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Results for "

CAL

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Angiotensin-converting Enzyme (ACE) (1) Apoptosis (2) Autophagy (2) CFTR (2) Chemerin Receptor (1) Chloride Channel (1) Endogenous Metabolite (1) HDAC (3) Influenza Virus (1) Molecular Glues (1) Monocarboxylate Transporter (1) Mps1 (1) Neprilysin (1) Parasite (1) PI3K (6) Proteasome (1)
By Research Areas:	Cancer (13) Cardiovascular Disease (2) Endocrinology (2) Infection (2) Inflammation/Immunology (2) Neurological Disease (1)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16122B

CAL-130 Hydrochloride	PI3K	Cancer
CAL-130 is a PI3Kδ and PI3Kγ inhibitor with IC₅₀s of 1.3 and 6.1 nM, respectively.

HY-13026

Idelalisib 40+ Cited Publications CAL-101; GS-1101	PI3K Autophagy	Cancer
Idelalisib (CAL-101; GS-1101) is a highly selective and orally bioavailable p110δ inhibitor with an IC₅₀ of 2.5 nM, showing 40- to 300-fold selectivity for p110δ over other PI3K class I enzymes.

HY-12644

Acalisib 1 Publications Verification GS-9820; CAL-120	PI3K	Cancer
Acalisib is a potent and selective PI3Kδ inhibitor with an IC₅₀ of 12.7 nM.

HY-13026S

Idelalisib-d5 CAL-101 d₅; GS-1101 d₅	PI3K Autophagy	Cancer
Idelalisib-d₅ is a deuterium labeled Idelalisib. Idelalisib is a highly selective and orally bioavailable p110δ inhibitor .

HY-126536

ChemR23-IN-1	Chemerin Receptor	Inflammation/Immunology
ChemR23-IN-1 (compound 2) is a ChemR23 inhibitor with IC₅₀s of 38 nM and 100 nM for human and mouse ChemR23, respectively. ChemR23-IN-1 inhibits chemotaxis of CAL-1 triggered by Chemerin in vitro .

HY-16122

CAL-130 Racemate	PI3K	Cancer
CAL-130 Racemate is the racemate of CAL-130. CAL-130 Racemate is a PI3Kδ inhibitor.

HY-P991498

CAL-203	Influenza Virus	Infection
CAL-203 is a human monoclonal antibody (mAb) targeting F, Fusion glycoprotein F0. CAL-203 can be used in respiratory tract infections research.

HY-16122A

CAL-130	PI3K	Cancer
CAL-130 is a PI3Kδ and PI3Kγ inhibitor with IC₅₀s of 1.3 and 6.1 nM, respectively.

HY-115753

Calpain Inhibitor-1	Proteasome	Neurological Disease
Calpain Inhibitor-1 (compound 36) is a potent and selective cysteine protease calpain 1 (Cal1) inhibitor (IC₅₀=100 nM; K_i=2.89 μM) .

HY-P10806

kCAL01	CFTR	Endocrinology
kCAL01 is a *CAL* inhibitor with a K_i value of 2.3 μM. kCAL01 is promising for research of cystic fibrosis (CF) .

HY-157401

HDAC6-IN-29	HDAC Apoptosis	Cancer
HDAC6-IN-29 (compound 11g), hydroxamic analogue, is a HDAC6 inhibitor. HDAC6-IN-29 has potent antiproliferative activity against CAL-51 cells (IC₅₀ = 1.17 μM) and is able to induce apoptosis and cause accumulation of cells in the S phase of the cell cycle. HDAC6-IN-29 can be used for the research of cancer .

HY-162533

GSPT1 degrader-4	Molecular Glues	Cancer
GSPT1 degrader-4 (3) is a GSPT1 molecule glue (DC₅₀ of 25.4 nM), with an IC₅₀ of 39 nM for CAL51 proliferation .

HY-P10226

PGD97	Chloride Channel CFTR	Endocrinology
PGD97 is a selective cyclic peptide inhibitor against *CAL/CFTR* interactions, with a K_D value of 6 nM towards the CAL PDZ domain for its desulfide cyclized form. PGD97 (desulfide cyclized form) has selectivity ≥ 130-fold compared to NHERF1/2 PDZ domains. PGD97 is capable of stabilizing F508del-CFTR at the cell membrane and improving CFTR function required for proper fluid homeostasis in tne lung. PGD97 can be used for the research of cystic fibrosis .

HY-173064

DS-103	HDAC Parasite	Infection Cancer
DS-103 is an inhibitor for HDAC that inhibits HDAC1, HDAC2, HDAC3, HDAC6 and HDAC8 with IC₅₀s of 0.029, 0.123, 0.022, 0.367 and 9.26 μM, respectively. DS-103 inhibits Plasmodium falciparum 3D7 with IC₅₀ of 5.08 μM. DS-103 exhibits cytotoxicity in cells A2780 and Cal27 with IC₅₀ of 1.48 μM and 1.47 μM, reverses Cisplatin (HY-17394) resistance in A2780 and Cal27 with IC₅₀ of 4.62 μM and 2.23 μM. DS-103 exhibits synergistic effect with Cisplatin (HY-17394), enhances Cisplatin-induced apoptosis .

HY-W704079

1-Stearoyl-sn-glycerol MG(18:0/0:0/0:0); L-(+)-1-Monostearin; 1-Octadecanoyl-sn-glycerol	Endogenous Metabolite	Cardiovascular Disease
1-Stearoyl-sn-glycerol is (MG(18:0/0:0/0:0); L-(+)-1-Monostearin; 1-Octadecanoyl-sn-glycerol) is a monoglyceride and also a metabolite found in plasma, which can be used in metabolomic analysis of plasma for coronary artery lesions (CAL) .

HY-170843

Antitumor agent-198	Apoptosis	Cancer
Antitumor agent-198 (Compound A3) exhibits cytotoxicity in head and neck squamous cell carcinoma (HNSCC) cells, that inhibits the proliferation of CAL27, HN6, HN30, SCC9 and SCC25 with IC₅₀ of 4 nM-77 nM. Antitumor agent-198 inhibits the HNSCC cell migration, arrests the cell cycle, and induces apoptosis .

HY-155382

Lactate transportor 1	Monocarboxylate Transporter	Others Cancer
Lactate transportor 1 (compound 1) is an active lactate transporter in living cells. Lactate transportor 1 displays the cytotoxic effect, with IC₅₀ values of 3.36, 3.27,5.58 and 7.66 μM in Hela, CAL27, MCF7 and MCF10A, respectively. Lactate transportor 1 has an additive effect with Cisplatin (HY-17394) observed in HeLa cells .

HY-169923

HDAC-IN-83	HDAC	Cancer
HDAC-IN-83 (compound 9D) is an inhibitor of deacetylases (HDACs) (IC₅₀=0.01 μM/0.44 μM HDAC1/HDAC6) with anticancer, antiproliferative and caspase 3/7 activation activities. HDAC-IN-83 inhibits Cal27, HepG2 and MRC-5 with IC_{50_{s of 0.693 μM, 0.427 μM and 3.19 μM, respectively .}}

HY-12862

Mps1-IN-7	Mps1	Cancer
Mps1-IN-7 is a potent MPS1 inhibitor (IC₅₀ of 0.020 μM) over JNK1 and JNK2 (JNK1 IC₅₀= 0.11 μM, JNK2 IC₅₀=0.22 μM). Mps1-IN-7 inhibit SW620, CAL51, Miapaca-2, RMG1 cell growth with GI₅₀ values of 0.065, 0.068, 0.25, and 0.110 μM,respectively .

HY-123348

Sampatrilat UK-81252	Angiotensin-converting Enzyme (ACE) Neprilysin	Cardiovascular Disease Inflammation/Immunology
Sampatrilat (UK-81252) is a potent and orally active vasopeptidase inhibitor of ACE and neutral endopeptidase (NEP). Sampatrilat inhibits C-domain ACE (K_i=13.8 nM) 12.4-fold more potent than that for the N-domain (K_i=171.9 nM). Sampatrilat (UK-81252) can be used for the study of chronic heart failure and blood pressure regulation .

Cat. No.	Product Name	Target	Research Area

HY-P10806

kCAL01	CFTR	Endocrinology
kCAL01 is a *CAL* inhibitor with a K_i value of 2.3 μM. kCAL01 is promising for research of cystic fibrosis (CF) .

HY-P10226

PGD97	Chloride Channel CFTR	Endocrinology
PGD97 is a selective cyclic peptide inhibitor against *CAL/CFTR* interactions, with a K_D value of 6 nM towards the CAL PDZ domain for its desulfide cyclized form. PGD97 (desulfide cyclized form) has selectivity ≥ 130-fold compared to NHERF1/2 PDZ domains. PGD97 is capable of stabilizing F508del-CFTR at the cell membrane and improving CFTR function required for proper fluid homeostasis in tne lung. PGD97 can be used for the research of cystic fibrosis .

Cat. No.	Product Name	Target	Research Area

HY-P991498

CAL-203	Influenza Virus	Infection
CAL-203 is a human monoclonal antibody (mAb) targeting F, Fusion glycoprotein F0. CAL-203 can be used in respiratory tract infections research.

Species:	Human (2) Mouse (1)
Tag:	His (3)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P73708

	PIST Protein, Human (His) Golgi-associated PDZ and coiled-coil motif-containing protein; PIST; GOPC; CAL; FIG	Human	E. coli
	PIST (PDZ domain-containing protein that interacts with Stx6) is critical in intracellular protein trafficking and degradation. It modulates CFTR chloride currents and acid-induced ASIC3 currents, thereby potentially regulating their cell surface expression. PIST Protein, Human (His) is the recombinant human-derived PIST protein, expressed by E. coli , with N-His labeled tag.

HY-P74586

	S100A10 Protein, Human (His) Protein S100-A10; p11; S100A10; ANX2LG; CAL1L; CLP11	Human	E. coli
	S100A10 Protein is pivotal in modulating protein phosphorylation by promoting ANXA2/p36 dimerization. The ANXA2 monomer is the favored substrate for tyrosine-specific kinase activity in vitro. A heterotetramer, composed of S100A10/p11 and ANXA2/p36, highlights intricate regulatory dynamics. This interaction landscape includes SCN10A and TASOR, showcasing S100A10's multifaceted involvement in cellular processes. S100A10 Protein, Human (His) is the recombinant human-derived S100A10 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P77561

	Annexin A2/ANXA2 Protein, Mouse (His) Chromobindin-8; Lipocortin II; PAP-IV; ANX2; ANX2L4; CAL1H; LPC2D; ANXA2; Annexin A2; Annexin II; LIP2PAP-IV; LPC2D; LPC2DP36; p36	Mouse	E. coli
	Annexin A2/ANXA2 protein is a calcium-regulated membrane-binding protein that binds two calcium ions. Annexin A2/ANXA2 Protein, Mouse (His) is the recombinant mouse-derived Annexin A2/ANXA2 protein, expressed by E. coli , with N-His labeled tag.

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Idelalisib-d5
Idelalisib-d₅ is a deuterium labeled Idelalisib. Idelalisib is a highly selective and orally bioavailable p110δ inhibitor .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80889

	S100A10 Antibody (YA675) S100A10; 42C; ANX2L; ANX2LG; CAL1L; CLP11; Ca[1]; GP11; P11; p10	WB, ICC/IF, IP	Human, Mouse, Rat
	S100A10 Antibody (YA675) is a non-conjugated and Mouse origined monoclonal antibody about 11 kDa, targeting to S100A10 (6F4). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P84191

	CALB2 Antibody (YA3888) CR; CAL2; CAB29	WB, FC, ELISA	Human, Monkey

HY-P81902

	PIST Antibody (YA1647) GOPC; CAL; CFTR-associated ligand; GOPC1; FIG; PIST	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse
	PIST Antibody (YA1647) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1647), targeting PIST, with a predicted molecular weight of 51 kDa (observed band size: 51 kDa). PIST Antibody (YA1647) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse background.

HY-P82966

	Annexin 2 Antibody (YA2711) ANXA2; ANX2; ANX2L4; CAL1H; LPC2D; Annexin A2; Annexin II; Annexin-2; CALpactin I heavy chain; CALpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; PAP-IV; Protein I; p36	WB, IP	Human
	Annexin 2 Antibody (YA2711) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2711), targeting Annexin 2, with a predicted molecular weight of 39 kDa (observed band size: 39 kDa). Annexin 2 Antibody (YA2711) can be used for WB, IP experiment in human background.

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