CLEC5A

By Targets:	Akt (2) Apoptosis (2) ERK (2) HIV (2) Integrin (2) PI3K (2) PKC (2) PPAR (2) Reference Standards (1) Sirtuin (2) Small Interfering RNA (siRNA) (3) STAT (2) Toll-like Receptor (TLR) (2)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2110

Phellopterin	Akt Sirtuin Integrin STAT PI3K Apoptosis ERK PPAR PKC Toll-like Receptor (TLR) HIV	Inflammation/Immunology
Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the *PU.1/CLEC5A/PI3K-AKT* loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus ^[5] .

HY-RS02798

CLEC5A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CLEC5A Human Pre-designed siRNA Set A contains three designed siRNAs for CLEC5A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CLEC5A Human Pre-designed siRNA Set A CLEC5A Human Pre-designed siRNA Set A

HY-RS18419

Clec5a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Clec5a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Clec5a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Clec5a Mouse Pre-designed siRNA Set A Clec5a Mouse Pre-designed siRNA Set A

HY-RS24900

Clec5a Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Clec5a Rat Pre-designed siRNA Set A contains three designed siRNAs for Clec5a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Clec5a Rat Pre-designed siRNA Set A Clec5a Rat Pre-designed siRNA Set A

HY-N2110R

Phellopterin (Standard)	Reference Standards Akt Sirtuin Integrin STAT PI3K Apoptosis ERK PPAR PKC Toll-like Receptor (TLR) HIV	Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Phellopterin (Standard) is the analytical standard of Phellopterin. Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the *PU.1/CLEC5A/PI3K-AKT* loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2110

Phellopterin	Classification of Application Fields Source classification Coumarins Phenylpropanoids Umbelliferae Helogyne apaloidea Nutt. Plants Inflammation/Immunology Disease Research Fields	Akt Sirtuin Integrin STAT PI3K Apoptosis ERK PPAR PKC Toll-like Receptor (TLR) HIV
Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the *PU.1/CLEC5A/PI3K-AKT* loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus ^[5] .

HY-N2110R

Phellopterin (Standard)	Source classification Coumarins Phenylpropanoids Umbelliferae Helogyne apaloidea Nutt. Plants	Reference Standards Akt Sirtuin Integrin STAT PI3K Apoptosis ERK PPAR PKC Toll-like Receptor (TLR) HIV
Phellopterin (Standard) is the analytical standard of Phellopterin. Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the *PU.1/CLEC5A/PI3K-AKT* loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus.

Species:	Human (2) Rhesus Macaque (2) Mouse (2) Rat (1)
Tag:	His (4) Strep (1) Avi (1) Fc (3)
Source:	HEK293 (7)

Cat. No.	Compare	Product Name	Species	Source

HY-P77632

	CLEC5A/MDL-1 Protein, Human (HEK293, Fc) MDL-1; CLECSF5; MDL1; CLEC5A; DAP12-associating lectin 1	Human	HEK293
	The CLEC5A/MDL-1 protein positively regulates osteoclastogenesis and regulates inflammatory responses. It acts as a critical macrophage receptor for dengue virus serotypes 1-4, triggering signaling through TYROBP phosphorylation. This interaction stimulates the release of pro-inflammatory cytokines without viral entry. CLEC5A/MDL-1 Protein, Human (HEK293, Fc) is the recombinant human-derived CLEC5A/MDL-1 protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P77906

	CLEC5A/MDL-1 Protein, Mouse (HEK293, Fc) MDL-1; CLECSF5; MDL1; CLEC5A; DAP12-associating lectin 1	Mouse	HEK293
	CLEC5A/MDL-1 Protein positively regulates osteoclastogenesis and acts as a cell surface receptor signaling via TYROBP. Its expression relies on the TYROBP interaction and it plays a role in regulating inflammatory responses. CLEC5A/TYROBP/HCST complex formation highlights its intricate involvement in immune and inflammatory processes. CLEC5A/MDL-1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CLEC5A/MDL-1 protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P76269

	CLEC5A/MDL-1 Protein, Rat (HEK293, His) C-type lectin domain family 5 member A; MDL-1; CLECSF5	Rat	HEK293
	The CLEC5A/MDL-1 protein positively regulates osteoclastogenesis and regulates inflammatory responses. It acts as a critical macrophage receptor for dengue virus serotypes 1-4, triggering signaling through TYROBP phosphorylation. This interaction stimulates the release of pro-inflammatory cytokines without viral entry. CLEC5A/MDL-1 Protein, Rat (HEK293, His) is the recombinant rat-derived CLEC5A/MDL-1 protein, expressed by HEK293 , with N-His labeled tag.

HY-P77337

	CLEC5A/MDL-1 Protein, Rhesus Macaque (HEK293, His) C-type lectin domain family 5 member A; MDL-1; CLECSF5	Rhesus Macaque	HEK293
	CLEC5A Protein is a cell surface receptor that signals via TYROBP, and functions as a positive regulator of osteoclastogenesis. CLEC5A Protein regulates inflammatory responses. CLEC5A/MDL-1 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived CLEC5A/MDL-1 protein, expressed by HEK293 , with N-His labeled tag.

HY-P704543

	CLEC5A/MDL-1 Protein, Human (HEK293, His) MDL-1; CLECSF5; MDL1; CLEC5A; DAP12-associating lectin 1	Human	HEK293
	The CLEC5A/MDL-1 protein positively regulates osteoclastogenesis and regulates inflammatory responses. It acts as a critical macrophage receptor for dengue virus serotypes 1-4, triggering signaling through TYROBP phosphorylation. This interaction stimulates the release of pro-inflammatory cytokines without viral entry. CLEC5A/MDL-1 Protein, Human (HEK293, His) is the recombinant human-derived CLEC5A/MDL-1 protein, expressed by HEK293, with N-His labeled tag.

HY-P703963

	CLEC5A/MDL-1 Protein, Mouse (Biotinylated, HEK293, His, Avi) MDL-1; CLECSF5; MDL1; CLEC5A; DAP12-associating lectin 1	Mouse	HEK293
	CLEC5A/MDL-1 Protein positively regulates osteoclastogenesis and acts as a cell surface receptor signaling via TYROBP. Its expression relies on the TYROBP interaction and it plays a role in regulating inflammatory responses. CLEC5A/TYROBP/HCST complex formation highlights its intricate involvement in immune and inflammatory processes. CLEC5A/MDL-1 Protein, Mouse (Biotinylated, HEK293, His, Avi) is the recombinant mouse-derived CLEC5A/MDL-1 protein, expressed by HEK293, with N-Avi and N-His labeled tag.

HY-P77338

	CLEC5A/MDL-1 Protein, Rhesus Macaque (HEK293, Fc) C-type lectin domain family 5 member A; MDL-1; CLECSF5	Rhesus Macaque	HEK293
	CLEC5A Protein is a cell surface receptor that signals via TYROBP, and functions as a positive regulator of osteoclastogenesis. CLEC5A Protein regulates inflammatory responses. CLEC5A/MDL-1 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived CLEC5A/MDL-1 protein, expressed by HEK293 , with N-mFc labeled tag.

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HY-P84835

	CLEC5A Antibody (YA4532) MDL1; MDL-1; CLECSF5	WB, FC, ELISA	Human
	CLEC5A Antibody (YA4532) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CLEC5A.

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Cat. No.	Product Name		Classification

HY-RS02798

CLEC5A Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CLEC5A Human Pre-designed siRNA Set A contains three designed siRNAs for CLEC5A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS18419

Clec5a Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Clec5a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Clec5a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24900

Clec5a Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Clec5a Rat Pre-designed siRNA Set A contains three designed siRNAs for Clec5a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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