Hsp90β

Isoforms Recommended:	HSP90

By Targets:	Akt (1) Antibiotic (2) Apoptosis (6) Autophagy (3) Bacterial (2) Beta-lactamase (2) EGFR (1) HSP (12)
By Research Areas:	Cancer (11) Endocrinology (1) Infection (2)
Click Chemistry:	Alkynes (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10215

Luminespib Maximum Cited Publications 21 Publications Verification VER-52296; AUY922; NVP-AUY922	HSP Autophagy Apoptosis	Cancer
Luminespib (VER-52296) is a potent *HSP90* inhibitor with IC₅₀s of 7.8 and 21 nM for HSP90α and HSP90β, respectively .

HY-13469

Debio 0932 5 Publications Verification CUDC-305	HSP	Cancer
Debio 0932 (CUDC-305) is an orally active *HSP90* inhibitor, with IC₅₀s of 100 and 103 nM for HSP90α and HSP90β, respectively .

HY-B1434

7-Aminocephalosporanic acid 1 Publications Verification 7-ACA	Beta-lactamase Bacterial Antibiotic	Infection
7-aminocephalosporanic acid (7-ACA) is a *HSP90β* inhibitor and an antibiotic. 7-Aminocephalosporanic acid is the core chemical structure of the synthesis of cephalosporin antibiotics and an effective β-lactamase inhibitor .

HY-15190

NVP-HSP990 3 Publications Verification Hsp-990	HSP Apoptosis	Cancer
NVP-HSP990 is a potent, selective and orally active *Hsp90* inhibitor, with IC₅₀ values of 0.6, 0.8, and 8.5 nM for Hsp90α, Hsp90β, and Grp94, respectively.

HY-110042

CCT018159	HSP Apoptosis	Cancer
CCT018159, a 3,4-diaryl pyrazoleresorcinol, is a ATP-competitive HSP90 ATPase activity inhibitor with IC₅₀s of 3.2 and 6.6 µM for human Hsp90β and yeast Hsp90, respectively. CCT018159 caused cell cytostasis associated with a G1 arrest and induces apoptosis. CCT018159 inhibits key endothelial and tumor cell functions implicated in invasion and angiogenesis .

HY-117395

PU-H54	HSP	Cancer
PU-H54, a Grp94-selective inhibitor, can be used for the research of breast cancer. Hsp90 chaperone family, comprised in humans of four paralogs, Hsp90α, Hsp90β, Grp94 and Trap-1, has important roles in malignancy . PU-H54 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10942

VER-82576 5 Publications Verification NVP-BEP800	HSP	Cancer
VER-82576 (NVP-BEP800) is a potent, orally available and selective *Hsp90* inhibitor, with an IC₅₀ of 58 nM for Hsp90β; VER-82576 also slightly blocks Grp94 and Trap-1, with IC₅₀s of 4.1 and 5.5 μM, respectively.

HY-15785

Pimitespib 5+ Cited Publications TAS-116	HSP	Cancer
Pimitespib (TAS-116) is an oral bioavailable, ATP-competitive, highly specific *HSP90α/HSP90β* inhibitor (K_is of 34.7 nM and 21.3 nM, respectively) without inhibiting other HSP90 family proteins such as GRP94 . Pimitespib demonstrates less ocular toxicity .

HY-10215R

Luminespib (Standard) VER-52296 (Standard); AUY922 (Standard); NVP-AUY922 (Standard)	HSP Autophagy Apoptosis	Cancer
Luminespib (Standard) is the analytical standard of Luminespib. This product is intended for research and analytical applications. Luminespib (VER-52296) is a potent HSP90 inhibitor with IC50s of 7.8 and 21 nM for HSP90α and HSP90β, respectively .

HY-B1434R

7-Aminocephalosporanic acid (Standard)	Beta-lactamase Bacterial Antibiotic	Infection
7-Aminocephalosporanic acid (Standard) is the analytical standard of 7-Aminocephalosporanic acid. This product is intended for research and analytical applications. 7-aminocephalosporanic acid (7-ACA) is a HSP90β inhibitor and an antibiotic. 7-Aminocephalosporanic acid is the core chemical structure of the synthesis of cephalosporin antibiotics and an effective β-lactamase inhibitor .

HY-10214

SNX-2112 2 Publications Verification PF-04928473	HSP Autophagy	Cancer
SNX-2112 (PF 04928473) is an orally active *Hsp90* inhibitor, with a K_d of 16 nM for *Hsp90* and IC₅₀s of 30 nM, 30 nM for Hsp90 α and Hsp90 β, also induces Her-2 degradation, and inhibits Grp94 and Trap-1, with IC₅₀s of 10 nM, 4.275 μM and 0.862 μM, respectively . SNX-2112 (PF 04928473) binds Hsp90 isoforms Hsp90α, Hsp90β and Hsp90b1/Grp94 with K_ds of 4 nM, 6 nM and 484 nM, respectively .

HY-168205

HSP90-IN-33	HSP Apoptosis	Cancer
HSP90-IN-33 (compound 24e) is a potent *Hsp90* inhibitor with K_d values of ≥200, 7.3 µM for Hsp90α, Hsp90β, respectively. HSP90-IN-33 induces apoptosis and cell cycle arrest at G0/G1 phase. HSP90-IN-33 decreases the protein expression of ERα, CDK4 and Akt .

HY-162751

Anticancer agent 249	HSP Apoptosis	Cancer
Anticancer agent 249 (Compound 89) is an inhibitor for *Hsp90β* with IC₅₀ of 16.5 μM in PC3MM2 cell. Anticancer agent 249 inhibits proliferation of cancer cells MCF-7, T47D, MDA-MB-231, MDA-MB-468 and SKBr3 with IC₅₀ of 1.8-5.3 μM. Anticancer agent 249 induces apoptosis in MDA-MB-231. Anticancer agent 249 exhibits antitumor efficacy in mice .

HY-123035

Gamendazole	HSP Akt EGFR	Endocrinology
Gamendazole, an indazole carboxylic acid (ICA), is an orally active, selective HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A) inhibitor. Gamendazole binds to the C-terminal nucleotide binding pocket of HSP90 and cause downregulation of clients AKT1 and ERBB2, but stabilizes the HSP90 heterocomplex. Gamendazole specifically inhibits the actin bundling function of EEF1A1, but does not bind to the nucleotide docking pocket nor inhibits the ribosome charging or protein translation functions of EEF1A1. Gamendazole, an antispermatogenic compound with antifertility effects, has the potential for reversible non-hormonal male contraceptive agent research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1434

7-Aminocephalosporanic acid 1 Publications Verification 7-ACA	Infection Classification of Application Fields Disease Research Fields	Beta-lactamase Bacterial Antibiotic
7-aminocephalosporanic acid (7-ACA) is a *HSP90β* inhibitor and an antibiotic. 7-Aminocephalosporanic acid is the core chemical structure of the synthesis of cephalosporin antibiotics and an effective β-lactamase inhibitor .

Cat. No.	Compare	Product Name	Species	Source

HY-P72238

	HSP90AA1 Protein, Human (His-SUMO) 1 Publications Verification Heat shock 86 kDa; Heat shock protein 90kDa alpha cytosolic class A member 1; Heat shock protein 90kDa alpha cytosolic class B member 1; Heat shock protein Hsp 90 alpha ; Heat shock protein Hsp 90 beta; Heat shock protein Hsp 90-alpha; HS90A_HUMAN; Hsp 84; Hsp 86; Hsp 90; Hsp86; Hsp90A; Hsp90AA1; Hsp90AB1; Hsp90B; HspC1; HspC2; HspCAL1 ; HspCAL4; Renal carcinoma antigen NY-REN-38	Human	E. coli
	The HSP90AA1 protein is an important molecular chaperone that coordinates the maturation and regulation of specific target proteins critical for cell cycle control and signal transduction. Its ATPase activity drives a functional cycle that induces conformational changes in client proteins for activation. HSP90AA1 Protein, Human (His-SUMO) is the recombinant human-derived HSP90AA1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

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HY-P80187

	Hsp90 beta Antibody (YA355)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Hsp90 beta Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 83 kDa, targeting to Hsp90 beta. It can be used for WB,ICC/IF,IHC-P,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P84003

	HSP90AB1 Antibody (YA3700) HspC2; HspCB; D6S182; Hsp90B; FLJ26984; Hsp90-BETA	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey

HY-P80714

	Hsp90 alpha/beta Antibody (YA356) Hsp90AA1; Hsp90A; HspC1; HspCA; Heat shock protein Hsp 90-alpha; Heat shock 86 kDa; Hsp 86; Hsp86; Renal carcinoma antigen NY-REN-38; Hsp90AB1; Hsp90B; HspC2; HspCB; Heat shock protein Hsp 90-beta; Hsp 90; Heat shock 84 kDa; Hsp 84; Hsp84	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Hsp90 alpha/beta Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 85 kDa, targeting to Hsp90 alpha/beta. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

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Cat. No.	Product Name		Classification

HY-117395

PU-H54		Alkynes
PU-H54, a Grp94-selective inhibitor, can be used for the research of breast cancer. Hsp90 chaperone family, comprised in humans of four paralogs, Hsp90α, Hsp90β, Grp94 and Trap-1, has important roles in malignancy . PU-H54 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Hsp90β

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