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Results for "

DpC

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (1) EGFR (1) Estrogen Receptor/ERR (1) Factor Xa (3) Glucocorticoid Receptor (2) HIV (4) HIV Protease (1) Ligands for Target Protein for PROTAC (1) PARP (2) PROTACs (1) Reverse Transcriptase (3) Target Protein Ligand-Linker Conjugates (1) Thrombin (1) Thyroid Hormone Receptor (2) TNF Receptor (2) Wnt (2)
By Research Areas:	Cancer (5) Cardiovascular Disease (2) Endocrinology (4) Infection (4) Inflammation/Immunology (4) Metabolic Disease (1)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

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Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114243

*DpC*	Others	Cancer
DpC is an anti-tumor agent. DpC inhibits cancer cell proliferation (IC₅₀: 0.007-0.096 μM). DpC synergizes with multiple anti-cancer therapeutics .

HY-19400

DPC-681 DPH-153893	HIV Protease HIV	Infection
DPC-681 is a potent and selective inhibitor of HIV protease with IC90s for wild-type HIV-1 of 4 to 40 nM.

HY-P1418A

DPC-AJ1951 TFA	Thyroid Hormone Receptor	Endocrinology
DPC-AJ1951 TFA, a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). And characterized the activity of DPC-AJ1951 TFA in ex vivo and in vivo assays of bone resorption .

HY-117477

DPC 963	Reverse Transcriptase HIV	Infection
DPC-963 is an oral active non-nucleoside reverse transcriptase inhibitor with the IC₅₀ of 18 nM. DPC-963 can be used for study of HIV .

HY-107001

DPC 961 (S)-DpC 961; DMP 961	HIV Reverse Transcriptase	Infection
DPC 961 (DMP 961) is a non-nucleoside reverse transcriptase inhibitor (NNRTI). DPC 961 is a potent and specific inhibitor of HIV-1 reverse transcriptase, which inhibits the activity of HIV-1 reverse transcriptase in a non-competitive manner, thereby preventing viral replication. DPC 961 can be used for research on AIDS .

HY-10278

Razaxaban DpC 906; BMS 561389	Factor Xa	Others
Razaxaban (DPC 906; BMS 561389) is a bioavtive small molecular compound.

HY-P1418

DPC-AJ1951	Thyroid Hormone Receptor	Endocrinology
DPC-AJ1951, a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). And characterized the activity of DPC-AJ1951 in ex vivo and in vivo assays of bone resorption .

HY-11090A

DPC423	Factor Xa	Cardiovascular Disease
DPC423 is a highly potent, selective, and orally active factor Xa inhibitor with a K_i of 0.15 nM .

HY-15352

BMS 561390 DpC 083	Reverse Transcriptase HIV	Infection
BMS 561390 (DPC 083) is an orally available non-nucleoside reverse transcriptase inhibitor (NNRTI) with broad inhibitory effects on wild-type HIV-1 and mutant strains .

HY-19667

BMS-561392 DpC 333	TNF Receptor	Inflammation/Immunology
BMS-561392 is a TNF alpha-converting enzyme (TACE) inhibitor. BMS-561392 is also an ADAM17 blocker. BMS-561392 can be used for research of inflammatory bowel disease .

HY-19667A

BMS-561392 formate 1 Publications Verification DpC 333 formate	TNF Receptor	Inflammation/Immunology
BMS-561392 formate is the formate form of BMS-561392 (HY-19667). BMS-561392 is a TNF alpha-converting enzyme (TACE) inhibitor. BMS-561392 is also an ADAM17 blocker. BMS-561392 can be used for research of inflammatory bowel disease .

HY-11091

Razaxaban hydrochloride BMS 561389 hydrochloride; DpC 906 hydrochloride	Factor Xa Thrombin	Cardiovascular Disease
Razaxaban hydrochloride (BMS 561389 hydrochloride) is a highly potent, selective and orally active factor Xa inhibitor with a K_i of 0.19 nM. Razaxaban hydrochloride exhibits excellent selectivity (>5000-fold) for factor Xa over other related serine proteases. Razaxaban hydrochloride is also a potent thrombin inhibitor with a K_i of 540 nM. Razaxaban hydrochloride has strongly antithrombotic activity .

HY-141481

DP-C-4	PROTACs EGFR PARP	Cancer
DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP .

HY-112746

Etacstil DpC974; GW5638	Estrogen Receptor/ERR	Cancer
Etacstil (GW5638) is a estrogen receptor antagonist that displays minimal uterotropic activity in ovariectomized rats and inhibits the agonist activity of Estradiol (HY-B0141), Tamoxifen (HY-13757A) and Raloxifene (HY-13738) in the environment. Etacstil is promising for research of breast cancer and bone protection .

HY-W129790

N-Decylphosphorylcholine, 98% DpC, 98%	Biochemical Assay Reagents	Others
N-Decylphosphorylcholine, 98% is a short-chain lipid-like zwitterionic detergent, used as a decontaminant for dissolving and purifying membrane proteins.

HY-B0415

Fluocinolone (Acetonide)	Glucocorticoid Receptor Wnt	Inflammation/Immunology Endocrinology
Fluocinolone is a glucocorticoid glucocorticoid receptor agonist. Fluocinolone is effective in preventing both lipid accumulation and inflammation. Fluocinolone can promote the proliferation of DPCs and has the potential role in repairing injured pulp tissues. Fluocinolone can be used to study the prevention of chemotherapy-induced peripheral neuropathy caused by Paclitaxel (HY-B0015) .

HY-B0415R

Fluocinolone (Acetonide) (Standard)	Glucocorticoid Receptor Wnt	Inflammation/Immunology Endocrinology
Fluocinolone (Acetonide) (Standard) is the analytical standard of Fluocinolone (Acetonide). This product is intended for research and analytical applications. Fluocinolone is a glucocorticoid glucocorticoid receptor agonist. Fluocinolone is effective in preventing both lipid accumulation and inflammation. Fluocinolone can promote the proliferation of DPCs and has the potential role in repairing injured pulp tissues. Fluocinolone can be used to study the prevention of chemotherapy-induced peripheral neuropathy caused by Paclitaxel (HY-B0015) .

HY-N1141

Torachrysone-8-O-b-D-glucoside	Others	Metabolic Disease
Torachrysone-8-O-b-D-glucoside could be isolated from root of Polygonum multiflorum. Torachrysone-8-O-b-D-glucoside increases the proliferation of DPCs (dermal papilla cells) .

HY-141486

(Rac)-PROTAC PARP/EGFR ligand 1	Target Protein Ligand-Linker Conjugates	Cancer
(Rac)-PROTAC PARP/EGFR ligand 1 incorporates a ligand for PARP and EGFR , and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). (Rac)-PROTAC PARP/EGFR ligand 1 can be used in the synthesis of DP-C-4, which is CRBN-based dual PROTAC for simultaneous degradation of EGFR and PARP .

HY-75706

N-Descyclopropanecarbaldehyde Olaparib	PARP Ligands for Target Protein for PROTAC	Cancer
N-Descyclopropanecarbaldehyde Olaparib is an analogue of Olaparib (HY-10162) containing DOTA moiety. N-Descyclopropanecarbaldehyde Olaparib is a PARP inhibitor used for synthesizing novel dual EGFR and PARP PROTAC, DP-C-4 (HY-141481) . N-Descyclopropanecarbaldehyde Olaparib can be radiolabeled with F-18 or fluorophore for positron emission tomography (PET) or optical imaging in several types of tumor .

Cat. No.	Product Name

HY-L077

Anti-Pancreatic Cancer Compound Library	3,308 compounds
Pancreatic cancer is a devastating disease with a low overall survival rate. Chemotherapy is the most common treatment for patients presenting with advanced pancreatic cancer. More recently, the era of targeted therapies has generated a lot of interest in discovering better approaches for patients with pancreatic cancer. Commonly mutated genes in pancreatic cancer include K-ras (in 74-100% of cases), p16INK4a (up to 98%), p53 (43 to 76%), DPC4 (about 50%), HER-2/neu (in about 65%) and FHIT (found in 70% of cases). Other genes involved are notch1, Akt-2, BRCA2 and COX-2. These proteins are important targets of target therapies for pancreatic cancer. MCE offers a unique collection of 3,308 compounds with identified and potential anti- pancreatic cancer activity. These compounds target K-Ras, p53, HER2, Notch, AKT, etc. MCE anti-pancreatic cancer compound library is a useful tool for anti-pancreatic cancer drugs screening and other related research.

Anti-Pancreatic Cancer Compound Library

3,308 compounds

Pancreatic cancer is a devastating disease with a low overall survival rate. Chemotherapy is the most common treatment for patients presenting with advanced pancreatic cancer. More recently, the era of targeted therapies has generated a lot of interest in discovering better approaches for patients with pancreatic cancer. Commonly mutated genes in pancreatic cancer include K-ras (in 74-100% of cases), p16INK4a (up to 98%), p53 (43 to 76%), DPC4 (about 50%), HER-2/neu (in about 65%) and FHIT (found in 70% of cases). Other genes involved are notch1, Akt-2, BRCA2 and COX-2. These proteins are important targets of target therapies for pancreatic cancer.

MCE offers a unique collection of 3,308 compounds with identified and potential anti- pancreatic cancer activity. These compounds target K-Ras, p53, HER2, Notch, AKT, etc. MCE anti-pancreatic cancer compound library is a useful tool for anti-pancreatic cancer drugs screening and other related research.

Cat. No.	Product Name	Type

HY-W129790

N-Decylphosphorylcholine, 98% DpC, 98%	Surfactants
N-Decylphosphorylcholine, 98% is a short-chain lipid-like zwitterionic detergent, used as a decontaminant for dissolving and purifying membrane proteins.

Cat. No.	Product Name	Target	Research Area

HY-P1418A

DPC-AJ1951 TFA	Thyroid Hormone Receptor	Endocrinology
DPC-AJ1951 TFA, a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). And characterized the activity of DPC-AJ1951 TFA in ex vivo and in vivo assays of bone resorption .

HY-P1418

DPC-AJ1951	Thyroid Hormone Receptor	Endocrinology
DPC-AJ1951, a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). And characterized the activity of DPC-AJ1951 in ex vivo and in vivo assays of bone resorption .

HY-P5494

DPc10	Peptides	Others
DPc10 is a biological active peptide. (This is amino acids 2460 to 2495 fragment of cardiac ryanodine receptor (RyR2). RyR2 controls calcium release from the sarcoplasmic reticulum, which begins muscle contraction. Mutated RyR2 is associated to ventricular tachycardia (VT) and sudden death.)

Torachrysone-8-O-b-D-glucoside	Monophenols other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Metabolic Disease Plants Disease Research Fields	Others
Torachrysone-8-O-b-D-glucoside could be isolated from root of Polygonum multiflorum. Torachrysone-8-O-b-D-glucoside increases the proliferation of DPCs (dermal papilla cells) .

Cat. No.	Compare	Product Name	Species	Source

HY-P71324

	SMAD4 Protein, Human (His) Mothers Against Decapentaplegic Homolog 4; MAD Homolog 4; Mothers Against DPP Homolog 4; Deletion Target in Pancreatic Carcinoma 4; SMAD Family Member 4; SMAD 4; Smad4; hSMAD4; SMAD4; DpC4; MADH4	Human	E. coli
	SMAD4 is a class of common mediator SMAD (Co-SMAD), which belongs to the dwarfin/SMAD family. It conducts cell signals through the SMAD4/TGF-β pathway and plays an important role in promoting bone development and tissue homeostasis. SMAD4 induces chondrogenesis of human bone marrow mesenchymal stem cells, and specifically targets stem cells to participate in self-renewal of hematopoietic stem cells. SMAD4 can also protect cell apoptosis and inhibit epithelial cell proliferation, showing antitumor effects. SMAD4 Protein, Human (His) has the 552 a.a. sequence (M1-D552), produced in E.coli with C-terminal 6*His-tag.

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