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Results for "

Hmox1

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

2

Natural
Products

2

Recombinant Proteins

1

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-124815
    CP-312

    		Reactive Oxygen Species Others
    CP-312 is a potent Heme Oxygenase-1 (HO-1) inducer. CP-312 protects hiPSC-CM viability by targeting the antioxidant response network through induction of HMOX1 expression. CP-312 protects human iPSC-derived cardiomyocytes from oxidative stress [1].
    CP-312
  • HY-N0643
    Carnosol
    10+ Cited Publications

    		 Ribosomal S6 Kinase (RSK) Keap1-Nrf2 Endogenous Metabolite Cancer
    Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC50 of ~5.5 μM [1]. Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) .
    Carnosol
  • HY-147517
    Keap1-Nrf2-IN-9

    		Keap1-Nrf2 Neurological Disease Inflammation/Immunology
    Keap1-Nrf2-IN-9 (compound 11) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein protein interaction) inhibitor with an IC50 of 0.575 μM. Keap1-Nrf2-IN-9 increases the expression of Nrf2 target genes including heme oxygenase 1 (Hmox1), glutathione S-transferase P (GstP), and glutamate-cysteine ligase catalytic (Gclc) and modulatory (Gclm) subunits. Keap1-Nrf2-IN-9 shows not cytotoxic activity in ARPE19 cells [1].
    Keap1-Nrf2-IN-9
  • HY-RS16718
    Hmox1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Hmox1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hmox1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Hmox1 Mouse Pre-designed siRNA Set A
    Hmox1 Mouse Pre-designed siRNA Set A
  • HY-RS06249
    HMOX1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    HMOX1 Human Pre-designed siRNA Set A contains three designed siRNAs for HMOX1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    HMOX1 Human Pre-designed siRNA Set A
    HMOX1 Human Pre-designed siRNA Set A
  • HY-RS23153
    Hmox1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Hmox1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hmox1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Hmox1 Rat Pre-designed siRNA Set A
    Hmox1 Rat Pre-designed siRNA Set A
  • HY-N0643R
    Carnosol (Standard)

    		Ribosomal S6 Kinase (RSK) Keap1-Nrf2 Endogenous Metabolite Cancer
    Carnosol (Standard) is the analytical standard of Carnosol. This product is intended for research and analytical applications. Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC50 of ~5.5 μM [1]. Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) .
    Carnosol (Standard)
  • HY-173444
    HDAC11-IN-3

    		HDAC Transferrin Receptor Apoptosis Ferroptosis Cancer
    HDAC11-IN-3 (Compound A9) is a selective HDAC11 inhibitor (IC50: 4.1 nM). HDAC11-IN-3 has inhibitory effects on U937 and OCI-AML2 acute myeloid leukemia (AML) cell lines (IC50: 10 μM). HDAC11-IN-3 has significant anti-AML activity, inducing apoptosis, cell cycle arrest, and differentiation. HDAC11-IN-3 upregulates the iron transporters transferrin (TF) and transferrin receptor (TFRC), and activates the p62-Keap1-Nrf2-HMOX1 pathway, which together lead to increased intracellular iron levels and induce ferroptosis in AML cells. HDAC11-IN-3 can be used alone or in combination with Cytarabine (HY-13605) for AML research [1].
    HDAC11-IN-3
  • HY-170968
    EGFR-IN-150

    		EGFR Apoptosis Cancer
    EGFR-IN-150 is an EGFR inhibitor that effectively suppresses the phosphorylation of mutant epidermal growth factor receptor (EGFR) and its downstream AKT signaling pathway, thereby exerting antitumor effects and inducing HMOX1 expression to trigger ferroptosis. EGFR-IN-150 exhibits an IC50 of 0.386 μM against the non-small cell lung cancer (NSCLC) cell line H1975, and significantly inhibits colony formation and migration of both H1975 and A549 cells while inducing apoptosis. In addition, EGFR-IN-150 markedly suppresses tumor growth in the H1975 cell-derived xenograft (CDX) mouse model. EGFR-IN-150 holds promise for research related to non-small cell lung cancer [1].
    EGFR-IN-150
  • HY-149245
    Keap1-Nrf2-IN-15

    		Keap1-Nrf2 Inflammation/Immunology
    Keap1-Nrf2-IN-15 (Compound 24a) is a potent Keap1-Nrf2 protein-protein interaction inhibitor with IC50s of 77 nM and 2.5 nM in FP assay and TR-FRET assay, respectively [1].
    Keap1-Nrf2-IN-15
  • HY-121523
    MIND4-17

    		Keap1-Nrf2 Metabolic Disease
    MIND4-17 is a potent NRF2 activator that covalently modifies a C151 residue of Keap1. MIND4-17 disrupts Keap1-Nrf2 association, leading to Nrf2 protein stabilization and nuclear translocation. MIND4‐17 exerts potent antioxidant activity [1] .
    MIND4-17

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