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Doxorubicin hydrochloride (Standard)

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15142R
    Doxorubicin hydrochloride (Standard)
    2 Publications Verification

    Hydroxydaunorubicin hydrochloride (Standard); ADR (Standard)

    		 Reference Standards Topoisomerase ADC Payload AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial Infection Cancer
    Doxorubicin hydrochloride (Standard) is the analytical standard of Doxorubicin hydrochloride. This product is intended for research and analytical applications. Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .
    Doxorubicin hydrochloride (Standard)
  • HY-13624AR
    Epirubicin hydrochloride (Standard)

    4'-EpiDoxorubicin hydrochloride (Standard)

    		 Reference Standards DNA/RNA Synthesis Topoisomerase Apoptosis Antibiotic Cancer
    Epirubicin (hydrochloride) (Standard) is the analytical standard of Epirubicin (hydrochloride). This product is intended for research and analytical applications. Epirubicin hydrochloride (4'-Epidoxorubicin hydrochloride), a semisynthetic L-arabino derivative of doxorubicin, has an antineoplastic agent by inhibiting Topoisomerase . Epirubicin hydrochloride inhibits DNA and RNA synthesis. Epirubicin hydrochloride is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity .
    Epirubicin hydrochloride (Standard)
  • HY-100489R
    TBHQ (Standard)

    tert-Butylhydroquinone (Standard)

    		 Reference Standards Keap1-Nrf2 ERK Autophagy Apoptosis Ferroptosis Cancer
    TBHQ (Standard) is the analytical standard of TBHQ. This product is intended for research and analytical applications. TBHQ (tert-Butylhydroquinone) is a widely used Nrf2 activator, protects against Doxorubicin (DOX)-induced cardiotoxicity through activation of Nrf2 . TBHQ (tert-Butylhydroquinone) is also an ERK activator; rescues Dehydrocorydaline (DHC)-induced cell proliferation inhibitionin melanoma .
    TBHQ (Standard)
  • HY-121309R
    Doxorubicinone (Standard)

    Adriamycin aglycone (Standard); Adriamycinone (Standard)

    		 Reference Standards Endogenous Metabolite Cancer
    Doxorubicinone (Standard) is the analytical standard of Doxorubicinone. This product is intended for research and analytical applications. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin . Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively.
    Doxorubicinone (Standard)
  • HY-D0226R
    Quinizarin (Standard)

    1,4-Dihydroxyanthraquinone (Standard)

    		 Reference Standards DNA/RNA Synthesis Fungal Infection Cancer
    Quinizarin (Standard) is the analytical standard of Quinizarin. This product is intended for research and analytical applications. Quinizarin (1,4-Dihydroxyanthraquinone), a part of the anticancer agents such as Doxorubicin, Daunorubicin, and Adriamycin, interacts with DNA by intercalating mode (Kd=86.1 μM). Quinizarin is used as a fungicide and pesticide chemical and has shown the ability to inhibit tumor cell growth .
    Quinizarin (Standard)
  • HY-151165R
    LasR-IN-3 (Standard)

    		Reference Standards Antibiotic Bacterial Infection
    Quinizarin (Standard) is the analytical standard of Quinizarin. This product is intended for research and analytical applications. Quinizarin (1,4-Dihydroxyanthraquinone), a part of the anticancer agents such as Doxorubicin, Daunorubicin, and Adriamycin, interacts with DNA by intercalating mode (Kd=86.1 μM). Quinizarin is used as a fungicide and pesticide chemical and has shown the ability to inhibit tumor cell growth .
    LasR-IN-3 (Standard)
  • HY-N6635R
    trans-Nerolidol (Standard)

    		Reference Standards Fungal Infection Cancer
    trans-Nerolidol (Standard) is the analytical standard of trans-Nerolidol. This product is intended for research and analytical applications. trans-Nerolidol improves the anti-proliferative effect of Doxorubicin (DOX) (HY-15142A) against intestinal cancer and breast cancer cells in vitro. trans-Nerolidol increases accumulation of DOX inside cells in vitro. trans-Nerolidol activates apoptosis in vivo .
    trans-Nerolidol (Standard)
  • HY-B1041R
    Aminoguanidine hydrochloride (Standard)

    		NO Synthase Apoptosis Endocrinology
    Aminoguanidine (hydrochloride) (Standard) is the analytical standard of Aminoguanidine (hydrochloride). This product is intended for research and analytical applications. Aminoguanidine hydrochloride (Pimagedine hydrochloride) is an inhibitor of diamine oxidase and nitric oxide synthase. Aminoguanidine hydrochloride has a dose-dependent inhibitory effect on apoptosis induced by Doxorubicin (HY-15142). Aminoguanidine hydrochloride has antioxidant properties. Aminoguanidine hydrochloride can be used in diabetic nephropathy research .
    Aminoguanidine hydrochloride (Standard)
  • HY-147971
    Anticancer agent 75

    		Parasite Topoisomerase Infection Cancer
    Anticancer agent 75 is a potent anticancer agent. Anticancer agent 75 shows cytotoxicity and selectivity in cancer cell lines. Anticancer agent 75 shows cytotoxicity to normal human kidney cell lines is at least 35 times lower than that of the Doxorubicin standard. Anticancer agent 75 shows good activity of antiplasmodial .
    Anticancer agent 75
  • HY-17507R
    Pantoprazole (Standard)

    BY1023 (Standard); SKF96022 (Standard)

    		 Reference Standards Proton Pump Autophagy Apoptosis Bacterial Inflammation/Immunology Cancer
    Pantoprazole (Standard) is the analytical standard of Pantoprazole. This product is intended for research and analytical applications. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
    Pantoprazole (Standard)
  • HY-17507AR
    Pantoprazole sodium (Standard)

    BY1023 sodium (Standard); SKF96022 sodium (Standard)

    		 Reference Standards Proton Pump Autophagy Apoptosis Bacterial Inflammation/Immunology Cancer
    Pantoprazole (sodium) (Standard) is the analytical standard of Pantoprazole (sodium). This product is intended for research and analytical applications. Pantoprazole sodium (BY10232 sodium) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole sodium, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole sodium improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
    Pantoprazole sodium (Standard)
  • HY-17507BR
    Pantoprazole sodium hydrate (Standard)

    BY1023 sodium hydrate (Standard); SKF96022 sodium hydrate (Standard)

    		 Reference Standards Proton Pump Autophagy Apoptosis Bacterial Inflammation/Immunology Cancer
    Pantoprazole (sodium hydrate) (Standard) is the analytical standard of Pantoprazole (sodium hydrate). This product is intended for research and analytical applications. Pantoprazole sodium hydrate (BY10232 sodium hydrate) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole sodium hydrate, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole sodium hydrate improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium hydrate significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
    Pantoprazole sodium hydrate (Standard)
  • HY-100353R
    C12-Ceramide (Standard)

    N-Lauroyl-D-erythro-sphingosine (Standard); N-Laurylsphingosine (Standard)

    		 Reference Standards Others Metabolic Disease Cancer
    C12-Ceramide (Standard) is the analytical standard of C12-Ceramide. This product is intended for research and analytical applications. C12-Ceramide (N-Lauroyl-D-erythro-sphingosine), a naturally occurring ceramide, is formed by hydrolysis of C12 sphingomyelin. C12-Ceramide can enhance the Doxorubicin toxicity in MDA-MB-231 cells. C12-Ceramide also can be used to diagnose types A and B Niemann-Pick disease .
    C12-Ceramide (Standard)
  • HY-N1346R
    Robinin (Standard)

    		Reference Standards Toll-like Receptor (TLR) Apoptosis Inflammation/Immunology
    Robinin (Standard) is the analytical standard of Robinin. This product is intended for research and analytical applications. Robinin is a flavonoid that can be extracted from the leaves of purple cowpea, inhibiting TGF-β, TLR4/NF-κB and TLR2-PI3k-AKT signaling pathways. Robinin exerts anti-inflammatory and anti-tumor effects. The combination of Robinin and Methotrexate (HY-14519) reduces inflammation in experimental arthritis, Robinin can decrease the Doxorubicin (HY-15142A) induced cardiac toxicity effect .
    Robinin (Standard)
  • HY-N1441R
    Afzelin (Standard)

    Kaempferol-3-O-rhamnoside (Standard)

    		 Mitochondrial Metabolism PTEN Autophagy Bacterial Reference Standards Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology
    Afzelin (Standard) is the analytical standard of Afzelin. This product is intended for research and analytical applications. Afzelin (Kaempferol-3-O-rhamnoside)It is a flavonol glycoside that has anti-inflammatory, anti-oxidative stress response, anti-apoptotic, and anti-cardiac cytotoxic effects. AfzelinIt can reduce mitochondrial damage, enhance mitochondrial biosynthesis, and reduce mitochondria-related proteins. Parkinand PTENinduced putative kinase 1 (putative kinase 1)s level. AfzelinCan be improved D-galactosamine(GalN)/LPSSurvival rate of mice treated with doxorubicin prophylaxis (HY-15142A)Induced cardiotoxicity and scopolamine (HY-N0296)-induced neurological injury. AfzelinAlso inhibits asthma and allergies caused by ovalbumin .
    Afzelin (Standard)
  • HY-N6712R
    Thiolutin (Standard)

    Acetopyrrothin (Standard)

    		 Reference Standards Antibiotic Bacterial Deubiquitinase NOD-like Receptor (NLR) DNA/RNA Synthesis Pyroptosis HMG-CoA Reductase (HMGCR) Cardiovascular Disease Inflammation/Immunology Cancer
    Thromycin (Standard) is the analytical standard of thromycin (HY-N6712). Thiolutin (Acetopyrrothin) is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. Thiolutin can be produced by Streptomyces. Thiolutin inhibits AMSH (IC50 = 4 μM) and Rpn11 (IC50 = 0.53 μM). Thiolutin is a dual inhibitor of BRCC36 and the NLRP3 inflammasome, exhibiting anti-inflammatory effects. Thiolutin effectively suppresses the interaction between BRCC36 and HMGCR, leading to the inhibition of HCC growth. Thiolutin attenuates pyroptosis and NLRP3 inflammasome activation. Thiolutin markedly alleviates renal injury and inflammatory process in IgAN. Thiolutin is an anti-angiogenic compound which can ease Doxorubicin-induced cardiotoxicity (DOXIC) [1][2][3][4][5].
    Thiolutin (Standard)
  • HY-B1398R
    Ampyrone (Standard)
    1 Publications Verification

    4-Aminophenazone (Standard)

    		 Reference Standards COX Drug Metabolite Neurological Disease Inflammation/Immunology Cancer
    Ampyrone (4-Aminophenazone) (Standard) is the analytical standard of Ampyrone (HY-B1398). This product is intended for research and analytical applications. Ampyrone (4-Aminophenazone; 4-Aminoantipyrine) is a reversible and low-damage optical clearing agent and non-selective COX inhibitor based on UV absorption properties. Ampyrone can improve the optical transmittance of mouse skin and other tissues. Ampyrone can induce tissue refractive index matching by enhancing UV absorption, reduce light scattering, and achieve tissue transparency in vivo. Ampyrone reduces the synthesis of prostaglandin PGE2, thereby exerting anti-inflammatory, analgesic and antipyretic effects. Ampyrone inhibits DNA damage, cell apoptosis and immune cell phagocytosis induced by Doxorubicin (HY-15142A) and Cisplatin (HY-17394), etc., and participates in the regulation of toxicity in tumor chemotherapy .
    Ampyrone (Standard)
  • HY-N0103R
    Sophocarpine (Standard)

    		Reference Standards Autophagy Apoptosis NF-κB PI3K Akt MEK ERK Cardiovascular Disease Inflammation/Immunology Cancer
    Sophocarpine (Standard) is the analytical standard of Sophocarpine (HY-N0103). This product is intended for research and analytical applications. Sophocarpine is a PTEN activator and an inhibitor of PI3K/Akt, MEK/ERK, and NF-κB signaling pathways. Sophocarpine upregulates PTEN expression and inhibits PI3K/Akt phosphorylation, arrests tumor cell cycle and induces apoptosis. Sophocarpine inhibits MEK/ERK phosphorylation and VEGF secretion, reducing tumor cell migration. Sophocarpine can also inhibit NF-κB activation and p38 and JNK phosphorylation, reduce the expression of inflammatory factors such as iNOS and COX-2, and activate the Nrf2/HO-1 pathway to reduce oxidative stress. Sophocarpine has anti-tumor, anti-inflammatory, antioxidant and anti-apoptotic effects, and can be used in the research of cancers such as glioblastoma and colorectal cancer, inflammation-related diseases, and Doxorubicin (HY-15142A)-induced cardiac damage .
    Sophocarpine (Standard)
  • HY-N0394R
    L-Cystine (Standard)

    		Reference Standards Endogenous Metabolite Ferroptosis ROS Kinase Keap1-Nrf2 Metabolic Disease Inflammation/Immunology Cancer
    L-Cystine (Standard) is the analytical standard of L-Cystine. This product is intended for research and analytical applications. L-Cystine, the extracellular form of L-Cysteine (HY-Y0337), is a nutritionally dispensable semiessential sulfur-containing amino acid, occurring in proteins of plants and animals. L-Cystine induces Nrf2 protein elevation in a Keap1 (HY-P75897)-dependent manner and activates Nrf2 transcription factor. L-cystine can elicit cytoprotection by reducing ROS generation and protecting against oxidant- or doxorubicin-induced apoptosis. The reduced reabsorption of L-Cystine in renal tubules and its poor solubility in urine are the important causes of cystine precipitation and cystine crystal formation eventually leading to kidney stones. L-Cystine combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine is promising for research of cystinuria and cystinosis
    L-Cystine (Standard)

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