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Human monoamine oxidase B

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Monoamine Oxidase (20) 5-HT Receptor (1) Adrenergic Receptor (3) Carbonic Anhydrase (1) Cholinesterase (ChE) (2) Fluorescent Dye (1) Histamine Receptor (1) Imidazoline Receptor (3) Interleukin Related (1) Isotope-Labeled Compounds (1) Phosphatase (1) Reference Standards (2) TNF Receptor (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Inflammation/Immunology (2) Neurological Disease (18)

Inhibitors & Agonists

Fluorescent Dye

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Targets Recommended: Monoamine Oxidase Monoamine Transporter Lysyl Oxidase Glycolate Oxidase Amino Acid Oxidase Pyruvate Oxidase Xanthine Oxidase NADPH Oxidase Aldehyde Oxidase (AO) Protoporphyrinogen IX oxidase VAP-1 Human leukocyte immunoglobulin (Ig)-like receptors (LILR)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-123665

PSB-1410	Monoamine Oxidase	Neurological Disease
PSB-1410 is a selective and competitive monoamine oxidase B (MAO-B) inhibitor with IC₅₀ for human MAO-B and rat MAO-B Values are 0.23 and 1.01 nM respectively .

HY-W083062

hMAO-B-IN-5	Monoamine Oxidase	Neurological Disease
hMAO-B-IN-5 (Compound B15) is a potent, selective and reversible **human monoamine oxidase-B (hMAO-B) inhibitor with an IC₅₀ of 120 nM and a K_i** of 33 nM. hMAO-B-IN-5 can be used in the research of neurodegenerative diseases .

HY-163380

CA/MAO-B-IN-1	Carbonic Anhydrase	Neurological Disease
CA/MAO-B-IN-1 (Compound 78) is a dual inhibitor for human brain carbonic anhydrases (CA) and Monoamine Oxidase-B (MAO-B), with IC₅₀s of 8.8 and 7.0 nM, respectively. CA/MAO-B-IN-1 reveals a human oral absorption of 71.9% through in silico prediction .

HY-161674

Monoamine Oxidase B inhibitor 4	Monoamine Oxidase	Neurological Disease
Monoamine Oxidase B inhibitor 4 (compound 1l) is a selective inhibitor of human monoamine oxidase-B (hMAO-B) (IC50=8.3 nM). Monoamine Oxidase B inhibitor 4 also has anti-neuroinflammatory and low neurotoxicity. Monoamine Oxidase B inhibitor 4 can inhibit the release of NO, TNF-α and IL-1β stimulated by LPS and Aβ1-42, and can also attenuate Aβ(1-42)-induced cytotoxicity .

HY-147362

MAO-B-IN-14	Monoamine Oxidase	Neurological Disease
MAO-B-IN-14 (Compound 9) is a potent and selective monoamine oxidase-B (MAO-B) inhibitor with an IC₅₀ of 0.95 μM and a K_i of 0.55 μM against human MAO-B.

HY-N8200

Cassiaside B2	Phosphatase Monoamine Oxidase 5-HT Receptor	Inflammation/Immunology
Cassiaside B2 is a protein tyrosine phosphatase 1B *(PTP1B)* and human monoamine oxidase A (hMAO-A) inhibitor. Cassiaside B2 possesses antiallergic and is a 5-HT2C receptor agonist . ..

HY-117502

SL-25.1188	Monoamine Oxidase	Others
SL-25.1188 is a potent **monoamine oxidase B (MAO-B) inhibitor with K_i** values of 2.9 and 8.5 nM for human MAO-B and rat MAO-B, respectively. SL-25.1188 can be used for positron emission tomography .

HY-168728

MAO-B-IN-37	Monoamine Oxidase	Neurological Disease
MAO-B-IN-37 (Compound 37) is a derivative of TT01001 (HY-114520), and a selective inhibitor for **monoamine oxidase B (MAO-B) with an IC₅₀** of 270 nM. MAO-B-IN-37 exhibits good metabolic stability in mice microsomes and good affinity with human serum albumin .

HY-157400

hMAO-B-IN-7	Monoamine Oxidase	Neurological Disease
hMAO-B-IN-7 (compound 11n) is a potent and blood–brain barrier (BBB) penetrable inhibitor of human monoamine oxidase-B (hMAO-B), with the IC₅₀ value of 0.79±0.05 μM. hMAO-B-IN-7 can be used for Alzheimer’s disease (AD) and Parkinson’s disease (PD) research .

HY-173334

hMAO-B-IN-11	Monoamine Oxidase Interleukin Related TNF Receptor	Neurological Disease
hMAO-B-IN-11 (Compound 12) is a selective and reversible inhibitor of human monoamine oxidase B (hMAO-B) with an IC₅₀ of 0.11 µM. hMAO-B-IN-11 acts through competitive binding to the hMAO-B active site, preventing oxidative deamination of monoamines and reducing hydrogen peroxide production. hMAO-B-IN-11 also inhibits pro-inflammatory mediators (NO, TNF-α, IL-1β) in activated microglia, hMAO-B-IN-11 is promising for research of neurodegenerative diseases like Parkinson’s and Alzheimer’s .

HY-178139

hMAO-B-IN-12	Monoamine Oxidase	Cardiovascular Disease
hMAO-B-IN-12 (Compound 6E) is a highly selective human monoamine oxidase B (hMAO-B) inhibitor (IC₅₀=17.7 nM). hMAO-B-IN-12 reduces oxidative stress/lipid metabolism-derived products (e.g., H₂O₂). hMAO-B-IN-12 is promising for research of atherosclerosis .

HY-N4037

Homopterocarpin (-)-Homopterocarpin; 3,9-Dimethoxypterocarpan	Monoamine Oxidase	Inflammation/Immunology
Homopterocarpin is an isoflavonoid that can be isolated from Pterocarpus erinaceus. Homopterocarpin has hepatoprotective and antioxidant properties. Homopterocarpin is a competitive reversible inhibitor of human monoamine *oxidase-B* with an IC₅₀ and a K_i of 0.72 and 0.21 μM for hMAO-B, respectively. Homopterocarpin can be used for the research of liver injury and oxidative stress .

HY-D0004

Azure B Azure B chloride	Monoamine Oxidase	Neurological Disease
Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC₅₀s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects .

HY-152671

hMAO-B-IN-4	Monoamine Oxidase	Neurological Disease
hMAO-B-IN-4 (compound B10) is a selective, reversible and blood–brain barrier (BBB) penetrable human monoamine oxidase-B (hMAO-B) inhibitor with an IC₅₀ value and a K_i value of 0.067 and 0.03 μM, respectively. hMAO-B-IN-4 inhibits hMAO-A with an IC₅₀ value of 33.82 μM. hMAO-B-IN-4 can be used for Alzheimer’s disease (AD) and Parkinson’s disease (PD) research .

HY-D0004R

Azure B (Standard) Azure B chloride (Standard)	Reference Standards Monoamine Oxidase	Neurological Disease
Azure B (Standard) is the analytical standard of Azure B. This product is intended for research and analytical applications. Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC50s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects .

HY-151562

AChE/BuChE/MAO-B-IN-1	Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
AChE/BuChE/MAO-B-IN-1 (compound 19) is an inhibitor of human acetyl- (hAChE), butyrylcholinesterase (hBuChE) and monoamine oxidase-B (hMAO-B) with IC₅₀s of 4.8 μM, 13.7 μM, and 1.11 μM, respectively. AChE/BuChE/MAO-B-IN-1 also exhibits high affinity to both the σ₁ and σ₂ receptors with K_i values of 42.8 nM (human σ₁ receptor) and 191 nM (rat σ₂ receptor), respectively. AChE/BuChE/MAO-B-IN-1 can be used for Alzheimer’s disease research .

HY-146383

H3R antagonist 2	Histamine Receptor Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
H3R antagonist 2 (Compound 23) is a multitarget histamine H₃ receptor (H₃R) antagonist with a K_i of 170 nM for hH₃R . H3R antagonist 2 shows inhibitory effects with IC₅₀ values of 180, 880 and 775 nM for acetylcholinesterase, butyrylcholinesterase and human monoamine oxidase B (hMAO B), respectively. H3R antagonist 2 shows favorable anti-neuropathic pain and memory-enhancing effects. H3R can across BBB .

HY-W205529

RO 16-6491 free base	Fluorescent Dye	Neurological Disease
RO 16-6491 Free base is a selective, reversible inhibitor of monoamine oxidase type B (MAO-B), exhibiting high affinity and specificity for binding sites in human frontal cortex mitochondria and platelet membranes. RO 16-6491 demonstrates a fast dissociation of bound radioactivity at 20 degrees C, indicating its dynamic binding properties. RO 16-6491 also acts as a substrate for MAO-B, suggesting that its oxidation may produce a stable intermediate responsible for its potent inhibitory effects. RO 16-6491 serves as an excellent radioligand probe for investigating the regional tissue distribution of MAO-B in various physiological and pathological states.

HY-163031

MAO-B-IN-28	Monoamine Oxidase	Neurological Disease
MAO-B-IN-28 (compound 10e) is a potent hMAO-B inhibitor with an IC₅₀ of 1.9±0.5 nM. MAO-B-IN-28 can be used as a candidate for neurodegenerative diseases research .

HY-101392S

Harmane-d1	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor	Neurological Disease Cancer
Harmane-d is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC₅₀=30 nM) over α2-adrenoceptor (IC₅₀=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC₅₀s=0.5 and 5 μM for human MAO A/B, respectively) .

HY-101392S1

Harmane-d2	Isotope-Labeled Compounds Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor	Neurological Disease Cancer
Harmane-d₂ is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC₅₀=30 nM) over α2-adrenoceptor (IC₅₀=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC₅₀s=0.5 and 5 μM for human MAO A/B, respectively) .

HY-101392R

Harmane (Standard)	Reference Standards Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor	Neurological Disease Cancer
Harmane (Standard) is the analytical standard of Harmane. This product is intended for research and analytical applications. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC₅₀=30 nM) over α2-adrenoceptor (IC₅₀=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC₅₀s=0.5 and 5 μM for **human MAO A/B**, respectively). Harmane exhibits comutagenic effect .

Cat. No.	Product Name	Type

HY-D0004

Azure B Azure B chloride	Dyes
Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC₅₀s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects .

HY-D0004R

Azure B (Standard) Azure B chloride (Standard)	Dyes
Azure B (Standard) is the analytical standard of Azure B. This product is intended for research and analytical applications. Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC50s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects .

Azure B (Standard)

Azure B chloride (Standard)

Dyes

Azure B (Standard) is the analytical standard of Azure B. This product is intended for research and analytical applications. Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC50s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects .

Cassiaside B2	Monophenols Classification of Application Fields Source classification Phenols Caesalpiniaceae Cassia obtusifolia (L.) H. S. Irwin & Barneby Plants Inflammation/Immunology Disease Research Fields	Phosphatase Monoamine Oxidase 5-HT Receptor
Cassiaside B2 is a protein tyrosine phosphatase 1B *(PTP1B)* and human monoamine oxidase A (hMAO-A) inhibitor. Cassiaside B2 possesses antiallergic and is a 5-HT2C receptor agonist . ..

Homopterocarpin (-)-Homopterocarpin; 3,9-Dimethoxypterocarpan	Other Terpenoids Pterocarpus indicus willd. Leguminosae Terpenoids Source classification Plants	Monoamine Oxidase
Homopterocarpin is an isoflavonoid that can be isolated from Pterocarpus erinaceus. Homopterocarpin has hepatoprotective and antioxidant properties. Homopterocarpin is a competitive reversible inhibitor of human monoamine *oxidase-B* with an IC₅₀ and a K_i of 0.72 and 0.21 μM for hMAO-B, respectively. Homopterocarpin can be used for the research of liver injury and oxidative stress .

Harmane (Standard)	Alkaloids other families Source classification Plants	Reference Standards Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor
Harmane (Standard) is the analytical standard of Harmane. This product is intended for research and analytical applications. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC₅₀=30 nM) over α2-adrenoceptor (IC₅₀=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC₅₀s=0.5 and 5 μM for **human MAO A/B**, respectively). Harmane exhibits comutagenic effect .

Cat. No.	Compare	Product Name	Species	Source

HY-P704121

	MAOB Protein, Human (Active, sf9, His) MAOB, MAO-B,monoamine oxidase B,monoamine oxidase type B	Human	Sf9 insect cells
	MAOB Protein, Human (Active, sf9, His) is the recombinant human-derived MAOB protein, expressed by Sf9 insect cells, with N-His tag. This product contains detergent and is not suitable for cell-related experiments.

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Cat. No.	Product Name	Chemical Structure

HY-101392S

Harmane-d1
Harmane-d is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC₅₀=30 nM) over α2-adrenoceptor (IC₅₀=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC₅₀s=0.5 and 5 μM for human MAO A/B, respectively) .

Harmane-d1

Harmane-d is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC₅₀=30 nM) over α2-adrenoceptor (IC₅₀=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC₅₀s=0.5 and 5 μM for human MAO A/B, respectively) .

HY-101392S1

Harmane-d2
Harmane-d₂ is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC₅₀=30 nM) over α2-adrenoceptor (IC₅₀=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC₅₀s=0.5 and 5 μM for human MAO A/B, respectively) .

Harmane-d2

Harmane-d₂ is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC₅₀=30 nM) over α2-adrenoceptor (IC₅₀=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC₅₀s=0.5 and 5 μM for human MAO A/B, respectively) .

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