CD123

By Targets:	ADC Antibody (1) CD3 (2) Interleukin Related (4) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (5) Inflammation/Immunology (2)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99234

Pivekimab	Interleukin Related ADC Antibody	Cancer
Pivekimab is a human IgG1 monoclonal antibody that targets interleukin-3 (IL-3) and CD123. Pivekimab is used to synthesize pivekimab sunirine, a CD123-directed antibody-active molecule conjugate (ADC). Pivekimab is used in the study of blastic plasmacytoid dendritic cell neoplasm (BPDCN) .

HY-P99521

Vibecotamab XmAb14045	CD3	Inflammation/Immunology Cancer
Vibecotamab (XmAb14045) is a potent bispecific antibody targeting both *CD123* and CD3. Vibecotamab targets T cell-mediated killing of CD123-expressing cells, regardless of T cell antigen specificity. Vibecotamab is a full length immunoglobulin molecule. Vibecotamab can be studied in research for diseases such as Myelodysplastic syndrome and acute myeloid leukemia. Recommend Isotype Control: half-IG G1-kappa/(scFv-heavy-lambda)-h-CH2-CH3 .

HY-P99395

Talacotuzumab 1 Publications Verification JNJ 56022473; CSL 362	Interleukin Related	Cancer
Talacotuzumab (JNJ 56022473; CSL 362) is an IgG1-type fully humanized, *CD123*-neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has K_Ds of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models .

HY-P99623

Flotetuzumab MGD006; S80880	CD3	Cancer
Flotetuzumab (MGD006; S80880) is an investigational *CD123/CD3* bispecific dual-affinity retargeting antibody (DART) molecule. Flotetuzumab reactivates T cells by simultaneously binding to *CD123* in target cells and CD3 in effector T cells, leading to T-cell-mediated cytotoxicity in target cells. Flotetuzumab shows inhibitory effect on a mouse model of patient-derived xenograft (PDX) in acute myeloid leukemia (AML) .

HY-P990451

*Anti-IL-3Ra/CD123* Antibody (SNG-CD123A)** SNG-CD123A	Interleukin Related	Inflammation/Immunology
Anti-IL-3Ra/CD123 Antibody (SNG-CD123A) is a CHO-expressed human antibody that targets *IL-3Ra/CD123. The predicted molecular weight (MW) of Anti-IL-3Ra/CD123* Antibody (SNG-CD123A) is 146.14 kDa. The isotype control for Anti-IL-3Ra/CD123 Antibody (SNG-CD123A) can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991282

KHK2823	Interleukin Related	Cancer
KHK2823 is a humanized monoclonal anti-human CD123/IL3RA antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001). KHK2823 can be used in research related to leukemia .

HY-RS06764

IL3RA Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL3RA Human Pre-designed siRNA Set A contains three designed siRNAs for IL3RA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL3RA Human Pre-designed siRNA Set A IL3RA Human Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area

HY-P99234

Pivekimab	Interleukin Related ADC Antibody	Cancer
Pivekimab is a human IgG1 monoclonal antibody that targets interleukin-3 (IL-3) and CD123. Pivekimab is used to synthesize pivekimab sunirine, a CD123-directed antibody-active molecule conjugate (ADC). Pivekimab is used in the study of blastic plasmacytoid dendritic cell neoplasm (BPDCN) .

HY-P99521

Vibecotamab XmAb14045	CD3	Inflammation/Immunology Cancer
Vibecotamab (XmAb14045) is a potent bispecific antibody targeting both *CD123* and CD3. Vibecotamab targets T cell-mediated killing of CD123-expressing cells, regardless of T cell antigen specificity. Vibecotamab is a full length immunoglobulin molecule. Vibecotamab can be studied in research for diseases such as Myelodysplastic syndrome and acute myeloid leukemia. Recommend Isotype Control: half-IG G1-kappa/(scFv-heavy-lambda)-h-CH2-CH3 .

HY-P99395

Talacotuzumab 1 Publications Verification JNJ 56022473; CSL 362	Interleukin Related	Cancer
Talacotuzumab (JNJ 56022473; CSL 362) is an IgG1-type fully humanized, *CD123*-neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has K_Ds of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models .

HY-P99623

Flotetuzumab MGD006; S80880	CD3	Cancer
Flotetuzumab (MGD006; S80880) is an investigational *CD123/CD3* bispecific dual-affinity retargeting antibody (DART) molecule. Flotetuzumab reactivates T cells by simultaneously binding to *CD123* in target cells and CD3 in effector T cells, leading to T-cell-mediated cytotoxicity in target cells. Flotetuzumab shows inhibitory effect on a mouse model of patient-derived xenograft (PDX) in acute myeloid leukemia (AML) .

HY-P990451

*Anti-IL-3Ra/CD123* Antibody (SNG-CD123A)** SNG-CD123A	Interleukin Related	Inflammation/Immunology
Anti-IL-3Ra/CD123 Antibody (SNG-CD123A) is a CHO-expressed human antibody that targets *IL-3Ra/CD123. The predicted molecular weight (MW) of Anti-IL-3Ra/CD123* Antibody (SNG-CD123A) is 146.14 kDa. The isotype control for Anti-IL-3Ra/CD123 Antibody (SNG-CD123A) can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991282

KHK2823	Interleukin Related	Cancer
KHK2823 is a humanized monoclonal anti-human CD123/IL3RA antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001). KHK2823 can be used in research related to leukemia .

Recombinant Proteins Recommended:

CD123

Species:	Human (7) Mouse (2) Cynomolgus (1) Canine (1)
Tag:	His (6) Avi (3) Fc (4)
Source:	HEK293 (11)

Cat. No.	Compare	Product Name	Species	Source

HY-P70461

	*IL-3R alpha/CD123* Protein, Cynomolgus (HEK293, His)** Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA; CD123	Cynomolgus	HEK293
	IL-3R α/CD123 protein is an important member of the type I cytokine receptor family and mediates cellular responses to a variety of cytokines, emphasizing its key role in hematopoiesis and immune regulation. IL-3R alpha/CD123 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-3R alpha/CD123 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70468

	*IL-3R alpha/CD123* Protein, Human (HEK293, His)** Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA; CD123	Human	HEK293
	FITC-tagged IL-3R α/CD123 is a cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes, and B lymphocytes, regulating their production and differentiation. IL-3R alpha/CD123 Protein, Human (HEK293, His) is the recombinant human-derived IL-3R alpha/CD123 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P78634

	*IL-3R alpha/CD123* Protein, Canine (HEK293, His)** IL3R; IL3RA; IL-3Ra; IL-3R-alpha; IL3RAY; IL3RX; IL3RY; CD123 antigen; CD123; hIL3Ra; hIL-3Ra; MGC34174; IL-3 R alpha	Canine	HEK293
	IL-3R α/CD123 protein is an important member of the type I cytokine receptor family and mediates cellular responses to a variety of cytokines, emphasizing its key role in hematopoiesis and immune regulation.IL-3R alpha/CD123 Protein, Canine (HEK293, His) is the recombinant canine-derived IL-3R alpha/CD123 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P700747

	*IL-3R alpha/CD123* Protein, Human (Biotinylated, HEK293, His-Avi)** CD123; IL-3R subunit alpha; IL3R; IL3RA; IL-3Ra; IL3RAY; IL3RX; IL3RY; MGC34174; IL-3 R alpha	Human	HEK293
	FITC-tagged IL-3R α/CD123 is a cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes, and B lymphocytes, regulating their production and differentiation. IL-3R alpha/CD123 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IL-3R alpha/CD123 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P72542

	*IL-3R alpha/CD123* Protein, Mouse (HEK293, His)** Interleukin-3 receptor subunit alpha; IL-3R-alpha; IL-3RA; CD123; Sut-1	Mouse	HEK293
	IL-3R alpha/CD123 protein, a receptor for IL3, is expressed on hematopoietic cells and governs their production and differentiation. Upon ligand binding, it heterodimerizes with IL3RB, activating JAK2 and PI3K. This activation leads to cell proliferation and differentiation, mediated by STAT5. IL-3R alpha interacts with IL3 and forms heterodimers with alpha and beta subunits, contributing to hematopoietic cell development. IL-3R alpha/CD123 Protein, Mouse (HEK293, His) is the recombinant mouse-derived IL-3R alpha/CD123 protein, expressed by HEK293 , with C-8*His labeled tag.

HY-P75862

	*IL-3R alpha/CD123* Protein, Mouse (HEK293, Fc)** Interleukin-3 receptor subunit alpha; IL-3R-alpha; IL-3RA; CD123; Sut-1	Mouse	HEK293
	IL-3R alpha/CD123 protein, a receptor for IL3, is expressed on hematopoietic cells and governs their production and differentiation.Upon ligand binding, it heterodimerizes with IL3RB, activating JAK2 and PI3K.This activation leads to cell proliferation and differentiation, mediated by STAT5.IL-3R alpha interacts with IL3 and forms heterodimers with alpha and beta subunits, contributing to hematopoietic cell development.IL-3R alpha/CD123 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IL-3R alpha/CD123 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72349

	*IL-3R alpha/CD123* Protein, Human (Biotinylated, HEK293, Fc-Avi)** Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunitalpha; IL-3R-alpha; IL-3RA; CD123	Human	HEK293
	FITC-tagged IL-3R α/CD123 is a cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes, and B lymphocytes, regulating their production and differentiation. IL-3R alpha/CD123 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived IL-3R alpha/CD123 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.

HY-P701285

	*FITC-Labeled IL-3R alpha/CD123* Protein, Human (HEK293, His)** IL3R; IL3RA; IL-3Ra; IL-3R-alpha; IL3RAY; IL3RX; IL3RY; CD123 antigen; CD123; hIL3Ra; hIL-3Ra; MGC34174; IL-3 R alpha	Human	HEK293
	FITC-tagged IL-3R α/CD123 is a cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes, and B lymphocytes, regulating their production and differentiation. FITC-Labeled IL-3R alpha/CD123 Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled IL-3R alpha/CD123 protein, expressed by HEK293 , with His labeled tag.

HY-P704715

	*IL-3R alpha/CD123* Protein, Human (HEK293, Fc)** Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA; CD123	Human	HEK293
	FITC-tagged IL-3R α/CD123 is a cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes, and B lymphocytes, regulating their production and differentiation. IL-3R alpha/CD123 Protein, Human (HEK293, Fc) is the recombinant human-derived IL-3R alpha/CD123 protein, expressed by HEK293, with C-hFc labeled tag.

HY-P704299

	*IL-3R alpha/CD123* Protein, Human (HEK293, Llama Fc)** Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA; CD123	Human	HEK293
	FITC-tagged IL-3R α/CD123 is a cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes, and B lymphocytes, regulating their production and differentiation. IL-3R alpha/CD123 Protein, Human (HEK293, Llama Fc) is the recombinant human-derived IL-3R alpha/CD123 protein, expressed by HEK293, with C-Llama Fc labeled tag.

HY-P705046

	*IL-3R alpha/CD123* Protein, Human (Biotinylated, HEK293, Avi)** CD123; IL-3R subunit alpha; IL3R; IL3RA; IL-3Ra; IL3RAY; IL3RX; IL3RY; MGC34174; IL-3 R alpha	Human	HEK293

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HY-P81713

	CD123 Antibody (YA1458) IL3RA; IL3R; Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA; CD123	FC, ELISA	Human
	CD123 Antibody (YA1458) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1458), targeting CD123. CD123 Antibody (YA1458) can be used for FC, ELISA experiment in human background.

HY-P84958

	CD123 Antibody (YA4650) C10orf7 antibody; CD123_HUMAN antibody; CDC123 antibody; Cell division cycle 123 antibody; Cell division cycle 123 homolog antibody; Cell division cycle protein 123 homolog antibody; D123 antibody; HT 1080 antibody; HT-1080 antibody; Protein D123 antibody; PZ32 antibody
	CD123 Antibody (YA4650) is a non-conjugated antibody, targeting to CD123.

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Cat. No.	Product Name		Classification

HY-RS06764

IL3RA Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IL3RA Human Pre-designed siRNA Set A contains three designed siRNAs for IL3RA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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