GPRC5D

By Targets:	Antibody-Drug Conjugates (ADCs) (1) CD3 (4) Small Interfering RNA (siRNA) (3) TNF Receptor (1)
By Research Areas:	Cancer (4) Inflammation/Immunology (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99394

Talquetamab JNJ-64407564	CD3	Cancer
Talquetamab (JNJ-64407564) is a humanized bispecific antibody that binds to *GPRC5D* (member of G protein-coupled receptor family C5 group D) and CD3 to induce T cell-mediated killing of GPRC5D-expressing MM cells through T cell recruitment and activation. Talquetamab (JNJ-64407564) has antitumor activity .

HY-RS05752

GPRC5D Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GPRC5D Human Pre-designed siRNA Set A contains three designed siRNAs for GPRC5D gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GPRC5D Human Pre-designed siRNA Set A GPRC5D Human Pre-designed siRNA Set A

HY-RS17133

Gprc5d Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gprc5d Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gprc5d gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gprc5d Mouse Pre-designed siRNA Set A Gprc5d Mouse Pre-designed siRNA Set A

HY-RS23579

Gprc5d Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gprc5d Rat Pre-designed siRNA Set A contains three designed siRNAs for Gprc5d gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gprc5d Rat Pre-designed siRNA Set A Gprc5d Rat Pre-designed siRNA Set A

HY-P991197

*Anti-GPRC5D Antibody*	CD3	Cancer
Anti-GPRC5D Antibody is a humanized IgG1 monoclonal antibody that targets *GPRC5D. Anti-GPRC5*D Antibody is the antibody part of the ADC molecule LM-305. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-171754

LM-305	Antibody-Drug Conjugates (ADCs)	Cancer
LM-305 is an anti-G protein-coupled receptor class 5 member D (GPRC5D) antibody-drug conjugate (ADC). LM-305 consists of Anti-GPRC5D Antibody (HY-P991197) and VcMMAE (HY-15575). LM-305 exhibits potent cytotoxicity against multiple myeloma cells (NCI-H929 and MM.1R) with IC₅₀ values ranging from 0.1 to 0.3 nM. LM-305 can be used in the study of GPRC5D-related relapsed and refractory multiple myeloma (RRMM) .

HY-P991155

Ramantamig	CD3 TNF Receptor	Cancer
Ramantamig is a humanized monoclonal antibody targeting human CD3ε, *GPRC5D, and TNFRSF17* (tumor necrosis factor receptor superfamily member 17)。Ramantamig is promising for research of cancers, especially hematological malignancies such as multiple myeloma .

HY-P991055

Forimtamig RG-6234; RO-7425781	CD3	Inflammation/Immunology
Forimtamig (RG-6324) is a *GPRC5DxCD3* T-cell-engaging bispecific antibody. Forimtamig has a 2 + 1 format, comprising two high-affinity GPRC5D binding moieties and one CD3 binder. Forimtamig further features a P329G LALA mutated Fc domain that inhibits Fcγ receptor and C1q binding, yet retains binding to the neonatal Fc receptor. The isotype control for Forimtamig can refer to Human IgG1 kappa, Isotype Control (HY-P99001) .

Cat. No.	Product Name	Target	Research Area

HY-P99394

Talquetamab JNJ-64407564	CD3	Cancer
Talquetamab (JNJ-64407564) is a humanized bispecific antibody that binds to *GPRC5D* (member of G protein-coupled receptor family C5 group D) and CD3 to induce T cell-mediated killing of GPRC5D-expressing MM cells through T cell recruitment and activation. Talquetamab (JNJ-64407564) has antitumor activity .

HY-P991197

*Anti-GPRC5D Antibody*	CD3	Cancer
Anti-GPRC5D Antibody is a humanized IgG1 monoclonal antibody that targets *GPRC5D. Anti-GPRC5*D Antibody is the antibody part of the ADC molecule LM-305. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991155

Ramantamig	CD3 TNF Receptor	Cancer
Ramantamig is a humanized monoclonal antibody targeting human CD3ε, *GPRC5D, and TNFRSF17* (tumor necrosis factor receptor superfamily member 17)。Ramantamig is promising for research of cancers, especially hematological malignancies such as multiple myeloma .

HY-P991055

Forimtamig RG-6234; RO-7425781	CD3	Inflammation/Immunology
Forimtamig (RG-6324) is a *GPRC5DxCD3* T-cell-engaging bispecific antibody. Forimtamig has a 2 + 1 format, comprising two high-affinity GPRC5D binding moieties and one CD3 binder. Forimtamig further features a P329G LALA mutated Fc domain that inhibits Fcγ receptor and C1q binding, yet retains binding to the neonatal Fc receptor. The isotype control for Forimtamig can refer to Human IgG1 kappa, Isotype Control (HY-P99001) .

Recombinant Proteins Recommended:

G Protein-Coupled Receptor Class C Group 5 Member D (GPRC5D)

Species:	Human (3) Mouse (1) Cynomolgus (1)
Tag:	His (1) Tag Free (4)
Source:	HEK293 (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P77958

	GPRC5D Protein-VLP, Human (HEK293) GPRC5D; MGC129713; MGC129714; orphan G-protein coupled receptor	Human	HEK293
	GPRC5D Protein-VLP, Human (HEK293) is recommended for animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.

HY-P700731

	GPRC5D Protein-VLP, Cynomolgus (HEK293) GPRC5D; MGC129713; MGC129714; orphan G-protein coupled receptor	Cynomolgus	HEK293
	GPRC5D Protein-VLP, Cynomolgus (HEK293) is recommended for animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.

HY-P700998

	GPRC5D Protein-VLP, Mouse (HEK293) GPRC5D; MGC129713; MGC129714; orphan G-protein coupled receptor	Mouse	HEK293
	GPRC5D Protein-VLP, Mouse (HEK293 ,solutin) is recommended for animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.

HY-P77959

	GPRC5D Protein-VLP, Human (Biotinylated, HEK293) GPRC5D; MGC129713; MGC129714; orphan G-protein coupled receptor	Human	HEK293
	GPRC5D Protein-VLP, Human (Biotinylated, HEK293) is available in solution form, no concentration information, recommended only for SPR analysis. HY-P77958 can be used in animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.

HY-P700457

	GPRC5D Protein-VLP, Human (HEK293, C-His) GPRC5D; G protein-coupled receptor, family C, group 5, member D; G-protein coupled receptor family C group 5 member D; orphan G-protein coupled receptor; MGC129713; MGC129714;	Human	HEK293
	GPRC5D Protein-VLP, Human (HEK293, C-His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81701

	GPRC5D Antibody (YA1446) GPRC5D	FC, ELISA	Human
	GPRC5D Antibody (YA1446) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1446), targeting GPRC5D. GPRC5D Antibody (YA1446) can be used for FC, ELISA experiment in human background.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-RS05752

GPRC5D Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
GPRC5D Human Pre-designed siRNA Set A contains three designed siRNAs for GPRC5D gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17133

Gprc5d Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Gprc5d Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gprc5d gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23579

Gprc5d Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Gprc5d Rat Pre-designed siRNA Set A contains three designed siRNAs for Gprc5d gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Oligonucleotides

Name
Email *

	Sorry, but the email address you supplied was invalid.