Search Result

Results for "

HT22

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA Carboxylase (1) Akt (1) Amyloid-β (3) Apoptosis (5) ATF6 (1) Bacterial (3) Bombesin Receptor (1) Calcium Channel (1) Caspase (2) Cholinesterase (ChE) (2) COX (1) Cytochrome P450 (1) ERK (1) Ferroptosis (1) G-quadruplex (1) Glutathione Peroxidase (1) GSK-3 (1) HBV (1) Heme Oxygenase (HO) (1) Integrin (2) JNK (1) LXR (1) MDM-2/p53 (1) MMP (1) mTOR (1) NAMPT (1) NF-κB (2) NO Synthase (1) P2Y Receptor (1) p38 MAPK (1) Phosphodiesterase (PDE) (1) PI3K (1) Potassium Channel (1) Prostaglandin Receptor (1) Reactive Oxygen Species (ROS) (3) Sigma Receptor (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (2) Endocrinology (1) Infection (3) Inflammation/Immunology (6) Neurological Disease (16)

By Targets:

Acetyl-CoA Carboxylase (1)

Akt (1)

Amyloid-β (3)

Apoptosis (5)

ATF6 (1)

Bacterial (3)

Bombesin Receptor (1)

Calcium Channel (1)

Caspase (2)

Cholinesterase (ChE) (2)

COX (1)

Cytochrome P450 (1)

ERK (1)

Ferroptosis (1)

G-quadruplex (1)

Glutathione Peroxidase (1)

GSK-3 (1)

HBV (1)

Heme Oxygenase (HO) (1)

Integrin (2)

JNK (1)

LXR (1)

MDM-2/p53 (1)

MMP (1)

mTOR (1)

NAMPT (1)

NF-κB (2)

NO Synthase (1)

P2Y Receptor (1)

p38 MAPK (1)

Phosphodiesterase (PDE) (1)

PI3K (1)

Potassium Channel (1)

Prostaglandin Receptor (1)

Reactive Oxygen Species (ROS) (3)

Sigma Receptor (1)

Toll-like Receptor (TLR) (1)

By Research Areas:

Cancer (6)

Cardiovascular Disease (2)

Endocrinology (1)

Infection (3)

Inflammation/Immunology (6)

Neurological Disease (16)

Inhibitors & Agonists

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153383

PDCD4-IN-1 1 Publications Verification	Others	Cancer
PDCD4-IN-1(compound 20031600) is a PDCD4 inhibitor with a K_d value of 350 nM, which can promote the expression of BDNF in hippocampal neuron cell HT-22 .

HY-136674

Aftin-5	Amyloid-β	Neurological Disease
Aftin-5 is an inducer for Amyloid-β 42 (Aβ42). Aftin-5 upregulates Aβ42 and downregulates Aβ38 levels in a β-secretase- and γ-secretase-dependent manner by altering the ultrastructure of mitochondria. Aftin-5 exhibits slightly cytotoxicity in cell SH-SY5Y, HT22, N2a and N2a-AβPP695, with IC₅₀s of 180, 194, 178 and 150 μM, respectively .

HY-120553

B-355252	Apoptosis	Neurological Disease
B355252, a phenoxy thiophene sulfonamide small molecule, is a potent NGF receptor agonist. B355252 potentiates NGF-induced neurite outgrowth. B355252 protects ischemic neurons from neuronal loss by attenuating DNA damage, reducing ROS production and the LDH level, and preventing neuronal apoptosis. B355252 has anti-apoptotic effects in glutamate-induced excitotoxicity, as well as in a murine hippocampal cell line (HT22) model of Parkinson disease (PD) .

HY-161327

HBV-IN-44	HBV	Infection
HBV-IN-44 (Compound (S)-2a) is a HBV inhibitor with a IC₅₀ value of 23 nM for HbsAg. HBV-IN-44 is less toxic to the neurite growth of HT22 cells and DRG neurons in vitro .

HY-N8464

Juncuenin D	Bacterial	Cancer
Juncuenin D induces caspase-3-mediated cytotoxicity in HT22 cells. Juncuenin D also has anti-bacterial activity against MRSA strains. Juncuenin D can be isolated from J. effusus .

HY-N9966

Sanggenol O	Others	Others
Sanggenol O? is an active product that can be extracted from Morus alba. Sanggenol O? has hepatoprotective and neuroprotective activities with EC₅₀s more than 80 μM in HepG2 and HT22 cells .

HY-N8412

4-O-Methylbutein	Others	Neurological Disease
4-O-Methylbutein is a phenolic glucoside that can be isolated from Elsholtzia ciliata.4-O-Methylbutein exhibits neuroprotective effects against glutamate-induced HT22 cell death with an EC₅₀ of 35.2 μM .

HY-170367

Antimicrobial agent-35	Bacterial	Infection
Antimicrobial agent-35 (Compound c9) exhibits antibacterial agent, that inhibits S. aureus, E. coli, E. faecalis, and S. maltophilia with MIC of 0.5-2 μg/mL. Antimicrobial agent-35 exhibits cytotoxicity against HT-22 with IC₅₀ of 130.4 μg/mL .

HY-163280

JGB-1-155	NAMPT	Neurological Disease
JGB-1-155 is a positive allosteric modulators (N-PAMs), which enhances the activity of nicotinamide phosphoribosyltransferase NAMPT with EC₅₀ of 3.29 μM. JGB-1-155 counteracts the oxidative stress, through upregulating the NAD ⁺ in THP-1 human monocytes. JGB-1-155 attenuates TNFα-induced ROS in HT-22 cells .

HY-W670700

2,5-Dihydroxy-4-methoxyacetophenone	Others	Others
2,5-Dihydroxy-4-methoxyacetophenone (compounds 3) can be isolated from the 80% methanol extract of roots of Cynanchum paniculatum Kitagawa. 2,5-Dihydroxy-4-methoxyacetophenone inhibits glutamate-induced cytotoxicity in hippocampal HT22 cell line .

HY-139382

2-(Isopentylamino)naphthalene-1,4-dione	Cytochrome P450	Neurological Disease
2-(Isopentylamino)naphthalene-1,4-dione (compound 3d), a Vitamin K (HY-B2172) analogue, shows protection in Pentylenetetrazole (PTZ)-induced seizure model. 2-(Isopentylamino)naphthalene-1,4-dione significantly increases ATP levels in zebrafish as well as HT-22 cells. 2-(Isopentylamino)naphthalene-1,4-dione shows excellent permeability into the brain .

HY-135981

CMS-121 1 Publications Verification	Acetyl-CoA Carboxylase	Neurological Disease Inflammation/Immunology
CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC₅₀ values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities .

HY-149763

Aβ42 agonist-1	Amyloid-β	Neurological Disease
Aβ42 agonist-1 is a compound that can promote Aβ42 aggregation. Aβ42 agonist-1 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-1 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells .

HY-149764

Aβ42 agonist-2	Amyloid-β	Neurological Disease
Aβ42 agonist-2 (compound 7b) is a small molecule compound that can promote Aβ42 aggregation. Aβ42 agonist-2 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-2 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells .

HY-100218B

(1R,3S)-RSL3	Glutathione Peroxidase Ferroptosis	Cancer
(1R,3S)-RSL3 is the less active (1R,3S)-enantiomer of RSL3 ((1S,3R)-RSL3). (1R,3S)-RSL3 and RSL3 induce cell death in HT22 wild-type cells with EC₅₀ values of 5.2 µM and 0.004 µM, rspectively .

HY-170562

STEP-IN-1	Reactive Oxygen Species (ROS) Apoptosis	Neurological Disease
STEP-IN-1 (Compound 14b) is a potent and selective STEP inhibitor with an IC₅₀ of 5.27 μM. STEP-IN-1 has a neuroprotective effect, which can protect nerve cells from glutamate-induced toxicity, reduce cellular ROS accumulation, and inhibit apoptosis. STEP-IN-1 can be used in the study of neurodegenerative diseases .

HY-114892

15-A2t-Isoprostane 8-iso Prostaglandin A2	Prostaglandin Receptor	Endocrinology
15-A2t-Isoprostane (8-iso Prostaglandin A2) is an isoprostaglandin produced by the non-enzymatic oxidation of arachidonic acid .

HY-135776

BMVC2 o-BMVC	G-quadruplex	Cancer
BMVC2 (o-BMVC) is a bisubstitute carbazole derivative of BMVC. BMVC2 is a G-quadruplex (G4) stabilizer .

HY-N6778

Paxilline Maximum Cited Publications 6 Publications Verification	Potassium Channel Calcium Channel Reactive Oxygen Species (ROS)	Neurological Disease
Paxilline is an indole alkaloid mycotoxin derived from Penicillium paxilli, which effectively inhibits the BK channel through a channel-blocking mechanism. Paxilline also inhibits sarco/endoplasmic reticulum Ca ²⁺-stimulated ATPase (SERCA), with IC₅₀ values ranging from 5 μM to 50 μM for different SERCA isoforms. Paxilline exhibits significant anticonvulsant and neuroprotective effects, as well as certain antioxidant activity .

HY-174260

Neuroprotective agent 11	NO Synthase COX Caspase MDM-2/p53	Neurological Disease
Neuroprotective agent 11 (Compound 1a) is an orally active polyphenol compound with significant protective effects against cerebral ischemia. The main activities of Neuroprotective agent 11 include inhibiting neuronal inflammation and apoptosis, reducing cerebral infarction volume, and improving behavioral symptoms of cerebral ischemic mice. Neuroprotective agent 11 exerts its regulatory mechanism by downregulating the expression of inflammatory factors (iNOS、COX-2) and apoptotic proteins (cleaved-Caspase3, p53). Neuroprotective agent 11 can be used in the study of cerebral ischemia-related diseases (such as ischemic stroke) .

HY-170976

BuChE-IN-16	Cholinesterase (ChE)	Neurological Disease
BuChE-IN-16 (Compound 6a) is an orally active, BBB-permeable, and selective BuChE inhibitor with an IC₅₀ of 0.33 μM. BuChE-IN-16 has anti-inflammatory and neuroprotective effects. BuChE-IN-16 can improve the cognitive function of zebrafish with Alzheimer's disease (AD) and alleviate memory impairment in mice induced by Scopolamine (HY-N0296). BuChE-IN-16 can be used for the research of AD .

HY-146195

MAPK-IN-1 2 Publications Verification	Toll-like Receptor (TLR) p38 MAPK JNK ERK Cholinesterase (ChE)	Neurological Disease Inflammation/Immunology
MAPK-IN-1 (Compound 2) is a MAPK signaling pathway inhibitor. MAPK-IN-1 exhibits AChE inhibitory activity with an IC₅₀ of 23.84 μM. MAPK-IN-1 shows anti-neuroinflammatory and neuroprotective activity and can be used for Alzheimer's disease research .

HY-174126

P2Y1 antagonist 2	P2Y Receptor	Cardiovascular Disease
P2Y1 antagonist 2 (Compound 19) is a P2Y1 receptor antagonist (IC₅₀: 0.49 μM). P2Y1 antagonist 2 has significant antiplatelet aggregation activity and exerts its effects by inhibiting P2Y1 receptor. P2Y1 antagonist 2 can upregulate nuclear Nrf2 protein levels, exhibit neuroprotective effects, and resist oxidative stress damage. P2Y1 antagonist 2 can effectively reduce cerebral infarction area and improve neurobehavioral function, and can be used in the study of ischemic stroke .

HY-101484A

NE-100 hydrochloride	Sigma Receptor ATF6	Neurological Disease
NE-100 hydrochloride is an orally active and selective sigma-1 receptor antagonist with an IC₅₀ of 4.16 nM. NE-100 hydrochloride can improve cognitive impairment and has neuroprotective and antipsychotic activities. NE-100 hydrochloride can be used for research on nervous system diseases .

HY-174339

Neuroprotective agent 12	Phosphodiesterase (PDE) Heme Oxygenase (HO) NF-κB	Neurological Disease Inflammation/Immunology
Neuroprotective agent 12 is an orally active and BBB-penetrable neuroprotective agent. Neuroprotective agent 12 has potent neuroprotective effects with robust anti-oxidation and anti-inflammation. Neuroprotective agent 12 significantly inhibits glutamate- and acrolein-induced cell death, reduces PDE4B expression but increases the HO-1, p-CREB and BDNF levels. Neuroprotective agent 12 exhibits potent neuroprotection in traumatic brain injury (TBI) mice model, promising for TBI and other central nervous system diseases .

HY-N4247

Kuwanon G	Bombesin Receptor Bacterial Apoptosis Reactive Oxygen Species (ROS) PI3K Akt GSK-3 MMP mTOR NF-κB LXR	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Kuwanon G is a flavonoid compound and an antagonist of the bombesin receptor. Kuwanon G has multiple activities such as bactericidal, anti-tumor, anti-inflammatory, antioxidant, anti-atherosclerotic, and neuroprotective effects. Kuwanon G exhibits strong antibacterial activity against oral pathogens, especially cariogenic bacteria and periodontal pathogens. Kuwanon G can induce apoptosis and inhibit proliferation, migration, and invasion of tumor cells. Kuwanon G can be used in the research of diseases such as gastric cancer and atherosclerosis .

HY-P1740

RGD peptide (GRGDNP) 5 Publications Verification	Integrin Apoptosis Caspase	Inflammation/Immunology
RGD peptide (GRGDNP) is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) plays an important role in cell adhesion, migration, growth, and differentiation .

HY-P1740A

RGD peptide (GRGDNP) (TFA) 5 Publications Verification	Integrin Apoptosis	Inflammation/Immunology Cancer
RGD peptide (GRGDNP) TFA is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) TFA competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) TFA promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) TFA plays an important role in cell adhesion, migration, growth, and differentiation .

Cat. No.	Product Name	Target	Research Area

HY-P1740

RGD peptide (GRGDNP) 5 Publications Verification	Integrin Apoptosis Caspase	Inflammation/Immunology
RGD peptide (GRGDNP) is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) plays an important role in cell adhesion, migration, growth, and differentiation .

HY-P1740A

RGD peptide (GRGDNP) (TFA) 5 Publications Verification	Integrin Apoptosis	Inflammation/Immunology Cancer
RGD peptide (GRGDNP) TFA is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) TFA competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) TFA promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) TFA plays an important role in cell adhesion, migration, growth, and differentiation .

Paxilline 5+ Cited Publications	Alkaloids Structural Classification Microorganisms other families Neurological Disease Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Disease Research Fields Indole Alkaloids	Potassium Channel Calcium Channel Reactive Oxygen Species (ROS)
Paxilline is an indole alkaloid mycotoxin derived from Penicillium paxilli, which effectively inhibits the BK channel through a channel-blocking mechanism. Paxilline also inhibits sarco/endoplasmic reticulum Ca ²⁺-stimulated ATPase (SERCA), with IC₅₀ values ranging from 5 μM to 50 μM for different SERCA isoforms. Paxilline exhibits significant anticonvulsant and neuroprotective effects, as well as certain antioxidant activity .

Kuwanon G	Infection Structural Classification Flavonoids Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Moraceae Disease Research Fields Morus alba Linn.	Bombesin Receptor Bacterial Apoptosis Reactive Oxygen Species (ROS) PI3K Akt GSK-3 MMP mTOR NF-κB LXR
Kuwanon G is a flavonoid compound and an antagonist of the bombesin receptor. Kuwanon G has multiple activities such as bactericidal, anti-tumor, anti-inflammatory, antioxidant, anti-atherosclerotic, and neuroprotective effects. Kuwanon G exhibits strong antibacterial activity against oral pathogens, especially cariogenic bacteria and periodontal pathogens. Kuwanon G can induce apoptosis and inhibit proliferation, migration, and invasion of tumor cells. Kuwanon G can be used in the research of diseases such as gastric cancer and atherosclerosis .

Juncuenin D	Structural Classification Natural Products Juncaceae Source classification Plants Juncus acutus L.	Bacterial
Juncuenin D induces caspase-3-mediated cytotoxicity in HT22 cells. Juncuenin D also has anti-bacterial activity against MRSA strains. Juncuenin D can be isolated from J. effusus .

Sanggenol O	Structural Classification Flavonoids Flavonones Source classification Morus alba L. Plants Moraceae	Others
Sanggenol O? is an active product that can be extracted from Morus alba. Sanggenol O? has hepatoprotective and neuroprotective activities with EC₅₀s more than 80 μM in HepG2 and HT22 cells .

4-O-Methylbutein	Structural Classification Labiatae Source classification Anthyllis vulneraria L. Phenols Polyphenols Plants	Others
4-O-Methylbutein is a phenolic glucoside that can be isolated from Elsholtzia ciliata.4-O-Methylbutein exhibits neuroprotective effects against glutamate-induced HT22 cell death with an EC₅₀ of 35.2 μM .

2,5-Dihydroxy-4-methoxyacetophenone	Structural Classification Source classification Asclepiadaceae Phenols Polyphenols Cynanchum paniculatum (Bunge) Kitagawa Plants	Others
2,5-Dihydroxy-4-methoxyacetophenone (compounds 3) can be isolated from the 80% methanol extract of roots of Cynanchum paniculatum Kitagawa. 2,5-Dihydroxy-4-methoxyacetophenone inhibits glutamate-induced cytotoxicity in hippocampal HT22 cell line .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks