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Isoforms Recommended: ErbB3/HER3
Results for "

HER3

" in MedChemExpress (MCE) Product Catalog:

28

Inhibitors & Agonists

14

Inhibitory Antibodies

16

Recombinant Proteins

3

Antibodies

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P99813

    HER3-DXd; U3-1402

    Antibody-Drug Conjugates (ADCs) Cancer
    Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) consisting of a fully human anti-HER3 IgG1 monoclonal antibody Patritumab (HY-P99275) attached to a topoisomerase I inhibitor payload via a tetrapeptide-based cleavable linker. Patritumab deruxtecan shows anticancer activity .
    Patritumab deruxtecan
  • HY-153796

    PROTACs Cancer
    PROTAC Her3 Degrader-8 (Compound PP2) is a PROTAC that can degrade Her3 protein in vitro and cell experiments, and can be used to study diseases regulated by HER family proteins .
    PROTAC Her3 Degrader-8
  • HY-107444

    Ligands for Target Protein for PROTAC Cancer
    PROTAC HER3-binding moiety 1 (compound 1b) is a Her3 Ligand for PROTAC .
    PROTAC Her3-binding moiety 1
  • HY-P99936

    LJM716

    EGFR Cancer
    Elgemtumab(LJM716) is a fully human IgG monoclonal antibody. Elgemtumab can specifically bind to HER3, block ligand-dependent and independent HER3 signal transduction and cell proliferation, and has good anti-tumor potential .
    Elgemtumab
  • HY-RS04470

    HER3; Erbb-3; Erbb3r

    Small Interfering RNA (siRNA) EGFR Others

    Erbb3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Erbb3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Erbb3 Mouse Pre-designed siRNA Set A
    Erbb3 Mouse Pre-designed siRNA Set A
  • HY-RS04469

    HER3; FERLK; LCCS2; VSCN1; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3

    Small Interfering RNA (siRNA) EGFR Others

    ERBB3 Human Pre-designed siRNA Set A contains three designed siRNAs for ERBB3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ERBB3 Human Pre-designed siRNA Set A
    ERBB3 Human Pre-designed siRNA Set A
  • HY-P991245

    EGFR Cancer
    Anti-ERBB3/HER3 (SGP1) is a human monoclonal antibody (mAb) targeting ERBB3/HER3. Anti-ERBB3/HER3 (SGP1) inhibits Neuregulin stimulated growth of cultured breast cancer cells. Anti-ERBB3/HER3 (SGP1) can be used in breast cancer research .
    Anti-ERBB3/HER3 (SGP1)
  • HY-P991241

    EGFR Cancer
    Anti-ERBB3/HER3 (29Z6) is an antibody inhibitor, targeting to human ERBB3/HER3.
    Anti-ERBB3/HER3 (29Z6)
  • HY-P991505

    AMT-562 antibody

    ADC Antibody EGFR Cancer
    Anti-HER3 Antibody (Ab562) is an anti-HER3 monoclonal antibody. Anti-HER3 Antibody (Ab562) can be used to synthesize the antibody-drug conjugate (ADC) AMT-562 (HY-171747) .
    Anti-HER3 Antibody (Ab562)
  • HY-P991237

    EGFR Cancer
    HMBD-001 is a humanized IgG1 monoclonal antibody inhibitor targeting HER3. HMBD-001 inhibits the dimerization of HER3 and inhibits the growth, proliferation and other activities of tumor cells. HMBD-001 is promising for research of cancers, such as pancreatic cancer and non-small cell lung cancer .
    HMBD-001
  • HY-P99866

    MEHD-7945A; RG 7597

    EGFR Others
    Duligotuzumab (MEHD-7945A; RG 7597) is a humanized IgG-κ monoclonal antibody that specifically targets Her3 (ErbB3) .
    Duligotuzumab
  • HY-100848
    TX1-85-1
    1 Publications Verification

    EGFR Cancer
    TX1-85-1 is an irreversible Her3 (ErbB3) inhibitor with an IC50 of 23 nM. TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling .
    TX1-85-1
  • HY-P99507

    MCLA-128; PB4188; R040517

    EGFR Cancer
    Zenocutuzumab (MCLA-128) is a bispecific humanized IgG1 antibody containing two different Fab arms, targeting extracellular domains of HER2 and HER3 .
    Zenocutuzumab
  • HY-P991234

    EGFR p38 MAPK PI3K Akt Cancer
    COVA208 is a bispecific FynomAb (a fusion protein of an antibody and a Fyn SH3-derived binding protein) that targets HER2. COVA208 induces the degradation of HER2, reduces the levels of HER2, HER3, and EGFR, thereby effectively blocking the downstream signaling pathways of HER2, including the HER3-PI3K-AKT and MAPK pathways, and simultaneously inducing apoptosis of tumor cells. COVA208 is promising for research of cancers, such as HER2-positive breast cancer, gastric cancer, and colorectal cancer .
    COVA208
  • HY-172091

    EGFR Cancer
    CZY43 is a HER3 degrader. CZY43 can effectively induce HER3 degradation in a dose- and time-dependent manner in breast cancer SKBR3 cells. CZY43 potently inhibits HER3-dependent signaling and cancer cell growth and outperforms Bosutinib (HY-10158) .
    CZY43
  • HY-118998

    PROTACs EGFR ERK Akt Cancer
    TX2-121-1 is a potent and selective Her3 (ErbB3) degrader that contains a hydrophobic adamantane moiety. TX2-121-1 has an IC50 of 49 nM for Her3. TX2-121-1 inhibits Her3-dependent signaling and heterodimerization of Her3. TX2-121-1 has the ability to inhibit cell proliferation. TX2-121-1 can be used in the study of tumors. (Pink: Her3 inhibitor (HY-164988); Black: Linker; Blue: Adamantane (HY-N2427)) .
    TX2-121-1
  • HY-P99676

    SI-B001

    EGFR Cancer
    Izalontamab (SI-B001) is a bispecific anti-EGFR/HER3 monoclonal antibody with high selectivity for EGFR/HER3 heterodimer. Izalontamab can be used for the research of cancer .
    Izalontamab
  • HY-164988

    EGFR Cancer
    TX2-120-1 possesses the ability to bind to Her3, with an IC50 value of 56 nM for Her3. TX2-120-1 can be used for the synthesis of TX2-121-1 (HY-118998) .
    TX2-120-1
  • HY-P990055

    EGFR Cancer
    Nezutatug is an anti-HER3 antibody, and used for cancer research .
    Nezutatug
  • HY-158016

    EGFR Apoptosis Cancer
    Antiproliferative agent-49 (Compound 5a) is a EGFR-TK inhibitor with an IC50 of 0.09 μM. Antiproliferative agent-49 is a anti-proliferative agent. Antiproliferative agent-49 displays good activities against HER3 and HER4 with IC50 values 0.18 and 0.37 µM. Antiproliferative agent-49 induces mitochondrial apoptotic pathway and increased accumulation of ROS .
    Antiproliferative agent-49
  • HY-157813

    Drug-Linker Conjugates for ADC Topoisomerase Cancer
    2-MSP-5-HA-GGFG-NH-CH2-O-CH2-CO-Exatecan is a drug-linker conjugates for ADC, consiting of a cleavable linker and Exatecan (HY-13631). 2-MSP-5-HA-GGFG-NH-CH2-O-CH2-CO-Exatecan can be linked to anti-Her3 antibody .
    2-MSP-5-HA-GGFG-NH-CH2-O-CH2-CO-Exatecan
  • HY-141676

    EGFR Others
    HyT36 is a low molecular weight hydrophobic tag that promotes the degradation of fusion protein and pseudokinase Her3 [3].
    HyT36
  • HY-P99304

    Anti-Human ERBB3 Recombinant Antibody

    EGFR Cancer
    Lumretuzumab (Anti-Human ERBB3 Recombinant Antibody) is a humanized anti-HER3 (ERBB3) monoclonal antibody that can be used for the research of cancer .
    Lumretuzumab
  • HY-P99268

    SAR 256212; MM 121; Anti-Human ERBB3/ErbB 3 Recombinant Antibody

    EGFR Apoptosis Cancer
    Seribantumab (MM 121) is a fully human IgG2 monoclonal antibody that targets HER3. Seribantumab blocks the activation of epidermal growth factor receptor (ErbB) family members and its downstream signal. Seribantumab inhibits neuregulin 1 (NRG1) fusion-dependent tumorigenesis in vitro and in vivo in breast, lung and ovarian patient-derived cancer models .
    Seribantumab
  • HY-164702

    Antibody-Drug Conjugates (ADCs) EGFR Cancer
    BL-B01D1 is a bispecific ADC, which targets EGFR and HER3 through bispecific antibody Izalontamab (HY-P99676), and exhibits cytotoxicity against various cancer cells via inhibition of DNA replication and DNA synthesis by its ADC toxin ED04 (HY-153891) .
    BL-B01D1
  • HY-P99275
    Patritumab
    1 Publications Verification

    Human Anti-ERBB3 Recombinant Antibody

    EGFR Akt ERK PARP Survivin Cancer
    Patritumab (Human Anti-ERBB3 Recombinant Antibody) is a neutralizing monoclonal antibody to ERBB3. Patritumab shows a synergy with Cetuximab (HY-P9905), potently inhibits the phosphorylation of EGFR, HER2, HER3, ERK, and AKT. Patritumab also induces cell apoptosis and suppresses the growth of pancreatic, non-small cell lung cancer, and colorectal cancer xenograft tumors .
    Patritumab
  • HY-111553

    EGFR Cancer
    TAS0728 is a potent, selective, orally active, irreversible and covalent-binding HER2 inhibitor, with an IC50 of 13 nM. TAS0728 also shows IC50s of 4.9, 8.5, 31, 65, 33, 25 and 86 nM for BMXHER4BLK、EGFR、JAK3SLK and LOK respectively. Furthermore, TAS0728 exhibits robust and sustained inhibition of the phosphorylation of HER2, HER3, and downstream effectors .
    TAS0728
  • HY-171747

    Antibody-Drug Conjugates (ADCs) EGFR Topoisomerase Apoptosis Cancer
    AMT-562 is an antibody-drug conjugate (ADC) consisting of a novel anti-HER3 antibody Ab562 (HY-P991505) conjugated to the linker Mc-VC-PAB and the topoisomerase I inhibitor Exatecan (HY-13631). The ADC toxic molecule and linker portion are MC-VA-PAB-Exatecan (HY-147270). AMT-562 can induce apoptosis and has antitumor activity against pancreatic, esophageal, and gastric cancers .
    AMT-562

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