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DYNE-251 Oligomer

" in MedChemExpress (MCE) Product Catalog:

2

Inhibitors & Agonists

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-177484
    Rostudirsen

    DYNE-251 Oligomer

    		 Transferrin Receptor Antibody-Oligonucleotide Conjugates (AOCs) Others
    Rostudirsen, one of the components of Zeleciment rostudirsen (HY-177485), is a phosphorodiamidate morpholino oligomer. Zeleciment rostudirsen consists of Rostudirsen (HY-177484) conjugated to a fragment antibody (Fab), Zeleciment (HY-P990780), which binds to the transferrin receptor 1 (TfR1) that is highly expressed in muscle. It is designed to enable targeted muscle tissue delivery and promote exon skipping in the nucleus, allowing muscle cells to create internally shortened, near full-length dystrophin protein.
    Rostudirsen
  • HY-177485
    Zeleciment rostudirsen

    DYNE-251

    		 Antibody-Oligonucleotide Conjugates (AOCs) Transferrin Receptor Others
    Zeleciment rostudirsen (DYNE-251) consists of a phosphorodiamidate morpholino oligomer (PMO) Rostudirsen (HY-177484) conjugated to a fragment antibody (Fab), Zeleciment (HY-P990780), which binds to the transferrin receptor 1 (TfR1) that is highly expressed in muscle. It is designed to enable targeted muscle tissue delivery and promote exon skipping in the nucleus, allowing muscle cells to create internally shortened, near full-length dystrophin protein.
    Zeleciment rostudirsen

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