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Results for "

GPR54

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Kisspeptin Receptor (11) GnRH Receptor (4) PKA (2) PKC (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (5) Cardiovascular Disease (6) Endocrinology (6) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Peptides

Oligonucleotides

Targets Recommended: Kisspeptin Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1196A

Kisspeptin 234 TFA	Kisspeptin Receptor	Cardiovascular Disease
Kisspeptin 234 TFA, is a 10 amino acid peptide as well as a kisspeptin receptor (KISS1, GPR54) antagonist. Kisspeptin 234 TFA is an analog of Kisspeptin 10 .

HY-P1022A

Kisspeptin-54(human) TFA 2 Publications Verification Metastin(human) TFA	GnRH Receptor	Endocrinology Cancer
Kisspeptin-54(human) TFA (Metastin(human) TFA) is an endogenous ligand for kisspeptin receptor (KISS1, GPR54). Kisspeptin-54(human) TFA binds to rat and *human GPR54* receptors with K_i** values of 1.81 nM and 1.45 nM, respectively. Kisspeptin-54(human) TFA hinders tumor metastasis and stimulates gonadotropin secretion .

HY-P1022

Kisspeptin-54(human) 2 Publications Verification Metastin(human)	GnRH Receptor	Endocrinology Cancer
Kisspeptin-54(human) (Metastin(human)) is an endogenous ligand for kisspeptin receptor (KISS1, GPR54). Kisspeptin-54(human) binds to rat and *human GPR54* receptors with K_i** values of 1.81 nM and 1.45 nM, respectively. Kisspeptin-54(human) inhibits tumor metastasis and stimulates the secretion of gonadotropin (LH) and testosterone .

HY-P0254

Kisspeptin-10, human 1 Publications Verification	Kisspeptin Receptor	Cardiovascular Disease Cancer
Kisspeptin-10, human is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, human acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression .

HY-P0254A

Kisspeptin-10, human TFA 1 Publications Verification	Kisspeptin Receptor	Cardiovascular Disease Cancer
Kisspeptin-10, human TFA is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, human TFA acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression .

HY-P1197

Kisspeptin-10 (mouse, rat) 1 Publications Verification	Kisspeptin Receptor	Cardiovascular Disease Inflammation/Immunology
Kisspeptin-10 (mouse, rat) is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10 (mouse, rat) is a ligand for the rodent kisspeptin receptor (KISS1, GPR54). Kisspeptin-10 reduces Methotrexate-induced reproductive toxicity as a potential antioxidant compound .

HY-P1197A

Kisspeptin-10 (mouse, rat) (TFA) 1 Publications Verification	Kisspeptin Receptor	Cardiovascular Disease Inflammation/Immunology
Kisspeptin-10 (mouse, rat) TFA is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10 (mouse, rat) TFA is a ligand for the rodent kisspeptin receptor (KISS1, GPR54). Kisspeptin-10 (mouse, rat) TFA reduces Methotrexate-induced reproductive toxicity as a potential antioxidant compound .

HY-P10489

Kisspeptin-14 human	Kisspeptin Receptor	Cancer
Kisspeptin-14 human is a peptide hormone encoded by the KiSS-1 gene. Kisspeptin-14 human, along with several other similar peptide hormones, is produced from a common precursor protein by cleavage by different proteases. Kisspeptin-14 human is an endogenous ligand of KISS1R. Kisspeptin-14 human has the same receptor binding efficiency and potency as full-length kisspeptin. Kisspeptin-14 human binds to its receptor *GPR54* and is able to activate this G protein-coupled receptor and activate multiple intracellular signaling pathways. Kisspeptin-14 human can be used to study reproductive development and tumor metastasis .

HY-P1196

Kisspeptin 234	Kisspeptin Receptor	Cardiovascular Disease
Kisspeptin 234, is a 10 amino acid peptide as well as a kisspeptin receptor (KISS1, GPR54) antagonist. Kisspeptin 234 is an analog of Kisspeptin 10 .

HY-P10256

Kiss2 peptide	Kisspeptin Receptor PKA PKC	Endocrinology
Kiss2 peptide is a positive regulator of reproduction. Kiss2 peptide binds with its cognate receptor Kiss2R (GPR54) in COS-7 cells, activates PKA and PKC signaling pathways through Gas and Gaq proteins, and thus enhances the activity of cAMP response element-dependent luciferase (CRE-luc) and serum response element-dependent luciferase (SRE-luc) .

HY-P3641

Kisspeptin 13	GnRH Receptor	Neurological Disease Metabolic Disease
Kisspeptin 13 inhibits glucose-induced insulin secretion with an IC₅₀ of 1.2 nM. Kisspeptin 13 activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research .

HY-P11341

Kisspeptin antagonist p271	Kisspeptin Receptor	Endocrinology
Kisspeptin antagonist p271 is a Kisspeptin antagonist with cell-penetrating ability. Kisspeptin antagonist p271 can block the binding of endogenous Kisspeptin to *GPR54* on pituitary somatotropes, thereby relieving the inhibition of growth hormone secretion. Kisspeptin antagonist p271 can specifically and significantly stimulate growth hormone secretion, while inhibiting luteinizing hormone without affecting prolactin or cortisol. Kisspeptin antagonist p271 can be used in the research of diseases related to insufficient growth hormone secretion .

HY-P10256A

Kiss2 peptide acetate	Kisspeptin Receptor PKA PKC	Endocrinology
Kiss2 peptide acetate is the acetate form of Kiss2 pepride (HY-P10256). Kiss2 peptide acetate is a positive regulator of reproduction. Kiss2 peptide acetate binds with its cognate receptor Kiss2R (GPR54) in COS-7 cells, activates PKA and PKC signaling pathways through Gas and Gaq proteins, and thus enhances the activity of cAMP response element-dependent luciferase (CRE-luc) and serum response element-dependent luciferase (SRE-luc) .

HY-P3641A

Kisspeptin 13 TFA	GnRH Receptor	Neurological Disease Metabolic Disease
Kisspeptin 13 TFA is the TFA salt form of Kisspeptin 13 (HY-P3641). Kisspeptin-13 TFA inhibits glucose-induced insulin secretion with an IC₅₀ of 1.2 nM. Kisspeptin 13 TFA activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 TFA interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 TFA is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research .

HY-RS07318

Kiss1r Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Kiss1r Rat Pre-designed siRNA Set A contains three designed siRNAs for Kiss1r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kiss1r Rat Pre-designed siRNA Set A Kiss1r Rat Pre-designed siRNA Set A

HY-P1414

Canine KP-10	Kisspeptin Receptor	Endocrinology
Canine KP-10 is a potent kisspeptin that elicits strong gonadotropin and estradiol responses in female dogs in estrus .

HY-RS07317

Kiss1r Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Kiss1r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kiss1r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kiss1r Mouse Pre-designed siRNA Set A Kiss1r Mouse Pre-designed siRNA Set A

HY-RS07316

KISS1R Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
KISS1R Human Pre-designed siRNA Set A contains three designed siRNAs for KISS1R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

KISS1R Human Pre-designed siRNA Set A KISS1R Human Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area