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CDC-25B

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Bacterial (1) c-Myc (1) CDK (2) DNA/RNA Synthesis (1) Epigenetic Reader Domain (1) Histone Methyltransferase (1) MAPKAPK2 (MK2) (1) p38 MAPK (1) Parasite (1) Phosphatase (16) SHP1 (1) Small Interfering RNA (siRNA) (3) Wee1 (1)
By Research Areas:	Cancer (17) Infection (1) Inflammation/Immunology (1) Metabolic Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Natural
Products

Antibodies

Oligonucleotides

Targets Recommended: Cdc42-binding kinase p97 Ack1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-137175A

CDC25B-IN-2	Phosphatase	Cancer
CDC25B-IN-2 is a potent *cdc25B* inhibitor .

HY-126246

CDC25B-IN-1	Phosphatase	Cancer
CDC25B-IN-1 (compound 4a) is a potent inhibitor of *cell division cycle 25B (CDC25B) phosphatase, with a K_i* of 8.5 μM. CDC25B-IN-1 potently inhibits cell proliferation and colony formation, causes an increase of the G2/M phase .

HY-100034

NSC 663284 4 Publications Verification DA-3003-1	Phosphatase Histone Methyltransferase	Cancer
NSC 663284 (DA-3003-1) is a potent, cell-permeable, and irreversible Cdc25 dual specificity phosphatase inhibitor, has an IC₅₀ for Cdc25B2 of 0.21 μM. NSC 663284 exhibits mixed competitive kinetics against Cdc25A, Cdc25B(2), and Cdc25C with Ki values of 29, 95, and 89 nM, respectively . NSC 663284 inhibits NSD2 (IC₅₀ of 170 nM) through a direct interaction with the catalytic SET domain (K_d of 370 nM) .

HY-108543

NSC 95397 Maximum Cited Publications 7 Publications Verification	Phosphatase Apoptosis	Cancer
NSC 95397 is a potent, selective *Cdc25* dual specificity phosphatase inhibitor (K_i=32 nM (Cdc25A), 96 nM (Cdc25B), 40 nM (Cdc25C); IC₅₀=22.3 nM (human Cdc25A), 56.9 nM (human Cdc25C), 125 nM (Cdc25B)) . NSC 95397 inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) and suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway .

HY-W024644

Hydroxyethylthio Vitamine K3	Phosphatase	Cancer
Hydroxyethylthio Vitamin K3 is a Cdc25 phosphatase inhibitor, with IC₅₀ values of 4.56 μM and 23.63 μM for Cdc25A and Cdc25B, respectively. Hydroxyethylthio Vitamin K3 can be used in tumor research .

HY-151986

FOXM1-IN-1	DNA/RNA Synthesis	Cancer
FOXM1-IN-1 is a potent FOXM1 inhibitor with an IC₅₀ value of 2.65 µM. FOXM1-IN-1 shows antiproliferative activity. FOXM1-IN-1 decreases the the expression of FOXM1, PLK1, CDC25B protein .

HY-RS19767

Cdc25b Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cdc25b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cdc25b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cdc25b Mouse Pre-designed siRNA Set A Cdc25b Mouse Pre-designed siRNA Set A

HY-RS02292

CDC25B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CDC25B Human Pre-designed siRNA Set A contains three designed siRNAs for CDC25B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CDC25B Human Pre-designed siRNA Set A CDC25B Human Pre-designed siRNA Set A

HY-RS26264

Cdc25b Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cdc25b Rat Pre-designed siRNA Set A contains three designed siRNAs for Cdc25b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cdc25b Rat Pre-designed siRNA Set A Cdc25b Rat Pre-designed siRNA Set A

HY-135564B

(Rac)-RK-682	Phosphatase	Cancer
(Rac)-RK-682, a racemate of RK-682, is a protein tyrosine phosphatases (PTPases) inhibitor. (Rac)-RK-682 inhibits protein tyrosine phosphatase 1B (PTP-1B), low molecular weight protein tyrosine phosphatases (LMW-PTP), and cell division cycle 25B (CDC-25B) with IC₅₀s of 8.6 μM, 12.4 μM, and 0.7 μM, respectively .

HY-N12177

Cryptosporioptide A	Phosphatase SHP1	Metabolic Disease
Cryptosporioptide A (Compound 3) is a pigment protein tyrosine phosphatase inhibitor derived from the insect-parasitic fungus Cordyceps gracilioides. Cryptosporioptide A inhibits PTP1B, SHP2, CDC25B, LAR and SHP1 enzymes with IC₅₀ of 7.3, 5.7, 7.6, >50, 4.9 μg/mL, respectively .

HY-132578

M5N36	Phosphatase	Cancer
M5N36 is a potent and selective *Cdc25C* inhibitor with IC₅₀ values of 0.15, 0.19, 0.06 µM for Cdc25A, Cdc25B, Cdc25C, respectively. M5N36 shows anti-proliferative activity and increases the expression of p-CDK1 and p-CDK2 .

HY-135457

JMS-053 1 Publications Verification	Phosphatase	Cancer
JMS-053 is a potent, selective and reversible PTP4A inhibitor, with IC₅₀s of 29.1 nM, 48.0 nM, 34.7 nM, 92.6 nM, and 207.6 nM for PTP4A1, PTP4A2, PTP4A3, *CDC25B, and DUSP3*, respectively. JMS-053 can inhibit cancer cell migration and spheroid growth in vitro, attenuate in vivo ovarian tumor growth .

HY-128769

M2N12	CDK	Cancer
M2N12 is a potent and highly selective cell division cycle 25C protein phosphatase (Cdc25C) inhibitor with an IC₅₀ value of 0.09  μM. M2N12 also has promising activity against Cdc25A and Cdc25B with IC₅₀ values of  0.53  μM and 1.39 μM, respectively. M2N12 has anti-tumor activity and can be used for cancer research .

HY-118529

JUN-1111	Phosphatase	Cancer
JUN-1111 is an irreversible and selective Cdc25 phosphatase inhibitor with IC₅₀ values of 0.38, 1.8, 0.66, 28, 37 µM for Cdc25A, Cdc25B, Cdc25C, VHR, PTP1B, respectively. JUN-1111 induces cell cycle arrest at G1 and G2/M phases. JUN-1111 decreases the expression of phosphoCdk1 .

HY-137990

Questin	Bacterial Parasite Phosphatase	Infection Cancer
Questin is an anthraquinone compound and antibacterial agent. Questin can be isolated from marine-derived fungi and plants. Questin inhibits *Cdc25B* phosphatase. Questin exhibits antibacterial activity against V. harveyi, V. anguillarum, V. cholerae, and V. parahemolyticus with MIC values of 31.25 µg/mL, 62.5 µg/mL, 62.5 µg/mL, and 125 µg/mL. Questin displays antiprotozoal activity against the animal protozoan pathogen Tritrichomonas foetus, with a MIC of 12.5 µg/mL. Questin has anticancer activity against lung and colon cancer .

HY-172807

p38α-IN-9	p38 MAPK MAPKAPK2 (MK2) CDK Wee1	Cancer
p38α-IN-9 (Compound 2015) is a p38α inhibitor and blocks p38α’s enzymatic activity with an IC₅₀ lower than 20 nM. p38α-IN-9 inhibits MK2 ^T334 phosphorylation. p38α-IN-9 activates Cdc25b and Cdc25c and simultaneously inactivates Wee1, leading to mitotic catastrophe, aneuploidy or polyploidy and DNA damage. p38α-IN-9 Inhibits colorectal cancer (CRC) metastasis .

HY-175033

BRD4-IN-11	Epigenetic Reader Domain Phosphatase c-Myc Apoptosis	Inflammation/Immunology
BRD4-IN-11 is an orally active and selective BRD4 inhibitor (IC₅₀ = 26.35 nM (BD1), IC₅₀ = 72.81 nM (BD2)). BRD4-IN-11 is approximately 3- to 18-fold more potent against BRD4 than against BRr2, BRD3, and BRDT. BRD4-IN-11 enhances H2S release and inhibits the upregulation of fibrotic markers (α-SMA and fibronectin), c-Myc, and CDC25B. BRD4-IN-11 reduces apoptosis in LO2 hepatocytes. BRD4-IN-11 significantly improves liver and lung function in a hepatopulmonary fibrosis model and can be used to study hepatopulmonary fibrosis .

HY-121065

BN-82685 IRC-083065	Phosphatase	Cancer
BN-82685 is a a quinone-based *CDC25* inhibitor with IC₅₀ of 201 nM, 117 nM, 109 nM, 160 nM, 249 nM, for CDC25C, CDC25C-cat, CDC25A, CDC25B2, CDC25B3, respectively. BN-82685 plays an important role in cancer research .

HY-112776

BN82002	Phosphatase	Cancer
BN82002 is a potent, selective and irreversible inhibitor of CDC25 phosphatase family. BN82002 inhibits CDC25A, CDC25B2, CDC25B3, CDC25C CDC25A, and 25C-cat with IC₅₀ values of 2.4, 3.9, 6.3, 5.4, and 4.6 µM, respectively. BN82002 displays ~20-fold greater selectivity over CD45 tyrosine phosphatase .

HY-112776A

BN82002 hydrochloride 1 Publications Verification	Phosphatase	Cancer
BN82002 hydrochloride is a potent, selective and irreversible inhibitor of CDC25 phosphatase family. BN82002 hydrochloride inhibits CDC25A, CDC25B2, CDC25B3, CDC25C CDC25A, and 25C-cat with IC₅₀ values of 2.4, 3.9, 6.3, 5.4, and 4.6 µM, respectively. BN82002 hydrochloride displays ~20-fold greater selectivity over CD45 tyrosine phosphatase .

HY-W102931

6,7-Dichloroquinoline-5,8-dione	Phosphatase	Cancer
6,7-Dichloroquinoline-5,8-dione (compound DA3002) is a potent *CDC25B2* inhibitor with an IC₅₀ value of 4.6 µM. 6,7-Dichloroquinoline-5,8-dione has the potential for the research of cancer .

Questin	Structural Classification Classification of Application Fields Marine natural products Source classification Endogenous metabolite Infection Quinones Human Gut Microbiota Metabolites Microorganisms Anthraquinones Phenols Polyphenols Marine microorganism Disease Research Fields	Bacterial Parasite Phosphatase
Questin is an anthraquinone compound and antibacterial agent. Questin can be isolated from marine-derived fungi and plants. Questin inhibits *Cdc25B* phosphatase. Questin exhibits antibacterial activity against V. harveyi, V. anguillarum, V. cholerae, and V. parahemolyticus with MIC values of 31.25 µg/mL, 62.5 µg/mL, 62.5 µg/mL, and 125 µg/mL. Questin displays antiprotozoal activity against the animal protozoan pathogen Tritrichomonas foetus, with a MIC of 12.5 µg/mL. Questin has anticancer activity against lung and colon cancer .

Cryptosporioptide A	Structural Classification Flavonoids Microorganisms Source classification Other Flavonoids	Phosphatase SHP1
Cryptosporioptide A (Compound 3) is a pigment protein tyrosine phosphatase inhibitor derived from the insect-parasitic fungus Cordyceps gracilioides. Cryptosporioptide A inhibits PTP1B, SHP2, CDC25B, LAR and SHP1 enzymes with IC₅₀ of 7.3, 5.7, 7.6, >50, 4.9 μg/mL, respectively .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80072

	Cdc25B Antibody (YA520)	WB, IP	Human
	Cdc25B Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 65 kDa, targeting to Cdc25B. It can be used for WB,IP assays with tag free, in the background of Human.

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Cdc25b Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Cdc25b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cdc25b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

CDC25B Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CDC25B Human Pre-designed siRNA Set A contains three designed siRNAs for CDC25B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cdc25b Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Cdc25b Rat Pre-designed siRNA Set A contains three designed siRNAs for Cdc25b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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