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DENV2 replication

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CHIKV (1) Dengue Virus (4) DNA/RNA Synthesis (2) Flavivirus (1) Nucleoside Antimetabolite/Analog (1) SARS-CoV (1) Virus Protease (5)
By Research Areas:	Infection (8) Inflammation/Immunology (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-162485

DV-B-120	Dengue Virus Virus Protease	Infection
DV-B-120 is a competitive inhibitor for dengue virus (DENV) with IC₅₀s of 5.35, 7.39, 10.49 and 8.58 μM, for DENV-1, DENV-2, DENV-3 and DENV-4, respectively, by inhibiting NS2B-NS3 protease. DV-B-120 exhibits antiviral activity through inhibition of DENV replication .

HY-136574

2-Hydroxy-4-methylbenzenesulphonic acid ammonium	Virus Protease	Infection
2-Hydroxy-4-methylbenzenesulphonic acid ammonium is an impurity of Policresulen. Policresulen is a potent NS2B/NS3 protease inhibitor with an IC₅₀ of 0.48 μg/mL. Policresulen effectively inhibits the replication of DENV2 virus in BHK-21 cells with an IC₅₀ of 4.99 μg/mL. Policresulen acted as a competitive inhibitor of the protease, and slightly affected the protease stability .

HY-117813

2-Thiouridine	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Dengue Virus Flavivirus CHIKV SARS-CoV	Infection
2-Thiouridine is an orally active modified nucleobase. 2-Thiouridine stabilizes U:A base pairs and destabilizes U:G wobble base pairs. 2-Thiouridine significantly improves the efficiency and accuracy of nonenzymatic replication of mixed-sequence A/U-containing RNA templates. 2-Thiouridine exhibits antiviral activity against multiple positive-sense single-stranded RNA viruses (DENV2, ZIKV, YFV, JEV, WNV, CHIKV, human coronaviruses ( [HCoV]-229E, HCoV-OC43, SARS-CoV), and MERS-CoV) .

HY-W129596

Policresulen	Virus Protease Dengue Virus	Infection Inflammation/Immunology
Policresulen is a competitive inhibitor for DENV2 NS2B/NS3 protease with an IC₅₀ of 0.48 μg/mL. Policresulen can be used as a local hemostatic and antibacterial agent for research of cervical and vaginal inflammation, skin lesions, oral mucosa and gingival inflammation .

HY-157405

DENV-IN-11	Dengue Virus	Infection
DENV-IN-11 (SC27), a sulfonamide chalcone, is a potent DENV inhibitor that targeted viral methyltransferase. DENV-IN-11 reduced DENV2 replicon replication. DENV-IN-11 can be used for dengue infection research .

HY-155129

Antiviral agent 36	DNA/RNA Synthesis	Infection
Antiviral agent 36 (compound 27) is a potent dengue (DENV) and Zika (ZIKV) viruses inhibitor. Antiviral agent 36 inhibits replication of Zika and dengue virus with EC₅₀s of 100 nM, 90 nM, 210 nM, and 120 nM for ZIKV-FLR, ZIKV-HN16, DENV-2, and DENV-3, respectively .

HY-136575

4-Hydroxy-2-methylbenzenesulfonic acid ammonium	Virus Protease	Infection
4-Hydroxy-2-methylbenzenesulfonic acid ammonium is an impurity of Policresulen. Policresulen is a potent NS2B/NS3 protease inhibitor with an IC₅₀ of 0.48 μg/mL. Policresulen effectively inhibits the replication of DENV2 virus in BHK-21 cells with an IC₅₀ of 4.99 μg/mL. Policresulen acted as a competitive inhibitor of the protease, and slightly affected the protease stability .

HY-136573

5-Hydroxytoluene-2,4-disulphonic acid diammonium	Virus Protease	Infection
5-Hydroxytoluene-2,4-disulphonic acid diammonium is an impurity of Policresulen. Policresulen is a potent NS2B/NS3 protease inhibitor with an IC₅₀ of 0.48 μg/mL. Policresulen effectively inhibits the replication of DENV2 virus in BHK-21 cells with an IC₅₀ of 4.99 μg/mL. Policresulen acted as a competitive inhibitor of the protease, and slightly affected the protease stability .

Cat. No.	Product Name	Type

HY-117813

2-Thiouridine	Gene Sequencing and Synthesis
2-Thiouridine is an orally active modified nucleobase. 2-Thiouridine stabilizes U:A base pairs and destabilizes U:G wobble base pairs. 2-Thiouridine significantly improves the efficiency and accuracy of nonenzymatic replication of mixed-sequence A/U-containing RNA templates. 2-Thiouridine exhibits antiviral activity against multiple positive-sense single-stranded RNA viruses (DENV2, ZIKV, YFV, JEV, WNV, CHIKV, human coronaviruses ( [HCoV]-229E, HCoV-OC43, SARS-CoV), and MERS-CoV) .

2-Thiouridine

Gene Sequencing and Synthesis

2-Thiouridine is an orally active modified nucleobase. 2-Thiouridine stabilizes U:A base pairs and destabilizes U:G wobble base pairs. 2-Thiouridine significantly improves the efficiency and accuracy of nonenzymatic replication of mixed-sequence A/U-containing RNA templates. 2-Thiouridine exhibits antiviral activity against multiple positive-sense single-stranded RNA viruses (DENV2, ZIKV, YFV, JEV, WNV, CHIKV, human coronaviruses ( [HCoV]-229E, HCoV-OC43, SARS-CoV), and MERS-CoV) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-117813

2-Thiouridine	Source classification	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Dengue Virus Flavivirus CHIKV SARS-CoV
2-Thiouridine is an orally active modified nucleobase. 2-Thiouridine stabilizes U:A base pairs and destabilizes U:G wobble base pairs. 2-Thiouridine significantly improves the efficiency and accuracy of nonenzymatic replication of mixed-sequence A/U-containing RNA templates. 2-Thiouridine exhibits antiviral activity against multiple positive-sense single-stranded RNA viruses (DENV2, ZIKV, YFV, JEV, WNV, CHIKV, human coronaviruses ( [HCoV]-229E, HCoV-OC43, SARS-CoV), and MERS-CoV) .

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DENV2 replication

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Natural
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