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Results for "

FKBPs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	FKBP (59) Antibiotic (7) Apoptosis (7) AUTACs (2) Autophagy (19) Bacterial (10) BCL6 (1) Biochemical Assay Reagents (1) Calcium Channel (2) Drug Intermediate (1) Drug Metabolite (2) E3 Ligase Ligand-Linker Conjugates (2) Endogenous Metabolite (5) Epigenetic Reader Domain (2) Estrogen Receptor/ERR (3) Fungal (2) HSP (2) Isotope-Labeled Compounds (5) Ligands for E3 Ligase (2) Ligands for Target Protein for PROTAC (6) mTOR (10) Parasite (1) Phosphatase (5) Progesterone Receptor (3) PROTACs (17) Small Interfering RNA (siRNA) (36) Target Protein Ligand-Linker Conjugates (2)
By Research Areas:	Cancer (56) Endocrinology (3) Infection (6) Inflammation/Immunology (8) Metabolic Disease (3) Neurological Disease (6)
Oligonucleotides:	Rat Pre-designed siRNA Sets (11) Mouse Pre-designed siRNA Sets (11) Human Pre-designed siRNA Sets (14) siRNAs (36)

109

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Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: FKBP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114872

SLF	Ligands for Target Protein for PROTAC FKBP	Cancer
SLF is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for *FKBP51* and an IC₅₀ of 2.6 μM for *FKBP12*. SLF can be used in the synthesis of PROTAC .

HY-114872A

SLF TFA	Ligands for Target Protein for PROTAC FKBP	Cancer
SLF TFA is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for *FKBP51* and an IC₅₀ of 2.6 μM for *FKBP12*. SLF TFA can be used in the synthesis of PROTAC .

HY-135345

*PROTAC FKBP* Degrader-3** 1 Publications Verification	PROTACs FKBP	Cancer
PROTAC FKBP Degrader-3 is a PROTAC that comprises a *FKBP* ligand binding group, a linker and an von Hippel-Lindau binding group. PROTAC FKBP Degrader-3 is a potent *FKBP* degrader .

HY-W017542

L-Pyrohomoglutamic acid	Drug Intermediate Biochemical Assay Reagents	Others
L-Pyrohomoglutamic acid is an amino acid building block. L-Pyrohomoglutamic acid can be used to synthesize ligands for FK506-binding proteins (FKBPs) and histone deacetylase (HDAC) inhibitors .

HY-107452

SLF-amido-C2-COOH PROTAC FKBP12-binding moiety 1	Ligands for Target Protein for PROTAC FKBP	Cancer
SLF-amido-C2-COOH (PROTAC FKBP12-binding moiety 1) is a synthetic ligand for *FKBP* (SLF). SLF-amido-C2-COOH (PROTAC FKBP12-binding moiety 1) can be used in the synthesis of PROTACs .

HY-134184

AUTAC2	AUTACs Autophagy	Inflammation/Immunology Cancer
AUTAC2 is a *FKBP12*-targeting autophagy-mediated degrader (AUTAC). AUTAC2 contains an FBnG (p-Fluorobenzyl Guanine) and an SLF (c ligand of FKBP) moiety. SLF binds non-covalently to FKBP12 .

HY-113646

Shield-2	FKBP	Others
Shield-2 is an efficient stabilizing ligand binding to the FKBP (F36V) protein with a dissociation constant of 29 nM. Shield-2 binds tightly to the *FKBP* mutants destabilizing domains and prevents degradation, thus providing small molecule regulation over intracellular protein levels .

HY-153990

FKBP51F67V-selective antagonist Ligand2	FKBP	Neurological Disease
FKBP51F67V-selective antagonist Ligand2 (example 3-3) is a potent FKBP51 F67V-selective antagonist ligand. FKBP51F67V-selective antagonist Ligand2 reverses the anxiogenic phenotype induced by overexpression of FKBP51 F67V in the amygdala. FKBP51F67V-selective antagonist Ligand2 binds to FKBP51 F67V, but not to wild-type FKBP51 or FKBP52 .

HY-158131

FKBP51-Hsp90-IN-2	FKBP HSP	Neurological Disease Cancer
FKBP51-Hsp90-IN-2 (Compound E08) is a selective *FKBP51-Hsp90* protein-protein interaction inhibitor with IC₅₀ values of 0.4 µM and 5 µM for *FKBP51* and *FKBP52, respectively. FKBP51-Hsp90-IN-2 also effectively stimulates cellular energy metabolism and neurite growth. FKBP*51-Hsp90-IN-2 can be used in research on neurodegenerative diseases and cancer .

HY-158130

FKBP51-Hsp90-IN-1	FKBP HSP	Neurological Disease Metabolic Disease Cancer
FKBP51-Hsp90-IN-1 (Compound D10) is a selective inhibitor of the *FKBP51-Hsp90* protein-protein interaction, with an IC₅₀ value of 0.1 μM against *FKBP51. FKBP*51-Hsp90-IN-1 can be used in the research of stress-related diseases, Alzheimer's disease, and metabolic disorders .

HY-114421

FKBP12 PROTAC dTAG-13 3 Publications Verification dTAG-13	PROTACs FKBP	Cancer
FKBP12 PROTAC dTAG-13 (dTAG-13), a PROTAC-based heterobifunctional degrader, is a selective degrader of FKBP12 ^F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 effectively engages FKBP12 ^F36V and CRBN, thereby selectively degrading FKBP12 ^F36V .

HY-172266

FKBP12 Ligand-Linker Conjugate 2	Target Protein Ligand-Linker Conjugates	Others
FKBP12 Ligand-Linker Conjugate 2 is a conjugate of the FKBP12 target protein ligand and a linker, and it can be used for the synthesis of FKBP12 PROTAC FM4 (HY-172265) .

HY-W520748

MJC13	FKBP	Cancer
MJC13 is an *FKBP52*-targeted agent with anti-tumor activity that can be used in prostate cancer research .

HY-102079

SAFit1	FKBP	Neurological Disease Metabolic Disease
SAFit1 is a FK506 binding protein 51 (FKBP51)-specific inhibitor with a K_i of 4±0.3 nM .

HY-170987

FKBP12 Ligand-Linker Conjugate 1	Target Protein Ligand-Linker Conjugates FKBP	Cancer
FKBP12 Ligand-Linker Conjugate 1 is the conjugate composed of a target protein ligand for *FKBP12* and a linker. FKBP12 Ligand-Linker Conjugate 1 can be used for synthesis of PROTAC degrader MC-25B (HY-170983) .

HY-112210

Shield-1 5 Publications Verification Shld1	FKBP	Others
Shield-1 (Shld1) is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to *mutated FKBP* (mtFKBP)*, allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize proteins tagged with a mutated FKBP*12-derived destabilization domain (DD) .

HY-170983

MC-25B	FKBP	Cancer
MC-25B is a specific *FKBP12* PROTAC degrader. MC-25B degrades *FKBP12* with a DC₅₀ of 0.35 μM and a D_max of 89%. MC-25B facilitates the degradation of nuclear-localized *FKBP12* through a DCAF16-dependent mechanism. (Pink: *FKBP12* ligand (HY-170988); Blue: E3 ligase ligand HY-170986); Black: linker (HY-128844); FKBP12 ligand+ linker (HY-170987)) .

HY-130835

FKBP12 PROTAC RC32 RC32	PROTACs FKBP	Cancer
FKBP12 PROTAC RC32 (RC32) is a potent *FKBP12* degrader based on PROTAC technology. FKBP12 PROTAC RC32 contains conjugation of Rapamycin (HY-10219) and a ligand for an Cereblon E3 ubiquitin ligase (Pomalidomide; HY-10984) .

HY-147098

dTAG-47	PROTACs FKBP	Cancer
dTAG-47, heterobifunctional dTAG molecule, targets mutant FKBP12 (FKBP12 ^F36V). FKBP12 ^F36V serves as a degradation tag (dTAG) and is fused to a protein of interest. dTAG-47 can be used for the research of basal-like breast cancers (BBC) .

HY-170988

FKBP12 ligand-1	FKBP Ligands for Target Protein for PROTAC	Cancer
FKBP12 ligand-1 is a targeting protein ligand of MC-25B (HY-170983), which is a specific *FKBP12* PROTAC .

HY-173082

10-SLF	PROTACs FKBP	Cancer
10-SLF is a PROTAC *FKBP12* degrader. 10-SLF induces a ternary complex between FKBP12 and FBXW7-R465C, and promotes FBXW7-R465C-dependent proteasomal degradation of FKBP12. 10-SLF selectively reduces FKBP12 levels in cells expressing FBXW7-R465C. Pink: FKBP12 ligand (HY-170988); Black: linker (HY-W004640); Blue: E3 ligase ligand .

HY-RS04962

FKBP2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FKBP2 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FKBP2 Human Pre-designed siRNA Set A FKBP2 Human Pre-designed siRNA Set A

HY-RS23358

Fkbp5 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fkbp5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fkbp5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fkbp5 Rat Pre-designed siRNA Set A Fkbp5 Rat Pre-designed siRNA Set A

HY-RS04960

FKBP1A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FKBP1A Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FKBP1A Human Pre-designed siRNA Set A FKBP1A Human Pre-designed siRNA Set A

HY-RS20407

Fkbp7 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fkbp7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fkbp7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fkbp7 Mouse Pre-designed siRNA Set A Fkbp7 Mouse Pre-designed siRNA Set A

HY-RS16916

Fkbp5 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fkbp5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fkbp5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fkbp5 Mouse Pre-designed siRNA Set A Fkbp5 Mouse Pre-designed siRNA Set A

HY-RS22509

Fkbp9 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fkbp9 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fkbp9 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fkbp9 Mouse Pre-designed siRNA Set A Fkbp9 Mouse Pre-designed siRNA Set A

HY-RS04967

FKBP7 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FKBP7 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FKBP7 Human Pre-designed siRNA Set A FKBP7 Human Pre-designed siRNA Set A

HY-RS20408

Fkbp8 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fkbp8 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fkbp8 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fkbp8 Mouse Pre-designed siRNA Set A Fkbp8 Mouse Pre-designed siRNA Set A

HY-RS20405

Fkbp2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fkbp2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fkbp2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fkbp2 Mouse Pre-designed siRNA Set A Fkbp2 Mouse Pre-designed siRNA Set A

HY-RS04966

FKBP6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FKBP6 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FKBP6 Human Pre-designed siRNA Set A FKBP6 Human Pre-designed siRNA Set A

HY-RS18819

Fkbp4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fkbp4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fkbp4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fkbp4 Mouse Pre-designed siRNA Set A Fkbp4 Mouse Pre-designed siRNA Set A

HY-RS20406

Fkbp3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fkbp3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fkbp3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fkbp3 Mouse Pre-designed siRNA Set A Fkbp3 Mouse Pre-designed siRNA Set A

HY-RS20550

Fkbp14 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fkbp14 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fkbp14 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fkbp14 Mouse Pre-designed siRNA Set A Fkbp14 Mouse Pre-designed siRNA Set A

HY-RS04957

FKBP11 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FKBP11 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FKBP11 Human Pre-designed siRNA Set A FKBP11 Human Pre-designed siRNA Set A

HY-RS26917

Fkbp8 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fkbp8 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fkbp8 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fkbp8 Rat Pre-designed siRNA Set A Fkbp8 Rat Pre-designed siRNA Set A

HY-RS04969

FKBP9 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FKBP9 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FKBP9 Human Pre-designed siRNA Set A FKBP9 Human Pre-designed siRNA Set A

HY-RS18423

Fkbp11 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fkbp11 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fkbp11 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fkbp11 Mouse Pre-designed siRNA Set A Fkbp11 Mouse Pre-designed siRNA Set A

HY-RS26915

Fkbp3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fkbp3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fkbp3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fkbp3 Rat Pre-designed siRNA Set A Fkbp3 Rat Pre-designed siRNA Set A

HY-RS25196

Fkbp10 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fkbp10 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fkbp10 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fkbp10 Rat Pre-designed siRNA Set A Fkbp10 Rat Pre-designed siRNA Set A

HY-RS24787

Fkbp1a Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fkbp1a Rat Pre-designed siRNA Set A contains three designed siRNAs for Fkbp1a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fkbp1a Rat Pre-designed siRNA Set A Fkbp1a Rat Pre-designed siRNA Set A

HY-RS29030

Fkbp9 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fkbp9 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fkbp9 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fkbp9 Rat Pre-designed siRNA Set A Fkbp9 Rat Pre-designed siRNA Set A

HY-RS26916

Fkbp7 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fkbp7 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fkbp7 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fkbp7 Rat Pre-designed siRNA Set A Fkbp7 Rat Pre-designed siRNA Set A

HY-RS04959

FKBP15 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FKBP15 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP15 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FKBP15 Human Pre-designed siRNA Set A FKBP15 Human Pre-designed siRNA Set A

HY-RS26914

Fkbp2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fkbp2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fkbp2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fkbp2 Rat Pre-designed siRNA Set A Fkbp2 Rat Pre-designed siRNA Set A

HY-RS04964

FKBP4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FKBP4 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FKBP4 Human Pre-designed siRNA Set A FKBP4 Human Pre-designed siRNA Set A

HY-RS04965

FKBP5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FKBP5 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FKBP5 Human Pre-designed siRNA Set A FKBP5 Human Pre-designed siRNA Set A

HY-RS18309

Fkbp1a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fkbp1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fkbp1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fkbp1a Mouse Pre-designed siRNA Set A Fkbp1a Mouse Pre-designed siRNA Set A

HY-RS04963

FKBP3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FKBP3 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FKBP3 Human Pre-designed siRNA Set A FKBP3 Human Pre-designed siRNA Set A

HY-RS04956

FKBP10 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FKBP10 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FKBP10 Human Pre-designed siRNA Set A FKBP10 Human Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area

HY-P4581

Suc-Ala-Leu-Pro-Phe-pNA Suc-ALPF-pNA	FKBP	Others
Suc-Ala-Leu-Pro-Phe-pNA (Suc-ALPF-pNA) is a substrate of FK-506 binding protein (FKBP) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13756A

Tacrolimus monohydrate 80+ Cited Publications FK506 monohydrate; Fujimycin monohydrate; FR900506 monohydrate	Infection Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Disease Research Inflammation/Immunology Disease Research Fields	Phosphatase FKBP Autophagy Bacterial Antibiotic
Tacrolimus monohydrate (FK506 monohydrate), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

HY-10219

Rapamycin Maximum Cited Publications 981 Publications Verification Sirolimus; AY-22989	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Macrolide Antibiotics Classification of Application Fields Antibiotics Anti-aging Source classification Disease Research Disease Research Fields Cancer	mTOR FKBP Fungal Autophagy Endogenous Metabolite Antibiotic Bacterial
Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1 . Rapamycin is an autophagy activator, an immunosuppressant .

HY-13756

Tacrolimus 80+ Cited Publications FK506; Fujimycin; FR900506	Infection Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Macrolide Antibiotics Animals Classification of Application Fields Antibiotics Source classification Disease Research Inflammation/Immunology Disease Research Fields	Phosphatase FKBP Bacterial Autophagy Antibiotic
Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

HY-B0652

Etonogestrel 3-Oxodesogestrel; 3-keto-Desogestrel	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Drug Metabolite Estrogen Receptor/ERR Progesterone Receptor Endogenous Metabolite FKBP
Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs . Etonogestrel induce *FKBP51* mRNA and protein expression in cultured human endometrial stromal cells (HESCs) .

HY-13756R

Tacrolimus (Standard)	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Macrolide Antibiotics Animals Antibiotics Source classification Disease Research	Phosphatase FKBP Bacterial Autophagy Antibiotic
Tacrolimus (Standard) is the analytical standard of Tacrolimus. This product is intended for research and analytical applications. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

HY-10219R

Rapamycin (Standard)	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Macrolide Antibiotics Antibiotics Source classification Disease Research Endogenous metabolite	mTOR FKBP Fungal Autophagy Endogenous Metabolite Antibiotic Bacterial
Rapamycin (Standard) is the analytical standard of Rapamycin. This product is intended for research and analytical applications. Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1 . Rapamycin is an autophagy activator, an immunosuppressant .

HY-B0652R

Etonogestrel (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	Drug Metabolite Estrogen Receptor/ERR Progesterone Receptor Endogenous Metabolite FKBP
Etonogestrel (Standard) is the analytical standard of Etonogestrel. This product is intended for research and analytical applications. Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs . Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs) .

Cat. No.	Product Name	Chemical Structure

HY-10218S

Everolimus-d4
Everolimus-d₄ is the deuterium labeled Everolimus. Everolimus (RAD001) is a Rapamycin derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities .

HY-10219S

Rapamycin-d3
Rapamycin-d₃ is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant .

HY-13756S

Tacrolimus-13C,d2
Tacrolimus- ¹³C,d₂ is a ¹³C-labeled and deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

HY-10219S1

Rapamycin-13C,d3
Rapamycin- ¹³C,d₃ (Sirolimus- ¹³C,d₃; AY-22989- ¹³C,d₃) is the ¹³C and deuterium labeled Rapamycin (HY-10219) .Rapamycin is a potent and specific mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant .

HY-10218S1

Everolimus-13C2,d4

Everolimus- ¹³C₂,d₄ (RAD001- ¹³C₂,d₄) is ¹³C labeled Everolimus. Everolimus (RAD001) is a Rapamycin (HY-10219) derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities .

HY-B0652S1

Etonogestrel-d6
Etonogestrel-d₆ is deuterium labeled Etonogestrel. Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs . Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs) .

HY-13756S2

Tacrolimus-d3
Tacrolimus-d₃ (FK506-d₃) is deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

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