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Results for "

DSS-induced IBD

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Phosphodiesterase (PDE) (1) RIP kinase (1)
By Research Areas:	Inflammation/Immunology (2)

Inhibitors & Agonists

Isotope-Labeled Compounds

Targets Recommended: PINK1/Parkin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155199

PDE1-IN-5	Phosphodiesterase (PDE)	Inflammation/Immunology
PDE1-IN-5 (Compound 10c) is a selective PDE1C inhibitor (IC₅₀: 15 nM). PDE1-IN-5 has anti- inflammatory activity, and inhibits expression of iNOS, TNF-α, IL-1α, IL-1β, and IL-6 induced by LPS. PDE1-IN-5 has anti-inflammatory bowel disease (IBD) effects in the dextran sodium sulfate (DSS)-Induced colitis mice model. PDE1-IN-5 can be used for research of IBD .

HY-178762S

RIPK1-IN-35	RIP kinase	Inflammation/Immunology
RIPK1-IN-35 is a selective and orally active RIPK1 inhibitor with an IC₅₀ of 5.33 nM. RIPK1-IN-35 has a potent protective effect against necroptosis in both human and murine cells. RIPK1-IN-35 shows good therapeutic effects in both TNF-α-induced systemic inflammatory response syndrome and DSS (HY-116282C)-induced inflammatory bowel disease models. RIPK1-IN-35 can be used to the study of inflammatory diseases related to necroptosis .

Cat. No.	Product Name	Chemical Structure

HY-178762S

RIPK1-IN-35
RIPK1-IN-35 is a selective and orally active RIPK1 inhibitor with an IC₅₀ of 5.33 nM. RIPK1-IN-35 has a potent protective effect against necroptosis in both human and murine cells. RIPK1-IN-35 shows good therapeutic effects in both TNF-α-induced systemic inflammatory response syndrome and DSS (HY-116282C)-induced inflammatory bowel disease models. RIPK1-IN-35 can be used to the study of inflammatory diseases related to necroptosis .

RIPK1-IN-35

RIPK1-IN-35 is a selective and orally active RIPK1 inhibitor with an IC₅₀ of 5.33 nM. RIPK1-IN-35 has a potent protective effect against necroptosis in both human and murine cells. RIPK1-IN-35 shows good therapeutic effects in both TNF-α-induced systemic inflammatory response syndrome and DSS (HY-116282C)-induced inflammatory bowel disease models. RIPK1-IN-35 can be used to the study of inflammatory diseases related to necroptosis .

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