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D3 ligands

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By Targets:	Ligands for E3 Ligase (1) 5-HT Receptor (1) Apoptosis (2) Aryl Hydrocarbon Receptor (1) CDK (1) Cholinesterase (ChE) (1) Dopamine Receptor (13) Endogenous Metabolite (8) iGluR (1) Isotope-Labeled Compounds (7) LXR (1) mAChR (1) nAChR (1) PROTACs (1) Reference Standards (2) ROR (1) VD/VDR (11)
By Research Areas:	Cancer (3) Endocrinology (1) Inflammation/Immunology (2) Metabolic Disease (10) Neurological Disease (14)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Ligands for Target Protein for PROTAC Ligands for E3 Ligase Target Protein Ligand-Linker Conjugates E3 Ligase Ligand-Linker Conjugates

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-115953

*Dopamine D3 receptor ligand-1*	Dopamine Receptor	Neurological Disease
Dopamine D₃ receptor ligand is a potent, selective and high affinity ligand for Dopamine D₃ receptor with 89-fold selective for D₃ over D₂ (D₃ K_i= 8 nM, D₂ K_i= 715 nM) .

HY-115955

*Dopamine D3 receptor ligand-3*	Dopamine Receptor	Neurological Disease
Dopamine D3 receptor ligand-3 (compound 12C) is a potent D3 receptor ligand with a Ki of 3.6 nM. Dopamine D3 receptor ligand-3 have high selectivity for D3 over D2 (Ki=353 nM).

HY-115954

*Dopamine D3 receptor ligand-2*	Dopamine Receptor	Neurological Disease
Dopamine D3 receptor ligand-2 (compound 8) is a potent D₃ receptor ligand with a K_i of 11.4 nM. Dopamine D3 receptor ligand-2 have high selectivity for D₃ over D₂ (K_i=1228 nM) .

HY-174307

*Dopamine D3 receptor ligand-6*	Dopamine Receptor	Neurological Disease
Dopamine D3 receptor ligand-6 (Compound 196476) is a selective dopamine D3 receptor (D3) antagonist. Dopamine D3 receptor ligand-6 is promising for research of substance use disorders (such as opioid and psychostimulant addiction) .

HY-115968

*Dopamine D3 receptor ligand-4*	Dopamine Receptor	Neurological Disease
Dopamine D3 receptor ligand-4 (compound 6) is a potent and selective dopamine D₃ receptor ligand, with a K_i of 0.5 nM. Dopamine D3 receptor ligand-4 shows high level of selectivity for D₃ over D₂ (K_i=7.43 nM) .

HY-156239

*Dopamine D3 receptor ligand-5*	Dopamine Receptor 5-HT Receptor	Neurological Disease
Dopamine D3 receptor ligand-5 (13a), a Cariprazine (HY-14763) analogue, is a dopamine D3 receptor ligand, with K_i values of 2.85 nM and 0.14 nM for D₂R and D₃R, respectively .

HY-154825

20-Hydroxyvitamin D3 20(OH)D3; 20S-Hydroxyvitamin D3	VD/VDR LXR ROR Aryl Hydrocarbon Receptor	Metabolic Disease Inflammation/Immunology
20-Hydroxyvitamin D3 (20(OH)D3) is a hydroxy metabolite of vitamin D₃. 20-Hydroxyvitamin D3 functions as a ligand for vitamin D receptor (VDR), aryl hydrocarbon receptor (AhR), liver X receptor (LXR), and retinoic acid-related orphan receptor (ROR). 20-Hydroxyvitamin D3 inhibits cell proliferation, induces differentiation. 20-Hydroxyvitamin D3 can be used for inflammatory and autoimmune diseases study .

HY-139680

Dopamine D3 receptor antagonist-1	Dopamine Receptor	Neurological Disease
Dopamine D3 receptor antagonist-1 is a dopamine D₃ receptor-selective or multitarget bitopic ligand (K_i = 1.58 nM) potentially useful for central nervous system disorders.

HY-139681

Dopamine D3 receptor antagonist-2	Dopamine Receptor	Neurological Disease
Dopamine D3 receptor antagonist-2 is a dopamine D3 receptor-selective (K_i = 2.16 nM) or multitarget bitopic ligand potentially useful for central nervous system disorders.

HY-109743

BP14979	Dopamine Receptor	Neurological Disease
BP14979 is a dopamine D3 receptor agonist with activity in the study of neurological diseases. BP14979 can be used to develop ligands with higher selectivity and affinity for D3 receptors. The structural characteristics of BP14979 make it potential in modulating the efficacy of D3 receptors. The design of BP14979 is based on the difference in efficacy with D3R selective antagonists, providing opportunities for optimizing new drug development .

HY-13332

Calcifediol-d6 25-hydroxy Vitamin D3-d₆	VD/VDR	Metabolic Disease
Calcifediol-d₆ is the deuterium labeled Calcifediol. Calcifediol, a major circulating metabolite of vitamin D3, is a potent VDR ligand .

HY-15329

Maxacalcitol-d6	VD/VDR	Metabolic Disease
Maxacalcitol-d₆6 is the deuterated form of Maxacalcitol (22-Oxacalcitriol), which is a non-calcemic vitamin D3 analog and VDR ligand of VDR-like receptors.

HY-17360S

Tiotropium-d3 bromide BA679 BR-d₃	Isotope-Labeled Compounds mAChR	Neurological Disease
Tiotropium-d₃ (bromide) is the deuterium labeled Tiotropium (Bromide). Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.

HY-170126S

9-Amino-1,2,3,4-tetrahydroacridin-1-ol-d3 Maleate	Isotope-Labeled Compounds Ligands for E3 Ligase	Cancer
9-Amino-1,2,3,4-tetrahydroacridin-1-ol-d₃ Maleate is the deuterium labeled CRBN ligand-74 (HY-170126). CRBN ligand-74 is a CRBN-type E3 ubiquitin ligase ligand that can be used to prepare PROTAC.

HY-15238A

ST-836 hydrochloride	Dopamine Receptor	Neurological Disease
ST-836 hydrochloride (compound 34) is a potent dopamine receptor ligand with K_i values of 4.5 nM, 132 nM for D3 and D2, respectively. ST-836 hydrochloride has the potential for Parkinson’s disease .

HY-100539

PD 128907	Dopamine Receptor	Others
PD 128907 is a D3 receptor ligand with activities of activating dopamine receptors, inhibiting cell firing, and inhibiting dopamine release. The active (+) enantiomer of PD 128907 has high affinity and selectivity for rat D3 dopamine receptors. PD 128907 inhibits cell firing in the ventral tegmental area and substantia nigra pars compacta with EC₅₀ values of 33nM and 38nM, respectively. PD 128907 also inhibits dopamine release in the caudate putamen with an EC₅₀ of 66nM. However, the selective D2 receptor antagonist L-741,626 has high affinity for receptors activated by PD 128907, indicating that the effects of PD 128907 are more likely on D2 autoreceptors rather than D3 dopamine receptor subtypes.

HY-32351

Calcifediol Maximum Cited Publications 10 Publications Verification 25-Hydroxy Vitamin D3	VD/VDR Endogenous Metabolite	Metabolic Disease
Calcifediol (25-hydroxy Vitamin D3) is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-32351A

Calcifediol monohydrate Maximum Cited Publications 10 Publications Verification 25-hydroxy Vitamin D3 monohydrate	VD/VDR Endogenous Metabolite	Metabolic Disease
Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-32351S

Calcifediol-d3 25-Hydroxy Vitamin D3-d₃	Isotope-Labeled Compounds VD/VDR Endogenous Metabolite	Metabolic Disease
Calcifediol-d₃ is a deuterium labeled Calcifediol. Calcifediol, is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-N0368S

Linalool-d3	Apoptosis iGluR Endogenous Metabolite	Cancer
Linalool-d₃ is the deuterium labeled Linalool . Linalool is natural monoterpene in essential olis of coriander, acts as a competitive antagonist of Nmethyl d-aspartate (NMDA) receptor, with anti-tumor, anti-cardiotoxicity activity .Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome .

HY-32351AS

Calcifediol-d6 monohydrate 25-hydroxy Vitamin D3-d₆ monohydrate	Isotope-Labeled Compounds VD/VDR Endogenous Metabolite	Metabolic Disease
Calcifediol-d₆ monohydrate is the deuterium labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-32351AS1

Calcifediol-13C5 monohydrate 25-Hydroxy Vitamin D3-¹³C₅ monohydrate	Isotope-Labeled Compounds VD/VDR Endogenous Metabolite	Metabolic Disease
Calcifediol- ¹³C₅ monohydrate is the ¹³C-labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-32351R

Calcifediol (Standard) 25-hydroxy Vitamin D3 (Standard)	Reference Standards VD/VDR Endogenous Metabolite	Metabolic Disease
Calcifediol (Standard) is the analytical standard of Calcifediol. This product is intended for research and analytical applications. Calcifediol (25-hydroxy Vitamin D3) is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-32351AR

Calcifediol monohydrate (Standard) 25-hydroxy Vitamin D3 monohydrate (Standard)	Reference Standards VD/VDR Endogenous Metabolite	Metabolic Disease
Calcifediol monohydrate (Standard) is the analytical standard of Calcifediol (monohydrate). This product is intended for research and analytical applications. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-168660

CPD-10 1 Publications Verification	PROTACs Apoptosis CDK	Cancer
CPD-10 is a potent CCND1 and CDK4 PROTAC degrader. CPD-10 shows anti-proliferation. CPD-10 induces apoptosis. CPD-10 decreases the protein expression of cyclin D1, cyclin D3, CDK4, P-Rb(5807/811) in a dose-dependent manner. (Pink: ligand for target protein (HY-50767); black: linker (HY-22391); Blue: E3 ligase ligand (HY-168667)) .

HY-A0009S

Galanthamine-d3 hydrobromide Galantamine-d₃ hydrobromide	Isotope-Labeled Compounds Cholinesterase (ChE) nAChR	Neurological Disease
Galanthamine-d₃ (hydrobromide) is deuterium labeled Galanthamine (hydrobromide). Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC₅₀ of 0.35 μM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α3β4, α4β2, α6β4 nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD) .

HY-N10634S

D-Glucosyl-β-N-palmitoylsphingosine-d3 N-ω-CD₃-Hexadecaoyl-glucopsychosie; GluCe(d18:1/16:0-d₃); Glucosylceamide-d₃ (d18:1/16:0-D3)	Isotope-Labeled Compounds Others	Inflammation/Immunology
D-Glucosyl-β-N-palmitoylsphingosine-d₃ (N-ω-CD₃-Hexadecaoyl-glucopsychosie) is deuterium labeled D-Glucosyl-β-1,1′-N-palmitoylsphingosine (HY-N10634). D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) is an endogenous Mincle ligand possessing immunostimulatory activity .

HY-11056

PF-04363467	Dopamine Receptor	Neurological Disease
PF-04363467 is a highly preferring D3R antagonist. PF-04363467 produces dose-dependent changes in the EEG profile of freely moving rats. PF-4363467 attenuates opioid drug-seeking behavior without concomitant D2 side effects. PF-04363467 can be used for the study of addiction, cognitive and mental illness .

HY-149337

*D3R ligand* 1**	Dopamine Receptor	Neurological Disease
D3R ligand 1 (compound 23b) is a potent and selective ligand of dopamine receptor *D3R* (Ki=66 nM), containing a THPB template. D3R ligand 1 is also an antagonist for both G-protein- and β-arrestin-based signaling .

HY-12397

ZK159222 1 Publications Verification	VD/VDR	Endocrinology
ZK159222, a 25-carboxylic ester analogue of 1α,25-(OH)2D3, is a potent 1α,25-(OH)2D3 receptor (VDR) antagonist. The mechanism of ZK159222 antagonistic action is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators. ZK159222 has a partial agonistic character .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-32351

Calcifediol 5+ Cited Publications 25-Hydroxy Vitamin D3	Structural Classification Natural Products Other disease Classification of Application Fields Source classification Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields	VD/VDR Endogenous Metabolite
Calcifediol (25-hydroxy Vitamin D3) is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-32351A

Calcifediol monohydrate 5+ Cited Publications 25-hydroxy Vitamin D3 monohydrate	Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	VD/VDR Endogenous Metabolite
Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-32351R

Calcifediol (Standard) 25-hydroxy Vitamin D3 (Standard)	Natural Products Microorganisms Other disease Source classification Disease markers Endogenous metabolite	Reference Standards VD/VDR Endogenous Metabolite
Calcifediol (Standard) is the analytical standard of Calcifediol. This product is intended for research and analytical applications. Calcifediol (25-hydroxy Vitamin D3) is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-32351AR

Calcifediol monohydrate (Standard) 25-hydroxy Vitamin D3 monohydrate (Standard)	Natural Products Source classification Endogenous metabolite	Reference Standards VD/VDR Endogenous Metabolite
Calcifediol monohydrate (Standard) is the analytical standard of Calcifediol (monohydrate). This product is intended for research and analytical applications. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

Cat. No.	Product Name	Chemical Structure

HY-13332

Calcifediol-d6
Calcifediol-d₆ is the deuterium labeled Calcifediol. Calcifediol, a major circulating metabolite of vitamin D3, is a potent VDR ligand .

HY-15329

Maxacalcitol-d6
Maxacalcitol-d₆6 is the deuterated form of Maxacalcitol (22-Oxacalcitriol), which is a non-calcemic vitamin D3 analog and VDR ligand of VDR-like receptors.

HY-32351S

Calcifediol-d3
Calcifediol-d₃ is a deuterium labeled Calcifediol. Calcifediol, is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-N0368S

Linalool-d3
Linalool-d₃ is the deuterium labeled Linalool . Linalool is natural monoterpene in essential olis of coriander, acts as a competitive antagonist of Nmethyl d-aspartate (NMDA) receptor, with anti-tumor, anti-cardiotoxicity activity .Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome .

HY-32351AS

Calcifediol-d6 monohydrate
Calcifediol-d₆ monohydrate is the deuterium labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-17360S

Tiotropium-d3 bromide
Tiotropium-d₃ (bromide) is the deuterium labeled Tiotropium (Bromide). Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.

HY-170126S

9-Amino-1,2,3,4-tetrahydroacridin-1-ol-d3 Maleate
9-Amino-1,2,3,4-tetrahydroacridin-1-ol-d₃ Maleate is the deuterium labeled CRBN ligand-74 (HY-170126). CRBN ligand-74 is a CRBN-type E3 ubiquitin ligase ligand that can be used to prepare PROTAC.

HY-32351AS1

Calcifediol-13C5 monohydrate
Calcifediol- ¹³C₅ monohydrate is the ¹³C-labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-A0009S

Galanthamine-d3 hydrobromide
Galanthamine-d₃ (hydrobromide) is deuterium labeled Galanthamine (hydrobromide). Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC₅₀ of 0.35 μM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α3β4, α4β2, α6β4 nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD) .

Galanthamine-d3 hydrobromide

Galanthamine-d₃ (hydrobromide) is deuterium labeled Galanthamine (hydrobromide). Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC₅₀ of 0.35 μM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α3β4, α4β2, α6β4 nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD) .

HY-N10634S

D-Glucosyl-β-N-palmitoylsphingosine-d3
D-Glucosyl-β-N-palmitoylsphingosine-d₃ (N-ω-CD₃-Hexadecaoyl-glucopsychosie) is deuterium labeled D-Glucosyl-β-1,1′-N-palmitoylsphingosine (HY-N10634). D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) is an endogenous Mincle ligand possessing immunostimulatory activity .

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D3 ligands

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products