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Results for "

CaSR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CaSR (44) Biochemical Assay Reagents (1) Calcium Channel (1) Isotope-Labeled Compounds (2) mGluR (1) Mixed Lineage Kinase (2) Reference Standards (3) RIP kinase (2) SARS-CoV (1) Small Interfering RNA (siRNA) (3) TGF-beta/Smad (2) Thyroid Hormone Receptor (1) TNF Receptor (1) Wnt (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (5) Endocrinology (11) Infection (1) Inflammation/Immunology (1) Metabolic Disease (24) Neurological Disease (9)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: CaSR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122819

Calindol hydrochloride	CaSR	Cardiovascular Disease
Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC₅₀ of 132 nM .

HY-117851

AC-265347	CaSR	Metabolic Disease Endocrinology
AC-265347 is a calcium-sensing receptor (CaSR) agonist and positive allosteric modulator (ago-PAM) with the functional affinity (pK_B) of 5.1. AC-265347 can be used for the research of hyperparathyroidism and related diseases .

HY-14401

Encaleret CLTX-305; JTT-305; MK-5442	CaSR Thyroid Hormone Receptor	Endocrinology
Encaleret (CLTX-305) is an orally active antagonist of the calcium-sensing receptor (CaSR), with an IC₅₀ of 0.012 μM. Encaleret can promote the secretion of parathyroid hormone. Encaleret can be used in the research of diseases such as osteoporosis and autosomal dominant hypocalcemia type 1 .

HY-12557

γ-Glutamylvaline γ-Glu-Val	CaSR Wnt TNF Receptor	Inflammation/Immunology
γ-Glutamylvaline (γ-Glu-Val) is an activator of *CaSR* with anti-inflammatory activity. γ-Glutamylvaline inhibits TNF-α-induced proinflammatory cytokine production and increases Wnt5a expression. γ-Glutamylvaline activates calcium-sensing receptor pathways in adipocytes of 3T3-L1 mice and prevents low-grade chronic inflammation .

HY-107773

GSK3004774	CaSR	Metabolic Disease
GSK3004774 is a potent, nonabsorbable agonist of *CaSR, with an pEC₅₀* of 7.3, 6.6 and 6.5 for human, mouse and rat CaSR, respectively. GSK3004774 shows an EC₅₀ of 50 nM for human CaSR .

HY-153258

CaSR antagonist-1	CaSR	Metabolic Disease
CaSR antagonist-1 is a calcium sensing receptor *(CaSR)* antagonist with an IC₅₀ value of 50 nM. CaSR antagonist-1 can be used for the research of disorders associated with abnormal bone or mineral homeostasis such as osteoporosis .

HY-RS01975

Casr Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Casr Mouse Pre-designed siRNA Set A contains three designed siRNAs for Casr gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Casr Mouse Pre-designed siRNA Set A Casr Mouse Pre-designed siRNA Set A

HY-RS01976

Casr Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Casr Rat Pre-designed siRNA Set A contains three designed siRNAs for Casr gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Casr Rat Pre-designed siRNA Set A Casr Rat Pre-designed siRNA Set A

HY-RS01974

CASR Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CASR Human Pre-designed siRNA Set A contains three designed siRNAs for CASR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CASR Human Pre-designed siRNA Set A CASR Human Pre-designed siRNA Set A

HY-177303

AXT-914	CaSR SARS-CoV	Infection Metabolic Disease Endocrinology
AXT-914 is a Calcium-sensing receptor (CaSR) inhibitor. AXT-914 has antiviral activity against the coronavirus HCoV 229E and SARS-CoV2. AXT914 reduces cytosolic calcium signalling activity of CaSR mutations. AXT-914 can be used for Bartter syndrome type 5 and autosomal dominant hypocalcemia (ADH) and coronavirus infections research .

HY-P4376

Gamma-Glu-Abu	CaSR	Neurological Disease
Gamma-Glu-Abu is an agonist for calcium sensing receptor (CaSR), that activates the *CaSR* with an EC₅₀ of 0.21 μM in HEK-293 cell .

HY-P4376A

Gamma-Glu-Abu TFA	CaSR	Neurological Disease
Gamma-Glu-Abu TFA is the TFA salt form of Gamma-Glu-Abu (HY-P4376). Gamma-Glu-Abu TFA is an agonist for calcium sensing receptor (CaSR), that activates the *CaSR* with an EC₅₀ of 0.21 μM in HEK-293 cell .

HY-11095

NPS 2390	mGluR CaSR	Cardiovascular Disease Neurological Disease
NPS 2390 is a noncompetitive antagonist of mGluR1 and mGluR5 . NPS 2390 is also a potent CaSR (calcium-sensing receptor) inhibitor .

HY-P11200

γ-Glu-Asn γ-Glutamylasparagine	Calcium Channel	Neurological Disease
γ-Glu-Asn (γ-Glutamylasparagine) is a calcium sensing receptor (CaSR) agonist. γ-Glu-Asn is a dipeptide composed of glutamic acid and asparagine .

HY-161113

Z8554052021	CaSR	Metabolic Disease
Z8554052021 (compound 2021) is a potent *CaSR* and indeed GPCR positive allosteric modulator (PAM) with an EC₅₀ of 3.3 nM. Z8554052021 has the potential for hyperparathyroidism research .

HY-121584

Lycoperodine-1 1 Publications Verification Cyclomethyltryptophan	CaSR	Metabolic Disease
Lycoperodine-1 (Cyclomethyltryptophan) is an active product that can be isolated from tomato fruits (Lycopersicon sculentum). Lycoperodine-1 act as an agonist of Ca ²⁺ sensing receptors (CaSR) .

HY-10167A

Tecalcet Hydrochloride 5+ Cited Publications R-568 hydrochloride; NPS R-568	CaSR	Others
Tecalcet Hydrochloride (R 568 Hydrochloride), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR). Tecalcet Hydrochloride (R 568 Hydrochloride) increases the sensitivity to activation by extracellular Ca ²⁺ .

HY-139201B

Poly-D-lysine hydrobromide (MW 84000) PDLHB (MW 84000)	CaSR	Neurological Disease Cancer
Poly-D-lysine hydrobromide (MW 84000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide is a *CaSR* agonist peptide .

HY-10167

Tecalcet R-568; NPS R-568 free base	CaSR	Others
Tecalcet (R 568), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR). Tecalcet (R 568) increases the sensitivity to activation by extracellular Ca ²⁺ .

HY-139201H

Poly-D-lysine hydrobromide (MW ≥300000) PDLHB (MW ≥300000)	CaSR	Others
Poly-D-lysine hydrobromide (PDLHB) (MW ≥300000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide is a CaSR agonist peptide .

HY-139201D

Poly-D-lysine hydrobromide (MW 4000-15000) PDLHB (MW 4000-15000)	CaSR	Others
Poly-D-lysine hydrobromide (PDLHB) (MW 4000-15000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide is a CaSR agonist peptide .

HY-17613

Evocalcet 3 Publications Verification KHK7580	CaSR	Metabolic Disease
Evocalcet (KHK7580) is an orally active calcium sensing receptor (CaSR) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism .

HY-139201E

Poly-D-lysine hydrobromide (MW 150000-300000) PDLHB (MW 150000-300000)	CaSR	Others
Poly-D-lysine hydrobromide (PDLHB) (MW 150000-300000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide is a CaSR agonist peptide .

HY-139201C

Poly-D-lysine hydrobromide (MW 1000-5000) PDLHB (MW 1000-5000)	CaSR	Others
Poly-D-lysine hydrobromide (PDLHB) (MW 1000-5000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide is a CaSR agonist peptide .

HY-139201A

Poly-D-lysine hydrobromide (MW 70000-150000) PDLHB (MW 70000-150000)	Biochemical Assay Reagents CaSR	Neurological Disease Cancer
Poly-D-lysine hydrobromide (MW 70000-150000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide is a *CaSR* agonist peptide .

HY-139201

Poly-D-lysine hydrobromide (MW 30000-70000) PDLHB (MW 30000-70000)	CaSR	Neurological Disease Metabolic Disease Cancer
Poly-D-lysine hydrobromide (MW 30000-70000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide is a *CaSR* agonist peptide .

HY-14752

Ronacaleret SB 751689	CaSR	Metabolic Disease Endocrinology
Ronacaleret (SB 751689) is an orally active, potent, and selective calcium-sensing receptor (CaSR) antagonist that stimulates endogenous parathyroid hormone release from the parathyroid glands. Ronacaleret (SB 751689) is used for the study of postmenopausal osteoporosis .

HY-15104

Ronacaleret hydrochloride SB 751689A	CaSR	Metabolic Disease Endocrinology
Ronacaleret hydrochloride (SB 751689A) is an orally active, potent, and selective calcium-sensing receptor (CaSR) antagonist that stimulates endogenous parathyroid hormone release from the parathyroid glands. Ronacaleret hydrochloride (SB 751689A) is used for the study of postmenopausal osteoporosis .

HY-W777503

Calindol hydrochloride-13C,D2	Isotope-Labeled Compounds CaSR	Cardiovascular Disease
Calindol hydrochloride- ¹³C,d₂ is the deuterium and ¹³C labeled Calindol hydrochloride (HY-122819). Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC₅₀ of 132 nM .

HY-W843885

H-Glu-Thr-OH L-α-Glutamyl-L-threonine	CaSR	Others
H-Glu-Thr-OH (L-α-Glutamyl-L-threonine) is a dipeptide made up of two amino acids—glutamic acid (Glu) and threonine (Thr)—connected by a peptide bond, and it acts as an agonist for the extracellular calcium-sensing receptor (CaSR) .

HY-17613R

Evocalcet (Standard) KHK7580 (Standard)	Reference Standards CaSR	Metabolic Disease
Evocalcet (Standard) is the analytical standard of Evocalcet. This product is intended for research and analytical applications. Evocalcet (KHK7580) is an orally active calcium sensing receptor (CaSR) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism .

HY-P1955

Etelcalcetide Velcalcetide; AMG 416; KAI-4169	CaSR	Metabolic Disease
Etelcalcetide (AMG 416; KAI-4169) is a synthetic calcimimetic as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis, which is promising for research in the field of secondary hyperparathyroidism and chronic kidney disease .

HY-P1955A

Etelcalcetide hydrochloride 2 Publications Verification Velcalcetide hydrochloride; AMG 416 hydrochloride; KAI-4169 hydrochloride	CaSR	Endocrinology
Etelcalcetide hydrochloride (AMG 416 hydrochloride; KAI-4169 hydrochloride) is a synthetic calcimimetic as an activator of the calcium sensing receptor (CaSR). Etelcalcetide hydrochloride is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis, which is promising for research in the field of secondary hyperparathyroidism and chronic kidney disease .

HY-121584R

Lycoperodine-1 (Standard)	CaSR	Metabolic Disease
Lycoperodine-1 (Standard) is the analytical standard of Lycoperodine-1. This product is intended for research and analytical applications. Lycoperodine-1 (Cyclomethyltryptophan) is an active product that can be isolated from tomato fruits (Lycopersicon sculentum). Lycoperodine-1 act as an agonist of Ca2+ sensing receptors (CaSR) .

HY-17613S

Evocalcet-d4 KHK7580-d₄	Isotope-Labeled Compounds CaSR	Metabolic Disease
Evocalcet-d₄ (KHK7580-d₄) is deuterium labeled Evocalcet. Evocalcet (KHK7580) is an orally active calcium sensing receptor (CaSR) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism .

HY-103320

Calhex 231	CaSR	Metabolic Disease
Calhex 231 is a potent negative allosteric modulator that blocks (IC₅₀ = 0.39 μM) increases in [ ³H]inositol phosphates elicited by activating the human wild-type *CaSR* transiently Ca ²⁺-sensing receptor. Calhex 231 can be used in the study of traumatic hemorrhagic shock (THS) and diabetic cardiomyopathy (DCM) .

HY-103320A

Calhex 231 hydrochloride 5+ Cited Publications	CaSR	Metabolic Disease
Calhex 231 hydrochloride is a potent negative allosteric modulator that blocks (IC₅₀ = 0.39 μM) increases in [ ³H]inositol phosphates elicited by activating the human wild-type *CaSR* transiently Ca ²⁺-sensing receptor. Calhex 231 hydrochloride can be used in the study of traumatic hemorrhagic shock (THS) and diabetic cardiomyopathy (DCM) .

HY-17397

Strontium Ranelate 2 Publications Verification Distrontium renelate; S12911	CaSR	Metabolic Disease
Strontium Ranelate (S12911) is an antiosteoporotic agent that acts by reducing bone resorption and promoting bone formation, thereby inducing a positive bone balance. Strontium Ranelate can also activate the calcium-sensing receptor (CaSR) in non skeletal cells, resulting in the activation of inositol 1, 4, 5-triphosphate production and mitogen-activated protein kinase signaling .

HY-171446

TAK-075	CaSR	Metabolic Disease
TAK-075 is an orally active *CaSR* antagonist with an IC₅₀ value of 0.94 nM. TAK-075 can stimulate the transient secretion of parathyroid hormone (PTH) in rats and can effectively prevent a significant reduction in PTH secretion caused by the accumulation of active metabolites, maintaining the normal secretion pattern of PTH. TAK-075 can be used in the research of metabolic diseases and osteoporosis .

HY-10171

NPS-2143 hydrochloride Maximum Cited Publications 25 Publications Verification SB-262470A hydrochloride	CaSR	Metabolic Disease
NPS-2143 hydrochloride (SB-262470A hydrochloride), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 hydrochloride (SB-262470A hydrochloride) blocks increases in cytoplasmic Ca ²⁺ concentrations (IC₅₀=43 nM) elicited by activating the Ca ²⁺ receptor in HEK 293 cells expressing the human Ca ²⁺ receptor .

HY-10007

NPS-2143 Maximum Cited Publications 25 Publications Verification SB-262470A	CaSR	Metabolic Disease
NPS-2143 (SB-262470A), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 (SB-262470A) blocks increases in cytoplasmic Ca ²⁺ concentrations (IC₅₀=43 nM) elicited by activating the Ca ²⁺ receptor in HEK 293 cells expressing the human Ca ²⁺ receptor .

HY-103320B

(1R,2R)-Calhex 231 hydrochloride	CaSR	Metabolic Disease
(1R,2R)-Calhex 231 hydrochloride is the isomer of Calhex 231 hydrochloride (HY-103320A), and can be used as an experimental control. Calhex 231 hydrochloride is a *CaSR* inhibitor via negative allosteric modulation. Calhex 231 hydrochloride blocks Ca ²⁺-induced accumulation of [ ³H]inositol phosphate with an IC₅₀ of 0.39 μM in HEK293 cells. Calhex 231 hydrochloride has the potential for diabetic cardiomyopathy (DCM) treatment .

HY-17397R

Strontium Ranelate (Standard) Distrontium renelate (Standard); S12911 (Standard)	Reference Standards CaSR	Metabolic Disease
Strontium Ranelate (Standard) is the analytical standard of Strontium Ranelate. This product is intended for research and analytical applications. Strontium Ranelate (S12911) is an antiosteoporotic agent that acts by reducing bone resorption and promoting bone formation, thereby inducing a positive bone balance. Strontium Ranelate can also activate the calcium-sensing receptor (CaSR) in non skeletal cells, resulting in the activation of inositol 1, 4, 5-triphosphate production and mitogen-activated protein kinase signaling .

HY-N0546

Ligustroflavone 1 Publications Verification Nuezhenoside	CaSR RIP kinase Mixed Lineage Kinase TGF-beta/Smad	Cardiovascular Disease Neurological Disease Metabolic Disease Endocrinology
Ligustroflavone is an orally active flavonoid compound. Ligustroflavone can be extracted from Ligustrum lucidum. Ligustroflavone antagonizes the calcium-sensing receptor (CaSR), inhibits the RIPK1/RIPK3/MLKL pathway, and downregulates TGF-β/Smad signaling. Ligustroflavone regulates calcium metabolism, protects bone tissue, reduces cerebral ischemic injury, and inhibits liver fibrosis. Ligustroflavone can be used in the study of diabetic osteoporosis, ischemic stroke, and liver fibrosis .

HY-109106A

Upacicalcet sodium SK-1403; AJT240; PLS240	CaSR	Endocrinology
Upacicalcet sodium is a non-peptide calcimimetic that acts as a *CaSR* agonist (EC₅₀ = 10.8 nM). Upacicalcet sodium reduces serum intact parathyroid hormone (iPTH) and serum Ca ²⁺ levels, reducing hypocalcemia and gastrointestinal complications. Upacicalcet sodium sodium improves vascular calcification and bone disorders in the Adenine (HY-B0152)-induced secondary hyperparathyroidism (SHPT) rat model. Upacicalcet sodium sodium inhibits cortical pore formation and reduces bone fibrosis in rats with chronic kidney disease (CKD). Upacicalcet sodium is useful for studying SHPT .

HY-109106

Upacicalcet SK-1403 free acid; AJT240 free acid; PLS240 free acid	CaSR	Endocrinology
Upacicalcet is a non-peptide calcimimetic that acts as a *CaSR* agonist (EC₅₀ = 10.8 nM). Upacicalcet reduces serum intact parathyroid hormone (iPTH) and serum Ca2+ levels, reducing hypocalcemia and gastrointestinal complications. Upacicalcet improves vascular calcification and bone disorders in the Adenine (HY-B0152)-induced secondary hyperparathyroidism (SHPT) rat model. Upacicalcet inhibits cortical pore formation and reduces bone fibrosis in rats with chronic kidney disease (CKD). Upacicalcet is useful for studying SHPT .

HY-109106B

(Rac)-Upacicalcet (Rac)-SK-1403 free acid; (Rac)-AJT240 free acid; (Rac)-PLS240 free acid	CaSR	Endocrinology
(Rac)-Upacicalcet is the racemate of Upacicalcet (HY-109106). Upacicalcet is a non-peptide calcimimetic that acts as a *CaSR* agonist (EC₅₀ = 10.8 nM). Upacicalcet reduces serum intact parathyroid hormone (iPTH) and serum Ca2+ levels, reducing hypocalcemia and gastrointestinal complications. Upacicalcet improves vascular calcification and bone disorders in the Adenine (HY-B0152)-induced secondary hyperparathyroidism (SHPT) rat model. Upacicalcet inhibits cortical pore formation and reduces bone fibrosis in rats with chronic kidney disease (CKD). Upacicalcet is useful for studying SHPT .

HY-N0546R

Ligustroflavone (Standard) Nuezhenoside (Standard)	Reference Standards CaSR RIP kinase Mixed Lineage Kinase TGF-beta/Smad	Cardiovascular Disease Neurological Disease Metabolic Disease Endocrinology
Ligustroflavone (Standard) is the analytical standard of Ligustroflavone (HY-N0546). This product is intended for research and analytical applications. Ligustroflavone is an orally active flavonoid compound. Ligustroflavone can be extracted from Ligustrum lucidum. Ligustroflavone antagonizes the calcium-sensing receptor (CaSR), inhibits the RIPK1/RIPK3/MLKL pathway, and downregulates TGF-β/Smad signaling. Ligustroflavone regulates calcium metabolism, protects bone tissue, reduces cerebral ischemic injury, and inhibits liver fibrosis. Ligustroflavone can be used in the study of diabetic osteoporosis, ischemic stroke, and liver fibrosis .

Cat. No.	Product Name	Type