Search Result

Results for "

Caspase 3/7

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Caspase (31) Adrenergic Receptor (2) Akt (4) Aldehyde Dehydrogenase (ALDH) (1) Apoptosis (29) Aurora Kinase (1) Autophagy (1) Bacterial (1) Bcl-2 Family (7) Cannabinoid Receptor (2) CDK (2) Cholinesterase (ChE) (1) Dopamine β-hydroxylase (2) Drug Derivative (2) DYRK (1) EGFR (1) Endogenous Metabolite (1) ERK (1) FAK (1) Fluorescent Dye (1) Fungal (2) HDAC (3) IAP (1) IKK (1) Integrin (1) Interleukin Related (1) IRE1 (1) JNK (1) MDM-2/p53 (4) MEK (1) Microtubule/Tubulin (1) MMP (1) mTOR (4) Necroptosis (1) NF-κB (3) p38 MAPK (1) Parasite (1) PARP (5) PI3K (4) Pim (2) PKC (1) PROTACs (2) Reactive Oxygen Species (ROS) (2) Reference Standards (1) TGF-beta/Smad (2) Wnt (1)
By Research Areas:	Cancer (33) Cardiovascular Disease (2) Endocrinology (2) Infection (2) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (7)

By Targets:

Caspase (31)

Adrenergic Receptor (2)

Akt (4)

Aldehyde Dehydrogenase (ALDH) (1)

Apoptosis (29)

Aurora Kinase (1)

Autophagy (1)

Bacterial (1)

Bcl-2 Family (7)

Cannabinoid Receptor (2)

CDK (2)

Cholinesterase (ChE) (1)

Dopamine β-hydroxylase (2)

Drug Derivative (2)

DYRK (1)

EGFR (1)

Endogenous Metabolite (1)

ERK (1)

FAK (1)

Fluorescent Dye (1)

Fungal (2)

HDAC (3)

IAP (1)

IKK (1)

Integrin (1)

Interleukin Related (1)

IRE1 (1)

JNK (1)

MDM-2/p53 (4)

MEK (1)

Microtubule/Tubulin (1)

MMP (1)

mTOR (4)

Necroptosis (1)

NF-κB (3)

p38 MAPK (1)

Parasite (1)

PARP (5)

PI3K (4)

Pim (2)

PKC (1)

PROTACs (2)

Reactive Oxygen Species (ROS) (2)

Reference Standards (1)

TGF-beta/Smad (2)

Wnt (1)

By Research Areas:

Cancer (33)

Cardiovascular Disease (2)

Endocrinology (2)

Infection (2)

Inflammation/Immunology (3)

Metabolic Disease (2)

Neurological Disease (7)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

Targets Recommended: Caspase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W033813

Caspase-3/7 Inhibitor I	Caspase Apoptosis	Cancer
Caspase-3/7 inhibitor I is a potent and reversible inhibitor of *caspase-3* and *caspase-7, with K_is of 60 and 170 nM, respectively. Caspase-3/7* inhibitor I can inhibit apoptosis in Camptothecin (HY-16560)-treated Jurkat cells and in chondrocytes .**

HY-P1006

Ac-DEVD-pNA 1 Publications Verification	Caspase	Others
Ac-DEVD-pNA is a ligand for *caspase-3/-7* and related cysteine proteases .

HY-152756

Caspase-3/7 activator 2	Apoptosis Caspase	Cancer
Caspase-3/7 activator 2 is an effective activator of *Caspase-3/7. Caspase-3/7* activator 2 has tumor selectivity, anti-proliferative activity and high Apoptosis-inducing ability .

HY-152748

Caspase-3/7 activator 1	Apoptosis Caspase	Cancer
Caspase-3/7 activator 1 is an effective activator of *Caspase-3/7. Caspase-3/7* activator 1 has tumor selectivity, anti-proliferative activity and high Apoptosis-inducing ability .

HY-152758

Caspase-3/7 activator 3	Apoptosis Caspase	Cancer
Caspase-3/7 activator 3 is an effective activator of *Caspase-3/7. Caspase-3/7* activator 3 has tumor selectivity, anti-proliferative activity and high Apoptosis-inducing ability .

HY-W338079

Ac-Asp-Glu-Val-Asp-pNA	Caspase	Others
Ac-Asp-Glu-Val-Asp-pNA is a peptidic substrate of caspase-3/7 .

HY-161042

Neuroprotective agent 2	Others	Neurological Disease
Neuroprotective agent 2 (Compd 28) is a potent neuroprotective agent which has a protective effect in both salsolinol and glutamate-induced neurodegeneration models. Neuroprotective agent 2 reduces oxidative stress and *caspase-3/7* activity in the glutamate model .

HY-136733

Ac-DNLD-CHO Ac-Asp-Asn-Leu-Asp-CHO	Caspase	Infection Neurological Disease
Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is a *Caspase-3/7* inhibitor (IC₅₀: 9.89, 245 nM respectively; K_i ^app: 0.68, 55.7 nM respectively). Ac-DNLD-CHO can be used for research of caspase-mediated apoptosis diseases, such as neurodegenerative disorders and viral infection diseases .

HY-W689801

A-1208746	Bcl-2 Family Apoptosis	Cancer
A-1208746 is an inhibitor for MCL-1, with a K_i of 0.454 nM. A-1208746 activates *caspase-3/-7, induces apoptosis* in cell H929, and decreases mitochondrial membrane potential. A-1208746 synergies with Navitoclax (HY-10087), and can be used in cancer research .

HY-P4403

Z-DEVD-R110 (Z-Asp-Glu-Val-Asp)₂-Rhodamine 110	Fluorescent Dye Apoptosis Caspase	Others
Z-DEVD-R110 ((Z-Asp-Glu-Val-Asp)₂-Rhodamine 110) is a fluorogenic caspase-3/7 substrate. Z-DEVD-R110 can be used to detect apoptosis. Z-DEVD-R110 is a rhodamine derivative with two four–amino acid (DEVD) peptides linked to the fuorophore .

HY-169172

Bfl-1-IN-5	Bcl-2 Family Caspase	Cancer
Bfl-1-IN-5 (Compound (R,R,S)-26) is a selective inhibitor for Bfl-1 with an IC₅₀ of 0.022 μM. Bfl-1-IN-5 promotes the *caspase-3/7* activity with an EC₅₀ of 0.37 μM, and inhibits the cell viability of SU-DHL-1 with an EC₅₀ of 1.3 μM .

HY-N3126

Orsellinic acid	Drug Derivative Fungal Apoptosis Caspase PARP	Neurological Disease Cancer
Orsellinic acid is a Benzoic acid (HY-N0216) derivative. Orsellinic acid can be isolated from Chaetomium globosum endophytic on Ephedra fasciculata (Mormon tea). Orsellinic acid blocks PAF-mediated Apoptosis, inhibits *caspase-3/7* activation, and PARP cleavage. Orsellinic acid can be used in research of neurons and various tumors (non-small cell lung cancer, breast cancer, neuroblastoma, pancreatic cancer) .

HY-N3126R

Orsellinic acid (Standard)	Reference Standards Drug Derivative Fungal Apoptosis Caspase PARP	Neurological Disease Cancer
Orsellinic acid (Standard) is an analytical standard of Orsellinic acid (HY-N3126). This product is intended for research and analytical applications. Orsellinic acid is a Benzoic acid (HY-N0216) derivative. Orsellinic acid can be isolated from Chaetomium globosum endophytic on Ephedra fasciculata (Mormon tea). Orsellinic acid blocks PAF-mediated Apoptosis, inhibits *caspase-3/7* activation, and PARP cleavage. Orsellinic acid can be used in research of neurons and various tumors (non-small cell lung cancer, breast cancer, neuroblastoma, pancreatic cancer) .

HY-19696B

Tauroursodeoxycholate dihydrate Maximum Cited Publications 87 Publications Verification Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate	Caspase Apoptosis Endogenous Metabolite IRE1 NF-κB JNK Reactive Oxygen Species (ROS) Akt	Neurological Disease Metabolic Disease Inflammation/Immunology
Tauroursodeoxycholate dehydrate is an orally active taurine conjugate of Ursodeoxycholic acid (HY-13771). Tauroursodeoxycholate dehydrate inhibits *caspase-3/7, Apoptosis, IRE1α/TRAF2/NF-κB, prevents JNK* phosphorylation, inhibits ROS generation, and activates Akt signaling. Tauroursodeoxycholate dehydrate prevents cataract formation, reduces renal tubular damage in type 2 diabetic mice, reduces I/R injury in liver, and inhibits intestinal inflammation and barrier disruption in nonalcoholic fatty liver disease .

HY-136509

CIL62	Necroptosis	Cancer
CIL62 is a caspase-3/7-independent cell death inducer. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death .

HY-P10992

YVPGP	PI3K Akt mTOR Caspase Apoptosis Bcl-2 Family	Cancer
YVPGP is an oligopeptide exacted from Anthopleura anjunae. YVPGP has a significant antitumor activity by mediating PI3K/AKT/mTOR signaling pathway. YVPGP arrests DU-145 cells in the S phase and induces apoptosis via mitochondrial and death receptor pathways (caspase3, 7, 8, 9). YVPGP effectively inhibits tumor growth in DU-145 xenografts mice model, promising for prostate cancer research .

HY-178943

Neuroprotective agent 15	Cholinesterase (ChE) Cannabinoid Receptor Aldehyde Dehydrogenase (ALDH) Caspase Apoptosis	Neurological Disease
Neuroprotective agent 15 (Compound 3e) is a neuroprotective agent. Neuroprotective agent 15 is a selective butyrylcholinesterase (BChE) inhibitor, with IC₅₀ values of 2.6 and 114.3 μM for BChE and AChE respectively. Neuroprotective agent 15 has cannabinoid CB2 receptor (CB2 receptor) agonistic activity. Neuroprotective agent 15 can reduce cell death, LDH release and *Caspase-3/7* activity, and inhibit apoptosis. Neuroprotective agent 15 can reduce the formation of superoxide free radicals, maintain cell morphology, and significantly lower oxidative stress levels. Neuroprotective agent 15 can be used in the research of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease .

HY-178008

Mcl-1-IN-16	Bcl-2 Family Caspase Apoptosis	Cancer
Mcl-1-IN-16 is an effective macrocyclic myeloid cell leukemia 1 (Mcl-1) inhibitor with a K_i of below 0.08 nM. Mcl-1-IN-16 maintains high selectivity (>50,000-fold) for Mcl-1 over other antiapoptotic Bcl-2 family members Bcl-2 and Bcl-xL. Mcl-1-IN-16 leads to the activation of *caspase-3/7, thereby initiating cell apoptosis*. Mcl-1-IN-16 achieves tumor regression in a lung cancer-derived tumor xenograft mice model. Mcl-1-IN-16 can be used in the research of solid tumor such as nonsmall cell lung cancer (NSCLC) .

HY-123929

PAWI-2	MDM-2/p53 Wnt IKK Apoptosis Caspase	Cancer
PAWI-2 is a p53-Activator and Wnt Inhibitor. PAWI-2 inhibits β3-KRAS signaling independent of KRAS. PAWI-2 selectively inhibits phosphorylation of TBK1. PAWI-2 activates apoptosis (activation of caspase-3/7), and induces PARP cleavage. PAWI-2 promotes optineurin translocation into the nucleus and causes G2/M arrest. PAWI-2 reverses cancer stemness and overcomes drug resistance in an integrin β3 KRAS-dependent human pancreatic cancer stem cells (hPCSCs). PAWI-2 inhibits growth of tumors from hPCSCs in orthopic xenograft mice model .

HY-178861

dCDK9-202	PROTACs CDK Caspase PARP Apoptosis	Cancer
dCDK9-202 a potent CDK9 PROTAC degrader with an DC₅₀ value of 3.5 nM. dCDK9-202 exhibits broad-spectrum anti-tumor activity and extensively disrupts the oncogenic transcriptome. dCDK9-202 can activate *Caspase-3/7, increase the level of cleaved PARP, and directly induce apoptosis* of tumor cells. dCDK9-202 effectively inhibits TC-71 tumor growth without any signs of toxicity in mice. dCDK9-202 can be used for the study of EGFR-driven cancers such as sarcoma (Pink: CDK9 ligand (HY-178862); Blue: CRBN ligand (HY-W248665); Black: Linker (HY-N8015)) .

HY-123605

CAY10406	Caspase	Others
CAY10406 is an inhibitor for *caspase 3/7*. CAY10406 inhibits the expression of 28-kDa IL-1β fragment, without significant cytotoxicity (10 μM) .

HY-128483

Fusaric acid	TGF-beta/Smad PI3K NF-κB Akt Apoptosis Dopamine β-hydroxylase mTOR Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Fusaric acid is an orally active multi-pathway inhibitor with the activity of inducing oxidative stress and apoptosis. Fusaric acid can chelate divalent metal cations, damage mitochondrial membrane structure, and activate apoptosis-related proteases such as Caspase-3/7, -8, and -9. Fusaric acid also regulates Bax/Bcl-2 protein, inhibits fibrosis-related signaling pathways such as NF-κB, TGF-β₁/SMADs, and PI3K/AKT/mTOR, and reduces collagen deposition. Fusaric acid is also a dopamine β-hydroxylase inhibitor, which reduces endogenous levels of norepinephrine and epinephrine in the brain, heart, spleen, and adrenal glands. Fusaric acid can play a role in myocardial fibrosis and improve cardiac hypertrophy in heart disease, and can also be used in the study of esophageal cancer and liver cancer .

HY-117889

PARP14 inhibitor H10	PARP Apoptosis	Cancer
PARP14 inhibitor H10, compound H 10, is a selective inhibitor against PARP14 (IC₅₀=490 nM), over other PARPs (≈24 fold over PARP1). PARP14 inhibitor H10 induces caspase-3/7-mediated cell apoptosis .

HY-137225

HTS07944 HTS07944SC	Caspase Interleukin Related	Inflammation/Immunology Cancer
HTS07944 (HTS07944SC, C3) is a potent modulator of laminin receptor (37 LR). HTS07944 (HTS07944SC, C3) possesses anti-cancer activity in PC-3 cells and activates Caspase 3/7 .

HY-128483R

Fusaric acid (Standard)	TGF-beta/Smad PI3K NF-κB Akt Apoptosis Dopamine β-hydroxylase mTOR Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Fusaric acid (Standard) is the analytical standard of Fusaric acid (HY-128483). This product is intended for research and analytical applications. Fusaric acid is an orally active multi-pathway inhibitor with the activity of inducing oxidative stress and apoptosis. Fusaric acid can chelate divalent metal cations, damage mitochondrial membrane structure, and activate apoptosis-related proteases such as Caspase-3/7, -8, and -9. Fusaric acid also regulates Bax/Bcl-2 protein, inhibits fibrosis-related signaling pathways such as NF-κB, TGF-β₁/SMADs, and PI3K/AKT/mTOR, and reduces collagen deposition. Fusaric acid is also a dopamine β-hydroxylase inhibitor, which reduces endogenous levels of norepinephrine and epinephrine in the brain, heart, spleen, and adrenal glands. Fusaric acid can play a role in myocardial fibrosis and improve cardiac hypertrophy in heart disease, and can also be used in the study of esophageal cancer and liver cancer .

HY-P2569

Malformin A1	Apoptosis	Cancer
Malformin A1, a cyclic pentapeptide isolated from Aspergillus niger, possess a range of bioactive properties including antibacterial activity. Malformin A1 shows potent cytotoxic activities on human colorectal cancer cells. Malformin A1 induces apoptosis by activating PARP, caspase 3, -7, and -9 .

HY-169922

HDAC-IN-82	HDAC Parasite Caspase	Cancer
HDAC-IN-82 (Compound 18b) is a histone deacetylase (HDAC) inhibitor with selective antiplasmodial and anticancer activity. HDAC-IN-82 shows potent antiproliferative activity and caspase 3/7 activation in cancer cells. HDAC-IN-82 causes hyperacetylation of histone H3 and α-tubulin .

HY-P991235

FS102 BMS-986186	EGFR Caspase	Cancer
FS102 is a selective Fc fragment with antigen binding (Fcab) that targets HER2 with a K_D value of 0.8 nM. FS102 induces the degradation of HER2, activates Caspase 3/7 and disrupts the integrity of the cell membrane, triggering apoptosis of tumor cells. FS102 is promising for research of cancers such as breast cancer, gastric cancer, and colorectal cancer .

HY-162059

Pim-1 kinase inhibitor 10	Pim Apoptosis Caspase	Cancer
Pim-1 kinase inhibitor 10 (compound 13a) is a both competitive and non-competitive inhibitor of PIM-1/2 kinase. Pim-1 kinase inhibitor 10 can induce cell apoptosis and exhibits anticancer activity. Pim-1 kinase inhibitor 10 also induces *caspase 3/7* activation .

HY-161814

Apoptosis inducer 20	Apoptosis	Metabolic Disease
Apoptosis inducer 20 (12) causes G2/M cell cycle arrest and induction of apoptosis via caspase 3/7 activation, which occurred during M arrest. Apoptosis inducer 20 is a novel indolic benzenesulfonamide with anti-proliferative effect against a broad panel of cancer cell lines, which is proming for research of new anti-mitotic agents .

HY-151966

TD1092	PROTACs IAP Caspase	Cancer
TD1092 is a pan-IAP degrader, degrades cIAP1, cIAP2, and XIAP. TD1092 activates *Caspase* 3/7, and promotes cancer cells apoptosis via IAP degradation. TD1092 inhibits TNFα mediated NF-κB pathway and reduces the phosphorylation of IKK, IkBα, p65, and p38. TD1092 can act as PROTAC, and is used for cancer research .

HY-13265

AR-42 3 Publications Verification HDAC-42; OSU-HDAC42	HDAC Autophagy Apoptosis	Cancer
AR-42 (HDAC-42; OSU-HDAC42) is a potent, orally bioavailable pan-HDAC inhibitor (IC₅₀=16 nM). AR-42 induces growth inhibition, cell-cycle arrest, apoptosis, and activation of caspases-3/7. AR-42 promotes hyperacetylation of H3, H4, and alpha-tubulin, and up-regulation of p21. AR-42 shows cytotoxicity against various human cancer cell lines .

HY-107150

Reproxalap ADX-102; NS-2	PKC Caspase	Neurological Disease Inflammation/Immunology
Reproxalap (ADX-102) is an active aldehyde sequestering agent. Reproxalap reduces the PKCα activity. Reproxalap blocks *caspase 3/7* activation. Reproxalap protects cells from the cytotoxicity of C18:0-al. Reproxalap has anti-inflammatory and pain-relieving effects. Reproxalap is used in studies of dry eye, allergic conjunctivitis, and non-infectious anterior uveitis .

HY-103645

GW779439X	Bacterial Aurora Kinase Apoptosis	Infection Cancer
GW779439X is a pyrazolopyridazine identified in an inhibitor of the S. aureus PASTA kinase Stk1. GW779439X potentiates the activity of β-lactam antibiotics against various MRSA and MSSA isolates, some even crossing the breakpoint from resistant to sensitive. GW779439X is an AURKA inhibitor and induces apoptosis by the caspases 3/7 pathway . MRSA:methicillin-resistant S. aureus; MSSA: methicillin-sensitive S. aureus

HY-169923

HDAC-IN-83	HDAC	Cancer
HDAC-IN-83 (compound 9D) is an inhibitor of deacetylases (HDACs) (IC₅₀=0.01 μM/0.44 μM HDAC1/HDAC6) with anticancer, antiproliferative and *caspase 3/7* activation activities. HDAC-IN-83 inhibits Cal27, HepG2 and MRC-5 with IC_{50_{s of 0.693 μM, 0.427 μM and 3.19 μM, respectively .}}

HY-146444

Anticancer agent 56	Apoptosis Bcl-2 Family Caspase Reactive Oxygen Species (ROS)	Cancer
Anticancer agent 56 (compound 4d) is a potent anti-cancer agent with agent-likeness properties, possessing anticancer activity against several cancer cell lines (IC₅₀<3 μM). Anticancer agent 56 induces cell cycle arrest at G2/M phase and triggers mitochondrial apoptosis pathway. Anticancer agent 56 acts by accumulation of ROS, up regulation of BAX, down regulation of Bcl-2 and activation of caspases 3, 7, 9 .

HY-159938

p38α inhibitor 6	p38 MAPK Apoptosis Bcl-2 Family MDM-2/p53 Caspase	Cancer
p38α inhibitor 6 (compound 19) is a p38α inhibitor with the IC₅₀ of 0.68 μM. p38α inhibitor 6 induces cell apoptosis and arrests cell cycle at G0 and G2/M phase. p38α inhibitor 6 decreases the TNF-α concentration as well as increased the expression of tumor suppressor gene p53, Bax/BCL-2 ratio and *caspase 3/7* .

HY-174855

PI3K/mTOR-IN-17	PI3K mTOR Apoptosis Bcl-2 Family MDM-2/p53 Caspase	Cancer
PI3K/mTOR-IN-17 is a dual PI3K and mTOR inhibitor with IC₅₀ values of 1.21 μM (PI3K), and 0.21 μM (mTOR). PI3K/mTOR-IN-17 induces cells caspase-mediated apoptosis by arresting their growth in the G1-phase. PI3K/mTOR-IN-17 upregulates the levels of caspases-3, 7, 8, and 9, p53 expression and Bax/Bcl-2 ratio. PI3K/mTOR-IN-17 suppresses the PI3K/mTOR signaling pathway. PI3K/mTOR-IN-17 can be used for research of cancer, such as non-small cell lung cancer (NSCLC) .

HY-112296

T025 3 Publications Verification	CDK Apoptosis DYRK	Cancer
T025 is an orally active and highly potent inhibitor of Cdc2-like kinase (CLKs), with K_d values of 4.8, 0.096, 6.5, 0.61, 0.074, 1.5 and 32 nM for CLK1, CLK2, CLK3, CLK4, DYRK1A, DYRK1B and DYRK2, respectively. T025 induces caspase-3/7-mediated cell apoptosis. T025 reduces CLK-dependent phosphorylation. T025 exerts anti-proliferative activities in both hematological and solid cancer cell lines (IC₅₀ values: 30-300 nM). T025 has an anti-tumor efficiency, mainly for MYC-driven disease research .

HY-168338

CB2 receptor agonist 8	Cannabinoid Receptor Caspase	Cancer
CB2 receptor agonist 8 (Compound 17) is an agonist for cannabinoid receptor 2 (CB2 receptor). CB2 receptor agonist 8 exhibits cytotoxicity in cells U87, RPMI 8226, HL-60, and L929 with IC₅₀s of 91.03, 16.29, 23.51 and 564.6 μM, respectively. CB2 receptor agonist 8 activates *caspase 3/7, increases the expressions of pro-apoptotic genes BAX, BAD, BIM and tumor suppressor genes p53, and induces apoptosis* in U87. CB2 receptor agonist 8 inhibits the migration of U87 .

HY-139702

α5β1 integrin agonist-1	Integrin Apoptosis Caspase	Cancer
α5β1 integrin agonist-1 is an α5β1 integrin agonist, with an EC₅₀ of 1.5 nM. α5β1 integrin agonist-1 inhabits α4β1 integrin (IC₅₀ = 2.99 μM) in Jurkat/VCAM-1 adhesion assayα5β1 integrin agonist-1 induces concentration-dependent apoptosis and activates the *caspase 3/7* pathway in α5β1 integrin-expressing K562 cancer cells. α5β1 integrin agonist-1 can be used for the study of cancer .

HY-178133

Pim-1 kinase-IN-14	Pim Apoptosis Caspase	Cancer
Pim-1 kinase-IN-14 is a PIM-1 kinase inhibitor with an IC₅₀ value of 94 nM. Pim-1 kinase-IN-14 shows broad-spectrum and high-efficiency anticancer activity against multiple human cancer cell lines, including liver cancer (HepG-2), colon cancer (Caco-2), myeloid leukemia (NFS-60), and prostate cancer (PC-3) cells. Pim-1 kinase-IN-14exerts its anticancer effects by inducing apoptosis and activating *caspase 3/7*. Pim-1 kinase-IN-14 can be used for the study of cancers associated with PIM-1 kinase overexpression .

HY-120339

STK899704	Microtubule/Tubulin FAK MEK ERK MMP Caspase PARP Apoptosis MDM-2/p53	Cancer
STK899704 is a tubulin inhibitor. STK899704 inhibits microtubule polymerization, leading to microtubule depolymerization. STK899704 exhibits broad-spectrum inhibitory activity against various cancer cell lines, including cervical cancer, breast cancer, and lung cancer, with IC₅₀ values ranging from 0.2 to 1.0 μM. STK899704 disrupts the mitotic spindle structure, inducing G2/M phase cell cycle arrest. STK899704 inhibits the migration ability of HT29 cells by downregulating the FAK-MEK-ERK signaling pathway, thereby suppressing the expression and activity of MMP-2 and MMP-9. STK899704 activates *caspase-3/7/8/9, leading to PARP cleavage* and inducing apoptosis. STK899704 induces cellular senescence through the p53 pathway. STK899704 exhibits significant anti-tumor effects in mouse skin cancer. STK899704 can be used in research on skin cancer, lung cancer, colon cancer, and other cancers .

Ac-Asp-Glu-Val-Asp-pNA	Fluorescent Dyes/Probes
Ac-Asp-Glu-Val-Asp-pNA is a peptidic substrate of caspase-3/7 .

Cat. No.	Product Name	Target	Research Area