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GCase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (7) Fluorescent Dye (1) Glucosylceramide Synthase (GCS) (1) Glycosidase (24) Isotope-Labeled Compounds (2) Reference Standards (2) Small Interfering RNA (siRNA) (1) α-synuclein (1)
By Research Areas:	Cancer (1) Endocrinology (1) Metabolic Disease (11) Neurological Disease (19)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Fluorescent Dye

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-160426

Gcase activator 3	Glycosidase	Neurological Disease
Gcase activator 3 (compound 9Q) is a glucosidase (Glucosidase, GCase) activator that can partially stabilize GCase and increase its activity. Gcase activator 3 reduces mutant GCase protein misfolding and degradation in fibroblasts and dopaminergic midbrain neurons. Gcase activator 3 can be used in the study of Parkinson's disease (PD) and related synucleinopathies .

HY-156287

GCase modulator-1	Glycosidase	Cancer
GCase modulator-1 (compound 9g), a derivative of Quinazoline, is a modulator of GCase (Glucosidase) (AC₅₀=2.23 μM) .

HY-154823

Gcase activator 2	Glycosidase	Metabolic Disease
Gcase activator 2 (compound 14), a pyrrolo[2,3-b]pyrazine, is alos a β-Glucocerebrosidase (GCase) activator (EC₅₀=3.8 μM). Gcase activator 2 induces GCase dimerizatio (both K-type and V-type). And Gcase activator 2 has low metabolic clearance in human and mouse .

HY-139452

PFB-FDGlu	Glycosidase	Others
PFB-FDGlu is a selective lysosomal Glucocerebrosidase (GCase) substrate, which is metabolised by GCase to yield fluorescein. PFB-FDGlu is cell permeable and can be used with a flow cytometer to measure GCase activity in living cells on a single-cell basis .

HY-114615

AMP-Deoxynojirimycin AMP-DNM	Glycosidase Glucosylceramide Synthase (GCS)	Neurological Disease
AMP-Deoxynojirimycin (AMP-DNM) is a potent ceramide glucosyltransferase and GCase 2 inhibitor. AMP-Deoxynojirimycin also is a GlcCer biosynthesis inhibitor .

HY-B1039

Ambroxol 2 Publications Verification NA-872	Glycosidase Autophagy	Neurological Disease Metabolic Disease
Ambroxol (NA-872), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research .

HY-B1039A

Ambroxol hydrochloride 2 Publications Verification NA-872 hydrochloride	Glycosidase Autophagy	Neurological Disease Metabolic Disease
Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research .

HY-117861

ML198	Glycosidase	Metabolic Disease
ML198 is a glucocerebrosidase (GCase) modulator with an EC₅₀ of 0.4 μM. ML198 is an activator and non-inhibitory chaperone of glucocerebrosidase. ML198 can be used for the research of Gaucher disease . ML198 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-D1575

C6 NBD Galactosylceramide	Fluorescent Dye	Others
C6 NBD galactosylceramide is an active derivative of galactosylceramide that is tagged with fluorescent C6 nitrobenzoxadiazole (C6 NBD). C6 NBD galactosylceramide can be used as a substrate for neutral β-glycosylceramidase (GCase) to study intracellular localization and metabolism of galactosylceramide (Ex=nm, Em=525) .

HY-B1039C

Ambroxol (acefylline) NA-872 (acefylline); Acebrophylline	Glycosidase Autophagy	Neurological Disease Metabolic Disease
Ambroxol (NA-872) acefylline, an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol acefylline is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol acefylline induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research .

HY-B1039R

Ambroxol (Standard) NA-872 (Standard)	Reference Standards Glycosidase Autophagy	Neurological Disease Metabolic Disease
Ambroxol (Standard) is the analytical standard of Ambroxol. This product is intended for research and analytical applications. Ambroxol (NA-872), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research .

HY-126362

ML266	Glycosidase	Others
ML266 is glucocerebrosidase (GCase) molecule chaperone with IC₅₀ of 2.5 µM. ML266 binds to GCase and transports of the mutant protein to the lysosome, and resume the activity of GCase. ML266 dose not inhibit the GCase enzyme’s action. ML266 has the potential for the research of gaucher disease .

HY-120034

NCGC 607	Glycosidase α-synuclein	Neurological Disease Metabolic Disease
NCGC 607 is a noninhibitory small-molecule chaperone of glucocerebrosidase (GCase). NCGC 607 can increase *GCase* activity, reduce α-synuclein levels, and decrease glycolipid levels. NCGC 607 can be used in the research of Gaucher disease and Parkinson's disease .

HY-100944

Conduritol B epoxide Maximum Cited Publications 10 Publications Verification	Glycosidase	Neurological Disease
Conduritol B epoxide is an irreversible covalently bound acid β-glucosidase (GCase) inhibitor.

HY-174311

GT-02216	Glycosidase	Neurological Disease
GT-02216 can bind to *GCase* allosterically and enhance its activity. GT-02216 enhances the activity of GCase in primary human fibroblasts. GT-02216 reduces the Tau accumulation in mutant GBA1 fibroblasts. GT-02216 protects the hippocampal primary neurons challenged with Tau oligomer in rat model .

HY-14829

Afegostat D-Isofagomine; Isofagomine	Glycosidase	Neurological Disease
Afegostat is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity .

HY-14829B

Afegostat tartrate AT 2101; D-Isofagomine tartrate; Isofagomine tartrate	Glycosidase	Neurological Disease
Afegostat tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity .

HY-14829H

Afegostat TFA	Glycosidase	Neurological Disease
Afegostat TFA is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity .

HY-14829E

Afegostat D-Tartrate D-Isofagomine D-Tartrate; Isofagomine D-Tartrate	Glycosidase	Neurological Disease
Afegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity .

HY-104038

Pariceract LTI-291; BIA 28-6156	Glycosidase	Neurological Disease Endocrinology
Pariceract (LTI-291) is an activator of glucocerebrosidase (Gcase), with activation rates of more than 60% (1 μM) and between 10%-20% (0.1 μM). Pariceract can be used for Parkinson's disease and endometriosis research .

HY-147976A

Glucocerebrosidase-IN-1 hydrochloride	Glycosidase	Neurological Disease
Glucocerebrosidase-IN-1 (compound 11a) hydrochloride is a potent and selective *GCase* (glucocerebrosidase) inhibitor, with an IC₅₀ of 29.3 μM and a K_i of 18.5 μM. Glucocerebrosidase-IN-1 hydrochloride can be used for the research of Gaucher disease (GD) and Parkinson’s disease (PD) .

HY-147976

Glucocerebrosidase-IN-1	Glycosidase	Neurological Disease Metabolic Disease
Glucocerebrosidase-IN-1 (compound 11a) is a potent and selective *GCase* (glucocerebrosidase) inhibitor, with an IC₅₀ of 29.3 μM and a K_i of 18.5 μM. Glucocerebrosidase-IN-1 can be used for the research of Gaucher disease (GD) and Parkinson’s disease (PD) .

HY-RS20738

Gba1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gba1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gba1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gba1 Mouse Pre-designed siRNA Set A Gba1 Mouse Pre-designed siRNA Set A

HY-B1039AS

Ambroxol-d5 hydrochloride NA-872-d₅ hydrochloride	Isotope-Labeled Compounds Glycosidase Autophagy	Neurological Disease Metabolic Disease
Ambroxol-d₅ (hydrochloride) is the deuterium labeled Ambroxol hydrochloride. Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research .

HY-B1039AR

Ambroxol hydrochloride (Standard) NA-872 hydrochloride (Standard)	Reference Standards Glycosidase Autophagy	Neurological Disease Metabolic Disease
Ambroxol (hydrochloride) (Standard) is the analytical standard of Ambroxol (hydrochloride). This product is intended for research and analytical applications. Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research .

HY-W739944

Ambroxol-d5 NA-872-d₅	Isotope-Labeled Compounds Autophagy Glycosidase	Neurological Disease Metabolic Disease
Ambroxol-d₅ (NA-872-d₅) is deuterium labeled Ambroxol. Ambroxol (NA-872), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research .

Cat. No.	Product Name	Type

HY-D1575

C6 NBD Galactosylceramide	Dyes
C6 NBD galactosylceramide is an active derivative of galactosylceramide that is tagged with fluorescent C6 nitrobenzoxadiazole (C6 NBD). C6 NBD galactosylceramide can be used as a substrate for neutral β-glycosylceramidase (GCase) to study intracellular localization and metabolism of galactosylceramide (Ex=nm, Em=525) .

Cat. No.	Product Name	Chemical Structure

HY-B1039AS

Ambroxol-d5 hydrochloride
Ambroxol-d₅ (hydrochloride) is the deuterium labeled Ambroxol hydrochloride. Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research .

Ambroxol-d5 hydrochloride

Ambroxol-d₅ (hydrochloride) is the deuterium labeled Ambroxol hydrochloride. Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research .

HY-W739944

Ambroxol-d5
Ambroxol-d₅ (NA-872-d₅) is deuterium labeled Ambroxol. Ambroxol (NA-872), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83512

	GBA Antibody (YA3257) Alglucerase; betaGC; GBA1; GCase; GCB; GLUC; Glucosylceramidase; Imiglucerase	WB, IHC-P	Human, Rat
	GBA Antibody (YA3257) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3257), targeting GBA, with a predicted molecular weight of 60 kDa (observed band size: 60 kDa). GBA Antibody (YA3257) can be used for WB, IHC-P experiment in human, rat background.

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Cat. No.	Product Name		Classification

HY-117861

ML198		Alkynes
ML198 is a glucocerebrosidase (GCase) modulator with an EC₅₀ of 0.4 μM. ML198 is an activator and non-inhibitory chaperone of glucocerebrosidase. ML198 can be used for the research of Gaucher disease . ML198 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Gba1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Gba1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gba1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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