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Hyaluronidase

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By Targets:	Bacterial (1) Biochemical Assay Reagents (4) Collagen (1) Endogenous Metabolite (1) Fungal (1) Glycosidase (2) Leukotriene Receptor (1) NF-κB (1) NO Synthase (1) Parasite (1) Proteolytic Enzyme (1) TGF-β Receptor (1)
By Research Areas:	Cancer (2) Infection (2) Inflammation/Immunology (3) Metabolic Disease (3)

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Inhibitors & Agonists

1

Biochemical Assay Reagents

3

Natural
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4

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Hyaluronidase (human recombinant) Maximum Cited Publications 7 Publications Verification Hylenex; VorHyaluronidase alfa; rHuPH 20	Biochemical Assay Reagents Glycosidase	Metabolic Disease
Hyaluronidase (human recombinant) (Hylenex; Vorhyaluronidase alfa; rHuPH 20) is an enzyme that catalyzes the degradation of hyaluronic acid. Hyaluronidase (human recombinant) is used to improve the absorption and dispersal of parenteral fluids, medications, and contrast media .

Hyaluronidase, Ovine testes Maximum Cited Publications 7 Publications Verification	Glycosidase Biochemical Assay Reagents	Metabolic Disease
Hyaluronidase, Ovine testes is an enzyme responsible for catalyzing the degradation of hyaluronic acid. It is used to improve the absorption and dispersion of gastrointestinal fluids, drugs, and contrast agents. Hyaluronidase, Ovine testes can enhance the diffusion or delivery of local agent (LA) that can suppress or relieve pain or immunoglobulins (Igs) .

Hyaluronidase, Bovine testes Maximum Cited Publications 7 Publications Verification Hyaluronate 4-glycanohydrolase, Bovine testes; Hyaluronoglucosaminidase, Bovine testes	NF-κB	Inflammation/Immunology Cancer
Hyaluronidase, Bovine testes (Hyaluronate 4-glycanohydrolase; Hyaluronoglucosaminidase) is an endoglycosidase that depolymerizes Hyaluronic acid (HA) (HY-B0633A) by cleavage of glycosidic bonds. Hyaluronidase degrades HA and activates membrane receptors that trigger pathways converging in NF-κB activation. Hyaluronidase is employed in the research of granulomatous foreign body reactions, soft-tissue necrosis caused by vascular compromise and uncomplicated nodules, overcorrection, inflamed nodules or tissue ischemia associated with HA filler injection .

Isosaponarin	TGF-β Receptor Collagen	Infection Metabolic Disease Inflammation/Immunology Cancer
Isosaponarin is a flavone glycoside isolated from wasabi leaves. Isosaponarin is a P4HA2 enzymatic agonist. Isosaponarin increases collagen synthesis via up-regulated TGF-β type II receptor (TβR-II) and prolyl 4-hydroxylase (P4H) proteins production, promoting skin health and wound healing. Isosaponarin-rich plants exhibit strong antimicrobial, antioxidant, anti-hyaluronidase, antiplatelet, anti-atopic dermatitis, and anti-tumor effects .

*Hyaluronidase*	Biochemical Assay Reagents	Others
Hyaluronidase is an enzyme that can break down hyaluronic acid. Hyaluronidase can increase the absorption of drugs into tissues and reduce tissue damage in cases of drug extravasation .

Sutilains	Proteolytic Enzyme	Others
Sutilains is a proteolytic enzyme that dissolves necrotic tissue and hyaluronidase. Sutilains can be used as a topical debriding agent in burns .

Lunularic acid	Endogenous Metabolite	Others
Lunularic acid is a dihydrostilbene compound with anti-hyaluronidase activity (IC₅₀: 0.13 nM). Lunularic acid can be used as an endogenous growth inhibitor in liverworts, replacing the function of abscisic acid in higher plants .

Hyaluronic acid tetrasaccharide, 98%	Biochemical Assay Reagents	Others
Hyaluronic acid tetrasaccharide, 98% is a naturally occurring polysaccharide found in the extracellular matrix of connective tissues. Hyaluronic acid tetrasaccharide can be used as a substrate for enzyme assays to characterize hyaluronidases and other hyaluronic acid-degrading enzymes.

Nyasol (-)-Nyasol; (Z)-Hinokiresinol; cis-Hinokiresinol	NO Synthase Bacterial Fungal Parasite Leukotriene Receptor	Infection Inflammation/Immunology
Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, *hyaluronidase* inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells .

Cat. No.	Product Name	Type

Hyaluronic acid tetrasaccharide, 98%	Carbohydrates
Hyaluronic acid tetrasaccharide, 98% is a naturally occurring polysaccharide found in the extracellular matrix of connective tissues. Hyaluronic acid tetrasaccharide can be used as a substrate for enzyme assays to characterize hyaluronidases and other hyaluronic acid-degrading enzymes.

Species:	Human (2) Mouse (1)
Tag:	His (4)
Source:	HEK293 (3) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

	Hyaluronidase-1/HYAL1 Protein, Human (HEK293, His) rHuHyaluronidase-1/HYAL1, His; Hyaluronidase-1; Hyal-1; Hyaluronoglucosaminidase-1; Lung Carcinoma Protein 1; LuCa-1; HYAL1; LUCA1	Human	HEK293
	Hyaluronidase-1/HYAL1 Protein is implicated in tumor progression, suggesting its role in cancer advancement. It also inhibits TGFB1-enhanced cell growth, revealing its regulatory function. HYAL1's dual impact on promoting tumor progression and inhibiting specific cellular processes underscores its complex involvement in cellular behavior and potential significance in tumorigenesis. Hyaluronidase-1/HYAL1 Protein, Human (HEK293, His) is the recombinant human-derived Hyaluronidase-1/HYAL1 protein, expressed by HEK293 , with C-6*His labeled tag.

	Hyaluronidase-1/HYAL1 Protein, Human (HEK293, C-His) rHuHyaluronidase-1/HYAL1, His; Hyaluronidase-1; Hyal-1; Hyaluronoglucosaminidase-1; Lung Carcinoma Protein 1; LuCa-1; HYAL1; LUCA1	Human	HEK293
	Hyaluronidase-1/HYAL1 Protein is implicated in tumor progression, suggesting its role in cancer advancement. It also inhibits TGFB1-enhanced cell growth, revealing its regulatory function. HYAL1's dual impact on promoting tumor progression and inhibiting specific cellular processes underscores its complex involvement in cellular behavior and potential significance in tumorigenesis. Hyaluronidase-1/HYAL1 Protein, Human (HEK293, C-His) is the recombinant human-derived Hyaluronidase-1/HYAL1, expressed by HEK293 , with C-6*His labeled tag.

	Hyaluronan Lyase Protein, S. agActiae (His) Hyaluronidase; SAG1197	Others	E. coli
	Hyaluronan Lyase Protein, S. agActiae (His) is the recombinant Hyaluronan Lyase protein, expressed by E. coli , with N-6*His labeled tag.

	Hyaluronidase 2/HYAL2 Protein, Mouse (HEK293, His) Hyaluronidase-2; Hyaluronoglucosaminidase-2; Hyal2; Hyal-2	Mouse	HEK293

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