HOX

By Targets:	Androgen Receptor (3) Apoptosis (6) Endogenous Metabolite (1) Histone Methyltransferase (2) NF-κB (1) Orexin Receptor (OX Receptor) (1) Reference Standards (2) WDR5 (2)
By Research Areas:	Cancer (6) Cardiovascular Disease (2) Inflammation/Immunology (1) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P10948A

CS-VIP 8 hydrochloride	WDR5 Histone Methyltransferase	Cardiovascular Disease
CS-VIP 8 hydrochloride is a selective allosteric WDR5 protein inhibitor (K_i= 0.008 μM). CS-VIP 8 hydrochloride induces conformational changes in the MLL1 complex, leading to the dissociation of MLL1 from the complex, inhibiting MLL1 histone methyltransferase activity and regulating HOX gene expression. CS-VIP 8 hydrochloride is promising for research of hematological diseases such as leukemia .

HY-P3245A

HXR9 hydrochloride	Apoptosis	Cancer
HXR9 hydrochloride is a cell-permeable peptide and a competitive antagonist of HOX/PBX interaction. HXR9 hydrochloride antagonizes the interaction between HOX and a second transcrip-tion factor (PBX), which binds to HOX proteins in paralogue groups1 to 8. HXR9 hydrochloride selectively decreases cell proliferation and promotes apoptosis in cells with a high level of expression of the HOXA/PBX3 genes, such as MLL-rearranged leukemic cells .

HY-122611A

CSRM617 hydrochloride 1 Publications Verification	Androgen Receptor Apoptosis	Cancer
CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a K_d of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 hydrochloride induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 hydrochloride is well tolerated in the prostate cancer mouse model

HY-134188

JNJ-54717793	Orexin Receptor (OX Receptor)	Neurological Disease
JNJ-54717793, as a brain penetrant, is an orally active, selective and high affinity orexin-1 receptor (OX1R) antagonist (plasma EC₅₀=85 ng/mL). The K_i values of JNJ-54717793 for hOX1R (human OX1R) and hOX2R are 16 nM and 700 nM, respectively. JNJ-54717793 is a potent compound of anxiety disorders .

HY-P10948

CS-VIP 8	WDR5 Histone Methyltransferase	Cardiovascular Disease
CS-VIP 8 is a selective allosteric WDR5 protein inhibitor (K_i= 0.008 μM). CS-VIP 8 induces conformational changes in the MLL1 complex, leading to the dissociation of MLL1 from the complex, inhibiting MLL1 histone methyltransferase activity and regulating HOX gene expression. CS-VIP 8 is promising for research of hematological diseases such as leukemia .

HY-P3245

HXR9	Apoptosis	Cancer
HXR9 is a cell-permeable peptide and a competitive antagonist of HOX/PBX interaction. HXR9 antagonizes the interaction between HOX and a second transcrip-tion factor (PBX), which binds to HOX proteins in paralogue groups1 to 8. HXR9 selectively decreases cell proliferation and promotes apoptosis in cells with a high level of expression of the HOXA/PBX3 genes, such as MLL-rearranged leukemic cells .

HY-122611

CSRM617	Androgen Receptor Apoptosis	Cancer
CSRM617 is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a K_d of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 is well tolerated in the prostate cancer mouse model

HY-122611R

CSRM617 (Standard)	Reference Standards Androgen Receptor Apoptosis	Cancer
CSRM617 (Standard) is the analytical standard of CSRM617. This product is intended for research and analytical applications. CSRM617 is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 is well tolerated in the prostate cancer mouse model

HY-N1486R

Ursonic acid (Standard) 3-Ketoursolic acid (Standard)	Reference Standards Apoptosis Endogenous Metabolite NF-κB	Inflammation/Immunology Cancer
CSRM617 (Standard) is the analytical standard of CSRM617. This product is intended for research and analytical applications. CSRM617 is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 is well tolerated in the prostate cancer mouse model

Cat. No.	Product Name	Target	Research Area

HY-P10948A

CS-VIP 8 hydrochloride	WDR5 Histone Methyltransferase	Cardiovascular Disease
CS-VIP 8 hydrochloride is a selective allosteric WDR5 protein inhibitor (K_i= 0.008 μM). CS-VIP 8 hydrochloride induces conformational changes in the MLL1 complex, leading to the dissociation of MLL1 from the complex, inhibiting MLL1 histone methyltransferase activity and regulating HOX gene expression. CS-VIP 8 hydrochloride is promising for research of hematological diseases such as leukemia .

HY-P3245A

HXR9 hydrochloride	Apoptosis	Cancer
HXR9 hydrochloride is a cell-permeable peptide and a competitive antagonist of HOX/PBX interaction. HXR9 hydrochloride antagonizes the interaction between HOX and a second transcrip-tion factor (PBX), which binds to HOX proteins in paralogue groups1 to 8. HXR9 hydrochloride selectively decreases cell proliferation and promotes apoptosis in cells with a high level of expression of the HOXA/PBX3 genes, such as MLL-rearranged leukemic cells .

HY-P10948

CS-VIP 8	WDR5 Histone Methyltransferase	Cardiovascular Disease
CS-VIP 8 is a selective allosteric WDR5 protein inhibitor (K_i= 0.008 μM). CS-VIP 8 induces conformational changes in the MLL1 complex, leading to the dissociation of MLL1 from the complex, inhibiting MLL1 histone methyltransferase activity and regulating HOX gene expression. CS-VIP 8 is promising for research of hematological diseases such as leukemia .

HY-P3245

HXR9	Apoptosis	Cancer
HXR9 is a cell-permeable peptide and a competitive antagonist of HOX/PBX interaction. HXR9 antagonizes the interaction between HOX and a second transcrip-tion factor (PBX), which binds to HOX proteins in paralogue groups1 to 8. HXR9 selectively decreases cell proliferation and promotes apoptosis in cells with a high level of expression of the HOXA/PBX3 genes, such as MLL-rearranged leukemic cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1486R

Ursonic acid (Standard) 3-Ketoursolic acid (Standard)	Triterpenes Structural Classification Ziziphus jujuba Terpenoids Source classification Plants Endogenous metabolite Rhamnaceae	Reference Standards Apoptosis Endogenous Metabolite NF-κB
CSRM617 (Standard) is the analytical standard of CSRM617. This product is intended for research and analytical applications. CSRM617 is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 is well tolerated in the prostate cancer mouse model

Species:	Human (2)
Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P74879

	HOXA1 Protein, Human (His) Homeobox protein HOX-A1; HOXA1; HOX1F	Human	E. coli
	The HOXA1 protein is a sequence-specific transcription factor that complexly regulates multiple developmental processes in the brainstem, inner and outer ears, abducens nerves, and cardiovascular development. It also plays a key role in cognitive and behavioral processes. HOXA1 Protein, Human (His) is the recombinant human-derived HOXA1 protein, expressed by E. coli , with N-His labeled tag.

HY-P70308

	HOXB4 Protein, Human (His) rHuHomeobox protein B4-L175D, E176K, E178K, His; Homeobox Protein B4; Homeobox protein HOX-B4; Homeobox protein HOX-2.6; Homeobox protein HOX-2F; HOXB4; HOX2F	Human	E. coli
	HOXB4 protein, a sequence-specific transcription factor, critically participates in a developmental regulatory system, assigning specific positional identities to cells along the anterior-posterior axis. HOXB4 Protein, Human (His) is the recombinant human-derived HOXB4 protein, expressed by E. coli , with N-6*His labeled tag.

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HY-P82816

	HOXA13 Antibody (YA2561) Homeobox1J; HomeoboxA13; HOX 1; HOX 1J; HOX A13; HOX1; HOX1J; HOXA 13; HOXA13; Transcription factor HOXA13	WB	Human, Mouse, Rat
	HOXA13 Antibody (YA2561) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HOXA13.

HY-P83272

	HOXB9 Antibody (YA3017) Homeobox protein HOX-B9; HOX-2E; HOX-2.5; HOXB9; HOX2E	WB, ICC/IF, IP	Human
	HOXB9 Antibody (YA3017) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HOXB9.

HY-P83162

	HOXA5 Antibody (YA2907) HOX1; HOX1.3; HOX1C; HOXA5	WB	Human, Mouse, Rat
	HOXA5 Antibody (YA2907) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HOXA5.

HY-P83164

	HOXA9 Antibody (YA2909) HOX1; ABD-B; HOX1G; HOX1.7	WB	Human
	HOXA9 Antibody (YA2909) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HOXA9.

HY-P82942

	HOXB4 Antibody (YA2687) HOXB4; HOX2F; Homeobox protein HOX-B4; Homeobox protein HOX-2.6; Homeobox protein HOX-2F	WB, ICC/IF, IP	Human, Mouse, Rat
	HOXB4 Antibody (YA2687) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HOXB4.

HY-P81453

	HOXB13 Antibody (YA1198) HOXB13; Homeobox protein HOX-B13	IHC-P	Human
	HOXB13 Antibody (YA1198) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HOXB13.

HY-P86905

	HOXC6 Antibody (YA6598) CP25 antibody; HHO.C8 antibody; Homeo box 3C antibody; Homeo box C6 antibody; Homeo box C8 protein antibody; Homeobox C6 antibody; Homeobox protein CP25 antibody; Homeobox protein HHO.C8 antibody; Homeobox protein HOX-3C antibody; Homeobox protein HOX-C6 antibody; CP25 antibody; HHO.C8 antibody; Homeo box 3C antibody; Homeo box C6 antibody; Homeo box C8 protein antibody; Homeobox C6 antibody; Homeobox protein CP25 antibody; Homeobox protein HHO.C8 antibody; Homeobox protein HOX-3C antibody; Homeobox protein HOX-C6 antibody; HOX3 antibody; HOX3C antibody; HOXc6 antibody; HXC6_HUMAN antibody;	WB	Human, Rat
	HOXC6 Antibody (YA6598) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HOXC6.

HY-P85285

	MSX1 Antibody (YA4977) MSX1; HOX7; Homeobox protein MSX-1; Homeobox protein HOX-7; Msh homeobox 1-like protein	WB, ELISA	Human
	MSX1 Antibody (YA4977) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MSX1.

HY-P84234

	MSX1 Antibody (YA3931) HOX7; HYD1; STHAG1; MSX1	WB, ELISA	Human
	MSX1 Antibody (YA3931) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MSX1.

HY-P83045

	CHX10 Antibody (YA2790) CHX 10; HOX10; MCOP2; MCOPCB3; RET1; Vsx2	WB, FC	Human, Mouse, Rat
	CHX10 Antibody (YA2790) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CHX10.

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