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Dabcyl-LNKRLLHETQ-Edans

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Angiotensin Receptor (1) Apolipoprotein (1) Apoptosis (1) Bacterial (1) Beta-secretase (1) Cathepsin (1) CHIKV (1) Fluorescent Dye (4) HIV Protease (2) MMP (2) Parasite (1) Renin (1) SARS-CoV (1) Virus Protease (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (2)

Inhibitors & Agonists

Peptides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2295

Dabcyl-KTSAVLQSGFRKME-Edans TFA 1 Publications Verification	SARS-CoV	Others
Dabcyl-KTSAVLQSGFRKME-Edans TFA is a fluorogenic peptide. Dabcyl-KTSAVLQSGFRKME-Edans TFA is used as the substrate to measure the enzymatic activities of protease forms. Dabcyl-KTSAVLQSGFRKME-Edans TFA has the potential for study 2019-nCoV (COVID-19) infection .

HY-P5485

**Dabcyl-QALPETGEE-Edans**	Bacterial	Others
Dabcyl-QALPETGEE-Edans is a synthetic peptide substrate for fluorescence resonance energy transfer (FRET) detection of Sortase A (SrtA) enzymatic activity. Dabcyl-QALPETGEE-Edans is labeled at both ends with the fluorescent group Edans (donor) and the quencher Dabcyl (acceptor), respectively. Dabcyl-QALPETGEE-Edans's central sequence contains a conserved motif specifically recognized by SrtA. Dabcyl-QALPETGEE-Edans demonstrates high sensitivity in vitro assays, enabling precise determination of the half-maximal inhibitory concentration of SrtA .

HY-P5344

*Dabcyl-LNKRLLHETQ-Edans* Fluorigenic PEXEL peptide	Parasite	Others
Dabcyl-LNKRLLHETQ-Edans (Fluorigenic PEXEL peptide) is a biological active peptide. (This FRET substrate peptide for Plasmepsin V (PMV) is derived from the conserved Plasmodium Export Element (PEXEL) motif of Histidine-Rich Protein II (HRPII). PMV is an ER aspartic protease that recognizes and cleaves the RXL sequence within the PEXEL motif of proteins exported by human malaria parasite Plasmodium falciparum, allowing them to translocate into host erythrocytes.)

HY-P2344

HIV Protease Substrate 1	HIV Protease	Infection
HIV Protease Substrate 1, a fiuorogenic HIV protease substrate, can be used to study enzymatic activity of HIV protease .

HY-P2344A

HIV Protease Substrate 1 TFA	HIV Protease	Infection
HIV Protease Substrate 1 TFA, a fiuorogenic HIV protease substrate, can be used to study enzymatic activity of HIV protease .

HY-P11302

DABCYL-RAGGYIFS-(E-EDANS)-NH2	CHIKV Virus Protease	Infection
DABCYL-RAGGYIFS-(E-EDANS)-NH2, an octapeptide, is a FRET-based substrate peptide of CHIKV nsP2protease with highly sensitivity. DABCYL-RAGGYIFS-(E-EDANS)-NH2 can be cleaved by the active CHIKV nsP2protease, separating fluorophore and quencher and resulting in an increase of fluorescence signal. DABCYL-RAGGYIFS-(E-EDANS)-NH2 can used for the determination of CHIKV nsP2protease activity .

HY-P2492

Renin FRET Substrate I	Angiotensin Receptor	Metabolic Disease
Renin FRET Substrate I is a substrate of human renin. Renin FRET Substrate I is designed to incorporate the renin cleavage site that occurs in the N-terminal peptide of human angiotensinogen .

HY-P3878

Renin substrate 1	Renin	Cardiovascular Disease
Renin substrate 1 is a renin substrate with high affinity to the enzyme .

HY-P4899

*RE(EDANS)EVNLDAEFK(DABCYL)R*	Beta-secretase	Neurological Disease
RE (EDANS) EVNLDAEFK (DABCYL) R is an EDANS and DABCYL double-labeled peptide，serves as a fluorescent substrate for BACE1(Em=360nm，Ex=528nm). RE (EDANS) EVNLDAEFK (DABCYL) R can be used for BACE1 activity measurement and the enzyme activity level is directly proportional to the fluorescence reaction .

HY-P10163

α-Secretase Substrate II, Fluorogenic	Fluorescent Dye	Others
α-Secretase Substrate II, Fluorogenic is an internally quenched fluorogenic peptide substrate for α-Secretase that contains the α-secretase cleavage site of β-Amyloid precursor protein (APP) .Ex/Em = 340/490 nm

HY-P4787

*Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2*	Cathepsin	Others
Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 is a cathepsin D substrate, that can be used for cathepsin D FRET assay .

HY-P2136

COG1410 3 Publications Verification	Apolipoprotein Apoptosis	Neurological Disease Inflammation/Immunology
COG1410 is an apolipoprotein E-derived peptide and an apoptosis inhibitor. COG1410 exerts neuroprotective and antiinflammatory effects in a murine model of traumatic brain injury (TBI). COG1410 can be used for the research of neurological disease .

HY-P10073

Calpain-1 substrate, fluorogenic	Fluorescent Dye	Others
Calpain-1 substrate, fluorogenic serves as a sensitive and specific substrate for calpain-1 that cleaves Tyr-Gly bond and results in enhanced fluorescence .(Ex/Em = 490 nm/518 nm)

HY-P5380A

TNO211 TFA Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(Edans)-Ala-Lys-NH2 TFA	MMP Fluorescent Dye	Cancer
TNO211 (Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2) TFA is a fluorogenic substrate, containing the MMP cleavable Gly-Leu bond and EDANS/Dabcyl as fluorophore/quencer combination. TNO211 TFA can specifically detect MMP activity (Ex/Em = 340/485 nm) .

HY-P5380

TNO211 Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(Edans)-Ala-Lys-NH2	MMP Fluorescent Dye	Others
TNO211 (Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2) is a fluorogenic substrate, containing the MMP cleavable Gly-Leu bond and EDANS/Dabcyl as fluorophore/quencer combination. TNO211 can specifically detect MMP activity (Ex/Em = 340/485 nm) .

Cat. No.	Product Name	Target	Research Area

HY-P2295

Dabcyl-KTSAVLQSGFRKME-Edans TFA 1 Publications Verification	SARS-CoV	Others
Dabcyl-KTSAVLQSGFRKME-Edans TFA is a fluorogenic peptide. Dabcyl-KTSAVLQSGFRKME-Edans TFA is used as the substrate to measure the enzymatic activities of protease forms. Dabcyl-KTSAVLQSGFRKME-Edans TFA has the potential for study 2019-nCoV (COVID-19) infection .

HY-P5485

**Dabcyl-QALPETGEE-Edans**	Bacterial	Others
Dabcyl-QALPETGEE-Edans is a synthetic peptide substrate for fluorescence resonance energy transfer (FRET) detection of Sortase A (SrtA) enzymatic activity. Dabcyl-QALPETGEE-Edans is labeled at both ends with the fluorescent group Edans (donor) and the quencher Dabcyl (acceptor), respectively. Dabcyl-QALPETGEE-Edans's central sequence contains a conserved motif specifically recognized by SrtA. Dabcyl-QALPETGEE-Edans demonstrates high sensitivity in vitro assays, enabling precise determination of the half-maximal inhibitory concentration of SrtA .

HY-P5344

*Dabcyl-LNKRLLHETQ-Edans* Fluorigenic PEXEL peptide	Parasite	Others
Dabcyl-LNKRLLHETQ-Edans (Fluorigenic PEXEL peptide) is a biological active peptide. (This FRET substrate peptide for Plasmepsin V (PMV) is derived from the conserved Plasmodium Export Element (PEXEL) motif of Histidine-Rich Protein II (HRPII). PMV is an ER aspartic protease that recognizes and cleaves the RXL sequence within the PEXEL motif of proteins exported by human malaria parasite Plasmodium falciparum, allowing them to translocate into host erythrocytes.)

HY-P2344

HIV Protease Substrate 1	HIV Protease	Infection
HIV Protease Substrate 1, a fiuorogenic HIV protease substrate, can be used to study enzymatic activity of HIV protease .

HY-P2344A

HIV Protease Substrate 1 TFA	HIV Protease	Infection
HIV Protease Substrate 1 TFA, a fiuorogenic HIV protease substrate, can be used to study enzymatic activity of HIV protease .

HY-P11302

DABCYL-RAGGYIFS-(E-EDANS)-NH2	CHIKV Virus Protease	Infection
DABCYL-RAGGYIFS-(E-EDANS)-NH2, an octapeptide, is a FRET-based substrate peptide of CHIKV nsP2protease with highly sensitivity. DABCYL-RAGGYIFS-(E-EDANS)-NH2 can be cleaved by the active CHIKV nsP2protease, separating fluorophore and quencher and resulting in an increase of fluorescence signal. DABCYL-RAGGYIFS-(E-EDANS)-NH2 can used for the determination of CHIKV nsP2protease activity .

HY-P2492

Renin FRET Substrate I	Angiotensin Receptor	Metabolic Disease
Renin FRET Substrate I is a substrate of human renin. Renin FRET Substrate I is designed to incorporate the renin cleavage site that occurs in the N-terminal peptide of human angiotensinogen .

HY-P3878

Renin substrate 1	Renin	Cardiovascular Disease
Renin substrate 1 is a renin substrate with high affinity to the enzyme .

HY-P4780

*Glu(EDANS)-Pro-Leu-Phe-Ala-Glu-Arg-Lys(DABCYL)*	Peptides	Others
Glu(EDANS)-Pro-Leu-Phe-Ala-Glu-Arg-Lys(DABCYL) is a calpain substrate. The excitation wavelength is 380 nm and the emission wavelength is 500 nm for Glu(Edans)-Pro-Leu-Phe-Ala-Glu-Arg-Lys(Dabcyl) .

HY-P4899

*RE(EDANS)EVNLDAEFK(DABCYL)R*	Beta-secretase	Neurological Disease
RE (EDANS) EVNLDAEFK (DABCYL) R is an EDANS and DABCYL double-labeled peptide，serves as a fluorescent substrate for BACE1(Em=360nm，Ex=528nm). RE (EDANS) EVNLDAEFK (DABCYL) R can be used for BACE1 activity measurement and the enzyme activity level is directly proportional to the fluorescence reaction .

HY-P10163

α-Secretase Substrate II, Fluorogenic	Fluorescent Dye	Others
α-Secretase Substrate II, Fluorogenic is an internally quenched fluorogenic peptide substrate for α-Secretase that contains the α-secretase cleavage site of β-Amyloid precursor protein (APP) .Ex/Em = 340/490 nm

HY-P4787

*Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2*	Cathepsin	Others
Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 is a cathepsin D substrate, that can be used for cathepsin D FRET assay .

HY-P5510

*Ac-Asp-Glu-Asp(EDANS)-Glu-Glu-Abu-ψ-(COO)Ala-Ser-Lys(DABCYL)-NH2* HCV NS3 protease substrate	Peptides	Others
Ac-Asp-Glu-Asp(EDANS)-Glu-Glu-Abu-ψ-(COO)Ala-Ser-Lys(DABCYL)-NH2 (HCV NS3 protease substrate) is a biological active peptide. (This peptide is a HCV protease substrate incorporating an ester bond between residues P1 and P1. Due to ready transesterification of the scissile bond to the acyl-enzyme intermediate, this substrate shows very high kcat/Km values, enabling detection of activity with subnanomolar nonstructural protein 3 (NS3 protease) concentrations. It is widely used for the continuous assay of NS3 protease activity. Substrate cleavage is proportional to the enzyme concentration with a detection limit for NS3 between 1 nM and 250 pM.

HY-P2136

COG1410 3 Publications Verification	Apolipoprotein Apoptosis	Neurological Disease Inflammation/Immunology
COG1410 is an apolipoprotein E-derived peptide and an apoptosis inhibitor. COG1410 exerts neuroprotective and antiinflammatory effects in a murine model of traumatic brain injury (TBI). COG1410 can be used for the research of neurological disease .

HY-P10073

Calpain-1 substrate, fluorogenic	Fluorescent Dye	Others
Calpain-1 substrate, fluorogenic serves as a sensitive and specific substrate for calpain-1 that cleaves Tyr-Gly bond and results in enhanced fluorescence .(Ex/Em = 490 nm/518 nm)

HY-P5380A

TNO211 TFA Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(Edans)-Ala-Lys-NH2 TFA	MMP Fluorescent Dye	Cancer
TNO211 (Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2) TFA is a fluorogenic substrate, containing the MMP cleavable Gly-Leu bond and EDANS/Dabcyl as fluorophore/quencer combination. TNO211 TFA can specifically detect MMP activity (Ex/Em = 340/485 nm) .

HY-P5380

TNO211 Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(Edans)-Ala-Lys-NH2	MMP Fluorescent Dye	Others
TNO211 (Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2) is a fluorogenic substrate, containing the MMP cleavable Gly-Leu bond and EDANS/Dabcyl as fluorophore/quencer combination. TNO211 can specifically detect MMP activity (Ex/Em = 340/485 nm) .

HY-P5326

EDANS-CO-CH2-CH2-CO-ALERMFLSFP-Dap(DABCYL)OH	Peptides	Others
EDANS-CO-CH2-CH2-CO-ALERMFLSFP-Dap(DABCYL)OH is a biological active peptide. (Plasmepsin I substrate)

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