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HPK1-IN-57

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-172594
    HPK1-IN-57

    		MAP4K Interleukin Related Inflammation/Immunology Cancer
    HPK1-IN-57 (Compound 10c) is a hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 value of 0.09 nM. HPK1-IN-57 inhibits the activity of HPK1 kinase, hindering the phosphorylation of the downstream adaptor protein SLP76 (IC50 is 33.74 nM) and effectively stimulating the secretion of the T cell activation marker IL-2 (EC50 is 84.24 nM). HPK1-IN-57 is promising for research of tumor immunotherapy .
    HPK1-IN-57

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