Creatine Kinase

By Targets:	Creatine Kinase (1) Angiotensin-converting Enzyme (ACE) (1) ATP Synthase (2) Biochemical Assay Reagents (2) Endogenous Metabolite (9) Histone Demethylase (5) Isotope-Labeled Compounds (2) Mitochondrial Metabolism (5) Reference Standards (2)
By Research Areas:	Cancer (7) Cardiovascular Disease (3) Metabolic Disease (5) Neurological Disease (2)

Targets Recommended: Creatine Kinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2799A

Creatine Kinase (CPK/CK), Bovine Heart 1 Publications Verification CK, CPK, Creatine PhosphoKinase	Endogenous Metabolite Creatine Kinase	Others
Creatine Kinase (CPK/CK), Bovine Heart (CK, CPK, Creatine Phosphokinase) is a biological material or organic compound that can be used in life science research .

HY-P2799D

Creatine Kinase MB (rCK-MB), Recombinant Human 1 Publications Verification CK-MB	Biochemical Assay Reagents	Others
Creatine Kinase MB (rCK-MB), Recombinant Human (CK-MB) is a biological material or organic compound that can be used in life science research .

HY-W017540

Cyclocreatine 1 Publications Verification	ATP Synthase	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Cyclocreatine, a creatine analogue, acts as a brain-penetrant and potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine can be phosphorylated and dephosphorylated by creatine kinases. Cyclocreatine suppresses creatine metabolism ameliorating the cognitive, autistic and epileptic phenotype in a mouse model of creatine transporter defciency. Cyclocreatine protects against ischemic injury and enhances cardiac recovery during early reperfusion in dogs and rats. Cyclocreatine decreases plaque-adjacent neuronal dystrophy in TREM2-deficient mice with amyloid-β pathology. Cyclocreatine is proming for research of ischemic heart disease, cardiovascular diseases, Alzheimer’s disease and other neurodegenerative diseases associated with microglial dysfunction, prostate cancer .

HY-113039

L-2-Hydroxyglutaric acid (S)-2-Hydroxyglutaric acid	Histone Demethylase Mitochondrial Metabolism Endogenous Metabolite	Cancer
L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation . L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with K_m and K_i of 2.52 mM and 11.13 mM, respectively .

HY-W015114

L-2-Hydroxyglutaric acid disodium (S)-2-Hydroxyglutaric acid disodium	Histone Demethylase Mitochondrial Metabolism Endogenous Metabolite	Cancer
L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation . L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with K_m and K_i of 2.52 mM and 11.13 mM, respectively .

HY-P2799B

Creatine Kinase (CK/CPK), Porcine Heart CPK, CK, Creatine PhosphoKinase	Biochemical Assay Reagents	Others
Creatine Kinase (CK/CPK), Porcine Heart (CPK, CK, Creatine Phosphokinase) is a biological material or organic compound that can be used in life science research .

HY-P2799C

Creatine Kinase BB (CK-BB) Isoenzyme, Porcine Brain CPK-1, CKBB isoenyzme, CK-BB	Endogenous Metabolite	Others
Creatine Kinase BB (CK-BB) Isoenzyme, Porcine Brain (CPK-1, CKBB isoenyzme, CK-BB) is a biological material or organic compound that can be used in life science research .

HY-D0885A

Sodium creatine phosphate dibasic tetrahydrate Creatine phosphate disodium tetrahydrate; Creatinephosphoric acid disodium tetrahydrate	Endogenous Metabolite	Metabolic Disease
Phosphocreatine disodium tetrahydrate, primarily found in the skeletal muscles of vertebrates and one of organic compounds known as alpha amino acids and derivatives, is a substrate for the determination of creatine kinase and used to regenerate ATP during skeletal muscle contraction .

HY-W017540S

Cyclocreatine-13C3	Isotope-Labeled Compounds ATP Synthase	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Cyclocreatine- ¹³C₃ is the ¹³C-labeled Cyclocreatine (HY-W017540). Cyclocreatine, a creatine analogue, acts as a brain-penetrant and potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine can be phosphorylated and dephosphorylated by creatine kinases. Cyclocreatine suppresses creatine metabolism ameliorating the cognitive, autistic and epileptic phenotype in a mouse model of creatine transporter defciency. Cyclocreatine protects against ischemic injury and enhances cardiac recovery during early reperfusion in dogs and rats. Cyclocreatine decreases plaque-adjacent neuronal dystrophy in TREM2-deficient mice with amyloid-β pathology. Cyclocreatine is proming for research of ischemic heart disease, cardiovascular diseases, Alzheimer’s disease and other neurodegenerative diseases associated with microglial dysfunction, prostate cancer .

HY-125863A

Glucose-6-phosphate dehydrogenase (Leuconostoc sp., recombinant) G6PD (Leuconostoc sp., recombinant)	Endogenous Metabolite	Metabolic Disease
Glucose-6-phosphate dehydrogenase (Leuconostoc sp., recombinant) is an NADP-dependent enzyme in the pentose phosphate pathway, which is one of the ways glucose is metabolized. Glucose-6-phosphate dehydrogenase (Leuconostoc sp., recombinant) can be used to quantify ATP, glucose, and creatine kinase .

HY-113039R

L-2-Hydroxyglutaric acid (Standard) (S)-2-Hydroxyglutaric acid (Standard)	Reference Standards Histone Demethylase Mitochondrial Metabolism Endogenous Metabolite	Cancer
L-2-Hydroxyglutaric acid (Standard) is the analytical standard of L-2-Hydroxyglutaric acid. This product is intended for research and analytical applications. L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation . L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with K_m and K_i of 2.52 mM and 11.13 mM, respectively .

HY-W015114R

L-2-Hydroxyglutaric acid disodium (Standard) (S)-2-Hydroxyglutaric acid disodium (Standard)	Reference Standards Histone Demethylase Mitochondrial Metabolism Endogenous Metabolite	Cancer
L-2-Hydroxyglutaric acid (disodium) (Standard) is the analytical standard of L-2-Hydroxyglutaric acid (disodium). This product is intended for research and analytical applications. L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation . L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with K_m and K_i of 2.52 mM and 11.13 mM, respectively .

HY-A0113

Cilazaprilat Ro 31-3113	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Cilazaprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC₅₀=0.7 nM for the rat enzyme) and an active metabolite of Cilazapril (HY-A0043). It decreases creatine kinase release in primary neonatal rat cardiac myocytes in an in vitro model of ischemia-reperfusion injury induced by hypoxia and reoxygenation when used at a concentration of 10 μM.3 Intra-arterial administration of cilazaprilat (3 μg/kg per minute) increases coronary blood flow and fractional shortening in a dog model of coronary hypoperfusion-induced myocardial ischemia.

HY-W744986

L-2-Hydroxyglutaric acid-d5 disodium (2S)-2-Hydroxyglutaric acid-d₅ disodium	Isotope-Labeled Compounds Histone Demethylase Mitochondrial Metabolism Endogenous Metabolite	Cancer
L-2-Hydroxyglutaric acid-d₅ disodium ((2S)-2-Hydroxyglutaric acid-d₅ disodium) is the deuterium labeled L-2-Hydroxyglutaric acid disodium (HY-W015114). L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation . L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively .

Cat. No.	Product Name	Target	Research Area

HY-P4698

Tri-valine NSC 35938	Peptides	Metabolic Disease
Tri-valine (NSC 35938) is a polypeptide that can be separated from Creatine kinase (HY-P2799), β-enolase, Triosephosphate isomerase (HY-P2931) and glyceraldehyde 3-phosphate dehydrogenase .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113039

L-2-Hydroxyglutaric acid (S)-2-Hydroxyglutaric acid	Structural Classification Microorganisms Classification of Application Fields Anti-aging Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Histone Demethylase Mitochondrial Metabolism Endogenous Metabolite
L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation . L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with K_m and K_i of 2.52 mM and 11.13 mM, respectively .

HY-W015114

L-2-Hydroxyglutaric acid disodium (S)-2-Hydroxyglutaric acid disodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Histone Demethylase Mitochondrial Metabolism Endogenous Metabolite
L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation . L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with K_m and K_i of 2.52 mM and 11.13 mM, respectively .

HY-W015114R

L-2-Hydroxyglutaric acid disodium (Standard) (S)-2-Hydroxyglutaric acid disodium (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Histone Demethylase Mitochondrial Metabolism Endogenous Metabolite
L-2-Hydroxyglutaric acid (disodium) (Standard) is the analytical standard of L-2-Hydroxyglutaric acid (disodium). This product is intended for research and analytical applications. L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation . L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with K_m and K_i of 2.52 mM and 11.13 mM, respectively .

HY-D0885A

Sodium creatine phosphate dibasic tetrahydrate Creatine phosphate disodium tetrahydrate; Creatinephosphoric acid disodium tetrahydrate	Structural Classification Classification of Application Fields Source classification Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Phosphocreatine disodium tetrahydrate, primarily found in the skeletal muscles of vertebrates and one of organic compounds known as alpha amino acids and derivatives, is a substrate for the determination of creatine kinase and used to regenerate ATP during skeletal muscle contraction .

HY-113039R

L-2-Hydroxyglutaric acid (Standard) (S)-2-Hydroxyglutaric acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite	Reference Standards Histone Demethylase Mitochondrial Metabolism Endogenous Metabolite
L-2-Hydroxyglutaric acid (Standard) is the analytical standard of L-2-Hydroxyglutaric acid. This product is intended for research and analytical applications. L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation . L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with K_m and K_i of 2.52 mM and 11.13 mM, respectively .

Species:	Human (4) Mouse (1) Rat (2)
Tag:	His (6)
Source:	HEK293 (1) Sf9 insect cells (1) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P700577

	Creatine kinase M-type/CKM Protein, Mouse (His) rHuCreatine Kinase M-type/CKMM, His; Creatine Kinase M-type; Creatine Kinase M chain; M-CK; CKM; CKMM	Mouse	E. coli
	CKM is a creatine kinase M-type protein that centrally catalyzes reversible phosphate transfer between ATP and various phosphogens, especially creatine phosphate. As a creatine kinase isoenzyme, CKM plays a crucial role in energy transduction, particularly in tissues with large and fluctuating energy demands, such as skeletal muscle, heart, brain, and sperm. Creatine kinase M-type/CKM Protein, Mouse (His) is the recombinant mouse-derived Creatine kinase M-type/CKM protein, expressed by E. coli , with N-6*His labeled tag.

HY-P7827

	Creatine kinase M-type/CKM Protein, Human (HEK293, His) rHuCreatine Kinase M-type/CKMM, His; Creatine Kinase M-type; Creatine Kinase M chain; M-CK; CKM; CKMM	Human	HEK293
	KCRM is a cytoplasmic creatine kinase isoenzyme responsible for participating in energy transduction and maintaining energy homeostasis. KCRM reversibly catalyzes phosphate transfer between ATP and various phosphogens (e.g., creatine phosphate) and is an important serum marker of myocardial infarction. Creatine kinase M-type/CKM Protein, Human (HEK293, His) is the recombinant human-derived Creatine kinase M-type/CKM protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P7897

	Creatine kinase B-type/CKB Protein, Human (His) rHuCreatine Kinase B-type/CKB , His; B-CK; CKB; Creatine Kinase BB	Human	E. coli
	Creatine kinaseB-type/CKB Protein, Human (His) is the most abundant creatine kinase isoenzyme in purified brown adipocytes. CKB reversibly catalyzes the transfer of phosphate between ATP and various phosphogens.

HY-P75340

	Creatine kinase M-type/CKM Protein, Human (His) CKM; CKMM; CKMMCreatine Kinase M-type; M-CK	Human	E. coli
	Creatine kinase M-type/CKM Protein, Human (His) is the recombinant human-derived Creatine kinase M-type/CKM protein, expressed by E. coli, with N-His labeled tag.

HY-P76827

	CKMT2 Protein, Rat (His) Creatine Kinase; Basic-type mitochondrial Creatine Kinase; Mib-CK; S-MtCK	Rat	E. coli
	CKMT2 Protein is a member of the ATP:guanido phosphotransferase family. CKMT2 Protein, Rat (His) is the recombinant rat-derived CKMT2 protein, expressed by E. coli , with N-His labeled tag.

HY-P76827A

	CKMT2 Protein, Rat (His, Solution) Creatine Kinase; Basic-type mitochondrial Creatine Kinase; Mib-CK; S-MtCK	Rat	E. coli
	The CKMT2 protein is predicted to have ubiquitin protein transferase activity and participate in the regulation of the epidermal growth factor receptor signaling pathway. It is involved in autoubiquitination and ubiquitin-dependent protein catabolic processes through the multivesicular body sorting pathway. CKMT2 Protein, Rat (His, Solution) is the recombinant rat-derived CKMT2 protein, expressed by E. coli , with N-His labeled tag.

HY-P76264

	CKMT1A Protein, Human (sf9, His) Creatine Kinase U-type, mitochondrial; Mia-CK; U-MtCK; CKMT; CKMT1B	Human	Sf9 insect cells
	CKMT1A is a creatine kinase isoenzyme that plays a key role in the reversible transfer of phosphate between ATP and creatine phosphate. The function of this enzyme is critical for tissues with dynamic energy needs, such as skeletal muscle, heart, brain, and sperm. CKMT1A Protein, Human (sf9, His) is the recombinant human-derived CKMT1A protein, expressed by Sf9 insect cells , with N-His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-W017540S

Cyclocreatine-13C3
Cyclocreatine- ¹³C₃ is the ¹³C-labeled Cyclocreatine (HY-W017540). Cyclocreatine, a creatine analogue, acts as a brain-penetrant and potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine can be phosphorylated and dephosphorylated by creatine kinases. Cyclocreatine suppresses creatine metabolism ameliorating the cognitive, autistic and epileptic phenotype in a mouse model of creatine transporter defciency. Cyclocreatine protects against ischemic injury and enhances cardiac recovery during early reperfusion in dogs and rats. Cyclocreatine decreases plaque-adjacent neuronal dystrophy in TREM2-deficient mice with amyloid-β pathology. Cyclocreatine is proming for research of ischemic heart disease, cardiovascular diseases, Alzheimer’s disease and other neurodegenerative diseases associated with microglial dysfunction, prostate cancer .

Cyclocreatine-13C3

Cyclocreatine- ¹³C₃ is the ¹³C-labeled Cyclocreatine (HY-W017540). Cyclocreatine, a creatine analogue, acts as a brain-penetrant and potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine can be phosphorylated and dephosphorylated by creatine kinases. Cyclocreatine suppresses creatine metabolism ameliorating the cognitive, autistic and epileptic phenotype in a mouse model of creatine transporter defciency. Cyclocreatine protects against ischemic injury and enhances cardiac recovery during early reperfusion in dogs and rats. Cyclocreatine decreases plaque-adjacent neuronal dystrophy in TREM2-deficient mice with amyloid-β pathology. Cyclocreatine is proming for research of ischemic heart disease, cardiovascular diseases, Alzheimer’s disease and other neurodegenerative diseases associated with microglial dysfunction, prostate cancer .

HY-W744986

L-2-Hydroxyglutaric acid-d5 disodium
L-2-Hydroxyglutaric acid-d₅ disodium ((2S)-2-Hydroxyglutaric acid-d₅ disodium) is the deuterium labeled L-2-Hydroxyglutaric acid disodium (HY-W015114). L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation . L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively .

L-2-Hydroxyglutaric acid-d5 disodium

L-2-Hydroxyglutaric acid-d₅ disodium ((2S)-2-Hydroxyglutaric acid-d₅ disodium) is the deuterium labeled L-2-Hydroxyglutaric acid disodium (HY-W015114). L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation . L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P85625

	Creatine Kinase MM Antibody (YA5317) CKM; CKMM; Creatine Kinase M; Creatine Kinase M chain; Creatine Kinase M type; Creatine Kinase M-type; Creatine Kinase muscle; Creatine Kinase, muscle type; KCRM_HUMAN; M-CK; MCK; Muscle Creatine Kinase.	ELISA	Human
	Creatine Kinase MM Antibody (YA5317) is a mouse-derived and non-conjugated monoclonal antibody, targeting to CK-MM. It can be applicated for ELISA assays, in the background of human.

HY-P81316

	Creatine Kinase MM Antibody (YA1061) CKM; CKMM; Creatine Kinase M-type; Creatine Kinase M chain; M-CK	ELISA	Human
	Creatine Kinase MM Antibody (YA1061) is a mouse-derived non-conjugated IgG2b antibody (Clone NO.: YA1061), targeting CKM. Creatine Kinase MM Antibody (YA1061) can be used for ELISA experiment in human background.

HY-P80629

	Creatine Kinase B type Antibody (YA492) BCK; Ckb; CKBB; HEL 211; HEL S 29	WB, IHC-P, IP	Human, Mouse, Rat
	Creatine Kinase B type Antibody (YA492) is a non-conjugated and Rabbit origined monoclonal antibody about 43 kDa, targeting to Creatine Kinase B type. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P85548

	CKMT1 Antibody (YA5240) Acidic type mitochondrial Creatine Kinase; CKMT; CKMT1; CKMT1A; CKMT1B; Creatine Kinase mitochondrial 1 ubiquitous; Creatine Kinase U type, mitochondrial; Creatine Kinase ubiquitous mitochondrial; Creatine Kinase, mitochondrial 1; ubiquitous; Creatine Kinase, mitochondrial 1A; Creatine Kinase, mitochondrial 1B; Mia CK; U MtCK; Ubiquitous mitochondrial Creatine Kinase; UMTCK.	WB	Human, Mouse
	CKMT1 Antibody (YA5240) is a mouse-derived and non-conjugated monoclonal antibody, targeting to CKMT1. It can be applicated for WB assays, in the background of human, mouse.

HY-P85468

	CKMT2 Antibody (YA5160) CKMT2; Creatine Kinase S-type; mitochondrial; Basic-type mitochondrial Creatine Kinase; Mib-CK; Sarcomeric mitochondrial Creatine Kinase; S-MtCK	WB	Human, Mouse, Rat, Dog, Pig, Rabbit
	CKMT2 Antibody (YA5160) is a mouse-derived and non-conjugated monoclonal antibody, targeting to sMtCK. It can be applicated for WB assays, in the background of human, mouse, rat, dog, pig, rabbit.

HY-P85560

	CKMT2 Antibody (YA5252) CKMT 2; Basic-type mitochondrial Creatine Kinase; CKMT 2; CKMT2; CPK; Creatine Kinase mitochondrial 2; Creatine Kinase mitochondrial 2; sarcomeric; Creatine Kinase S-type; Creatine Kinase S-type, mitochondrial; KCRS_HUMAN; Mib CK; Mib-CK; mitochondrial; OTTHUMP00000147542; S-MtCK; Sarcomeric mitochondrial Creatine Kinase; SMTCK.	WB	Rat
	CKMT2 Antibody (YA5252) is a mouse-derived and non-conjugated monoclonal antibody, targeting to sMtCK. It can be applicated for WB assays, in the background of rat.

HY-P85480

	CKMT1 Antibody (YA5172) CKMT1A; CKMT; CKMT1B; CKMT; Creatine Kinase U-type; mitochondrial; Acidic-type mitochondrial Creatine Kinase; Mia-CK; Ubiquitous mitochondrial Creatine Kinase; U-MtCK	WB	Human, Mouse, Rat, Dog, Pig, Rabbit
	CKMT1 Antibody (YA5172) is a mouse-derived and non-conjugated monoclonal antibody, targeting to uMtCK. It can be applicated for WB assays, in the background of human, mouse, rat, dog, pig, rabbit.

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