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CHIKV Inhibitor

" in MedChemExpress (MCE) Product Catalog:

20

Inhibitors & Agonists

1

Peptides

2

Inhibitory Antibodies

3

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-161762
    RA-0002034

    RA-2034

    		 CHIKV Virus Protease Infection
    RA-0002034 is a Chikungunya virus (CHIKV) nsP2 protease inhibitor with an IC50 of 58 nM. RA-0002034 covalently modifies the catalytic cysteine in a site-specific manner .
    RA-0002034
  • HY-132174
    CHIKV-IN-2

    		Flavivirus Dengue Virus CHIKV Dihydroorotate Dehydrogenase Infection
    CHIKV-IN-2 is a potent inhibitor against Chikungunya virus (CHIKV), with excellent cellular antiviral activity (EC90=270 nM) and improved liver microsomal stability. CHIKV-IN-2 shows inhibitory activity against a cellular target Dihydroorotate Dehydrogenase (DHODH), which interacts with various viruses and regulate their replication via depleting intracellular pyrimidine pools .
    CHIKV-IN-2
  • HY-163088
    CHIKV-IN-4

    		CHIKV Flavivirus Infection
    CHIKV-IN-4 (compound 31b) is a potent and selective CHIKV inhibitor. CHIKV-IN-4 inhibits the Chikungunya virus with the EC50 value of 0.6 μM .
    CHIKV-IN-4
  • HY-175234
    CHIKV nsP2 protease-IN-2

    		Virus Protease Infection
    CHIKV nsP2 protease-IN-2 (Compound 2o) is a allosteric nonstructural protein 2 helicase (nsP2hel) inhibitor with IC50s of 0.5  μM and 0.9  μM for nsP2 ATPase and RNA unwindase, respectively. CHIKV nsP2 protease-IN-2 has broad-spectrum antialphaviral activity against chikungunya virus (CHIKV), Mayaro virus (MAYV), and Venezuelan equine encephalitis virus (VEEV) (EC50 of 120 nM for CHIKV-nLuc). CHIKV nsP2 protease-IN-2 can be used for alphaviruses infections research .
    CHIKV nsP2 protease-IN-2
  • HY-169429
    CHIKV-IN-5

    		Flavivirus Infection
    CHIKV-IN-5 (Compound 26) is a CHIKV inhibitor (EC90 = 0.45 μM). CHIKV-IN-5 inhibits CHIKV replication at a late stage in the virus life cycle by blocking structural protein translation. CHIKV-IN-5 has great in vitro mouse microsomal stability. CHIKV-IN-5 reduces footpad swelling and decreases virus dissemination to other tissues in mice infected with CHIKV .
    CHIKV-IN-5
  • HY-144334
    CHIKV-IN-3

    		CHIKV DNA/RNA Synthesis Infection
    CHIKV-IN-3 is a potent against two low-passage CHIKV inhibitor with EC50 values of 1.55 and 0.14 μM for CHIKV-122508 and CHIKV-6708, respectively. CHIKV-IN-3 acts on the host cells to interfere with the viral replication. CHIKV-IN-3 displays minimal cytotoxic liability (CC50>100 μM). Prophylactic effect .
    CHIKV-IN-3
  • HY-175279
    CHIKV nsP2 protease-IN-3

    		Virus Protease Infection
    CHIKV nsP2 protease-IN-3 (Compound 5) is an irreversible covalent inhibitor targeting the nonstructural protein 2 (nsP2) cysteine protease of chikungunya virus (CHIKV) (IC50=0.5 μM). CHIKV nsP2 protease-IN-3 inhibits viral RNA replication. CHIKV nsP2 protease-IN-3 is promising for research of alphaviruses .
    CHIKV nsP2 protease-IN-3
  • HY-169102
    CHIKV nsP2 protease-IN-1

    		CHIKV Virus Protease Infection
    CHIKV nsP2 protease-IN-1(compound J13) is an oral active non-structural protein 2 protease inhibitor with the EC50 of 0.39 μM aganist of CHIKV S27. CHIKV nsP2 protease-IN-1 can be used for study of Chikungunya virus .
    CHIKV nsP2 protease-IN-1
  • HY-168050
    SGC-NSP2PRO-1

    		CHIKV Virus Protease Infection
    SGC-NSP2PRO-1 is a potent irreversible covalent inhibitor of Chikungunya (CHIKV) nsP2 cysteine protease with an IC50 value of 60 nM. SGC-NSP2PRO-1 demonstrates potent antialphavirus activity, inhibiting CHIKV and VEEV replication with EC50 = 0.01 and 0.3 µM, respectively .
    SGC-NSP2PRO-1
  • HY-178334
    GAP-1173149

    		CHIKV Infection
    GAP-1173149 is a Chikungunya Virus polymerase inhibitor targeting the CHIKV nsP4 RNA-dependent RNA polymerase .
    GAP-1173149
  • HY-N0862
    Harringtonine
    10+ Cited Publications

    		 CHIKV Influenza Virus Infection Cancer
    Harringtonine is a natural Cephalotaxus alkaloid that inhibits protein synthesis. Harringtonine has anti-chikungunya virus (CHIKV) activities with an EC50 of 0.24 μM.
    Harringtonine
  • HY-161762A
    (E/Z)-RA-0002034

    (E/Z)-RA-2034

    		 Influenza Virus CHIKV Cancer
    (E/Z)-RA-0002034 is a Chikungunya virus (CHIKV) nsP2 protease inhibitor with IC50 of 58 nM. RA-0002034 covalently modifies the catalytic cysteine in a site-specific manner.
    (E/Z)-RA-0002034
  • HY-N2086
    Ethyl palmitate
    2 Publications Verification

    Ethyl hexadecanoate

    		 TNF Receptor Interleukin Related NF-κB Infection Inflammation/Immunology
    Ethyl palmitate (Ethyl hexadecanoate) is a CHIKV virus inhibitor with an EC50 value of 0.0068 μM. Ethyl palmitate can reduce levels of TNF-α, IL-6, and NF-κB in endotoxemic rats, showing anti-inflammatory activity .
    Ethyl palmitate
  • HY-B0641
    Felbinac

    4-Biphenylacetic acid

    		 COX Inflammation/Immunology
    Felbinac is a metabolite of fenbufen, an orally active nonsteroidal anti-inflammatory agent and a cyclooxygenase (COX) inhibitor with an IC50 of 865.68 nM for COX1 and 976 nM for COX2. Felbinac reduces the production of prostaglandins by inhibiting COX to relieve pain, reduce inflammation and reduce fever. Felbinac can inhibit CHIKV viral activity .
    Felbinac
  • HY-125033
    EIDD-1931
    Maximum Cited Publications
    32 Publications Verification

    β-D-N4-hydroxycytidine; NHC

    		 CHIKV SARS-CoV Enterovirus HCV Topoisomerase Infection
    EIDD-1931 (Beta-d-N4-hydroxycytidine; NHC) is a novel nucleoside analog and behaves as a potent anti-virus agent. EIDD-1931 effectively inhibits the replication activity of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV) .
    EIDD-1931
  • HY-135867D
    NHC-diphosphate
    1 Publications Verification

    		 CHIKV Endogenous Metabolite Enterovirus HCV Topoisomerase SARS-CoV Infection
    NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a diphosphate form . NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV) .
    NHC-diphosphate
  • HY-P990200
    Anti-Mouse Ly6C Antibody (Monts 1)

    		Transmembrane Glycoprotein CHIKV Infection Inflammation/Immunology Cancer
    Anti-Mouse Ly6C Antibody (Monts 1) is a rat-derived anti-mouse Ly6C IgG2a type antibody inhibitor. Anti-Mouse Ly6C Antibody (Monts 1) depletes monocytes, neutrophils, and some other granulocyte populations. Anti-Mouse Ly6C Antibody (Monts 1) can be used for the researches of cancer, immunology and infection, such as chikungunya (CHIKV) and aggressive tumor .
    Anti-Mouse Ly6C Antibody (Monts 1)
  • HY-116291
    4α-Phorbol 12,13-didecanoate

    4αPDD

    		 TRP Channel CHIKV Infection Inflammation/Immunology
    4α-Phorbol 12,13-didecanoate (4αPDD) is a transient receptor potential vanilloid 4 (TRPV4) agonist. 4α-Phorbol 12,13-didecanoate can promote Ca 2+ influx, induce ATP release and function as an osmoreceptor. 4α-Phorbol 12,13-didecanoate can inhibit water intake and increase maximal micturition pressure in rats. 4α-Phorbol 12,13-didecanoate can be used for the researches of inflammation and infection, such as chikungunya virus (CHIKV) .
    4α-Phorbol 12,13-didecanoate
  • HY-P990825
    Anti-Chikungunya virus E2 Antibody (CHK-265)

    		Flavivirus CHIKV Infection
    Anti-Chikungunya virus E2 Antibody (CHK-265) is mouse-derived IgG2c κ type antibody inhibitor, targeting to Chikungunya virus E2. Anti-Chikungunya virus E2 Antibody (CHK-265) reacts with a conserved epitope on the B domain of the E2 glycoprotein of chikungunya virus. Anti-Chikungunya virus E2 Antibody (CHK-265) can block viral entry and egress. Anti-Chikungunya virus E2 Antibody (CHK-265) can be used for the research of infection, such as Chikungunya virus (CHIKV), Mayaro (MAYV) and O’nyong’nyong virus (ONNV) .
    Anti-Chikungunya virus E2 Antibody (CHK-265)
  • HY-176268
    SGC-NSP2hel-1

    RA-0188293; RA-NSP2-1

    		 Virus Protease Flavivirus Infection
    SGC-NSP2hel-1 (RA-0188293), a chemical probe, is a potent, specific and orally active nsP2 inhibitor. SGC-NSP2hel-1 has broad spectrum activity against multiple alphaviruses of the nsP2 helicase with a CC50 > 250 μM. SGC-NSP2hel-1 (RA-0188293) shows selectivity index > 4000 against human RNA helicases. SGC-NSP2hel-1 reduces virus replication and limited virus-induced pathology by forming a stable complex with nsP2 and ATP in a preclinical small animal model of CHIKV disease.
    SGC-NSP2hel-1

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