GPRC5D Protein-Nanodisc, Human (HEK293, His, Flag)

GPRC5D，G 蛋白偶联受体，是一种 C 型 7 次跨膜受体蛋白。GPRC5D 是一种在恶性浆细胞上表达的孤儿受体，在正常组织中表达有限。GPRC5D 是治疗复发性或难治性 (R/R) 多发性骨髓瘤 (MM) 的有希望的靶点。 GPRC5D Protein-Nanodisc, Human (HEK293, His, Flag) is the recombinant human-derived GPRC5D protein, expressed by HEK293, with C-His and N-Flag labeled tag.

G protein-coupled receptor class C 5 member D (GPRC5D) is a G protein-coupled orphan receptor that shares homology with mammalian G protein-coupled receptors (GPCRs) superfamily C family group 5 member (related to metabotropic glutamate receptor-like) and belongs to the RAIG1 family along with two highly homologous orphan G protein-coupled receptors (oGPCRs), GPRC5B and GPRC5C (RAIG1 was originally isolated as an orphan GPCR by differential display, and its expression can be induced by all-trans retinoic acid (ATRA) in human head and neck squamous cell carcinoma (HNSCC)). As a member of the G protein-coupled receptor that only exists in eukaryotes (including yeast and flagella), GPRC5D is mainly expressed on malignant plasma cells, but limitedly expressed in normal tissues. It is a potential therapeutic target for relapsed/refractory multiple myeloma (R/R MM). Its targeted CAR-T, CAR-NK cell therapy and bispecific T cell engagers have significant anti-tumor activity, and it is also a target for CAR-T cell immunotherapy of multiple myeloma. In addition, G protein-coupled receptors can be bound and activated by a variety of ligands (ranging in size from small molecules to large proteins), such as photosensitive compounds, odors, and hormones, and are associated with a variety of diseases. Its signal transduction pathways include the cAMP signaling pathway and the phosphatidylinositol signaling pathway.

Human

HEK293

C-His;N-Flag

Q9NZD1-2 (Y2-C300)

55507

Greater than 90% as determined by reducing SDS-PAGE.

Supplied as 0.2 μm filtered solution in 20 mM HEPES, 150 mM NaCl, pH7.5 with trehalose as protectant.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.