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DDR1-IN-12

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-176849
    DDR1-IN-12

    		Discoidin Domain Receptor Cancer
    DDR1-IN-12 (Compound 7t) is a highly selective discoidin domain receptor 1 (DDR1) inhibitor (IC50=0.126 μM). DDR1-IN-12 blocks receptor tyrosine kinase autophosphorylation and downstream signaling (e.g., inhibition of TGF-β1-induced fibroblast activation), inhibiting tumor cell migration and pulmonary fibrosis progression. DDR1-IN-12 is promising for research of lung cancer (especially lung adenocarcinoma) .
    DDR1-IN-12

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