Search Result
Results for "
DNPs
" in MedChemExpress (MCE) Product Catalog:
12
Biochemical Assay Reagents
1
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-P3749
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Fluorescent Dye
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Others
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Mca-(ala7,lys(dnp)9)-bradykinin is a sensitive fluorogenic substrate for ECE-1 (endothelin-converting enzyme-1). The incorporation of a (7-methoxycoumarin-4-yl)acetyl (Mca) fluorescent group and a 2,4-dinitrophenyl (Dnp) quenching group has resulted in a large fluorescence increase upon substrate cleavage .
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- HY-P10172
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- HY-P3123A
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Fluorescent Dye
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Others
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Dnp-RPLALWRS TFA is a fluorescent peptide substrate designed for human matrilysin (MMP-7). After enzymatic cleavage of Dnp-RPLALWRS TFA at the alanine-leucine bond, the release of the Dnp group alleviates fluorescence quenching, thereby enabling real-time quantitative analysis of MMP-7 activity by increasing tryptophan emission. Dnp-RPLALWRS TFA provides a sensitive and efficient detection method for kinetic studies and inhibitor screenin .
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- HY-P4404
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Cathepsin
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Others
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Abz-GIVRAK(Dnp) is the most efficient substrate for cathepsin B and is highly selective for this enzyme among lysosomal cysteine proteases. After Abz-GIVRAK(Dnp) is hydrolyzed, aminoacylbenziminosulfosuccinic acid (Abz-SAS) is released, and dinitrobenzoyl (Dnp) is also released. The product of this hydrolysis reaction, Abz-SAS, is fluorescent under ultraviolet light and can emit a fluorescent signal .
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- HY-157182
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Biochemical Assay Reagents
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Cancer
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DNP-PEG2-NHCO-C2-DBCO is a clickable hapten that bears a dinitrophenyl (DNP) moiety as the antibody‐recruiting motif at one end, a polyethylene glycol chain as a spacer and a dibenzocyclooctene at the other end for the SPAAC chemistry .
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- HY-177344
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Biochemical Assay Reagents
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Cancer
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IAJD-97 is a single-component ionizable amphiphilic Janus dendrimer carrier targeting mRNA delivery, which self-assembles into dendrimersomes (DNPs) via pH-responsive mechanisms to efficiently encapsulate and protect mRNA, while facilitating cellular uptake and endosomal escape through ionizable amine groups. IAJD-97 is promising for research of cancers .
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- HY-P10870
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Peptide-Drug Conjugates (PDCs)
FGFR
Apoptosis
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Cancer
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Pep1-DNP conjugate 9 is a functionalized peptide which is composed of the DNP-Hapten and the FGFR1 binding peptide. Pep1-DNP conjugate 9 exhibits good affinity to FGFR1 with KD of 5.01 μM. Pep1-DNP conjugate 9 recruits anti-DNP antibodies to the surface of FGFR1-positive cells, inhibits the FGF2-induced proliferation in rat skeletal myoblast cells, and induces apoptosis. Pep1-DNP conjugate 9 exhibits antitumor efficacy in mouse models .
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- HY-130350
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PROTAC Linkers
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Cancer
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DNP-PEG3-DNP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-P2089
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MMP
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Others
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Dnp-PYAYWMR is a peptide substrate that selectively targets MMP3. Dnp-PYAYWMR is cleaved by MMP3 to produce Dnp-PYA (nonfluorescent) and YWMR (fluorophore detectable at 360 nm). After incubation of MMP3 with Dnp-PYAYWMR for 2 h, MMP3 fluorescence intensity was measured. Ex/Em=328/350 nm .
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- HY-174937
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DNP-PEG3-COOH
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Biochemical Assay Reagents
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Others
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DNP-PEG3-acid (DNP-PEG3-COOH) is a compound composed of 2,4-dinitroaniline (DNP), three PEG units, and propionic acid, which can be used for drug delivery.
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- HY-174936
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DNP-PEG8-acid
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Biochemical Assay Reagents
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Others
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DNP-PEG8-COOH (DNP-PEG8-acid) is a compound composed of 2,4-dinitroaniline (DNP), three PEG units, and a carboxyl group (-COOH) that can be used for drug delivery.
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- HY-P10173
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Angiotensin-converting Enzyme (ACE)
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Others
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Abz-LFK(Dnp)-OH is an angiotensin I-converting enzyme (ACE) peptide substrate. Abz-LFK(Dnp)-OH is selective for the C domain of ACE. Abz-LFK(Dnp)-OH can be used to assess ACE activity .
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- HY-D1050
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6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester
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Fluorescent Dye
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Metabolic Disease
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DNP-X, SE (6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester), the DNP-X acid modified by succinimidyl ester, is an amine-reactive building block for developing a probe, which can be recognized by anti-DNP antibodies. DNP-X, SE (6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester) is also an excellent amine-reactive FRET quencher paired with Trp or Tyr.
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- HY-D1049
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6-((2,4-Dinitrophenyl)amino)hexanoic acid
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Fluorescent Dye
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Metabolic Disease
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DNP-X acid (6-((2,4-Dinitrophenyl)amino)hexanoic acid), an amine-reactive building block for developing a probe, can be recognized by anti-DNP antibodies. DNP-X acid is also an excellent amine-reactive FRET quencher paired with Trp or Tyr.
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- HY-P1859A
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Biochemical Assay Reagents
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Others
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MCA-SEVNLDAEFR-K(Dnp)-RR, amide (acetate) is synthesized from MCA-SEVNLDAEFR-K(Dnp)-RR, amide (HY-P1859) by losing the H of the -OH group of acetic acid. MCA-SEVNLDAEFR-K(Dnp)-RR, amide is a FRET-based substrate.
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- HY-P3123
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Fluorescent Dye
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Others
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Dnp-RPLALWRS is a fluorescent peptide substrate designed for human matrilysin (MMP-7). After enzymatic cleavage of Dnp-RPLALWRS at the alanine-leucine bond, the release of the Dnp group alleviates fluorescence quenching, thereby enabling real-time quantitative analysis of MMP-7 activity by increasing tryptophan emission. Dnp-RPLALWRS provides a sensitive and efficient detection method for kinetic studies and inhibitor screenin .
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- HY-W190745
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Biochemical Assay Reagents
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Others
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DNP-PEG8-NHS ester is a PEG derivative that contains DNP (2,4-dinitroaniline), eight PEG units, and NHS ester. NHS ester can covalently bind to molecules with amino groups (such as proteins, antibodies, etc.). DNP-PEG8-NHS ester can be used for drug delivery.
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- HY-W190745A
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Biochemical Assay Reagents
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Others
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DNP-PEG2-NHS ester is a PEG derivative that contains DNP (2,4-dinitroaniline), two PEG units, and NHS ester. NHS ester can covalently bind to molecules with amino groups (such as proteins, antibodies, etc.). DNP-PEG2-NHS ester can be used for drug delivery.
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- HY-W190745B
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Biochemical Assay Reagents
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Others
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DNP-PEG3-NHS ester is a PEG derivative that contains DNP (2,4-dinitroaniline), three PEG units, and NHS ester. NHS ester can covalently bind to molecules with amino groups (such as proteins, antibodies, etc.). DNP-PEG3-NHS ester can be used for drug delivery.
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- HY-P4737
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- HY-W336372
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- HY-P10139
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MMP
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Others
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Dnp-PLGLWAr-NH2 is a synthetic collagenase/gelatinase substrate. Dnp-PLGLWAR-NH2 can be used to quantify total MMP activity in APMA-activated conditioned medium samples .
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- HY-P3476
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Fluorescent Dye
Caspase
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Cancer
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Mca-VDQVDGW-Lys(Dnp)-NH2 is a fluorogenic substrate of caspase-7. Mca-VDQVDGW-K(Dnp)-NH2 can be used to quantify caspase-7 activity.
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- HY-P3792
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Biochemical Assay Reagents
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Others
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Mca-Pro-Leu-Gly-Pro-D-Lys(Dnp) is a FRET substrate of Thimet oligopeptidase. Mca-Pro-Leu-Gly-Pro-D-Lys(Dnp) can be used for the determination of Thimet oligopeptidase activity .
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- HY-W040024
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- HY-P1859
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- HY-P2608
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Fluorescent Dye
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Others
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DNP-Pro-Leu-Ala-Leu-Trp-Ala-Arg-OH is the substrate for matrix metalloproteinase MMP-1, with a Km of 26.61 μM. DNP-Pro-Leu-Ala-Leu-Trp-Ala-Arg-OH is utilized as fluorescence probe for detecting protein activity .
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- HY-P3484
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MMP
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Cancer
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Dnp-PLGLWA-DArg-NH2 TFA is a fluorogenic substrate for MMP-1 and MMP-9. Dnp-PLGLWA-DArg-NH2 TFA can be used to quantify the activity of MMPs (Ex=280 nm, Em=360 nm) .
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- HY-P4919
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Beta-secretase
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Others
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Mca-SEVNLDAEFK(Dnp) is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Cleavage at -Leu-Asp- of Mca-SEVNLDAEFK(Dnp) liberates the highly fluorescent 7-methoxycoumarin (Mca) fragment from the proximity quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large and easily detectable increase in fluorescence intensity.
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- HY-P2614
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Caspase
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Others
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Mca-DEVDAP-K(Dnp)-OH is a fluorogenic substrate for caspase-3 .
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- HY-119984
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Cytochrome P450
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Others
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DNP-INT is a potent photosynthetic electron transport chain (PETC) inhibitor. DNP-INT competently inhibits the oxidation of plastid quinoline by binding to the Q0 site of Cyt-b6f (Kd=1.4 nM), thereby inhibiting electron transfer in plants .
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- HY-140619
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PROTAC Linkers
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Cancer
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DNP-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . DNP-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
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- HY-140496
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PROTAC Linkers
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Cancer
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DNP-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-140495
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PROTAC Linkers
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Cancer
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DNP-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-130198
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PROTAC Linkers
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Cancer
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DNP-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-140615
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PROTAC Linkers
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Cancer
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DNP-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-140618
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PROTAC Linkers
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Cancer
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DNP-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-W190756
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- HY-140616
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DNP-PEG6-t-butyl ester
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PROTAC Linkers
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Cancer
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DNP-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-W190791
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- HY-140614
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PROTAC Linkers
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Cancer
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DNP-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-N15882
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- HY-163057
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Others
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Inflammation/Immunology
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2,2',2''-Nitrilotris(NH-EG8-Lys-2,4-dinitroaniline) is a trivalent hapten. 2,2',2''-Nitrilotris(NH-EG8-Lys-2,4-dinitroaniline) can aggregate with monoclonal anti-2,4-DNP IgG (IgGDNP) .
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- HY-P10922
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Cathepsin
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Others
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Cathepsin E substrate e is a substrate of Cathepsin E. Cathepsin E substrate e was designed in such a way that due to the close proximity of a Mca-donor and a Dnp-acceptor, a near complete intramolecular quenching effect was achieved in its intact state. After the proteolytic cleavage of the hydrophobic motif of the peptide substrate, both Mca and Dnp would be further apart, resulting in bright fluorescence .
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- HY-P2616
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- HY-P2616A
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- HY-P10452
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Caspase
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Others
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Ac-LEVDGWK(Dnp)-NH2 is a substrate for Caspase-3, and can be used to detect Caspase-3 activity .
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- HY-P1883
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Fluorescent Dye
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Infection
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Bacterial Sortase Substrate III, Abz/DNP is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Cleavage of this substrate can be monitored at Ex/Em=320 nm/420 nm.
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- HY-130467
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PROTAC Linkers
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Cancer
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DNP-NH-PEG2-C2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
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- HY-P3477
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Fluorescent Dye
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Others
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Mca-PLA-Nva-Dap(Dnp)-AR-NH2 is a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) .
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- HY-P3475
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Fluorescent Dye
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Others
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Mca-VDQMDGWK-(Dnp)-NH2 is a fluorogenic substrate for caspase-3 and can be used to quantify caspase-3 activity .
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- HY-P3098
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MMP
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Others
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Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-26. Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 can be used to quantify MMP-1, MMP-3 and MMP-26 activity .
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- HY-P1883A
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Fluorescent Dye
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Infection
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Bacterial Sortase Substrate III, Abz/DNP TFA is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Cleavage of this substrate can be monitored at Ex/Em=320 nm/420 nm.
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- HY-130491
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PROTAC Linkers
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Cancer
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DNP-NH-PEG4-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-P2716
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MMP
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Others
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Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2 is a biological active peptide. (MMP substrate)
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- HY-140617
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PROTAC Linkers
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Cancer
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DNP-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . DNP-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-140617B
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Biochemical Assay Reagents
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Others
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DNP-PEG12-azide is a PEG derivative that can be used for drug delivery and other research. DNP-PEG12-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .
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- HY-140617A
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Biochemical Assay Reagents
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Others
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DNP-PEG2-azide is a PEG derivative that can be used for drug delivery and other research. DNP-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .
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- HY-P4931
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Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2
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MMP
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Cancer
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Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a fluorescent peptide that is a quenched MMP peptide substrate. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 can be used for real-time quantification of MMP enzymatic activity. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is an elongated peptide of MMP substrate (FS-1) and is active against collagenases (MMP-1, MMP-8, MMP-13 ) and MT1-MMP with higher specificity constants than FS-1 . (Ex/Em=325 nm/400 nm)
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- HY-P1853
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- HY-P3120
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MMP
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Others
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Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14).
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- HY-P2536
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- HY-167567
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1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamine-N-(2,4-dinitrophenyl) (ammonium)
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Biochemical Assay Reagents
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16:0 DNP PE (1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamine-N-(2,4-dinitrophenyl) (ammonium)) is a kind of biochemical reagent.
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- HY-N15876
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Fluorescent Dye
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Metabolic Disease
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18:1-6:0 DNP-C11 BODIPY 505/515 TG is a fluorescently-labeled triglyceride that can be used to study the effects of phosphoinositides (Ex/Em = 495/503 nm) .
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- HY-P5996
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Fluorescent Dye
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Others
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MCA-Gly-Asp-Ala-Glu-pTyr-Ala-Ala-Lys(DNP)-Arg-NH2 is a protein tyrosine phosphatase fluorogenic substrate that can be detected at 393 nm (with excitation at 325 nm) .
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- HY-P4926
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Amyloid-β
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Neurological Disease
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Mca-SEVKMDAEFRK(Dnp)RR-NH2, containing the wild-type amyloid precursor protein (APP) beta-secretase cleavage site, is the substrate of thimet oligopeptidase (TOP). It is used for Alzheimer's disease research .
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- HY-P10344
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Fluorescent Dye
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Infection
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MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 is a fluorescent substrate used for fluorescence resonance energy transfer (FRET) protease assays. This substrate is employed to measure the activity of SARS-CoV-2 3CLpro .
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- HY-136433
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1,4-Dinitrosopiperazine; DNP
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Others
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Cancer
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N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) is a carcinogen with specificity for nasopharyngeal epithelium and facilitates NPC metastasis. N,N'-Dinitrosopiperazine regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568 .
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- HY-124013
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4-(α-N-L-alanine)-NBD
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Fluorescent Dye
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Others
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NBDA (4-(α-N-L-alanine)-NBD) is a structural and functional analogue of the 2,4-dinitrophenyl group (DNP). NBDA can be used to detect and characterize antinitroaromatic antibodies, even in crude preparations, and possibly on cell surfaces .
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- HY-P4931A
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Fluorescent Dye
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Others
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Mca-KPLGL-Dap(Dnp)-AR-NH2 TFA is a fluorogenic substrate for matrix metalloproteinases (MMPs). 7-methoxycoumarin-4 acetyl (Mac) is released and its fluorescence can be used to quantify MMP activity. Mac displays Ex/Em of 328/420 nm .
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- HY-P2682
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MMP
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Metabolic Disease
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MMP-8/MMP-26 Fluorogenic substrate (DNP-Pro-Leu-Ala-Tyr-Trp-Ala-Arg) is a matrix metalloproteinase-8 (MMP-8) fluorogenic substrate. MMP-8/MMP-26 Fluorogenic substrate can be used for the research of atherosclerosis, pulmonary fibrosis, and sepsis .
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- HY-136433S
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1,4-Dinitrosopiperazine-d8; DNP-d8
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Isotope-Labeled Compounds
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Cancer
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N,N'-Dinitrosopiperazine-d8 is the deuterium labeled N,N'-Dinitrosopiperazine . N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine;DNP) is a carcinogen with specificity for nasopharyngeal epithelium and facilitates NPC metastasis. N,N'-Dinitrosopiperazine regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568 .
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- HY-132141
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5-Propargylamino-dUTP
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DNA/RNA Synthesis
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Others
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5-PA-dUTP (5-Propargylamino-dUTP) is a C5-modified nucleotide and can be incorporated into DNA nanoparticles (DNPs) for photosensitizer delivery . 5-PA-dUTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-N2252
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- HY-P4920
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Fluorescent Dye
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Others
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Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1 .
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- HY-P3624
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Guanylate Cyclase
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Cardiovascular Disease
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Cenderitide is a potent agonist of particulate guanylyl cyclase receptor (pGC). Cenderitide is a natriuretic peptide (NP) composed of C-type natriuretic peptide (CNP) fused to the C-terminus of Dendroaspis natriuretic peptide (DNP). Cenderitide activates both pGC-A and pGC-B, activates the second messenger cGMP, suppresses aldosterone, and preserves GFR without reducing blood pressure. Cenderitide can be used for heart failure research .
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- HY-P4905
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MMP
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Cancer
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Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 is highly selective substrate for matrix metalloproteases 12 (MMP12) substrate with a kcat/Km value of 1.85*10 5 M -1s -1, and poor substrate of other MMPs with the exception of MMP13 (kcat/Km = 0.53*10 5 M -1s -1) and MMP9 (0.33*10 5 M -1s -1) .
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- HY-N6711
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HIV Integrase
Bacterial
Antibiotic
Reactive Oxygen Species (ROS)
STAT
AMPK
11β-HSD
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Infection
Metabolic Disease
|
|
Equisetin is an N-methylserine-derived acyl tetramic acid, quorum sensing inhibitor (QSI), herbicides and antibiotics. Equisetin specifically inhibits the anionic carriers of substrates in the inner mitochondrial membrane. Equisetin inhibits the activity of HIV-1 integrase, 11β-HSD1, and 2,4-dinitrophenol (Dnp)-stimulated ATPase (IC50 = ~8 nmol per mg of protein). Equisetin exhibits growth inhibition of bacteria, anti-inflammatory, amelioration of lipid-associated disorders, and cytotoxic effects .
|
-
- HY-119725
-
|
|
Insecticide
|
Infection
|
|
Tetradifon is a broad-spectrum organochlorine insecticide and an inhibitor of the mitochondrial oligomycin sensitivity conferring protein (OSCP), which can be used to control a variety of mites. Tetradifon inhibits energy-related activities such as ADP-stimulated respiration, DNP and Mg 2+-stimulated ATPase, with an IC50 of 4.5-27 nmoL/mg mitochondrial protein. Tetradifon exerts oligomycin-like activity by inhibiting the oxidative phosphorylation process, inducing oxidative stress and interfering with bone metabolism. Tetradifon is currently mainly used in the research of mitochondrial function regulation, bone remodeling mechanism and nephrotoxicity of environmental pollutants .
|
-
- HY-119725R
-
|
|
Reference Standards
Insecticide
|
Infection
|
|
Tetradifon (Standard) is the analytical standard of Tetradifon (HY-119725). This product is intended for research and analytical applications. Tetradifon is a broad-spectrum organochlorine insecticide and an inhibitor of the mitochondrial oligomycin sensitivity conferring protein (OSCP), which can be used to control a variety of mites. Tetradifon inhibits energy-related activities such as ADP-stimulated respiration, DNP and Mg 2+-stimulated ATPase, with an IC50 of 4.5-27 nmoL/mg mitochondrial protein. Tetradifon exerts oligomycin-like activity by inhibiting the oxidative phosphorylation process, inducing oxidative stress and interfering with bone metabolism. Tetradifon is currently mainly used in the research of mitochondrial function regulation, bone remodeling mechanism and nephrotoxicity of environmental pollutants .
|
-
-
-
HY-L157
-
|
|
1,028 compounds
|
|
Natural product have great diversity and structural complexity of scaffolds. And the number of their drugs represents a large number of sources of new pharmacological entities, so natural products are of great significance in drug discovery. The Dictionary of Natural Products (DNP) shows that natural products mainly come from plants, animals and microorganisms, and animal sources are the second important source of natural products. Animal derived natural products exist to varying degrees in almost all forms of animals, generally secondary metabolite extracted from organisms.
MCE provides a unique collection of 1,028 animal-sourced natural products. MCE Animal-Sourced Natural Product Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).
|
| Cat. No. |
Product Name |
Type |
-
- HY-P3749
-
|
|
Fluorescent Dyes/Probes
|
|
Mca-(ala7,lys(dnp)9)-bradykinin is a sensitive fluorogenic substrate for ECE-1 (endothelin-converting enzyme-1). The incorporation of a (7-methoxycoumarin-4-yl)acetyl (Mca) fluorescent group and a 2,4-dinitrophenyl (Dnp) quenching group has resulted in a large fluorescence increase upon substrate cleavage .
|
-
- HY-D1050
-
|
6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester
|
Fluorescent Dyes/Probes
|
|
DNP-X, SE (6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester), the DNP-X acid modified by succinimidyl ester, is an amine-reactive building block for developing a probe, which can be recognized by anti-DNP antibodies. DNP-X, SE (6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester) is also an excellent amine-reactive FRET quencher paired with Trp or Tyr.
|
-
- HY-P2536
-
|
|
Fluorescent Dyes/Probes
|
|
Mca-Ala-Pro-Lys(Dnp)-OH, a specific ACE2 quenched fluorogenic substrate, can be used to detect ACE2 activity, such as urinary, heart and lung .
|
-
- HY-D1049
-
|
6-((2,4-Dinitrophenyl)amino)hexanoic acid
|
Fluorescent Dyes/Probes
|
|
DNP-X acid (6-((2,4-Dinitrophenyl)amino)hexanoic acid), an amine-reactive building block for developing a probe, can be recognized by anti-DNP antibodies. DNP-X acid is also an excellent amine-reactive FRET quencher paired with Trp or Tyr.
|
-
- HY-P3484
-
|
|
Fluorescent Dyes/Probes
|
|
Dnp-PLGLWA-DArg-NH2 TFA is a fluorogenic substrate for MMP-1 and MMP-9. Dnp-PLGLWA-DArg-NH2 TFA can be used to quantify the activity of MMPs (Ex=280 nm, Em=360 nm) .
|
-
- HY-P2614
-
-
- HY-P2616
-
|
|
Chromogenic Substrates
|
|
Mca-YVADAP-Lys(Dnp)-OH is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2) .
|
-
- HY-P3475
-
|
|
Fluorescent Dyes/Probes
|
|
Mca-VDQMDGWK-(Dnp)-NH2 is a fluorogenic substrate for caspase-3 and can be used to quantify caspase-3 activity .
|
-
- HY-P3098
-
|
|
Chromogenic Substrates
|
|
Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-26. Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 can be used to quantify MMP-1, MMP-3 and MMP-26 activity .
|
-
- HY-P3120
-
|
|
Chromogenic Substrates
|
|
Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14).
|
-
- HY-124013
-
|
4-(α-N-L-alanine)-NBD
|
Fluorescent Dyes/Probes
|
|
NBDA (4-(α-N-L-alanine)-NBD) is a structural and functional analogue of the 2,4-dinitrophenyl group (DNP). NBDA can be used to detect and characterize antinitroaromatic antibodies, even in crude preparations, and possibly on cell surfaces .
|
| Cat. No. |
Product Name |
Type |
-
- HY-174937
-
|
DNP-PEG3-COOH
|
Drug Delivery
|
|
DNP-PEG3-acid (DNP-PEG3-COOH) is a compound composed of 2,4-dinitroaniline (DNP), three PEG units, and propionic acid, which can be used for drug delivery.
|
-
- HY-174936
-
|
DNP-PEG8-acid
|
Drug Delivery
|
|
DNP-PEG8-COOH (DNP-PEG8-acid) is a compound composed of 2,4-dinitroaniline (DNP), three PEG units, and a carboxyl group (-COOH) that can be used for drug delivery.
|
-
- HY-W190745
-
|
|
Drug Delivery
|
|
DNP-PEG8-NHS ester is a PEG derivative that contains DNP (2,4-dinitroaniline), eight PEG units, and NHS ester. NHS ester can covalently bind to molecules with amino groups (such as proteins, antibodies, etc.). DNP-PEG8-NHS ester can be used for drug delivery.
|
-
- HY-W190745A
-
|
|
Drug Delivery
|
|
DNP-PEG2-NHS ester is a PEG derivative that contains DNP (2,4-dinitroaniline), two PEG units, and NHS ester. NHS ester can covalently bind to molecules with amino groups (such as proteins, antibodies, etc.). DNP-PEG2-NHS ester can be used for drug delivery.
|
-
- HY-W190745B
-
|
|
Drug Delivery
|
|
DNP-PEG3-NHS ester is a PEG derivative that contains DNP (2,4-dinitroaniline), three PEG units, and NHS ester. NHS ester can covalently bind to molecules with amino groups (such as proteins, antibodies, etc.). DNP-PEG3-NHS ester can be used for drug delivery.
|
-
- HY-W336372
-
-
- HY-W190756
-
|
|
Drug Delivery
|
|
DNP-PEG3-NH2 is a PEG derivative that can be used for drug delivery research.
|
-
- HY-W190791
-
|
|
Drug Delivery
|
|
DNP-PEG2-NH2 is a PEG derivative that can be used for drug delivery research.
|
-
- HY-140617B
-
|
|
Drug Delivery
|
|
DNP-PEG12-azide is a PEG derivative that can be used for drug delivery and other research. DNP-PEG12-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .
|
-
- HY-140617A
-
|
|
Drug Delivery
|
|
DNP-PEG2-azide is a PEG derivative that can be used for drug delivery and other research. DNP-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .
|
-
- HY-167567
-
|
1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamine-N-(2,4-dinitrophenyl) (ammonium)
|
Drug Delivery
|
|
16:0 DNP PE (1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamine-N-(2,4-dinitrophenyl) (ammonium)) is a kind of biochemical reagent.
|
-
- HY-132141
-
|
5-Propargylamino-dUTP
|
Gene Sequencing and Synthesis
|
|
5-PA-dUTP (5-Propargylamino-dUTP) is a C5-modified nucleotide and can be incorporated into DNA nanoparticles (DNPs) for photosensitizer delivery . 5-PA-dUTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P3749
-
|
|
Fluorescent Dye
|
Others
|
|
Mca-(ala7,lys(dnp)9)-bradykinin is a sensitive fluorogenic substrate for ECE-1 (endothelin-converting enzyme-1). The incorporation of a (7-methoxycoumarin-4-yl)acetyl (Mca) fluorescent group and a 2,4-dinitrophenyl (Dnp) quenching group has resulted in a large fluorescence increase upon substrate cleavage .
|
-
- HY-P10172
-
-
- HY-P4227A
-
|
|
Peptides
|
Metabolic Disease
|
|
WRVYEKC(dnp)ALK tetraTFA contains tryptophan that can be liberated from the dinitrophenol (DNP) quencher by aminopeptidase activity. WRVYEKC(dnp)ALK tetraTFA can be used as a hydrolysis reaction decapeptide substrate .
|
-
- HY-P10173
-
|
|
Angiotensin-converting Enzyme (ACE)
|
Others
|
|
Abz-LFK(Dnp)-OH is an angiotensin I-converting enzyme (ACE) peptide substrate. Abz-LFK(Dnp)-OH is selective for the C domain of ACE. Abz-LFK(Dnp)-OH can be used to assess ACE activity .
|
-
- HY-P3123A
-
|
|
Fluorescent Dye
|
Others
|
|
Dnp-RPLALWRS TFA is a fluorescent peptide substrate designed for human matrilysin (MMP-7). After enzymatic cleavage of Dnp-RPLALWRS TFA at the alanine-leucine bond, the release of the Dnp group alleviates fluorescence quenching, thereby enabling real-time quantitative analysis of MMP-7 activity by increasing tryptophan emission. Dnp-RPLALWRS TFA provides a sensitive and efficient detection method for kinetic studies and inhibitor screenin .
|
-
- HY-P4404
-
|
|
Cathepsin
|
Others
|
|
Abz-GIVRAK(Dnp) is the most efficient substrate for cathepsin B and is highly selective for this enzyme among lysosomal cysteine proteases. After Abz-GIVRAK(Dnp) is hydrolyzed, aminoacylbenziminosulfosuccinic acid (Abz-SAS) is released, and dinitrobenzoyl (Dnp) is also released. The product of this hydrolysis reaction, Abz-SAS, is fluorescent under ultraviolet light and can emit a fluorescent signal .
|
-
- HY-P10870
-
|
|
Peptide-Drug Conjugates (PDCs)
FGFR
Apoptosis
|
Cancer
|
|
Pep1-DNP conjugate 9 is a functionalized peptide which is composed of the DNP-Hapten and the FGFR1 binding peptide. Pep1-DNP conjugate 9 exhibits good affinity to FGFR1 with KD of 5.01 μM. Pep1-DNP conjugate 9 recruits anti-DNP antibodies to the surface of FGFR1-positive cells, inhibits the FGF2-induced proliferation in rat skeletal myoblast cells, and induces apoptosis. Pep1-DNP conjugate 9 exhibits antitumor efficacy in mouse models .
|
-
- HY-P2089
-
|
|
MMP
|
Others
|
|
Dnp-PYAYWMR is a peptide substrate that selectively targets MMP3. Dnp-PYAYWMR is cleaved by MMP3 to produce Dnp-PYA (nonfluorescent) and YWMR (fluorophore detectable at 360 nm). After incubation of MMP3 with Dnp-PYAYWMR for 2 h, MMP3 fluorescence intensity was measured. Ex/Em=328/350 nm .
|
-
- HY-P1859A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
MCA-SEVNLDAEFR-K(Dnp)-RR, amide (acetate) is synthesized from MCA-SEVNLDAEFR-K(Dnp)-RR, amide (HY-P1859) by losing the H of the -OH group of acetic acid. MCA-SEVNLDAEFR-K(Dnp)-RR, amide is a FRET-based substrate.
|
-
- HY-P3123
-
|
|
Fluorescent Dye
|
Others
|
|
Dnp-RPLALWRS is a fluorescent peptide substrate designed for human matrilysin (MMP-7). After enzymatic cleavage of Dnp-RPLALWRS at the alanine-leucine bond, the release of the Dnp group alleviates fluorescence quenching, thereby enabling real-time quantitative analysis of MMP-7 activity by increasing tryptophan emission. Dnp-RPLALWRS provides a sensitive and efficient detection method for kinetic studies and inhibitor screenin .
|
-
- HY-P4737
-
-
- HY-P10139
-
|
|
MMP
|
Others
|
|
Dnp-PLGLWAr-NH2 is a synthetic collagenase/gelatinase substrate. Dnp-PLGLWAR-NH2 can be used to quantify total MMP activity in APMA-activated conditioned medium samples .
|
-
- HY-P3476
-
|
|
Fluorescent Dye
Caspase
|
Cancer
|
|
Mca-VDQVDGW-Lys(Dnp)-NH2 is a fluorogenic substrate of caspase-7. Mca-VDQVDGW-K(Dnp)-NH2 can be used to quantify caspase-7 activity.
|
-
- HY-P3792
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mca-Pro-Leu-Gly-Pro-D-Lys(Dnp) is a FRET substrate of Thimet oligopeptidase. Mca-Pro-Leu-Gly-Pro-D-Lys(Dnp) can be used for the determination of Thimet oligopeptidase activity .
|
-
- HY-W040024
-
-
- HY-P1859
-
-
- HY-P2608
-
|
|
Fluorescent Dye
|
Others
|
|
DNP-Pro-Leu-Ala-Leu-Trp-Ala-Arg-OH is the substrate for matrix metalloproteinase MMP-1, with a Km of 26.61 μM. DNP-Pro-Leu-Ala-Leu-Trp-Ala-Arg-OH is utilized as fluorescence probe for detecting protein activity .
|
-
- HY-P3484
-
|
|
MMP
|
Cancer
|
|
Dnp-PLGLWA-DArg-NH2 TFA is a fluorogenic substrate for MMP-1 and MMP-9. Dnp-PLGLWA-DArg-NH2 TFA can be used to quantify the activity of MMPs (Ex=280 nm, Em=360 nm) .
|
-
- HY-P4919
-
|
|
Beta-secretase
|
Others
|
|
Mca-SEVNLDAEFK(Dnp) is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Cleavage at -Leu-Asp- of Mca-SEVNLDAEFK(Dnp) liberates the highly fluorescent 7-methoxycoumarin (Mca) fragment from the proximity quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large and easily detectable increase in fluorescence intensity.
|
-
- HY-P2689
-
|
|
Peptides
|
Others
|
|
DNP-PLGMWSR is a? fluorogenic substrate for MMP-2 and MMP-9 .
|
-
- HY-P2614
-
|
|
Caspase
|
Others
|
|
Mca-DEVDAP-K(Dnp)-OH is a fluorogenic substrate for caspase-3 .
|
-
- HY-P10922
-
|
|
Cathepsin
|
Others
|
|
Cathepsin E substrate e is a substrate of Cathepsin E. Cathepsin E substrate e was designed in such a way that due to the close proximity of a Mca-donor and a Dnp-acceptor, a near complete intramolecular quenching effect was achieved in its intact state. After the proteolytic cleavage of the hydrophobic motif of the peptide substrate, both Mca and Dnp would be further apart, resulting in bright fluorescence .
|
-
- HY-P2616
-
-
- HY-P2616A
-
-
- HY-P10452
-
|
|
Caspase
|
Others
|
|
Ac-LEVDGWK(Dnp)-NH2 is a substrate for Caspase-3, and can be used to detect Caspase-3 activity .
|
-
- HY-P1883
-
|
|
Fluorescent Dye
|
Infection
|
|
Bacterial Sortase Substrate III, Abz/DNP is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Cleavage of this substrate can be monitored at Ex/Em=320 nm/420 nm.
|
-
- HY-P3477
-
|
|
Fluorescent Dye
|
Others
|
|
Mca-PLA-Nva-Dap(Dnp)-AR-NH2 is a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) .
|
-
- HY-P3475
-
|
|
Fluorescent Dye
|
Others
|
|
Mca-VDQMDGWK-(Dnp)-NH2 is a fluorogenic substrate for caspase-3 and can be used to quantify caspase-3 activity .
|
-
- HY-P3098
-
|
|
MMP
|
Others
|
|
Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-26. Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 can be used to quantify MMP-1, MMP-3 and MMP-26 activity .
|
-
- HY-P1883A
-
|
|
Fluorescent Dye
|
Infection
|
|
Bacterial Sortase Substrate III, Abz/DNP TFA is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Cleavage of this substrate can be monitored at Ex/Em=320 nm/420 nm.
|
-
- HY-P2716
-
|
|
MMP
|
Others
|
|
Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2 is a biological active peptide. (MMP substrate)
|
-
- HY-P4931
-
|
Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2
|
MMP
|
Cancer
|
|
Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a fluorescent peptide that is a quenched MMP peptide substrate. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 can be used for real-time quantification of MMP enzymatic activity. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is an elongated peptide of MMP substrate (FS-1) and is active against collagenases (MMP-1, MMP-8, MMP-13 ) and MT1-MMP with higher specificity constants than FS-1 . (Ex/Em=325 nm/400 nm)
|
-
- HY-P1853
-
-
- HY-P5529
-
|
|
Peptides
|
Others
|
|
2Abz-GLQRALEI-Lys(Dnp)-NH2 is a biological active peptide. (C4 P4-P4′ substrate)
|
-
- HY-P3120
-
|
|
MMP
|
Others
|
|
Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14).
|
-
- HY-P2536
-
-
- HY-P5528
-
|
|
Peptides
|
Others
|
|
2Abz-SLGRKIQIK(Dnp)-NH2 is a biological active peptide. (This peptide is a second complement component (C2), the physiological substrate for the proenzyme Cls, first complement component. The complement system is a central component of host defense but can also contribute to the inflammation seen in pathological conditions. The C1s protease of the C1 complex initiates the host defense pathway. This peptide employs 2Abz/Dnp FRET pair for quantitation of complement enzyme activity.)
|
-
- HY-P5530
-
|
|
Peptides
|
Others
|
|
2Abz-SVARTLLV-Lys(Dnp)-NH2 is a biological active peptide. (C1-inhibitor P4-P4′ substrate)
|
-
- HY-P5996
-
|
|
Fluorescent Dye
|
Others
|
|
MCA-Gly-Asp-Ala-Glu-pTyr-Ala-Ala-Lys(DNP)-Arg-NH2 is a protein tyrosine phosphatase fluorogenic substrate that can be detected at 393 nm (with excitation at 325 nm) .
|
-
- HY-P4926
-
|
|
Amyloid-β
|
Neurological Disease
|
|
Mca-SEVKMDAEFRK(Dnp)RR-NH2, containing the wild-type amyloid precursor protein (APP) beta-secretase cleavage site, is the substrate of thimet oligopeptidase (TOP). It is used for Alzheimer's disease research .
|
-
- HY-P10344
-
|
|
Fluorescent Dye
|
Infection
|
|
MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 is a fluorescent substrate used for fluorescence resonance energy transfer (FRET) protease assays. This substrate is employed to measure the activity of SARS-CoV-2 3CLpro .
|
-
- HY-P4931A
-
|
|
Fluorescent Dye
|
Others
|
|
Mca-KPLGL-Dap(Dnp)-AR-NH2 TFA is a fluorogenic substrate for matrix metalloproteinases (MMPs). 7-methoxycoumarin-4 acetyl (Mac) is released and its fluorescence can be used to quantify MMP activity. Mac displays Ex/Em of 328/420 nm .
|
-
- HY-P2682
-
|
|
MMP
|
Metabolic Disease
|
|
MMP-8/MMP-26 Fluorogenic substrate (DNP-Pro-Leu-Ala-Tyr-Trp-Ala-Arg) is a matrix metalloproteinase-8 (MMP-8) fluorogenic substrate. MMP-8/MMP-26 Fluorogenic substrate can be used for the research of atherosclerosis, pulmonary fibrosis, and sepsis .
|
-
- HY-P4920
-
|
|
Fluorescent Dye
|
Others
|
|
Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1 .
|
-
- HY-P3624
-
|
|
Guanylate Cyclase
|
Cardiovascular Disease
|
|
Cenderitide is a potent agonist of particulate guanylyl cyclase receptor (pGC). Cenderitide is a natriuretic peptide (NP) composed of C-type natriuretic peptide (CNP) fused to the C-terminus of Dendroaspis natriuretic peptide (DNP). Cenderitide activates both pGC-A and pGC-B, activates the second messenger cGMP, suppresses aldosterone, and preserves GFR without reducing blood pressure. Cenderitide can be used for heart failure research .
|
-
- HY-P4905
-
|
|
MMP
|
Cancer
|
|
Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 is highly selective substrate for matrix metalloproteases 12 (MMP12) substrate with a kcat/Km value of 1.85*10 5 M -1s -1, and poor substrate of other MMPs with the exception of MMP13 (kcat/Km = 0.53*10 5 M -1s -1) and MMP9 (0.33*10 5 M -1s -1) .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-136433S
-
|
|
|
N,N'-Dinitrosopiperazine-d8 is the deuterium labeled N,N'-Dinitrosopiperazine . N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine;DNP) is a carcinogen with specificity for nasopharyngeal epithelium and facilitates NPC metastasis. N,N'-Dinitrosopiperazine regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568 .
|
-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-140619
-
|
|
|
PROTAC Synthesis
DBCO
|
|
DNP-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . DNP-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
|
-
- HY-140617
-
|
|
|
Azide
PROTAC Synthesis
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DNP-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . DNP-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-157182
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DBCO
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DNP-PEG2-NHCO-C2-DBCO is a clickable hapten that bears a dinitrophenyl (DNP) moiety as the antibody‐recruiting motif at one end, a polyethylene glycol chain as a spacer and a dibenzocyclooctene at the other end for the SPAAC chemistry .
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Classification |
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- HY-132141
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5-Propargylamino-dUTP
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Nucleotides and their Analogs
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5-PA-dUTP (5-Propargylamino-dUTP) is a C5-modified nucleotide and can be incorporated into DNA nanoparticles (DNPs) for photosensitizer delivery . 5-PA-dUTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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