagonist-1 inhibits Npsr1 in HEK293T cells with an IC50 of 2.1 nM[1].
NPSR1 antagonist-1 (0.001-10000 nM, 30 mins) inhibits IL6, CXCL8, IL20, and PTGS2 levels in NPSR1-A expressing fibroblasts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NPSR1 antagonist-1 Related Antibodies

RT-PCR[1]

Cell Line: NPSR1-A expressing fibroblasts
Concentration: 0.001, 0.01, 0.1, 1, 10,100, 1000 and 10000 nM
Incubation Time: 30 mins
Result: Reduced IL6, CXCL8, IL20, and PTGS2 levels.
In Vivo

NPSR1 antagonist-1 (Compound 6) (10 mg/kg, i.p., before zymosan injection) promotes inflammatory resolution in zymosan-induced peritonitis mice models[1].
NPSR1 antagonist-1 (40 mg/kg, i.p., before zymosan injection) reduces peritoneal levels of TNF-α in zymosan-induced peritonitis mice models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Zymosan-induced peritonitis mice models[1]
Dosage: 10 mg/kg
Administration: Intraperitoneally injection, before zymosan injection
Result: Increased the number of F4/80+ resident macrophages in the peritoneum.
Molecular Weight

528.68

Formula

C30H42F2N4O2
SMILES

O=C(C1CCCCC1)N(CC2(N3CCN(C)CC3)CCC(F)(F)CC2)CC4=CC5=C(N(C)C4=O)C=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

NPSR1 antagonist-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NPSR1 antagonist-1Neuropeptide S ReceptorInterleukin RelatedTNF ReceptorNPSRGPR154Vasopressin receptor-related receptor 1VRR1ILTumor Necrosis Factor ReceptorTNFRNPSR1IL-6PTGS2IL-20CXCL8TNF-αPeritonitisHEK293TFibroblastsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
NPSR1 antagonist-1
Cat. No.:
HY-175813
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.